---
title: 'Oversight Director, Clinical Operations at Maze Therapeutics'
canonical: 'https://feeny.ai/job/oversight-director-clinical-operations-maze-therapeutics-south-san-francisco-qxwr1q6bq364'
type: 'job'
last_seen: '2026-09-13'
---

# Oversight Director, Clinical Operations at Maze Therapeutics

- **Company:** Maze Therapeutics
- **Location:** South San Francisco, CA
- **Posted:** 2026-08-04
- **Last confirmed live:** 2026-09-13
- **Apply:** http://www.mazetx.com/careers/?gh_jid=8659934002

## Job description

The Position

At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As an Oversight Director, Clinical Operations supporting an asset spanning our CKD and PKU portfolio, you will provide strategic and operational direction across the full development lifecycle. You will be responsible for the successful execution of multiple studies within your assigned program, ensuring high-quality clinical trials are delivered on time, within budget, and in accordance with quality and regulatory expectations.

Working closely with the Clinical Science Lead, you will partner in guiding the Clinical Development Sub-Team, providing strategic direction and operational oversight to advance the development program. You will support and develop Study Leads and Clinical Operations team members, establish and oversee CRO and vendor strategies, and maintain accountability for study execution, operational risk management, resource planning, financial oversight, and inspection readiness across your assigned asset.

In partnership with the Head of Clinical Operations, you will help shape the operational strategy for your development program, contribute to key development planning, and build cross-functional alignment to enable successful execution from early development through pivotal studies. This role requires a highly collaborative professional who can anticipate challenges, provide thoughtful recommendations, and work effectively across the organization to advance innovative therapies for patients. If you thrive in a fast-paced biotech environment, enjoy developing high-performing teams, and are passionate about operational excellence, this role offers the opportunity to make a meaningful impact on the success of our clinical development programs.

The Impact You’ll Have

- Clinical Development & Portfolio Collaboration
- Provide strategic and operational direction across an assigned development asset spanning CKD and PKU clinical programs, ensuring alignment between clinical development strategy and operational execution from protocol development through study closeout and regulatory readiness.
- Serve as the Clinical Operations representative on Program Core Teams, providing strategic operational expertise to support asset-level development planning and decision processes.
- Partner with the Clinical Science Lead to guide the Clinical Development Sub-Team, fostering cross-functional collaboration, proactive risk management, and timely, informed decisions.
- Responsible for the successful operational execution of key program milestones (e.g., FPI, enrollment completion, interim analyses, database lock, CSR, regulatory submissions) across all studies within the asset.
- Study Execution Oversight:
- Provide oversight of multiple clinical studies across the assigned asset, ensuring consistent execution, quality, timelines, and operational excellence from early through late-stage development.
- Establish and oversee program-level enrollment, feasibility, country, and site strategies using data-informed forecasting and proactive risk mitigation.
- Anticipate operational risks and facilitate cross-functional problem-solving to maintain program objectives and timelines.
- Vendor, CRO & Site Management
- Develop and oversee CRO and vendor strategies, including partner selection, governance, performance management, and escalation pathways.
- Oversee and support strategic discussions with CROs and key vendors regarding budgets, work orders, change orders, and Master Service Agreements.
- Serve as the senior operational escalation point for CRO, vendor, and critical site performance issues.
- Budget & Financial Oversight
- Maintain accountability for Clinical Operations budgets across the assigned asset, ensuring accurate forecasting, financial stewardship, and alignment with program objectives.
- Partner with stakeholders to ensure effective resource planning and operational capacity across all studies within the asset.
- Support, coach, and develop Clinical Operations team members, fostering a high-performing and inclusive organization while building future capability.
- Data Quality, Compliance & Regulatory Readiness
- Ensure all studies maintain a continuous state of inspection readiness in partnership with Quality Assurance and cross-functional teams
- Oversee operational compliance with SOPs, ICH-GCP, applicable regulatory requirements, and internal quality standards.
- Foster a culture of quality and proactive issue identification, escalation, and resolution.
- Process Optimization & Technology Implementation
- Partner with the Head of Clinical Operations to advance scalable processes, operational best practices, and organizational capabilities.
- Encourage and support the adoption of new technologies and data-informed approaches (e.g., RBM, advanced data insights, AI/ML-enabled solutions) to enhance trial efficiency and decision quality.
- Oversee the implementation of enterprise Clinical Operations systems and tools (e.g., eTMF, CTMS, RBM platforms) that enhance operational effectiveness.
- Cross-functional Collaboration
- Collaborate closely with Clinical Science, Regulatory Affairs, Data Science, Pharmacovigilance, Biometrics, Medical Monitoring, Clinical Supply, CMC, Tech Ops, Finance, and other cross-functional partners to influence asset strategy and drive successful program execution.
- Build alignment across functions, effectively influence decision-making, and ensure operational considerations are integrated into asset-level development strategies.

Leadership Competencies

As a Director, we also expect our leaders to demonstrate the following Leadership Competencies:

- Communication and Influence
- Builds communication channels across Maze for sharing information
- Influences Senior Management decisions through persuasive arguments
- Respectfully addresses differing opinions leading to support of decision
- Teamwork and Collaboration
- Champions partnerships and connections across Maze
- Proactively addresses issues that could result in breakdown of team relationships
- Spotlights team and individual contributions in public forums
- Execution and Results
- Addresses gaps and leverages strengths to get best results
- Maintains a steadying presence and clarifies priorities during change
- Anticipates and removes barriers that put functional/corporate goals at risk
- Develop Others and Self
- Removes barriers to staff development and empowers them to make their own decisions
- Stays current on industry trends and keeps direct-reports prepared and responsive

## What We’re Looking For

You might be the right fit for this role if you have:

- A Bachelor’s degree in a scientific or health-related field with 12–15+ years of progressive clinical operations experience, including leadership of global Phase I–III clinical trials and oversight of one or more development assets.
- Demonstrated success providing operational direction across multiple studies within a development program, driving strategy, execution, and delivery of key program milestones.
- Proven experience guiding and developing high-performing Clinical Operations teams, including direct management, coaching, and mentoring of Study Leads and other Clinical Operations professionals
- Deep expertise in global clinical trial operations, including FDA, EMA, ICH-GCP, and other applicable regulatory requirements, with a strong track record of maintaining inspection readiness.
- Extensive experience developing and overseeing CRO and vendor partnerships, including governance, performance management, contract negotiations, and budget accountability.
- Strong financial acumen with experience managing large, complex clinical trial budgets, forecasting, and resource planning.
- Demonstrated ability to identify operational risks, facilitate cross-functional problem-solving, and contribute to strategic planning in a fast-paced development environment.
- Experience building scalable processes, implementing operational best practices, and contributing to organizational growth within a biotech or similarly dynamic environment.
- Excellent communication, collaboration, and relationship-building skills, with the ability to build trust, foster alignment, and work effectively across all levels of the organization, including senior leadership and external partners.
- Willingness to travel up to 30% to support study needs.

## About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $232,000 - $283,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

#LI-Hybrid

## About Maze Therapeutics

## Company Overview
- **One-liner**: Maze Therapeutics is a clinical-stage biopharmaceutical company developing small molecule precision medicines for common diseases, primarily kidney disease, by leveraging human genetics and its proprietary Compass platform.
- **Entity Type**: Public (NASDAQ: MAZE)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2018
- **Founders**: Not publicly listed as individual founders; the company was established by a team of geneticists and industry veterans.

## Core Business
- **Primary industry/industries**: Biotechnology / Biopharmaceuticals (Precision Medicine)
- **Target customers**: B2B (partners and investors), B2C (patients with APOL1-mediated kidney disease, chronic kidney disease, and phenylketonuria)
- **Mission or purpose statement**: "Harnessing the power of genetics to transform the lives of patients" by translating genetic insights into effective precision medicines.

## Products & Services
- **MZE829 (Lead Program)**: An oral, small molecule, dual-mechanism APOL1 inhibitor for the treatment of APOL1-mediated kidney disease (AMKD). Recently reported positive topline Phase 2 HORIZON trial data.
- **MZE782 (SLC6A19 Inhibitor)**: A precision medicine in development for chronic kidney disease (CKD) and phenylketonuria (PKU), currently in clinical trials.
- **Maze Compass™ Platform**: A proprietary platform that leverages variant functionalization to link genetic variants to disease pathways, enabling the discovery and design of precision medicines.
- **Other Pipeline Programs**: Several additional programs in drug discovery targeting renal, cardiovascular, and metabolic diseases.

## Market Standing
- **Valuation/Market Cap**: Approximately **$1.48 Billion** (as of mid-2026, per CB Insights market cap data).
- **Key Metric**: **Total Raised** (including IPO): **$496 Million**. The company also announced a **$150 Million registered offering** in 2026.
- **Notable Investors/Partners**: Key investors include **Third Rock Ventures**, **Gilead Sciences**, **Genentech**, **Denali Therapeutics**, and **Calico Life Sciences** (as top talent sources and likely institutional backers). The company went public via a PIPE/IPO structure.
- **Growth Signals**: 
    - Positive topline data from the Phase 2 HORIZON trial of MZE829 (announced March 2026).
    - Three clinical-stage programs and several discovery-stage programs.
    - Active job postings increased by **120% year-over-year**.
    - Headcount of approximately 150 employees (based on LinkedIn data showing ~150 total employees).

## Competitive Advantages
- **Proprietary Compass Platform**: A unique, data-driven platform that functionally validates genetic variants, giving Maze a differentiated ability to identify and target disease-causing pathways that are often overlooked.
- **Focus on Common Diseases**: Unlike many precision medicine companies that focus on rare diseases, Maze targets large, unmet medical needs (e.g., chronic kidney disease), which represents a massive market opportunity.
- **Strong Genetic Foundation**: The company’s entire strategy is built on robust human genetic evidence, reducing the risk of late-stage clinical failures and increasing the probability of success.
- **Experienced Leadership Team**: The team includes veterans from leading biotech and pharma companies (Gilead, Genentech, Amgen), providing deep industry expertise in drug development and commercialization.

## Strategic Focus
- **Advance Lead Programs**: Primary focus is on progressing MZE829 through Phase 2/3 trials for APOL1-mediated kidney disease and advancing MZE782 for CKD and PKU.
- **Expand Pipeline**: Leveraging the Compass platform to identify and develop additional precision medicines for renal, cardiovascular, and metabolic diseases.
- **Clinical Data Generation**: Delivering key clinical readouts to support regulatory filings and potential partnerships.
- **Commercial Preparation**: Building the infrastructure and team (e.g., Senior Director, Talent Acquisition; Senior Director, Pharmaceutical Development) to prepare for potential late-stage success and launch.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "harnessing the power of genetics to transform the lives of patients," with core values of "Impact Obsessed," "Stand True" (integrity), and "Further Together" (teamwork and resilience).
- **Supportive Work Environment**: Maze promotes a culture that encourages "vision, initiative, and the development of talent," with a "stimulating atmosphere where people enjoy coming to work."
- **Comprehensive Benefits**: Offers "comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of employees and their families."
- **Equal Opportunity Employer**: Committed to diversity and non-discrimination.
- **Growth Trajectory**: As a public clinical-stage company with positive clinical data and a 120% increase in job postings year-over-year, there are significant opportunities for career growth and impact.
- **Location**: Based in South San Francisco (a major biotech hub), though specific remote/hybrid policy is not publicly detailed.

## Sources
1. [mazetx.com](https://mazetx.com/)
2. [mazetx.com](https://mazetx.com/about-us/)
3. [mazetx.com](https://mazetx.com/careers/)
4. [cbinsights.com](https://www.cbinsights.com/company/maze-therapeutics)
5. [linkedin.com](https://www.linkedin.com/company/mazetx)

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