---
title: 'People Operations Manager at Radical Numerics'
canonical: 'https://feeny.ai/job/people-operations-manager-radical-numerics-san-francisco-76vd7w8jmevm'
type: 'job'
last_seen: '2026-10-19'
---

# People Operations Manager at Radical Numerics

- **Company:** Radical Numerics
- **Location:** San Francisco, CA
- **Employment:** full-time
- **Posted:** 2026-09-30
- **Last confirmed live:** 2026-10-19
- **Apply:** https://jobs.ashbyhq.com/radical-numerics/317129e6-520c-46a8-9265-ab59da6879f2

## Job description

## About Us

[Radical Numerics](http://radicalnumerics.ai) is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering.

Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of [Science](https://www.science.org/doi/10.1126/science.ado9336), and presented by our CEO on the main stage of [TED2025](https://www.youtube.com/watch?v=EnbfoFUFm2s). Evo was used to create the first AI-generated CRISPR-Cas9, and the first [AI whole genome](https://www.biorxiv.org/content/10.1101/2025.09.12.675911v1) from scratch. [Evo 2](https://www.nature.com/articles/s41586-026-10176-5), featured in Nature, is the largest fully open source AI project across any domain.

Radical Numerics is bringing the rigor of distributed systems, model architecture, and numerics research to the challenges of biology. We’ve redesigned the foundation model training stack to turn the world’s raw scientific data (e.g. biological sequences, experiments, and physical processes), into intelligible, generative models that can expand and accelerate what humanity can understand, design, and cure.

The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend.

## About the Role

As our first dedicated People Operations lead, you'll own the full scope of how Radical Numerics supports its team: compensation, benefits, immigration, onboarding, compliance, and the systems that keep a fast-growing research lab running smoothly. This is a high-impact role for someone who enjoys building from the ground up and wants their work to directly shape how a company grows.

You'll work closely with our CEO, Recruiter, and Operations Manager to shape the employee experience from start to finish. Once a candidate accepts an offer, you'll take the lead and stay with them throughout their time here, from securing visas to making day one seamless, to running performance reviews and handling exits with care. Your goal is to make sure every person on our team feels supported, informed, and set up to do their best work.

Our team spans Tokyo and San Francisco. You'll bring clarity and structure the onboarding process, coordinating across countries, regulations, and time zones so that our people can focus on their research.

Much of our people infrastructure is still being built, and that's where you come in. You'll design the policies and processes we need, run them for the first time, and refine them into repeatable systems that scale as we grow. If you're energized by ambiguity and want to build something lasting, we'd love to hear from you.

## What You'll Do

- Own compensation and leveling. Maintain comp ranges and the employee-levels mapping, and run equity scenario modeling and benchmarking for new roles.
- Plan and run performance review cycles in Complete.
- Own onboarding and offboarding end to end, including welcome and pre-start communications, background checks, I-9 verification, system access, and departing-employee accounts.
- Serve as primary contact with immigration counsel for O-1 petitions, OPT/EAD cases, and green card renewals, and act as company signatory where appropriate.
- Administer Justworks, including benefits, open enrollment, and state registrations for remote employees.
- Answer employee and candidate questions about benefits and policy.
- Set up and manage international employment through EOR arrangements as needed.
- Partner with outside employment counsel on employee relations, performance concerns, terminations, and changes to offer letters and CIIAs.
- Lead planning on office move scenarios and timelines with our real estate partners alongside our Operations Manager.
- Build the policies, handbook, and compliance practices a growing company needs before it needs them.

## What We're Looking For

- You have run People Operations at an early-stage company and can explain the systems you built, not just the ones you inherited.
- You have hands-on experience with U.S. employment immigration, especially O-1, OPT and H1Bs and know how to keep timelines and counsel moving.
- You understand startup compensation, including bands, leveling, and equity, and can model tradeoffs clearly for leadership.
- You know PEO and EOR platforms such as Justworks, and understand multi-state and international employment compliance.
- You exercise judgment on sensitive issues and know when to bring in counsel.
- You are organized enough to run many open threads at once without dropping any, and you document them so someone else could pick them up.
- You are comfortable creating a process before there is a playbook.
- You are excited about building a generational company at the intersection of AI and biology.

Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws. It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.

Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.

## About Radical Numerics

## Company Overview
- **One-liner**: Radical Numerics is a next-generation AI lab building general biological intelligence, developing multimodal models trained on the fabric of biology to enable discovery, design, and defense in the life sciences.
- **Entity Type**: Private (Seed stage)
- **Headquarters**: San Francisco, California, USA (with a presence in Tokyo, Japan)
- **Founded**: Not publicly available (recently announced a $50M seed round)
- **Founders**: Not publicly listed (the founding team previously trained Evo and Evo 2, the largest biological AI models trained on DNA)

## Core Business
- **Primary industry**: Artificial Intelligence / Biotechnology (AI for Biology)
- **Target customers**: B2B — partnerships with diagnostics companies, U.S. national labs, and pharmaceutical/therapeutic organizations; also serves the broader scientific community through open-source models.
- **Mission or purpose statement**: "To master the code of life and to ensure this power is used to save lives." The company is building general biological intelligence to enable faster discovery, deeper understanding, and entirely new capabilities in biology, while simultaneously building biodefense systems to safeguard against misuse.

## Products & Services
- **Evo & Evo 2**: The founding team's prior open-source generative genomics models, trained on millions of genomes across all of life. Evo was used to generate the world's first complete genome from scratch using AI (a bacteriophage). These models established the field of generative genomics.
- **Omnii**: The company's next-generation genome language model (gLM). It features a multi-hybrid architecture with a 2M-token context window, multimodality, and is the first aligned large-scale genome model. It surpasses specialized models across core genetics benchmarks, especially in noncoding and regulatory regions. Omnii is being piloted for early cancer detection (with a diagnostics partner) and for biodefense/biosurveillance (with a U.S. national lab).
- **Biodefense Platform (Omnii for Biosecurity)**: A system designed to detect "deepfake" pathogens, identify suspicious sequences, and attribute engineered function — aimed at global biological resilience against natural, synthetic, and AI-generated threats.

## Market Standing
- **Valuation/Market Cap**: Not disclosed (private company)
- **Key Metric**: $50 million seed round (announced in 2025)
- **Notable Investors/Partners**: Not publicly named in the seed round announcement. Advisors include Eric Horvitz (CSO of Microsoft), Chris Ré (Stanford), George Church (Harvard), and Andrew Weber (former Assistant Secretary of Defense for Nuclear, Chemical and Biological Defense Programs). Partners include a U.S. national lab (for Omnii biodefense pilot) and a diagnostics company (for early cancer detection).
- **Growth Signals**: Raised a $50M seed round; has a data center under construction filled with NVIDIA Blackwells; actively hiring for 11+ roles across San Francisco and Tokyo; building the next generation of biological AI models with a 2M-token context window; partnering with a U.S. national lab and a diagnostics company.

## Competitive Advantages
- **Proven Track Record**: The founding team created Evo and Evo 2, the largest open-source biological AI models, which established the field of generative genomics. Evo generated the world's first complete AI-designed genome.
- **First-Mover in Alignment for Biology**: Omnii is the first large-scale genome model to incorporate alignment methods (mid- and post-training), transforming a language model into a reliable scientific instrument.
- **Dual Mandate (Design + Defense)**: Uniquely positioned as both a design lab and a defense lab under one roof, addressing the inseparable forces of biological advancement and biosecurity.
- **World-Class Advisors**: Eric Horvitz (Microsoft CSO), Chris Ré (Stanford), George Church (Harvard), and Andrew Weber (former Assistant Secretary of Defense).
- **Technical Depth**: Team has pioneered models with one-million-token context windows and is now scaling toward one billion, with a focus on novel architectures and systems engineering for scientific data.

## Strategic Focus
- **Scaling Biological AI**: Building the infrastructure (data center with NVIDIA Blackwells) to train the most powerful biological AI models in the world.
- **Dual Application**: Simultaneously advancing human health (cancer detection, therapeutic design, variant interpretation) and biodefense (pathogen detection, biosurveillance with U.S. national labs).
- **Model Innovation**: Developing new multi-hybrid architectures, long-context windows (2M tokens and scaling to 1B), multimodality, and mechanistic interpretability tools for biology.
- **Open Science Foundation**: While building proprietary systems, the team's prior work (Evo, Evo 2) was released fully open source, establishing credibility in the scientific community.

## Why Work Here
- **Mission-Driven**: The company is tackling "the most important scientific and technological challenge of our time" — mastering the code of life to cure disease, engineer new medicines, and defend against biological threats.
- **Cutting-Edge Technical Work**: Engineers and researchers work on frontier AI challenges including distributed systems, model architecture, numerics research, long-context models, and mechanistic interpretability — all applied to biological data.
- **On-Site Culture**: The vast majority of roles (10 of 11 listed) are on-site in San Francisco, with some roles also available in Tokyo. This suggests a strong in-person collaboration culture.
- **Interdisciplinary Team**: Brings together AI researchers, systems engineers, computational biologists, and scientists from institutions including Stanford, MIT, and Google DeepMind.
- **High Ambition, Early Stage**: With a $50M seed round and a small team, new hires have the opportunity to shape the company's technical direction and infrastructure from the ground up.
- **Dual Focus on Impact and Responsibility**: The company explicitly states that "the design lab and the defense lab need to be the same entity," offering engineers a chance to work on both creation and safeguarding of powerful technology.

## Sources
1. [radicalnumerics.ai](https://www.radicalnumerics.ai/)
2. [radicalnumerics.ai/about](https://www.radicalnumerics.ai/about)
3. [radicalnumerics.ai/blog](https://www.radicalnumerics.ai/blog/radical-numerics-seed)
4. [radicalnumerics.ai/join-us](https://www.radicalnumerics.ai/join-us)
5. [jobs.ashbyhq.com](https://jobs.ashbyhq.com/radical-numerics)

## Other roles at Radical Numerics

- [Technical Recruiter](https://feeny.ai/job/technical-recruiter-radical-numerics-san-francisco-aqrrd9ayv7yp) — San Francisco, CA
- [Business Associate](https://feeny.ai/job/business-associate-radical-numerics-san-francisco-p5nb2d3nw8jh) — San Francisco, CA
- [Product Lead, Biodefense](https://feeny.ai/job/product-lead-biodefense-radical-numerics-san-francisco-3wwjkb3vw9pn) — San Francisco, CA
- [Head of Business Development](https://feeny.ai/job/head-of-business-development-radical-numerics-san-francisco-318xb336bt1w) — San Francisco, CA
- [Product Lead - Discovery](https://feeny.ai/job/product-lead-discovery-radical-numerics-san-francisco-s2b2xmpxcrkj) — San Francisco, CA
- [Applications Engineer](https://feeny.ai/job/applications-engineer-radical-numerics-san-francisco-e99grz13f2db) — San Francisco, CA
- [Marketing Associate](https://feeny.ai/job/marketing-associate-radical-numerics-san-francisco-j0xem583abgd) — San Francisco, CA
- [Member of Technical Staff, ML Engineer](https://feeny.ai/job/member-of-technical-staff-ml-engineer-radical-numerics-san-francisco-mdtstmkpfgmz) — San Francisco, CA
- [Member of Technical Staff, Inference](https://feeny.ai/job/member-of-technical-staff-inference-radical-numerics-san-francisco-6dkvggf3cx25) — San Francisco, CA
- [Member of Technical Staff, Mechanistic Interpretability](https://feeny.ai/job/member-of-technical-staff-mechanistic-interpretability-radical-numerics-san-y3am83p861w6) — San Francisco, CA