--- title: 'Principal Clinical Database Systems Programmer at BridgeBio Pharma' canonical: 'https://feeny.ai/job/principal-clinical-database-systems-programmer-bridgebio-pharma-united-states-q01smtxf9bc3' type: 'job' last_seen: '2026-10-21' --- # Principal Clinical Database Systems Programmer at BridgeBio Pharma - **Company:** BridgeBio Pharma - **Location:** United States - **Compensation:** $172k–$189k - **Work type:** remote - **Posted:** 2026-10-21 - **Last confirmed live:** 2026-10-21 - **Apply:** https://job-boards.greenhouse.io/bridgebio/jobs/5269882007 ## Job description Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work. ## What You'll Do The Principal Clinical Database Systems Programmer will be responsible for performing SAS or SQL data programming to execute the design, build, and maintenance of clinical data collection systems.  This includes developing customized, programmed data listings and data reports/visualizations, and/or EDC study database builds. The Principal Clinical Programmer will manage the study-defined  specifications and requirements to lead clinical programming activities across one or more studies for the DM Operations and Clinical Development functional areas and liaise with our biostatisticians to understand final requirements and structure of study data/database design being presented. ## Responsibilities - Creates standard and/or custom programs/reports using data analytics tools such as SAS, Tableau, or other data visualization tools to support data oversight and review by data managers or other data reviewers. - Leads EDC database build programming, testing, and migration of CRFs and edit checks or dynamics (database specifications, etc.) using EDC platforms (e.g. Veeva Vault, Medidata Rave). - Collaborates with clients, peers, programmers, project teams, and/or requestors to clarify and finalize data specifications; uses expanded technical skills to meet evolving project needs. - Supports the development, delivery and maintenance of clinical data review standards, tools and systems, across various data sources (e.g., clinical data, safety and operational data). - Supports initiatives for Data Management and Clinical Programming for clinical data review bridging and database development activities, meetings, discussions. - Assists in the management of electronic data from external data sources/vendors in partnership with the Data Management Lead for import or integration to clinical database tools. Liaises with vendors as needed to facilitate electronic data transfers and/or data specification requirements. - Assists in review and approval of required study documentation, including design specifications, user requirements, data transfer specifications and data standards. - Provides leadership, training, guidance, and support to other department members on data review tools and clinical database development. Where You'll Work This is a U.S.-based remote role that will require quarterly, or as needed visits to our San Francisco Office. There is <10% travel anticipated for conference attendance, Biometrics/DM meetings, BBIO organization event attendance. ## Who You Are - Bachelor’s degree (or equivalent) in Science and/or Computer Systems/IT background - Minimum 5-7 year experience in a pharmaceutical/biotech setting - Advanced technical expertise in databases, EDC platforms (e.g. Medidata Rave, Veeva), data imports/integrations and data visualization tools (e.g. Tableau, Spotfire) and Python programming language is a plus - Advanced programming and analytical skills using SQL, BASE/SAS, SAS/STAT, SAS MACROS - Ability to work independently to create standard datasets, program edit checks and produce quality data review outputs - Demonstrated understanding of CDISC and SDTM requirements and implementation guidelines, able to create and validate CDISC standard datasets - Knowledge of ICH GCP and Good Clinical Data Management guidelines - <10% Travel to BridgeBio Headquarters or Biometrics/DM meetings, as required At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states. Salary $172,000—$188,600 USD As a global company, our comprehensive benefits may vary based on location.  We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return. For BridgeBio Full-Time U.S Based Roles: Financial & Rewards - Market-leading compensation - 401(k) with employer match - Employee Stock Purchase Program (ESPP) - Pre-tax commuter benefits (transit and parking) - Referral bonus for hired candidates - Subsidized lunch and parking on in-office days Health & Well-Being - 100% employer-paid medical, dental, and vision premiums for you and your dependents - Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA) - Fertility & family-forming benefits - Expanded mental health support (therapy and coaching resources) - Hybrid work model with flexibility - Flexible, “take-what-you-need” paid time off and company-paid holidays - Comprehensive paid medical and parental leave to care for yourself and your family Skill Development & Career Paths: - People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility - We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching - We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities By applying, you acknowledge that BridgeBio will process your personal information as described in our [Global Candidate Privacy Notice](https://bridgebio.com/bridgebio-global-candidate-privacy-notice). Questions or requests: dataprivacy@bridgebio.com ## About BridgeBio Pharma ## Company Overview - **One-liner**: BridgeBio Pharma develops transformative medicines for genetic conditions, using a decentralized hub-and-spoke model to accelerate drug development from early research to commercialization. - **Entity Type**: Public (Nasdaq: BBIO) - **Headquarters**: Palo Alto, California, USA (with hybrid offices in San Francisco, CA) - **Founded**: Not explicitly stated in provided sources; the company references “over the past 10 years” as of 2026, suggesting founding around 2015–2016. - **Founders**: Not publicly available from provided sources. ## Core Business - **Primary industry**: Biotechnology / Genetic disease therapeutics - **Target customers**: Patients living with genetic conditions, healthcare providers, payers, and academic research partners - **Mission**: “To develop transformative medicines for genetic conditions” and “bridge the gap between advancements in genetic science and meaningful medicines for underserved patient populations.” ## Products & Services BridgeBio’s pipeline includes both approved therapies and investigational candidates across dozens of indications. Key offerings: - **Acoramidis**: Approved for transthyretin amyloidosis (ATTR) – a first-in-class treatment with $8B+ peak year sales potential. - **Infigratinib**: Phase 3 completed for achondroplasia; published in the *New England Journal of Medicine* (2026). - **BBP-418**: Investigational for Limb-Girdle Muscular Dystrophy Type 2I/R9 (LGMD2I/R9). - **Encaleret**: Investigational for Autosomal Dominant Hypocalcemia Type 1 (ADH1). - **BBP-812**: Investigational for Canavan Disease. - **BridgeBio Oncology Therapeutics (BBOT)**: Subsidiary focused on RAS and PI3Kα-driven cancers. - **GondolaBio**: Subsidiary developing bioavailable small molecule inhibitors for oncology. - **Other programs**: Covering hypochondroplasia, chronic hypoparathyroidism, and more. The company has received **3 FDA approvals** and has over **70+ peer-reviewed publications**. ## Market Standing - **Valuation / Market Cap**: Not explicitly stated in provided data; as a public company, current market cap can be found on financial platforms (e.g., ~$8B based on peak sales potential, but not a direct valuation number). - **Key Metric**: **3 FDA-approved medicines**; **2000+ patients enrolled** in global clinical trials; **6 Phase 3 trials** conducted over the past 10 years. - **Notable Investors / Partners**: Not detailed in provided sources, but the company partners with leading academic institutions to advance early-stage research. - **Growth Signals**: Recent publication of Phase 3 PROPEL 3 trial results in NEJM (June 2026); expansion into oncology via BBOT and GondolaBio; 100% of pipeline is first-in-class or best-in-class; 48 unique disease indications targeted. ## Competitive Advantages - **Hub-and-spoke model**: Decentralized structure where autonomous affiliate teams (spokes) focus on specific conditions, while a central hub provides clinical, regulatory, and commercial expertise. This enables speed, scalability, and risk reduction. - **First-in-class / best-in-class focus**: 100% of pipeline aims to be first or best in class, targeting underserved genetic conditions with clear biological rationale. - **Speed and adaptability**: The model allows rapid pivoting to the most promising opportunities, reducing development timelines compared to traditional biotech. - **Strong scientific foundation**: Over 70 peer-reviewed papers and collaborations with top academic institutions. ## Strategic Focus - **Advance late-stage pipeline**: Prioritize Phase 3 programs (e.g., infigratinib for achondroplasia, acoramidis for ATTR) and seek additional FDA approvals. - **Expand into oncology**: Leverage subsidiaries BBOT and GondolaBio to address RAS/PI3Kα-driven cancers. - **Maintain urgency**: “Every minute counts” – continue to operate with speed and autonomy to bring treatments to patients faster. - **Build on commercial success**: Leverage existing approved products to fund further R&D and expand global reach. ## Why Work Here - **Award-winning culture**: Named **#1 Best Place to Work** by BioSpace (2026, small biotech category) with an **88% employee engagement score** in 2025. - **Flexible work model**: Hybrid policy with offices in San Francisco and Palo Alto, CA; “flexible working model” emphasized. - **Compensation and benefits**: Market-leading pay, comprehensive healthcare, and strong emphasis on growth and internal mobility. - **Impact-driven mission**: Work on transformative treatments for genetic conditions where patient need is urgent – “Impatient for Patients” is a core mantra. - **Values**: Put patients first, let science speak, think independently, speak up, and act with urgency. The culture is described as “high on standards, low on convention.” - **Growth opportunities**: 113 open jobs (as of mid-2026) across functions including clinical, regulatory, manufacturing, commercial, and corporate; talent community available for future roles. ## Sources 1. [bridgebio.com](https://bridgebio.com/) – Home page with pipeline overview and $8B peak sales potential 2. [bridgebio.com/about](https://bridgebio.com/about) – Company description, hub-and-spoke model, and key metrics 3. [bridgebio.com/careers](https://bridgebio.com/careers) – Careers page with awards, culture, and benefits 4. [investor.bridgebio.com](https://investor.bridgebio.com/overview/default.aspx) – Investor relations overview, latest news, and corporate presentation 5. [job-boards.greenhouse.io/bridgebio](http://job-boards.greenhouse.io/bridgebio) – Current job listings (113 roles) and departmental categories ## Other roles at BridgeBio Pharma - [Commercial Learning & Development, Associate Director](https://feeny.ai/job/commercial-learning-development-associate-director-bridgebio-pharma-san-trqgav8a5c7b) — San Francisco, CA - [Field Reimbursement Manager - Northern CA](https://feeny.ai/job/field-reimbursement-manager-northern-ca-bridgebio-pharma-united-states-th5wwrdfe4n0) — United States - [Senior Director, Commercial, EU Center](https://feeny.ai/job/senior-director-commercial-eu-center-bridgebio-pharma-germany-4t6tncfrnpf0) — Germany - [Field Reimburesement Manager - Pennsylvania](https://feeny.ai/job/field-reimburesement-manager-pennsylvania-bridgebio-pharma-united-states-h2c4mn5nf8fg) — United States - [Field Reimbursement Manager - Michigan](https://feeny.ai/job/field-reimbursement-manager-michigan-bridgebio-pharma-united-states-6shtx6w6zc4w) — United States - [Senior Manager, Medical Affairs Operations](https://feeny.ai/job/senior-manager-medical-affairs-operations-bridgebio-pharma-san-francisco-t05gjew4g5xx) — San Francisco, CA - [Sr. Manager/Associate Director, Medical Affairs](https://feeny.ai/job/sr-manager-associate-director-medical-affairs-bridgebio-pharma-united-states-52dejpfy2e92) — United States - [Field Reimbursement Manager-Southeast](https://feeny.ai/job/field-reimbursement-manager-southeast-bridgebio-pharma-united-states-9r2cmwtagmzc) — United States - [Field Reimbursement Manager-Pacific](https://feeny.ai/job/field-reimbursement-manager-pacific-bridgebio-pharma-united-states-rzn1q25j1qes) — United States - [Field Reimbursement Manager-Northeast](https://feeny.ai/job/field-reimbursement-manager-northeast-bridgebio-pharma-united-states-pw7vp013z0pf) — United States