---
title: 'Principal Engineer at Asteri AI, Inc.'
canonical: 'https://feeny.ai/job/principal-engineer-asteri-ai-inc-greece-g0pdfysy6cy8'
type: 'job'
last_seen: '2026-09-09'
---

# Principal Engineer at Asteri AI, Inc.

- **Company:** Asteri AI, Inc.
- **Location:** Greece
- **Employment:** full-time
- **Work type:** remote
- **Posted:** 2026-01-07
- **Last confirmed live:** 2026-09-09
- **Apply:** https://jobs.ashbyhq.com/asteriai/aba019d7-186b-470f-916a-d0f95d68a86d

## Job description

## ABOUT US

Asteri is an AI-native Work Intelligence and Orchestration Platform that gives large enterprises the intelligence to understand how work is performed today and how it should be performed in the era of AI, eliminating inefficiencies and identifying high-impact opportunities for AI augmentation. Our platform orchestrates AI and human work with enterprise-grade governance, auditability, and measurement built for production environments at scale.

## THE ROLE

As a Principal Engineer at Asteri, you will be a technical leader and architect, driving the design, development, and scaling of core product capabilities across our AI-native orchestration platform. You will provide technical vision and leadership at the intersection of enterprise workflows, AI agents, and human-in-the-loop processes, ensuring our systems meet the highest standards of reliability, scalability, and usability.

This is a high-impact leadership role with deep ownership over the technical roadmap and production systems used by global enterprise customers.

## WHAT YOU’LL DO

- Lead the architectural design and delivery of scalable full-stack systems, ensuring alignment with long-term business and technical goals
- Define and evolve backend and front end services and architectures with a focus on clean APIs, high availability, observability, security, compliance and and performance
- Drive the technical direction for frontend experiences, ensuring consistency, accessibility, and superior operational visibility
- Architect complex workflow and orchestration logic, establishing patterns for AI-human coordination, policy enforcement, and auditability
- Oversee the integration of enterprise-scale systems and data sources, ensuring robust end-to-end workflows, including policies, resiliency, SLAs, and auditability
- Set the standard for production excellence through advanced testing strategies, CI/CD evolution, and proactive operational monitoring
- Partner with product, AI, and design leaders to translate high-level requirements into strategic technical roadmaps and robust solutions
- Mentor senior engineers, lead technical reviews, and continuously elevate the engineering culture, developer experience, and system maintainability

## WHAT WILL MAKE YOU SUCCESSFUL

## MUST-HAVES

- 10+ years of experience as a software engineer, with a proven track record of architecting and operating large-scale production applications
- Deep experience building and securing enterprise-grade applications, ideally in highly regulated environments
- Expert-level backend development skills (e.g., Python, Node.js/TypeScript) and experience designing distributed systems
- Advanced experience with modern frontend frameworks (e.g., React with TypeScript) and building complex, stateful web applications
- Mastery of API design and database modeling with relational databases (e.g., Postgres) at scale
- Strong track record of technical leadership, including mentoring engineers and driving architectural decisions across teams
- Experience operating and optimizing mission-critical applications in cloud environments (AWS, Azure, or GCP)
- Exceptional ability to navigate ambiguity and take ownership of strategic technical initiatives in a fast-paced environment

## NICE-TO-HAVES

- Experience architecting AI-enabled enterprise products or ML-powered systems
- Expert-level knowledge of workflow orchestration, state machines, or event-driven architectures
- Experience with platform engineering, container orchestration (Kubernetes), and infrastructure-as-code (Terraform)
- Deep understanding of enterprise security and compliance requirements (SSO, RBAC, SOC2, etc.)
- Experience working in regulated or security-conscious environments
- Passion for fostering a culture of technical excellence and pragmatic innovation

## WHY JOIN US

Lead the next phase of an AI-native work intelligence and orchestration platform used by global enterprises. You’ll shape architecture and execution alongside a senior engineering team, with meaningful ownership and direct influence on technical and product direction. We offer competitive compensation with equity, a remote-friendly culture, and a pragmatic, safety-first approach to delivering reliable AI systems in production.

## About Asteri AI, Inc.

## Company Overview
- **One-liner**: Asteri is a vertical AI work orchestration platform purpose-built for Fortune 500 Life Sciences enterprises and other regulated industries.
- **Entity Type**: Private (startup; inferred early-stage)
- **Headquarters**: Palo Alto, California, USA
- **Founded**: 2021
- **Founders**: Julia Samoylenko (Founder & CEO)

## Core Business
- **Primary industry**: Life Sciences (pharma, biotech, med devices) and other regulated industries
- **Target customers**: B2B Enterprise – Fortune 500 Life Sciences companies
- **Mission/purpose**: “Enable Fortune 500 Life Sciences teams to unlock the full potential of AI, scale human–AI work safely, accelerate innovation, and deliver progress that improves lives.”

## Products & Services
- **Asteri Platform**: A vertical AI work orchestration platform that unifies three capabilities:
  - **Work Ontology**: An industry-specific Work Graph that models how work happens by linking tasks with roles, teams, functions, and systems.
  - **Work Intelligence**: Task-level analysis to reveal workflows, patterns, duplications, and AI-augmentation opportunities.
  - **Work Orchestration**: System that coordinates execution across humans and AI agents with approvals, oversight, and continuous evaluation.
- **Deep vertical use cases** include:
  - SOP Authoring & Change Control
  - Adverse Events Monitoring
  - Clinical Trial Summarization

The platform is delivered as a SaaS solution with built-in governance and audit-ready traceability.

## Market Standing
- **Valuation/Market Cap**: Not publicly available
- **Key Metric**: Total funding not disclosed; headcount of 11 employees (as of latest data)
- **Notable Investors/Partners**: Not publicly listed
- **Growth Signals**: Transitioning from a Palo Alto startup to serving Fortune 500 enterprise clients; targeting the high-stakes, regulated Life Sciences vertical

## Competitive Advantages
- Deep vertical focus on Life Sciences (not a horizontal AI tool)
- Task-level Work Graph and Work Intelligence that understand enterprise workflows at granular detail
- Built-in governance, review/approval loops, and audit readiness for regulated environments
- Human-centered closed-loop orchestration that keeps humans in the loop

## Strategic Focus
- Scaling governed human–AI work orchestration in Life Sciences
- Building deep vertical agentic systems for complex, regulated workflows
- Expanding to other regulated industries while maintaining Life Sciences as the beachhead

## Why Work Here
- **Culture**: Values include “Act boldly”, “Autonomy with accountability”, “Build shared value”, “Excellence in execution”, and “Move with speed and decisiveness”. Emphasizes ownership, high standards, and rapid iteration.
- **Work environment**: On-site in Palo Alto, CA (employees work from physical office; typical time on-site: full time)
- **Team size**: Small team (~11 employees, all product + tech) – high impact and autonomy
- **Perks**: Not detailed, but early-stage startup environment with direct exposure to founders and enterprise AI challenges
- **Engineering culture**: Strong emphasis on craftsmanship, deep thinking, and judgment; AI/ML engineering led by Kiran de Silva (Lead AI & ML Engineer) and Yonatan Goraly (VP Engineering)

## Sources
1. [asteri.ai/company](https://www.asteri.ai/company)
2. [asteri.ai](https://www.asteri.ai/)
3. [asteri.ai/platform](https://www.asteri.ai/platform)
4. [asteri.ai/careers](https://www.asteri.ai/careers)
5. [builtin.com/company/asteri-ai](https://builtin.com/company/asteri-ai)

## Other roles at Asteri AI, Inc.

- [Senior Frontend Engineer](https://feeny.ai/job/senior-frontend-engineer-asteri-ai-inc-remote-r66awneym47g)
- [Full Stack Engineer](https://feeny.ai/job/full-stack-engineer-asteri-ai-inc-remote-3efw83f8swf8)
- [QA Automation Engineer](https://feeny.ai/job/qa-automation-engineer-asteri-ai-inc-georgia-jjq359mwgzvz) — Georgia
- [AI & ML Engineer](https://feeny.ai/job/ai-ml-engineer-asteri-ai-inc-remote-6p8j4e7mdx8s)
- [Principal Engineer](https://feeny.ai/job/principal-engineer-raft-company-website-fort-hood-p1dh490tqyf9) — Fort Hood, TX
- [Principal Engineer](https://feeny.ai/job/principal-engineer-vitalize-san-francisco-jv4wadgac7d3) — San Francisco, CA
- [Principal Engineer](https://feeny.ai/job/principal-engineer-raft-company-website-tacoma-v4rnqr4vf505) — Tacoma, WA / Tampa, FL
- [Principal Engineer](https://feeny.ai/job/principal-engineer-weave-united-states-759qvysnv8w9) — United States
- [Principal Engineer](https://feeny.ai/job/principal-engineer-moo-london-p3tyvde544cb) — London, United Kingdom
- [Principal Engineer](https://feeny.ai/job/principal-engineer-digicert-herndon-s15dyztvfp9c) — Herndon, VA