---
title: 'Principal Engineer, Enterprise Data Integration / Associate Director at Xenon Pharmaceuticals'
canonical: 'https://feeny.ai/job/principal-engineer-enterprise-data-integration-associate-director-xenon-ffq2wv5zryyn'
type: 'job'
last_seen: '2026-09-10'
---

# Principal Engineer, Enterprise Data Integration / Associate Director at Xenon Pharmaceuticals

- **Company:** Xenon Pharmaceuticals
- **Location:** Boston, MA
- **Employment:** full-time
- **Work type:** hybrid
- **Posted:** 2026-08-21
- **Last confirmed live:** 2026-09-10
- **Apply:** https://jobs.ashbyhq.com/xenon/508cb232-aabd-4c86-a5f7-9d2b32dce3df

## Job description

Who We Are: Xenon Pharmaceuticals ([NASDAQ:XENE](https://www.nasdaq.com/market-activity/stocks/xene)) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an [exciting product pipeline](https://xenon-pharma.com/pipeline) to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. About the Role: We are seeking a Principal Engineer, Enterprise Data Integration, to join our Information Technology (IT) team. The position will help lead the design, implementation, and ongoing operation of Xenon’s enterprise integration, middleware, and data engineering capabilities. This individual will partner with leaders across IT, Commercial, Medical, Finance, Supply Chain, Clinical Development, Research, and Quality, and external partners to establish scalable, secure, and compliant data flows across Xenon’s enterprise application and analytics ecosystem. This role will be a key enabler of Xenon’s growth and commercialization readiness, helping connect core platforms such as ERP, CRM, data warehouse, master data management, clinical and research systems, quality systems, and external partner networks. The successful candidate will combine strong hands-on technical depth with strong architecture, governance, vendor management, and cross-functional leadership skills. This position reports to the Director, Data Architecture & Engineering and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

## RESPONSIBILITIES:

- Manage the implementation and maturation of Xenon’s enterprise integration and data engineering capabilities, including middleware/iPaaS, API-based integration, event/message-based integration, file-based ingestion, and ELT/data pipeline patterns.
- Partner with IT and business leaders to define and maintain an enterprise integration roadmap aligned to ERP, Commercial, Medical, Clinical, Research, Quality, MDM, and data warehouse priorities.
- In consultation with assigned stakeholders, evaluate, select, implement, and govern integration and ELT platforms such as Informatica/IICS, Boomi, MuleSoft, Azure Integration Services, Fivetran, dbt, Snowflake, or similar technologies.
- Design and oversee integrations and data pipelines between internal and external systems including ERP, Veeva CRM/Vault, commercial data providers, patient services platforms, EDC/clinical systems, safety systems, LIMS, eQMS, Dotmatics/ELN, HRIS/HCM, CLM, Concur, Adaptive Planning, banks, CDMOs/CMOs, 3PLs, and other partners.
- Establish reusable integration standards, data contracts, interface specifications, transformation patterns, naming conventions, monitoring/alerting practices, runbooks, and documentation standards.
- Collaborate with Xenon’s Architecture Review Board to ensure system and data-flow designs are consistent with company standards for security, infrastructure, data architecture, privacy, and operational supportability.
- Partner with business data owners and data stewards to establish and maintain effective data governance including master data management, data quality, metadata, lineage, cataloging, access controls, and common data definitions across domains.
- Provide technical leadership for data models, ELT transformations, curated data layers, and “gold” datasets that enable trusted analytics, self-service reporting, AI/ML, and operational decision-making.
- Ensure integration and data engineering solutions are designed with appropriate controls for GxP, SOX, HIPAA, GDPR, 21 CFR Part 11, auditability, data integrity, and role-based access, as applicable.
- Provide technical guidance and support for Computer Systems Assurance (CSA), SDLC, regulatory/risk assessment, testing, validation, and change control deliverables for regulated systems and data flows.
- Develop and manage the ongoing support model for integrations and data pipelines, including onboarding and managing qualified implementation partners and service providers.
- Ensure ongoing compliance with Xenon procedures including Change Management, Incident Management, Problem Management, SaaS Release Management, and other applicable IT operating processes.
- Monitor integration and pipeline performance, manage operational issues to resolution, drive root cause analysis, and lead continuous improvement of platform reliability, scalability, cost efficiency, and support processes.
- Translate business requirements into practical integration architecture, technical design, delivery plans, test strategies, and sustainable operating procedures.
- Lead, mentor, or coordinate internal and external data engineers, integration developers, analysts, and vendor resources as the capability grows.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics, and ensure policies are understood and followed by direct reports, if any.
- Some international travel may be required.
- Other duties as assigned.

## QUALIFICATIONS:

- A bachelor’s degree or advanced degree in Information Systems, Computer Science, Data Engineering, Engineering, Business Administration, with a minimum of 7-10 years prior experience with enterprise integration, data engineering, middleware, cloud data platform, analytics platform, or enterprise applications
- Experience in Life Sciences, pharmaceutical, biotechnology, healthcare, or another regulated industry is preferred. Direct pharma/biotech experience is an asset but not required
- Proven experience designing and delivering enterprise integrations, API integrations, batch/file-based interfaces, ELT/ETL pipelines, data orchestration, data quality checks, monitoring, and production support processes.
- Hands-on experience with one or more integration or data platforms such as Informatica/IICS, Boomi, MuleSoft, Azure Integration Services, Fivetran, dbt, Snowflake, Databricks, or similar technologies.
- Strong understanding of cloud data warehouse and analytics architectures, including source-to-target mapping, transformation logic, curated data layers, semantic models, and BI/analytics consumption patterns.
- Experience with data governance, master data management, stewardship, metadata, lineage, cataloging, and data quality practices; MDM platform implementation experience is an asset.
- Experience integrating enterprise SaaS platforms and life-sciences systems such as ERP (Oracle Fusion or SAP S/4HANA), Veeva, Workday/HCM, CLM, Concur, Adaptive Planning, ServiceNow, eQMS, LIMS, EDC, ELN, clinical data repositories, or commercial data platforms.
- Experience with Computer Systems Assurance, GxP systems validation, SDLC, 21 CFR Part 11, HIPAA, GDPR, SOX, audit trails, data integrity, and role-based access controls is preferred.
- Ability to balance strategic architecture with pragmatic delivery in a growing, fast-paced organization; comfortable building capability, standards, and operating models from the ground up.
- Experience managing external consultants, implementation partners, managed service providers, and/or application service providers.
- Excellent communication and coordination skills across business, technical, Quality, Security, and vendor teams.
- Ability to manage multiple priorities, lead through ambiguity, and drive decisions with appropriate documentation and stakeholder alignment.
- Strong problem-solving skills, attention to detail, and ability to simplify complex technical concepts for non-technical audiences.
- Project management experience; Agile, PMP, ITIL, cloud, data, or integration platform certifications are a plus.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions. Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

## About Xenon Pharmaceuticals

## Company Overview
- **One-liner**: Xenon Pharmaceuticals is a neuroscience-focused biopharmaceutical company dedicated to discovering, developing, and commercializing life-changing therapeutics for people living with neurological and psychiatric disorders.
- **Entity Type**: Public (Ticker: XENE on Nasdaq)
- **Headquarters**: Burnaby, British Columbia, Canada
- **Founded**: 1996
- **Founders**: Not publicly listed as individual founders; the company was founded based on a platform science capable of discovering new genetic targets to treat human disease.

## Core Business
- **Primary industry/industries**: Biotechnology, Neuroscience, Pharmaceuticals
- **Target customers**: Patients with neurological and psychiatric disorders (epilepsy, major depressive disorder, bipolar depression, pain); healthcare providers; payers.
- **Mission or purpose statement**: "To deliver innovative medicines that provide a brighter future for people living with neurological and psychiatric disorders." [xenon-pharma.com](https://xenon-pharma.com/about)

## Products & Services
Xenon’s pipeline is focused on ion channel science, specifically potassium (KV7) and sodium (NaV) channel modulators.

- **Azetukalner (KV7 Potassium Channel Opener)**: The lead late-stage investigational candidate. It is in multiple Phase 3 clinical trials for:
    - Focal onset seizures (Phase 3 X-TOLE2 completed, X-TOLE3 ongoing)
    - Primary generalized tonic-clonic seizures (Phase 3 X-ACKT)
    - Major depressive disorder (Phase 3 X-NOVA2 and X-NOVA3)
    - Bipolar depression (Phase 3 X-CEED)
- **XEN1120 (KV7 Potassium Channel Opener)**: An early-stage (Phase 1) candidate for the treatment of pain.
- **XEN1701 (NaV1.7 Sodium Channel Inhibitor)**: An early-stage (Phase 1) candidate for the treatment of pain.
- **NBI-921355 (Partnered with Neurocrine Biosciences)**: A NaV1.2/1.6 inhibitor in development for epilepsy, pain, and psychiatry. [xenon-pharma.com](https://xenon-pharma.com/pipeline)

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the provided search results. As a public company, this fluctuates daily.
- **Key Metric**: Annual Revenue of $7.5M (as per LinkedIn). As a clinical-stage biotech, the primary focus is on pipeline progress and cash runway rather than revenue.
- **Notable Investors/Partners**: Neurocrine Biosciences (partner for NBI-921355). The company has also had strategic partnerships with multiple premier biopharmaceutical companies focused on pain, metabolic, and cardiovascular disease. [xenon-pharma.com](https://xenon-pharma.com/about)
- **Growth Signals**: The company is in a significant growth phase, having initiated multiple Phase 3 clinical trials for its lead candidate, azetukalner, across epilepsy, major depressive disorder, and bipolar depression. This represents a major expansion of its clinical pipeline and a transition towards a late-stage, fully integrated biopharmaceutical company. [xenon-pharma.com](https://xenon-pharma.com/about)

## Competitive Advantages
- **Deep Expertise in Ion Channel Biology**: Xenon is one of the scientific leaders in ion channel drug discovery, with a specific focus on potassium (KV7) and sodium (NaV) channel modulators. This is a highly specialized and technically difficult area of drug development. [xenon-pharma.com](https://xenon-pharma.com/about)
- **Proprietary Pipeline**: The company has a wholly-owned, late-stage pipeline led by azetukalner, a novel KV7 potassium channel opener being studied across multiple high-need indications (epilepsy, MDD, bipolar depression). This provides significant potential upside and control over its future.
- **Strong Scientific Foundation**: Founded on a platform capable of discovering new genetic targets, the company has a deep history of translating genetic insights into novel therapeutic candidates. [xenon-pharma.com](https://xenon-pharma.com/about)
- **Strategic Partnerships**: A history of partnerships with premier biopharmaceutical companies (e.g., Neurocrine Biosciences) validates its platform and provides non-dilutive funding. [xenon-pharma.com](https://xenon-pharma.com/about)

## Strategic Focus
- **Advancing Late-Stage Pipeline**: The primary focus is on executing the Phase 3 clinical programs for azetukalner across epilepsy, major depressive disorder, and bipolar depression, with the goal of regulatory approval and commercialization.
- **Expanding Early-Stage Pipeline**: Continuing to advance early-stage candidates (XEN1120, XEN1701) for pain and other high-need indications.
- **Building a Fully Integrated Company**: Transitioning from a discovery and development company to one with commercial capabilities, as evidenced by the hiring of a Chief Commercial Officer. [xenon-pharma.com](https://xenon-pharma.com/about)
- **Deepening Ion Channel Leadership**: Maintaining its position as a scientific leader in ion channel drug discovery, with a deep focus on potassium (KV7) and sodium (NaV) channel modulators. [xenon-pharma.com](https://xenon-pharma.com/about)

## Why Work Here
- **Mission-Driven Work**: Employees are united by a clear and compelling mission to deliver innovative medicines for patients with neurological and psychiatric disorders who have been underserved for too long. [xenon-pharma.com](https://xenon-pharma.com/about)
- **Culture of Collaboration and Impact**: The company describes itself as collaborative, ambitious, resilient, ethical, and science-driven. The culture is shaped by the "XenonCARES" program, which focuses on professional growth, wellness, and community. [xenon-pharma.com](https://xenon-pharma.com/join-us)
- **Competitive Compensation & Benefits**: Offers a total compensation package including base salary, performance-based bonuses, and equity. Benefits include comprehensive medical, dental, and vision coverage (US and Canada), a retirement savings program with a generous employer match, and a tuition reimbursement program. [xenon-pharma.com](https://xenon-pharma.com/join-us)
- **Work Flexibility**: The company values flexibility and provides a stipend for work-from-home setups. They also offer generous paid vacation time and an annual holiday shutdown. [xenon-pharma.com](https://xenon-pharma.com/join-us)
- **Growth & Development**: Recognizes and supports team member growth through leadership and development opportunities, a tuition reimbursement program, and recognition programs for both big and small wins. [xenon-pharma.com](https://xenon-pharma.com/join-us)
- **Work Model**: Hybrid/Remote-friendly with a stipend for home office setups. Offices are located in Burnaby, British Columbia (HQ) and the United States. [xenon-pharma.com](https://xenon-pharma.com/join-us)
- **Diversity & Inclusion**: The company states it cultivates and celebrates diversity, viewing diverse backgrounds, experiences, and opinions as a great asset, and is committed to fostering a safe and inclusive environment. [xenon-pharma.com](https://xenon-pharma.com/join-us)

## Sources
1. [xenon-pharma.com](https://xenon-pharma.com/)
2. [xenon-pharma.com](https://xenon-pharma.com/about)
3. [xenon-pharma.com](https://xenon-pharma.com/join-us)
4. [xenon-pharma.com](https://xenon-pharma.com/pipeline)
5. [linkedin.com](https://www.linkedin.com/company/xenonpharma)

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