---
title: 'Principal Scientist, Analytical Development and QC, Small Molecule at Immunome, Inc.'
canonical: 'https://feeny.ai/job/principal-scientist-analytical-development-and-qc-small-molecule-immunome-inc-c2et009d2yat'
type: 'job'
last_seen: '2026-09-05'
---

# Principal Scientist, Analytical Development and QC, Small Molecule at Immunome, Inc.

- **Company:** Immunome, Inc.
- **Location:** Bothell Washington, United States
- **Compensation:** $170k–$196k
- **Posted:** 2026-08-28
- **Last confirmed live:** 2026-09-05
- **Apply:** https://job-boards.greenhouse.io/immunomeinc/jobs/5408462008

## Job description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

Immunome is seeking an experienced and collaborative Principal Scientist, Analytical Development and QC, Small Molecule to support our small molecule programs at various stages of development.

The successful candidate will bring deep expertise in phase-appropriate small molecule analytical methods, development validation, transfer, and outsourced development models. Reporting to the Director, Analytical Development & QC, this individual-contributor role will develop complex analytical methods, resolve technical issues, work collaboratively with internal and external stakeholders and advance Immunome's oncology pipeline.  In addition, this role will be part of a team to build and enhance internal analytical development capabilities, including method development, validation, and transfer processes. The ideal candidate will have a strong background in developing complex analytical methods spanning characterization and QC testing, experience in CDMO interactions, and familiarity with cGMP and authoring analytical documents for regulatory submissions.

## Responsibilities

- Develop and execute phase-appropriate analytical methods for small molecule Linker payload (LP) intermediate, including specifications and control strategies.
- Provide technical leadership for method development, qualification, validation, transfer, troubleshooting, and lifecycle management across various techniques such as LC, GC, LC-MSMS, Karl Fischer, and spectroscopy.
- Develop robust analytical testing methodologies to support complex small molecule manufacturing, characterization, release and stability testing, on-site or in collaboration with Contract Development/Manufacturing Organization (CDMO),
- Oversee and manage relationships with external testing labs ensuring alignment with project timelines, quality standards, and regulatory requirements.
- Lead investigations of method performance, manufacturing issues, deviations, and OOS/OOT results; root-cause analysis, corrective actions, and risk-based recommendations.
- Assume Analytical Lead responsibilities for Immunome pipeline programs, providing scientific guidance on data analysis and interpretation, contributing to the preparation of regulatory submissions and technical reports.
- Participate in the creation of essential documentation (SOPs, protocols, reports) to support GMP activities, regulatory submissions, and method transfers.
- Stay informed of emerging trends in analytical development and evolving regulatory requirements, integrating these into the company’s development and QC strategy.
- Work closely with cross-functional teams, including discovery and process chemistry, quality assurance, virtual management team and regulatory affairs to ensure alignment of project goals and objectives.
- Author and review analytical sections of CMC documents and regulatory submissions (IND/CTA, NDA/MAA, CTD), including methods, validation, specifications, impurities, and stability. Review batch records and batch release documentation.
- Establish analytical and stability plans, impurity-control approaches, reference standard programs, and comparability strategies supporting scale-up and technology transfer.
- Assist in establishing internal capabilities for small molecule analytical method development and product characterization.

## Qualifications

- A minimum of a Ph.D. With 3 years' experience, M.S. with 8 years, or B.S. with 10 years in the biopharmaceutical industry, or equivalent combination of experience and education. A degree in Analytical Chemistry, Pharmaceutical Sciences, Chemistry, or related fields are preferred.
- Demonstrated experience developing, validating, troubleshooting, and transferring analytical methods for small molecule compounds in cGMP environments, managing stability programs, and supporting global regulatory submissions.
- Experience providing technical oversight of CDMOs, CROs, and contract testing laboratories.
- Experience in Linker Payload (LP) product characteristics including understanding of conjugate type and linker-payload properties on product quality is highly preferred.
- Position may require occasional evening and/or weekend commitment.
- Position may require domestic and/or international travel, up to 25%.

Knowledge and Skills

- Hands-on expertise with LC, GC, LC-MSMS, NMR, DVS, Karl Fischer, spectroscopy, impurity profiling, and degradation studies
- Good understanding of small molecule control strategies, including specifications, impurities, stability, reference standards, and comparability.
- Strong scientific judgment and technical problem-solving skills for complex analytical and manufacturing challenges.
- Working knowledge of pharmacopoeias, cGMP, data integrity, analytical lifecycle management, and applicable ICH and compendial guidance.
- Excellent written and verbal communication skills for diverse technical and non-technical audiences.
- Exceptional organizational skills and the ability to work with minimum supervision in a fast-paced, dynamic biotech environment.
- Solution-oriented problem-solving skills, with the capacity to manage multiple projects and prioritize in a fast-paced setting.
- Commitment to scientific excellence, quality culture, data integrity, and technical mentorship.

Washington State Pay Range $170,000—$196,227 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: [E-Verify Participation Poster](https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk) | https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e | https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u.

## About Immunome, Inc.

## Company Overview
- **One-liner**: Immunome is a clinical-stage oncology company developing first-in-class and best-in-class targeted cancer therapies, with a primary focus on antibody-drug conjugates (ADCs).
- **Entity Type**: Public (Nasdaq: IMNM)
- **Headquarters**: Bothell, Washington, United States
- **Founded**: The company was formed through a merger of Morphimmune and Immunome in October 2023.
- **Founders**: The company is led by Clay Siegall, Ph.D. (Chairman, CEO, and President), who co-founded Seagen. The original Immunome entity was founded earlier, but the current company structure dates to the 2023 merger.

## Core Business
- Primary industry/industries: Biotechnology, Oncology, Drug Discovery & Development
- Target customers: Patients with cancer, healthcare providers, and clinical trial sites. The company is a B2B/B2C entity in the healthcare and life sciences space.
- Mission or purpose statement: "Our mission is to improve outcomes for cancer patients by advancing and expanding a portfolio of first-in-class and best-in-class therapeutic candidates." [immunome.com](https://immunome.com/)

## Products & Services
- **Varegacestat (formerly AL102)**: A late-clinical stage gamma secretase inhibitor for the treatment of desmoid tumors. The company submitted a New Drug Application (NDA) to the U.S. FDA in April 2026. [investors.immunome.com](https://investors.immunome.com/)
- **IM-1021**: A ROR1-targeted antibody-drug conjugate (ADC) currently in a Phase 1 trial.
- **IM-3050**: A FAP-targeted radioligand which received IND clearance in Q1 2025.
- **Preclinical ADC Pipeline (IM-1617, IM-1340, IM-1335)**: ADCs pursuing undisclosed targets with expression in multiple solid tumors. IM-1617 had its first patient dosed in a Phase 1 trial in June 2026. [investors.immunome.com](https://investors.immunome.com/)

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the search results. As a public company, this fluctuates. (Check recent filings for current data).
- **Key Metric**: The company is pre-revenue (clinical-stage) and has raised significant capital. Since the 2023 merger, CEO Clay Siegall has raised $355 million in equity financings. [immunome.com](https://immunome.com/about/)
- **Notable Investors/Partners**: The company is publicly traded. Key leadership previously worked at Seagen (acquired by Pfizer for $43 billion).
- **Growth Signals**: The company is rapidly advancing its pipeline. Key milestones include the NDA submission for varegacestat, first patient dosed for IM-1617, and positive Phase 3 data presented at ASCO 2026. The company currently lists 32 open positions on its careers page, indicating strong hiring momentum. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)

## Competitive Advantages
- **World-Class Leadership**: The executive team, led by Seagen co-founder Clay Siegall, has deep experience in designing, developing, and commercializing blockbuster ADCs (ADCETRIS, PADCEV, TIVDAK, TUKYSA). [immunome.com](https://immunome.com/about/)
- **Proprietary ADC Platform**: A systematic, data-driven process for optimizing antibodies, linkers, and payloads to create differentiated ADCs. [immunome.com](https://immunome.com/)
- **Near-Term Catalyst**: The NDA submission for varegacestat provides a potential near-term commercial opportunity.
- **Strong Financial Backing**: Raised $355M in equity since the merger, providing a solid runway for pipeline advancement.

## Strategic Focus
- **Advancing the Pipeline**: The primary focus is on executing clinical trials for varegacestat (Phase 3), IM-1021 (Phase 1), and IM-3050 (Phase 1), and advancing preclinical ADCs into the clinic.
- **Regulatory Filing**: Successfully navigating the FDA NDA submission and potential approval for varegacestat.
- **Discovery & Expansion**: Using their ADC discovery platform to generate new candidates and identify and acquire targeted oncology assets to expand the portfolio. [immunome.com](https://immunome.com/about/)

## Why Work Here
- **Mission-Driven**: The work directly impacts the lives of cancer patients, with a stated goal of developing transformative therapies. [immunome.com](https://immunome.com/about/)
- **High-Impact Team**: Opportunity to work with "some of the brightest and most experienced minds in ADC development," including leaders who have brought multiple drugs to market. [immunome.com](https://immunome.com/careers/)
- **Growth Stage**: With 32 open roles, the company is in a rapid growth phase, offering significant career advancement opportunities. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)
- **Comprehensive Benefits**: Includes 100% company-paid medical premiums for employees, a 401(k) with employer match, paid parental leave, and a week-long winter break. [immunome.com](https://immunome.com/careers/)
- **Location & Culture**: Based in Bothell, WA. The company describes a culture of "innovative, collaborative environment where employees are empowered to do their best work." [immunome.com](https://immunome.com/careers/)

## Sources
1. [Immunome Official Website](https://immunome.com/)
2. [Immunome About Page](https://immunome.com/about/)
3. [Immunome Investor Relations](https://investors.immunome.com/)
4. [Immunome Careers Page](https://immunome.com/careers/)
5. [Immunome Jobs on Greenhouse](http://job-boards.greenhouse.io/immunomeinc)

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