---
title: '(Principal) Senior Scientist, Pharmacology at Nosis Bio'
canonical: 'https://feeny.ai/job/principal-senior-scientist-pharmacology-nosis-bio-alameda-j539t9dmcb59'
type: 'job'
last_seen: '2026-11-06'
---

# (Principal) Senior Scientist, Pharmacology at Nosis Bio

- **Company:** Nosis Bio
- **Location:** Alameda, CA
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-09-14
- **Last confirmed live:** 2026-11-06
- **Apply:** https://jobs.ashbyhq.com/nosisbio/4b8feb70-0243-4c46-a4bf-937f2b6e731a

## Job description

## About Nosis Bio

Nosis Bio is a well-funded biotech startup focused on cell-specific delivery of RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts who believe targeted extrahepatic delivery is the key to making RNA therapies the standard of care for a wide range of chronic diseases. We combine deep expertise in receptor biology, generative AI, and high-throughput in vivo data generation to accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech companies.

## About the Role

We are seeking a Principal or Senior Scientist in Pharmacology to lead molecular biology strategy and execution for studies that characterize the pharmacokinetics, pharmacodynamics, biodistribution, target engagement, and activity of RNA therapeutic candidates. This hands-on scientific leadership role will own studies from experimental design through data interpretation and integrate molecular readouts with in vivo and program data to guide development decisions. The ideal candidate will bring deep expertise in quantitative molecular biology, assay development, and analysis of complex biological samples, with a record of setting technical direction, solving ambiguous scientific problems, and working effectively across pharmacology, discovery biology, chemistry, and data science. Title will be commensurate with experience. Scientific Responsibilities ● Design and lead quantitative molecular biology studies supporting pharmacokinetic, pharmacodynamic, biodistribution, target engagement, and gene expression assessments ● Develop, optimize, qualify, and oversee workflows for RNA and DNA extraction, cDNA synthesis, RT-qPCR, qPCR, ddPCR, and related molecular assays across programs ● Establish robust sample-processing workflows across cells, tissues, and biofluids, including homogenization, lysis, cleanup, quantification, normalization, and RNase-free handling ● Translate program questions into study strategies with appropriate controls, acceptance criteria, replication, timelines, and sample requirements ● Analyze and integrate complex datasets, including relative and absolute quantification, assay performance metrics, and relationships among molecular, exposure, efficacy, and other pharmacology readouts ● Lead troubleshooting and root-cause investigations for assay and instrument performance, and implement durable improvements to experimental workflows ● Establish and maintain SOPs, assay qualification summaries, data analysis templates, and training materials that support reproducible execution across the team ● Ensure accurate, real-time documentation in the electronic lab notebook, including protocols, raw data, deviations, quality-control decisions, and scientific interpretation ● Coordinate cross-functionally so sample generation, handling, analysis, and reporting remain aligned with study objectives and program timelines ● Present data with clear context, controls, conclusions, and recommendations, and use the results to guide experimental plans and program decisions Leadership Responsibilities ● Lead quantitative molecular biology strategy across one or more pharmacology programs, aligning assay plans with biological questions, technical feasibility, and program priorities ● Own molecular assay platforms end to end, including capability building, performance tracking, risk identification, resource planning, and continuous improvement ● Identify and implement new technologies, analytical approaches, and external capabilities that expand the pharmacology toolkit ● Mentor scientists and research associates, providing technical guidance and maintaining a high bar for rigor, reproducibility, documentation, and scientific interpretation ● Serve as a scientific leader across functions and external collaborations, integrating molecular and in vivo evidence into program strategy and scientific communications

## What We Are Looking For

● PhD in Molecular Biology, Biochemistry, Genetics, Pharmacology, Bioengineering, or a related field, or an equivalent combination of advanced training and relevant industry experience ● Deep hands-on experience with quantitative PCR methods and molecular assay development, including work with complex tissue or biofluid samples ● Demonstrated ability to design pharmacology studies, interpret pharmacokinetic and pharmacodynamic readouts, and integrate molecular results with cross-functional datasets ● Experience with RNA therapeutic development including preclinical pharmacology data preparation and presentation for scientific and regulatory interactions. ● Ability to work on site in our laboratory at Research Park at Marina Village in Alameda, California

## About Nosis Bio

## Company Overview
- **One-liner**: Nosis Bio is a biotechnology company developing receptor-targeted RNA medicines using an AI-native platform to enable cell-specific gene silencing for the treatment of chronic diseases.
- **Entity Type**: Private (Series stage not publicly disclosed)
- **Headquarters**: Berkeley, California, United States
- **Founded**: Not publicly disclosed
- **Founders**: Jim Martineau (CEO & Co-founder), Seth Myers (CTO & Co-founder), Chad Miller (Head of Research Platform & Co-founder)

## Core Business
- **Primary industry/industries**: Biotechnology, RNA Therapeutics, Drug Delivery, AI-Powered Drug Design
- **Target customers**: B2B (pharmaceutical partners for co-development and licensing) and B2C (patients via internal pipeline of therapeutics)
- **Mission or purpose statement**: To end chronic disease by changing the cost and risk curve of new therapeutic development.

## Products & Services
- **Connexa™ Platform**: An AI-native, physics-aware deep learning platform that designs RNA therapeutics capable of targeting any cell type. It co-selects and co-optimizes delivery ligands with specific RNA payloads to unlock therapeutic access for conditions of the heart, lungs, kidneys, muscle, small intestine, blood cells, and brain.
- **Internal Pipeline (Fibrosis)**: Nosis Bio nominated its first development candidate in fibrosis in July 2025, advancing its cell-targeted gene silencing platform into IND-enabling studies.

## Market Standing
- **Valuation**: Not disclosed
- **Key Metric**: Total funding amount not publicly disclosed; revenue not applicable (pre-commercial biotech)
- **Notable Investors/Partners**: Johnson & Johnson (strategic collaboration and license agreement, expanded in March 2026 for Neurology), Daiichi Sankyo (collaboration announced March 2025)
- **Growth Signals**: 46.2% year-over-year headcount growth (13 employees as of mid-2026); opened a new 16,000-square-foot facility in Alameda, CA; nominated first development candidate; secured major pharma partnerships with J&J and Daiichi Sankyo; active job postings (3 open roles as of July 2026).

## Competitive Advantages
- **Cell-specific delivery**: The company’s core differentiator is solving the "largest unmet need in RNA therapeutic development" — delivering RNA medicines to cells beyond the liver. This unlocks an entirely new class of treatable diseases.
- **Physics-aware AI**: Unlike many AI drug discovery companies that rely purely on pattern recognition, Nosis uses physics-informed machine learning (e.g., Deep Kernel Inversion) to scale accurate molecular interaction predictions, reducing the risk of overpromising.
- **Full-stack platform**: The Connexa platform integrates delivery vehicle design, payload selection, and high-throughput biochemistry in-house, allowing rapid, de-risked in vivo development.

## Strategic Focus
- **Neurology and beyond**: The expanded J&J collaboration (March 2026) signals a major push into central nervous system (CNS) indications, a notoriously difficult area for drug delivery.
- **Internal pipeline advancement**: With a development candidate nominated in fibrosis, the company is transitioning from a pure platform play to a pipeline-stage biotech, moving toward IND-enabling studies.
- **Partnership-driven growth**: Nosis is leveraging pharma collaborations to validate its platform while simultaneously advancing its own therapeutic programs, balancing near-term revenue with long-term value creation.

## Why Work Here
- **Culture**: The company emphasizes a culture of "empathy and respect," "first principles thinking," and "failing fast, failing often, and learning." They value patient-centric outcomes and hold themselves to the highest standards of scientific rigor.
- **Team**: Highly collaborative with a flat structure; the team includes brilliant scientists and engineers across computational, biochemistry, and translational disciplines. As of mid-2026, the team is small (~13 people) but growing rapidly (+46% YoY), offering significant impact and ownership.
- **Work Environment**: Based in a brand-new, 16,000-square-foot facility in Alameda, CA, equipped for in-house high-throughput biochemistry. The company is on-site (Alameda/Berkeley area), with a focus on wet-lab and computational science collaboration.
- **Notable Perks**: Opportunity to work at the frontier of AI and biology; direct exposure to major pharma partnerships (J&J, Daiichi Sankyo); early-stage equity potential in a high-growth startup; a mission-driven focus on curing chronic disease.

## Sources
1. [nosisbio.com](https://www.nosisbio.com/)
2. [nosisbio.com/about](https://www.nosisbio.com/about)
3. [nosisbio.com/careers](https://www.nosisbio.com/careers)
4. [linkedin.com/company/nosisbio](https://www.linkedin.com/company/nosisbio)
5. [jobs.ashbyhq.com/nosisbio](https://jobs.ashbyhq.com/nosisbio)

## Other roles at Nosis Bio

- [Molecular Biology Research Associate I/II/Snr RA, Pharmacology](https://feeny.ai/job/molecular-biology-research-associate-i-ii-snr-ra-pharmacology-nosis-bio-alameda-vnqw4wpsc5pd) — Alameda, CA
- [In Vivo Technical Specialist](https://feeny.ai/job/in-vivo-technical-specialist-nosis-bio-alameda-5krynm64qyg2) — Alameda, CA