---
title: 'Principal Software Architect | Luma at Dotmatics'
canonical: 'https://feeny.ai/job/principal-software-architect-luma-dotmatics-boston-702nhgbygafz'
type: 'job'
last_seen: '2026-11-12'
---

# Principal Software Architect | Luma at Dotmatics

- **Company:** Dotmatics
- **Location:** Boston, MA
- **Compensation:** $173k–$235k
- **Posted:** 2026-11-12
- **Last confirmed live:** 2026-11-12
- **Apply:** https://www.dotmatics.com/jobs/apply?gh_jid=4752587005

## Job description

Our Why At Dotmatics

At Dotmatics, a Siemens company,  we believe science, data, and decision-making must be deeply intertwined for innovation to thrive. Our Portfolio includes Luma, LumaLab Connect, ELN Platform, Graphpad Prism, Geneious, SnapGene, Protein Metrics, OMIQ, FCS Express, LabArchives, NQuery, EasyPanel, SoftGenetics and Virscidian.

We have a vision for a new Lab of the Future that will change the future of scientific research.

We have created the world’s most comprehensive digital science platform – best-of-breed software applications already used by more than 2 million scientists, together in a single ecosystem united by a powerful, flexible enterprise data platform. This is not flat data buried away in digital graveyards. This is dynamic, multi-dimensional decision-making.

Scientific enterprises need a new level of effectiveness to achieve tomorrow’s breakthroughs. Illness will not wait. The biosphere will not wait. We are tireless in our vision, because the time for innovation is now.

Shaping the Future of Science At Dotmatics

Our global team of more than 800 colleagues are dedicated to supporting our customers in over 180 countries. Together, with our scientific community of users, we accelerate scientific innovation in order to make the world a healthier, cleaner, and safer place to live.

You’ll join a collaborative, global team pushing the boundaries of scientific innovation.  Your ideas and efforts will have a tangible impact, accelerating scientific progress and discovery. We offer a dynamic, remote-friendly environment that fosters high integrity and collaboration, empowering you to excel. Dotmatics is a company built by scientists, for scientists. Combined, we are now the world’s largest cloud-based scientific research R&D platform. We need your help to keep growing and pioneering the future.

We are Science Driven. We are Customer Centric. We are Better Together.

What do we need

We are looking for an experienced Principal Engineering Architect to help shape the architecture of Dotmatics Luma, our next-generation, multi-tenant, AI-powered data management and workflow automation platform for multimodal scientific discovery. You will design and refine the AWS systems that deploy Luma efficiently to customers.

As a Principal Software Engineering Architect, you will be a key driver in delivering Luma to customers. This role will be an influential leader and advisor to the Engineering and Product teams. You will provide deep technical expertise on our current technologies, and technical leadership that promotes new ideas and improves how we build and release Luma, including how instruments, scientific data, and the AI agent at the core of the platform connect.

In this role you will get to

- Support and drive the end-to-end architecture of Luma, from instrument connectivity and data ingestion through to the platform services and AI agent experience
- Influence technology choices for the platform
- Design solutions that are enterprise scalable and maintainable, with the data isolation and auditability that regulated scientific customers
- Collaborate on architectural principles, frameworks, best practices, and standards, including how the AI agent and extension points such as MCP connect securely to platform services
- Drive strategic technology initiatives with Product Managers, other Architects, and Engineers
- Be hands-on in developing and delivering Luma, this includes prototyping and guiding the implementation of components inside of Luma.
- Help improve developer experience and software lifecycle by proposing tools and pipelines that increase the quality of the software development experience.
- Advise the product team in clarifying requirements for deploying Luma into customer clouds, including multi-tenant and regulated-environment needs
- Work with customer cloud teams.
- Facilitate the architecture processes, including architecture reviews and documentation
- Mentor other software engineers on the team
- Shape projects in a timely manner to established architecture patterns
- Work in a consultative fashion to improve communication, collaboration, and alignment among teams inside and outside the organization
- Analyse and provide feedback on Luma product strategy

We are looking for people who have a BSc in Computer Science and 10+ equivalent, with deep technical expertise in engineering architecture and engineering design. You will have expert knowledge of building, releasing, and maintaining a complex scientific enterprise software platform.

The Key Skills we are looking for:

- Deep understanding of modern cloud software architecture, including multi-tenant platforms
- Systems design and development, with a solid understanding of application development best practices and core enterprise applications
- Deep knowledge of AWS services
- Knowledge of cloud-native infrastructure such as Kubernetes and Kafka
- Working technical knowledge of integration strategies, including web services and APIs
- Experience setting up agentic harnesses for code generation
- Influential communication with core and cross-functional teams
- Infrastructure-as-code solutions (CloudFormation, Terraform)
- Software containerization concepts (Docker, Podman)
- CI/CD tools (Jenkins, TeamCity, CodePipeline)
- Knowledge of networking concepts in cloud environments
- Software development lifecycle processes and version control
- Modern back-end JavaScript and Node.js, Python
- Business requirements gathering and analysis, strategic planning, and project planning and management
- Engineering evaluation principles and practice

You may also have:

- Instrument integration and scientific data ingestion (e.g. SiLA, OPC-UA)
- Apache Spark, Databricks, or comparable data platforms
- Securing AI agent integrations (permissions, sandboxing, prompt injection defense)
- Experience using research informatics software and tools
- Scala

Total Rewards

Dotmatics utilises a national market-based approach to base pay benchmarking and pay band development. The candidate's final starting pay is based on job-related skills, experience, job specific qualifications & location. In addition to base salary, Dotmatics has implemented a total rewards strategy, which is the combination of compensation, benefits and recognition.

Certain positions are also eligible for variable pay; your recruiter will discuss the full compensation package details.

Other Total Rewards Offered

- Medical, Dental, Vision, Insurance
- Health Spending Accounts
- Wellness Benefits (Mental Health Apps and Fitness Perks)
- Company-paid Life and Disability Insurance
- 401k Retirement Plan (with 4% company match; immediate vesting)
- Flexible Time off Plan (for US exempt employees)

This is the range that we, in good faith, believe is the range of possible compensation for this role at the time of this posting. We may ultimately pay more or less than the posted range. This range may be modified in the future.

Base Pay Range $173,400—$234,600 USD

Research shows us the[confidence gap](https://www.theatlantic.com/magazine/archive/2014/05/the-confidence-gap/359815/) and imposter syndrome can get in the way of meeting outstanding candidates, so please don’t hesitate to apply — we’d love to hear from you.

By submitting your application, you agree that Dotmatics may collect your personal data for recruiting, global organization planning, and related purposes. Dotmatics [Privacy Notice](https://www.dotmatics.com/privacy-policy) explains what personal information we may process, where we may process your personal information, our purposes for processing your personal information, and the rights you can exercise over Dotmatics use of your personal information.

Dotmatics is an equal opportunity employer. We are a welcoming place for everyone, and we do our best to make sure all people feel supported and connected at work.

## About Dotmatics

## Company Overview
- **One-liner**: Dotmatics provides a cloud‑based scientific R&D platform that connects best‑in‑breed software applications to accelerate research and innovation.
- **Entity Type**: Private (wholly owned subsidiary of Siemens AG following a $5.1 billion acquisition completed July 1, 2025)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2005
- **Founders**: Stephen Gallagher, Alastair Hill

## Core Business
- **Primary industry**: Scientific R&D software for life sciences, biopharma, clinical research, and academia.
- **Target customers**: B2B – biopharma companies, contract research organizations (CROs), academic institutions, and forensic/genetic testing labs.
- **Mission**: “To accelerate scientific innovation and help make the world a healthier, cleaner, and safer place to live.”

## Products & Services
- **Dotmatics Platform**: Cloud‑based enterprise data management platform that harmonizes data from instruments and software for AI‑ready analysis.
- **Luma Agent**: Agentic AI assistant that plans, executes, and documents research workflows, from data query to audit‑ready reports.
- **GraphPad Prism**: Widely used statistical analysis and graphing software for scientists.
- **SnapGene**: Molecular biology visualization and cloning software with detailed documentation.
- **Geneious Suite**: Bioinformatics tools for molecular biology, genomics, and antibody screening.
- **LabArchives**: Electronic lab notebook for capturing and collaborating on experimental data.
- **Other Applications**: OMIQ (flow cytometry), Protein Metrics, nQuery, SoftGenetics (clinical/forensic genetics), and M‑Star.

## Market Standing
- **Valuation/Market Cap**: Acquired by Siemens AG for $5.1 billion (announced April 2025, closed July 2025)
- **Key Metric**: 2 million+ users, 10,000+ customers, 800+ employees (LinkedIn data: 364 employees as of mid‑2025, with 4.7% YoY growth)
- **Notable Investors/Partners**: Insight Partners (lead prior to acquisition), Siemens (current parent); customers include Illumina, GSK, Waters Corporation, and PerkinElmer.
- **Growth Signals**: Launch of Luma AI agent; acquisition of SoftGenetics expanding into clinical and forensic markets; 20%+ LinkedIn follower growth; 65% average NPS score.

## Competitive Advantages
- **Ecosystem play**: Open platform that unites multiple industry‑leading scientific applications (GraphPad Prism, SnapGene, Geneious) with a data‑driven backbone.
- **AI leadership**: Luma Agent provides end‑to‑end automation with full traceability, a key differentiator in the lab‑of‑the‑future space.
- **Siemens backing**: Access to global industrial reach, resources, and digital infrastructure after acquisition.
- **User base loyalty**: 2 million active scientists across 180+ countries; strong brand recognition in academia and biopharma.

## Strategic Focus
- Transitioning to an AI‑native "Lab of the Future" with Luma Agent as the central orchestrator.
- Expanding into clinical and forensic genetic analysis via recent acquisitions.
- Deepening integration with Siemens’ digital industry portfolio to offer end‑to‑end R&D solutions.
- Continuing to build a multimodal science platform that structures data for AI/ML applications.

## Why Work Here
- **Culture**: “Science Driven, Customer Centric, Better Together” – built by scientists for scientists.
- **Work model**: Remote‑friendly with hubs in Boston, UK (Bishop’s Stortford), San Diego, Auckland, Tokyo, Cork, and others.
- **Employee ratings**: 4.1/5 on LinkedIn (work‑life 4.2, culture 3.9, compensation 3.8, career 3.7).
- **Engineering roles**: Senior Full Stack Engineer (Node.js), Staff Data Engineer, Senior Data Analytics Engineer, Performance Test Engineer.
- **Impact**: Work on products used by millions of researchers globally, with the opportunity to shape AI‑driven scientific discovery.

## Sources
1. [dotmatics.com](https://www.dotmatics.com/) – Main site, product overview, Luma Agent details.
2. [dotmatics.com/about-us](https://www.dotmatics.com/about-us) – Mission, vision, company history, acquisition by Siemens.
3. [dotmatics.com/about-careers](https://www.dotmatics.com/about-careers) – Culture, remote/hybrid policy, 800+ employees, global hubs.
4. [linkedin.com/company/dotmatics](https://www.linkedin.com/company/dotmatics) – Employee count, revenue, funding, acquisitions, recent departures, job postings.
5. [dotmatics.com/jobs](https://www.dotmatics.com/jobs) – Current open positions.

## Other roles at Dotmatics

- [Director, Product | Lab Archives](https://feeny.ai/job/director-product-lab-archives-dotmatics-united-states-95hjvbmnjnp2) — United States
- [DevOps Engineer | Luma](https://feeny.ai/job/devops-engineer-luma-dotmatics-boston-3ggwe8t28jft) — Boston, MA
- [DevOps Engineer | Luma](https://feeny.ai/job/devops-engineer-luma-dotmatics-ireland-4grdmhw3ztnq) — Ireland
- [DevOps Engineer | Luma](https://feeny.ai/job/devops-engineer-luma-dotmatics-united-kingdom-bfv01tr5w01v) — United Kingdom
- [Scientific  QA -  User Testing | Luma](https://feeny.ai/job/scientific-qa-user-testing-luma-dotmatics-ireland-e9167s1xxny9) — Ireland
- [Scientific  QA -  User Testing | Luma](https://feeny.ai/job/scientific-qa-user-testing-luma-dotmatics-united-kingdom-q6sy1av9br2h) — United Kingdom
- [Staff Data Engineer | Luma (MEX)](https://feeny.ai/job/staff-data-engineer-luma-mex-dotmatics-mexico-city-ciudad-de-mexico-2qwhfac597fx) — Mexico City Ciudad de México, Mexico
- [Pre-sales Engineer - Japan | Luma](https://feeny.ai/job/pre-sales-engineer-japan-luma-dotmatics-japan-ddj5he482ey4) — Japan
- [Sales Manager | India](https://feeny.ai/job/sales-manager-india-dotmatics-chennai-pkkk28d4c0eg) — Chennai, India
- [Pre-sales Engineer, Chemistry | Luma](https://feeny.ai/job/pre-sales-engineer-chemistry-luma-dotmatics-chennai-xdj41t4bs4q3) — Chennai, India