--- title: 'Process Engineer I, Data and Knowledge Management at Vaxcyte' canonical: 'https://feeny.ai/job/process-engineer-i-data-and-knowledge-management-vaxcyte-san-carlos-a2fbd5dqkav5' type: 'job' last_seen: '2026-11-02' --- # Process Engineer I, Data and Knowledge Management at Vaxcyte - **Company:** Vaxcyte - **Location:** San Carlos, CA - **Posted:** 2026-10-30 - **Last confirmed live:** 2026-11-02 - **Apply:** https://boards.greenhouse.io/vaxcyte/jobs/5465543008?gh_jid=5465543008 ## Job description Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: As we grow, we are seeking a strategic and collaborative Process Engineer I, Data and Knowledge Management to ensure the integrity, accessibility, and effective use of data and knowledge assets across the organization. This role will execute component-level analysis, utilizing data and knowledge resources critical to our process development, regulatory, and operational activities. The Process Engineer I, Data and Knowledge Management is instrumental in ensuring scientific data integrity, regulatory readiness, and the preservation of institutional knowledge in a dynamic, fast-paced clinical environment. Essential Functions: Engineering Analytics & Process Insights: - Assess process trends and discrepancies using engineering knowledge, and evaluate the technical rationale and potential impact of proposed process improvements - Apply chemical and biochemical engineering principles to evaluate relationships between process parameters, unit operation performance, and product quality attributes - Partner with data science team to drive data visualization, reporting, and insights. - Support the use of AI/ML and automation for improved data analysis and knowledge extraction. Manufacturing Process Data Management & Governance: - Acquire, integrate, and technically evaluate manufacturing process data from internal teams and contract manufacturing sites to support process monitoring, continuous improvement, and CMC regulatory submissions. - Develop data management and verification workflows that preserve the accuracy, integrity, and traceability of manufacturing process data. - Lead and own data verification for all commercial regulatory submissions. Process Knowledge Management: - Develop structured systems and workflows to capture and retain organizational knowledge, including protocols, study results, lessons learned, and decision rationales. - Develop tools and processes that enable technical teams to access, share, and apply process knowledge to support manufacturing and process improvement. - Champion a knowledge-sharing culture across technical, scientific and operational functions. Collaboration & Technical Leadership: - Partner with regulatory, quality, R&D, IT and contract manufacturing teams to understand technical needs and develop appropriate solutions. Compliance & Risk Management: - Ensure compliance with data protection and clinical trial regulations, including GDPR, HIPAA, and 21 CFR Part 11. - Identify and mitigate risks related to data security, access, and retention. Requirements: Bachelor’s degree in Chemical Engineering, Bioprocess Engineering, or a related engineering discipline is required. 8+ years of relevant experience in biopharmaceutical process engineering, Manufacturing Science and Technology (MSAT), process development, manufacturing technical support, or related engineering work, including at least 3 years in the life sciences or biotechnology industry. Other combinations of education and/or experience may be considered. - Experience interpreting manufacturing process data and applying engineering and statistical methods to evaluate process performance. - Proven experience leading enterprise data governance and knowledge sharing initiatives in a highly regulated environment. - Strong technical communication, project management, and cross-functional collaboration skills, with the ability to work effectively with engineering, scientific, and manufacturing teams. - Experience with tools like SharePoint, Veeva Vault, Confluence, Tableau, and SQL is highly desirable. Preferred: - Experience supporting clinical trials and regulatory submissions (e.g., IND, BLA). - Background in immunology, vaccines, or infectious disease R&D. - Experience in scaling systems and processes in a high-growth, early- to mid-stage. Reports to: Senior Director, Process Validation, Global MSAT Location: United States Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Remote Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $121,000 - $142,000 Relocation: This role is not eligible for relocation assistance. ## Equal Opportunity We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Recruitment Fraud Notice Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at [vaxcyte.com/careers](https://vaxcyte.com/careers/). ## About Vaxcyte ## Company Overview - **One-liner**: Vaxcyte is a clinical-stage biotechnology company re-engineering how vaccines are made to eliminate bacterial infections, using a cell-free protein synthesis platform to develop high-fidelity, broad-spectrum vaccines. - **Entity Type**: Public (Ticker: PCVX) - **Headquarters**: San Carlos, California, United States - **Founded**: 2013 (as SutroVax; rebranded to Vaxcyte in 2020) - **Founders**: Not publicly available (the company emerged from Sutro Biopharma’s spin-out) ## Core Business - **Primary industry**: Biotechnology / Vaccines (Infectious Disease) - **Target customers**: Global healthcare systems, public health organizations, and ultimately patients (B2B/Institutional); the company develops vaccines for both pediatric and adult populations. - **Mission or purpose**: To protect humankind from the consequences of bacterial infections, eliminating diseases like invasive pneumococcal disease, Group A Strep, and Shigella. ## Products & Services - **VAX-31 (31-valent PCV)**: A broad-spectrum pneumococcal conjugate vaccine candidate in Phase 3 for adults and Phase 2 for infants. Designed to cover over 95% of circulating IPD serotypes in U.S. adults 50+ and ~94% in infants. FDA Breakthrough Therapy designation granted. - **VAX-24 (24-valent PCV)**: A pneumococcal conjugate vaccine candidate in Phase 2 for infants, designed to cover more serotypes than any infant PCV on the market today. - **VAX-A1 (Group A Strep)**: A preclinical conjugate vaccine candidate for Group A Strep, a disease with no currently approved vaccine. Phase 1 first-in-human study (adults) underway in Australia. - **VAX-GI (Shigella)**: A novel preclinical vaccine candidate targeting Shigella, a leading cause of diarrheal disease. - **Platform Technology**: A proprietary cell-free protein synthesis platform that enables site-specific, carrier-sparing conjugation to produce precisely targeted vaccines with enhanced immunogenicity. ## Market Standing - **Valuation/Market Cap**: ~$16.7 billion (as of early July 2026) - **Key Metric**: Total funding raised (private) is not applicable; as a public company, key metrics include cash position (~$2.0 billion as of Q1 2026) and R&D investment. The company is pre-revenue. - **Notable Investors/Partners**: Major institutional investors include Baker Bros. Advisors, Fidelity, and funds managed by BlackRock. Key partnership: exclusive license agreement with Sutro Biopharma for its cell-free protein synthesis platform. - **Growth Signals**: - Up to $1 billion commitment to expanding U.S. manufacturing with a new facility in North Carolina. - VAX-31 Phase 3 program (OPUS-1, OPUS-2, OPUS-3) topline data expected Q4 2026 – H1 2027. - Headcount growth: actively hiring across 100+ roles (Analytical, Commercial, Clinical, Conjugation, Quality, Regulatory). - Recognized as a Great Place to Work and Best Workplace in BioPharma (multiple years). ## Competitive Advantages - **Broadest-spectrum PCV candidates**: VAX-31 is the broadest-spectrum pneumococcal conjugate vaccine in the clinic, targeting up to 31 serotypes. - **Differentiated platform**: Cell-free protein synthesis allows for the creation of complex, high-fidelity vaccines that can overcome bacterial defense mechanisms (e.g., capsule-switching) that limit conventional cell-based vaccines. - **Carrier-sparing technology**: Site-specific conjugation enables a higher valency (more serotypes) without compromising immunogenicity or tolerability. - **Manufacturing scale**: Significant investment in U.S.-based production capacity provides a long-term supply chain advantage and aligns with "Investing in America" initiatives. ## Strategic Focus - **Primary**: Advance VAX-31 and VAX-24 through late-stage clinical trials to secure regulatory approval and establish a new standard of care for pneumococcal disease. - **Pipeline expansion**: Advance VAX-A1 (Group A Strep) and VAX-GI (Shigella) candidates through early clinical development. - **Manufacturing**: Scale up internal manufacturing capabilities to support commercial launch and global supply. - **Commercial readiness**: Building a commercial organization (e.g., hiring a VP of U.S. Market Access & Pricing, Senior Director of Product Launch) to prepare for potential VAX-31 launch. ## Why Work Here - **Culture**: Described as a "kindness-first" mindset with a focus on audacious goals, collaboration, and mutual support. Recognized as a *Great Place to Work* and *Best Workplace in BioPharma* (Fortune). - **Work Model**: Hybrid, Remote, and Onsite options available depending on role. San Carlos HQ offers a hybrid schedule. - **Total Rewards**: 100% paid health, dental, and vision insurance; 401k matching; flexible PTO and holidays; paid parental and sick leave; equity awards (stock options & RSUs); Employee Stock Purchase Plan; lifestyle spending account; mental health and wellness resources. - **Growth & Development**: Strong emphasis on learning culture, professional advancement through coaching, and career development programs. - **Mission-driven**: Employees are directly contributing to creating vaccines that protect every child born and every adult at risk from bacterial infections globally. ## Sources 1. [vaxcyte.com](https://vaxcyte.com/) 2. [vaxcyte.com/careers](https://vaxcyte.com/careers/) 3. [vaxcyte.com/job-listings](https://vaxcyte.com/job-listings/) 4. [vaxcyte.com/culture](https://vaxcyte.com/culture/) 5. 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