---
title: 'Production Supervisor, HPC, Marrow at Ossium Health'
canonical: 'https://feeny.ai/job/production-supervisor-hpc-marrow-ossium-health-indianapolis-c7s100bpyqh4'
type: 'job'
last_seen: '2026-11-02'
---

# Production Supervisor, HPC, Marrow at Ossium Health

- **Company:** Ossium Health
- **Location:** Indianapolis, IN
- **Posted:** 2026-09-22
- **Last confirmed live:** 2026-11-02
- **Apply:** https://ossiumhealth.com/jd?gh_jid=4715539006

## Job description

## About Ossium

Ossium’s mission is to improve the health, vitality, and longevity of human beings through bioengineering. We develop, manufacture, and bank cell therapy products that apply the power of stem cell science to revolutionize treatment for patients with blood, immune, and orthopedic diseases.  At Ossium, we empower our employees, maintain the highest standards of operational excellence, and are a force for good.

About the Production Supervisor, HPC, Marrow Job

Fixed DAY shift: Monday-Friday, 6:00 a.m.-2:30 p.m. with a 30 minute lunch break. No nights, no rotating shifts.

Onsite: Indianapolis Facility

BS or BA in a science field preferred; high school diploma required

This position provides oversight of daily operations and training within Ossium Health’s Production group relating to the processing of donor tissue and HPC, Marrow. The Supervisor will oversee first shift staff involved in the intake, processing, and storage of donor tissue and bone marrow products for pre-clinical and clinical use. The Supervisor will ensure a safe, controlled work environment in all areas of responsibility, be aware of the site safety objectives and quality standards, and make sure they are communicated and understood by all staff. This position will report directly to the Manager of Clinical Production.

Two things are worth knowing before you apply. First, the source material is human. Marrow is recovered from donated vertebral bodies, and every donation reflects a decision made by a family and is a gift we fully honor. Second, processing a donor requires you to be fully gowned, over the head, face, hands, feet, and body, inside a cleanroom, with limited breaks.

Required Qualifications

- High school diploma required
- 2+ years of experience managing people
- 4+ years of experience in manufacturing
- Knowledgeable with respect to manufacturing operations in a regulated environment
- Scientific aptitude and the ability to clearly and thoroughly document all work on existing forms and records
- High level of attention to detail in both operations and documentation
- Excellent written and oral communication skills
- Capability to operate with a high level of organization and excellent time management in a dynamic startup environment

## Preferred Qualifications

- BS or BA in biological sciences or equivalent
- Knowledgeable with respect to aseptic techniques, clean room environment, cellular and tissue processing
- 2+ years aseptic processing or management experience

## Key Responsibilities

- Oversees daily production of HPC, Marrow, including scheduling of staff and troubleshooting processing issues
- Leads daily 1st shift huddles, escalating issues related to safety, quality, delivery, cost, and people during Tier 2 huddle
- Regularly meets with direct reports and escalates any issues or concerns;
- Performs or verifies tasks in the production of HPC, Marrow as assigned
- Ensure necessary training is completed by all production staff
- Provide ongoing coaching and recognition of direct staff
- Review timesheets of direct reports
- Review bone marrow production batch records and associated documentation
- Perform allocation and authorization review for incoming donors and sample requests
- Ensures production activities are performed in accordance with current Good Tissue Practices, AATB standards, and other relevant regulations
- Author or assist in drafting and revising of departmental procedures
- Oversee the cryopreservation and initial inventory of HPC, Marrow product and samples in freezers
- Process quality monitoring, including manipulation of databases, documents and/or spreadsheets to support business reporting requirements, and communication with production specialists regarding the monitoring of processing and product trends
- Maintain the production areas and records in an inspection ready state at all times
- Work with Sterile Processing team and Equipment team to monitor production equipment/tools and ensure all is kept clean, in working order, and within calibration/PM schedule
- Interact with QA department to complete event reports, deviations, CAPAs, and change controls
- Interact with QC department to submit sample requests and prepare reports
- Interact with Management to provide updates, results, suggestions, and work area/process observations

Physical Requirements:

- Must be able to work in a moderately noisy environment
- Must be able to work around biohazardous materials and chemicals
- Required to work the majority of the shift aseptically in a controlled environment with limited breaks. This environment requires special gowning (ie. over the head, face, hands, feet and body).
- Must be able to lift, push, pull and/or carry up to 50 lbs
- Must have sufficient manual dexterity, hand/finger coordination, wrist mobility, wrist stability, and grip strength to handle, feel, grasp, manipulate, and operate objects, manual and power tools, equipment, and controls safely and accurately.
- Regularly required to sit, stand, walk, squat, balance, climb, stoop, kneel, crouch and reach with arms.

A pre-employment physical examination is required for this position. This examination will be conducted after a conditional offer of employment has been extended and will evaluate the candidate's ability to safely perform the essential functions listed above.

Schedule:

- Full-time (40 hours per week) onsite in our Indianapolis facility
- This is a salary, exempt role
- Monday through Friday, 6:00 a.m. to 2:30 p.m; no nights and no rotating shifts to cover
- Occasional holiday and overtime work required: Typically about one Saturday and one holiday per year, driven by donor recovery timing; overtime based on production processing needs
- No weekend shifts today: As we scale toward commercial production, we expect to add weekend coverage; any change will come with significant notice and input from the operators on the floor
- Room to grow. Supervisors have the ability to advance as they qualify and gain experience, with pay increases tied to milestones

We offer a full slate of employee benefits including:

- Competitive salaries
- Stock options
- 401(k) matching
- Medical, dental and vision coverage
- Four weeks of PTO accrued (vacation & sick time) annually  + 11 company holidays
- Employer paid life insurance and long term disability
- Gym membership/recreational sports reimbursements

Ossium Health provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, protected veteran status, sexual orientation, gender identity, gender expression, or any other protected characteristic. Our [Equal Employment Opportunity Policy Statement](https://ossiumhealth.com/wp-content/uploads/2025/05/Ossium-Health-2024-Equal-Employment-Opportunity-Policy-Statement.pdf) and the [Know Your Rights: Workplace Discrimination is Illegal Poster](https://www.eeoc.gov/sites/default/files/2023-06/22-088_EEOC_KnowYourRights6.12.pdf) reaffirm this commitment. Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

If reasonable accommodation is needed, please contact our People Team at careers@ossiumhealth.com or 650-285-0603. Ossium Health complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities.

Principals / direct applicants only please. Recruiters, please do not contact this job poster.

## Equal Opportunity Employer/Veterans/Disabled

## About Ossium Health

## Company Overview
- **One-liner**: Ossium Health is a clinical-stage bioengineering company that creates life-saving stem cell therapies from deceased donors for use in bone marrow transplants and other blood and immune system diseases.
- **Entity Type**: Private (Series C)
- **Headquarters**: San Francisco, California, USA (with a manufacturing facility in Indianapolis, Indiana, USA)
- **Founded**: 2016
- **Founders**: Kevin Caldwell (CEO, Co-Founder) and Erik Woods (Chief Science Officer, Co-Founder)

## Core Business
- **Industry**: Biotechnology / Cell Therapy
- **Target Customers**: B2B – healthcare providers (transplant centers), life science companies (biopharma partners), and organ procurement organizations (OPOs)
- **Mission**: “To improve human health through bioengineering” and “Establish a new source for life-saving stem cells” by bringing the deceased donor transplant ecosystem into the fight against diseases of the blood and immune systems.

## Products & Services
- **HPC, Marrow (Hematopoietic Progenitor Cells from marrow)**: An allogeneic stem cell product derived from vertebral body donors, used in bone marrow transplants. First patient successfully engrafted at Henry Ford Health in June 2024.
- **OssiGraft**: An orthopedic product (first patient treated November 2023) – marks the company’s entry into orthopedics.
- **CD34+ Product**: A purified hematopoietic stem cell product used in a multivisceral transplant study at Columbia University Medical Center (first patient November 2021).
- **Platform Model**: A proprietary process for recovering, processing, and cryopreserving cells from deceased donors, enabling off-the-shelf cell therapies.

## Market Standing
- **Valuation/Market Cap**: Not disclosed
- **Key Metric**: **Total Funding** – USD 128.9 million across multiple rounds (Seed, Series A, Series B, Series C, and a grant)
- **Notable Investors/Partners**:
  - Lead investors: CPMG (Series C lead), Vivo Capital (Series B co-lead), General Catalyst (Series B co-lead), First Round Capital (Series A lead)
  - Other investors: Manta Ray Ventures, Village Global, Asahi Kasei, Alumni Ventures
  - Federal partner: Biomedical Advanced Research and Development Authority (BARDA) – contract for radiological/nuclear emergency preparedness
- **Growth Signals**:
  - Headcount: ~75 employees, with +13.3% yearly growth (LinkedIn)
  - Active job postings: 14 (as of mid-2025)
  - Recent clinical milestones: first patient engrafted with HPC Marrow (June 2024) and first OssiGraft patient (Nov 2023)
  - Series C closed July 2023 ($52M)
  - Expanded into orthopedics and federal preparedness markets

## Competitive Advantages
- **Unique Cell Source**: Uses deceased donors (vertebral bodies) rather than living donors or iPSCs, leveraging an existing transplant network to produce scalable, off-the-shelf allogeneic cell therapies.
- **Proprietary Processing & Cryopreservation**: Founders have deep expertise in cryobiology; Dr. Woods co-invented the first closed-system cryovial for cell therapy (CellSeal®) and commercial human platelet lysate (Stemulate®).
- **Regulatory & Operational Infrastructure**: CLIA-certified lab, FDA-registered facility, and AABB accreditation; experienced in high-complexity clinical cell manufacturing.
- **Government Partnership**: BARDA contract validates the platform for national emergency preparedness, providing a stable, non-dilutive revenue stream and strategic credibility.

## Strategic Focus
- Advance clinical trials for HPC Marrow in bone marrow transplant (lead indication) and expand into orthopedics with OssiGraft.
- Strengthen partnerships with OPOs and healthcare systems to increase donor tissue access.
- Scale manufacturing capacity at the Indianapolis facility to meet commercial and federal contract demand.
- Continue to develop additional cell therapy programs (e.g., immune effector cells, mesenchymal stromal cells) using the same platform.

## Why Work Here
- **Culture & Values**: Emphasizes Truth (data-driven decision making), Ownership (high accountability), Grit (persistence toward mission), and Impact (improving human health).
- **Mission-Driven**: Employees are motivated by the chance to fight diseases like leukemia and lymphoma, and to contribute to national health security (BARDA partnership).
- **Work Environment**: Two locations – San Francisco HQ (office) and Indianapolis facility (cell manufacturing lab). Roles span clinical production, recovery services, quality assurance, research, and commercial. Likely on-site for lab and manufacturing roles.
- **Growth Opportunity**: Rapidly scaling company with recent clinical wins and a growing headcount; employees can take ownership of impactful projects early in their careers.
- **Notable Perks**: Not detailed in search results, but the company highlights “empowering employees, maintaining the highest standards of excellence, and being a force for good.”

## Sources
1. [Ossium Health – Careers Page](https://ossiumhealth.com/careers/)
2. [Ossium Health – Homepage](https://ossiumhealth.com/)
3. [Ossium Health – Company About](https://ossiumhealth.com/company/)
4. [Ossium Health – Our Team](https://ossiumhealth.com/our-team/)
5. [Ossium Health – LinkedIn Company Profile](https://www.linkedin.com/company/ossiumhealth)

## Other roles at Ossium Health

- [Controller](https://feeny.ai/job/controller-ossium-health-san-francisco-zkeha5vh6e4q) — San Francisco, CA
- [Operations Manager, HPC](https://feeny.ai/job/operations-manager-hpc-ossium-health-indianapolis-gha9s2wvmy47) — Indianapolis, IN
- [Chief Financial Officer](https://feeny.ai/job/chief-financial-officer-ossium-health-san-francisco-cra5q8ffrrrs) — San Francisco, CA
- [Regional Manager, Orthopedics](https://feeny.ai/job/regional-manager-orthopedics-ossium-health-e3frwsynacgq)
- [Tissue Recovery Specialist (Contract) - Northern OR Southern Indiana](https://feeny.ai/job/tissue-recovery-specialist-contract-northern-or-southern-indiana-ossium-health-rmvccntaz5r9) — Field Based: Northern, IN / Field Based: Southern, IN