--- title: 'Program Manager, Preclinical & Early Development at Nurix' canonical: 'https://feeny.ai/job/program-manager-preclinical-early-development-nurix-brisbane-california-226fsm3yv1mb' type: 'job' last_seen: '2026-09-10' --- # Program Manager, Preclinical & Early Development at Nurix - **Company:** Nurix - **Location:** Brisbane California, United States - **Posted:** 2026-08-14 - **Last confirmed live:** 2026-09-10 - **Apply:** https://job-boards.greenhouse.io/nurix/jobs/8710974002 ## Job description Program Manager, Preclinical & Early Development Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Reports to: Senior Vice President, Preclinical and Early Development Alliance & Program Management Level: Associate Director - Director Position: Nurix is growing its Preclinical and Early Development Alliance & Program Management capability to support a growing portfolio of IND-enabling and early clinical programs, including partnered assets. We’re looking for a Program Manager to join the team, reporting to the Senior Vice President, Preclinical and Early Development Alliance & Program Management. This role covers two closely related kinds of work. The first: build and maintain integrated project plans for early development programs, working with functional leads across Research, Translational Sciences, Discovery Biology, Medicinal Chemistry, DMPK, Nonclinical Safety/Toxicology, CMC, Clinical Development, Clinical Operations, Regulatory Affairs, and Biometrics to turn scientific and operational input into clear timelines, dependencies, and decision points. The second: run the day-to-day rhythm of a partnered governance committee, keeping the agenda, the record, and the follow-through, so a shared committee with an external partner can reclaim their focus between meetings. The PM will work closely with functional leads to understand how work gets done, map how pieces of a program depend on each other, and identify the critical path and the practical impact when priorities, timelines, or resources shift. The role also supports program-level resourcing and forecasting alongside Finance and functional leaders. Both parts of the role call for turning discussion into clear, documented decisions, then follow through on each one. The Program Manager will also help define the tools, templates, and processes the function uses. Responsibilities: - Build and maintain project plans for assigned programs, covering timelines, milestones, resourcing, and dependencies. - Work with functional leads and bench scientists to build realistic estimates of how long each piece of work will take, then turn those into program-level dependencies and critical path. - Coordinate work across Research, Translational Sciences, Nonclinical Safety, CMC, Clinical Development, Clinical Operations, Regulatory Affairs, and Biostats so each function's plan lines up with the program's plan. - Flag the practical impact of changes in scope, timing, or resourcing (what shifts, what's at risk, and the best next step) for program and functional leadership. - Facilitate project team meetings toward clear decisions and keep the decision log so the team has one record of what was decided and why. - Run the governance committee's day-to-day rhythm and its subteams: build each agenda with the partner's project manager counterpart, pull topics directly from members and subteam leads, and sequence items so the most urgent gets the time it needs. - Provide meeting materials and keep a shared repository that separates the current cycle from the archive. - Draft and circulate minutes promptly, tie decisions to the meeting where it was made. - Turn action items, internal or partnered, into named commitments with an owner and due date, and follow up before the next meeting to confirm they happened. - Track and escalate risks and issues, and build contingency plans with program, functional, and partner-side leads. - Prepare status reports, dashboards, and materials for program review and governance meetings, so leadership has clear, current visibility into program health. - Keep committee and subteam rosters current, flag staffing gaps early, support onboarding new members and leads, and track program and collaboration milestones. - Support program-level resourcing and forecasting with Finance and functional leaders. - Help define and improve the project management tools, templates, and processes used across Preclinical and Early Development as this capability grows. - Build strong working relationships across the project management team, functional stakeholders, and external partners, and help keep a consistent standard of practice across programs. ## Qualifications Required - Master’s degree in life sciences, engineering, or a related technical field; advanced degree a plus. - 7+ years of project or program management experience in a biotech, pharmaceutical, or CRO setting, spanning discovery through translational and early clinical development. - Demonstrated ability to build and manage integrated project plans and translate technical or scientific input from functional experts into realistic timelines and dependency maps. - Strong meeting facilitation skills, with a track record of driving cross-functional groups to clear, documented decisions. - Good judgment in weighing the downstream effects of program changes, with the ability to clearly explain trade-offs and recommendations to leadership. - Strong written and verbal communication skills, with the ability to work effectively with scientists, functional leads, and senior leadership. - Comfortable building relationships and getting things done without formal authority over the people involved. - Organized and able to juggle more than one complex program at a time. ## Preferred - Background in immunology, oncology, or another complex therapeutic area, particularly with exposure to clinical pharmacology. - Experience supporting formal governance structures with an external partner, such as joint committees or working teams under a collaboration agreement. - Experience working within a project management structure. - Alliance experience. - PMP or equivalent project management certification. - Comfortable with a role that will change as the project management capability grows. Salary:  $213,200 - $270,600 Location:  This role follows an onsite schedule, with an expectation to be onsite at our Brisbane, California headquarters at least five days per week. Fit with Nurix Culture and Values - Strong team orientation; highly collaborative - Solutions and results-oriented focus - Hands-on approach; resourceful and open to diverse points of view ## About Nurix ## Company Overview - **One-liner**: Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering targeted protein degradation medicines to outmatch disease by harnessing the cell’s natural protein disposal system. - **Entity Type**: Public (NASDAQ: NRIX) - **Headquarters**: San Francisco, California, USA - **Founded**: 2009 - **Founders**: Not publicly listed as individual founders; the company was spun out from research at UC Berkeley and UC San Francisco. ## Core Business - **Primary industry**: Biopharmaceuticals / Targeted Protein Degradation - **Target customers**: B2B (pharma partners) and B2C (patients via clinical trials and eventual commercial therapies); enterprise-level partnerships with major pharma. - **Mission or purpose statement**: "Writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease." [nurixtx.com](https://www.nurixtx.com/) ## Products & Services - **Bexobrutideg (NX-5948)**: A potential best-in-class BTK degrader in Phase 1b/2 clinical trials for relapsed/refractory CLL/SLL and chronic spontaneous urticaria. Co-developed and co-commercialized with Roche under a global collaboration announced June 2026. [nurixtx.com](https://www.nurixtx.com/) - **NX-2127**: A BTK degrader in clinical development for B-cell malignancies. - **CBL-B Inhibitor (NX-1607)**: An E3 ligase inhibitor designed to activate T cells for immuno-oncology, in Phase 1 clinical trials. - **IRAK4 Degrader**: A partnered program with Gilead in Phase 1 for inflammatory diseases. - **STAT6 Degrader**: A partnered program with Sanofi in IND-enabling studies. - **DEL-AI Discovery Engine**: A proprietary, fully AI-integrated platform combining DNA-encoded libraries (DEL), automated chemistry, and machine learning to design and optimize targeted protein degraders and degrader-antibody conjugates (DACs). ## Market Standing - **Valuation/Market Cap**: Not publicly available in the provided search results; as a public company (NRIX), market cap fluctuates daily. Check financial platforms for the latest figure. - **Key Metric**: Annual Revenue (public) — Not publicly available in the provided search results; as a clinical-stage biotech, revenue is typically minimal or pre-revenue. Total funding raised prior to IPO is not detailed in the provided results. - **Notable Investors/Partners**: Roche (global co-development and co-commercialization collaboration for bexobrutideg, announced June 2026), Gilead (partnered IRAK4 degrader program), Sanofi (partnered STAT6 degrader program). - **Growth Signals**: Announced a landmark global collaboration with Roche in June 2026 to co-develop and co-commercialize bexobrutideg across malignant hematology, immunology, and neurology. Presented positive Phase 1a/b data for bexobrutideg in CLL/SLL and chronic spontaneous urticaria in 2026. Multiple partnered and wholly owned pipeline programs advancing through clinical and preclinical stages. ## Competitive Advantages - **Proprietary DEL-AI Discovery Engine**: A fully AI-integrated platform combining DNA-encoded libraries, automated chemistry, and machine learning to design degraders against any protein class, providing a significant speed and innovation advantage. [nurixtx.com](https://www.nurixtx.com/) - **Unparalleled Ligase Expertise**: Deep understanding of E3 ligase biochemistry and biology, a critical and complex component of the protein degradation mechanism, giving them a unique moat. - **Multi-Modal Pipeline**: Developing both small molecule degraders and Degrader-Antibody Conjugates (DACs), expanding the therapeutic reach and creating multiple shots on goal. - **Strong Partnership Network**: Collaborations with top-tier pharma (Roche, Gilead, Sanofi) validate their platform and provide non-dilutive funding and shared risk. ## Strategic Focus - **Clinical Advancement**: Driving lead asset bexobrutideg through pivotal trials in CLL/SLL and expanding into immunology (chronic spontaneous urticaria) and neurology. - **Platform Expansion**: Leveraging the DEL-AI engine to develop Degrader-Antibody Conjugates (DACs) for enhanced cell specificity and safety. - **Pipeline Breadth**: Advancing a multi-modal pipeline across oncology, immunology, and neurology, both wholly owned and through strategic partnerships. - **Partnership Leverage**: Deepening collaborations with Roche, Gilead, and Sanofi to co-develop and co-commercialize programs, reducing risk and accelerating timelines. ## Why Work Here - **Culture**: Mission-focused, values-based, and spirited culture emphasizing "breakthrough innovation," "leadership," "accountability," and "zealousness." Employees are encouraged to "think big and act bold." [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Work with Industry Leaders**: The team includes scientific innovators who built the protein degradation field, seasoned executives with biotech scaling expertise, and leading clinicians. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Growth & Impact**: Employees can "wear many hats" and gain broad exposure in a lean, virtual drug developer environment. The company emphasizes career growth and opportunity-rich experiences. - **Work Policy**: Onsite in Brisbane, CA (San Francisco Bay Area) for most roles, as indicated by job postings. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) - **Benefits**: Comprehensive health and welfare plans, enhanced parental leave, wellness reimbursement, 401(k) employer match, and a highly collaborative culture. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Engineering/Science Culture**: Described as "mission-focused, values-based, and spirited," with a focus on "intellectual and technical ingenuity" and "intelligent risk-taking." The company is a "virtual drug developer" with a lean internal infrastructure, relying on SaaS and cloud platforms. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) ## Sources 1. [nurixtx.com](https://www.nurixtx.com/) 2. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) 3. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) 4. [nurixtx.com](https://www.nurixtx.com/our-story/) ## Other roles at Nurix - [Associate Director, electronic Quality Management System (eQMS)](https://feeny.ai/job/associate-director-electronic-quality-management-system-eqms-nurix-brisbane-k35rdgj6th4k) — Brisbane, CA - [Director, Nonclinical Toxicology Operations](https://feeny.ai/job/director-nonclinical-toxicology-operations-nurix-brisbane-california-a7ynjr847xvh) — Brisbane California, United States - [Director, Medical Affairs - Immunology](https://feeny.ai/job/director-medical-affairs-immunology-nurix-brisbane-california-8q3w67dea5xq) — Brisbane California, United States - [Senior Manager/Associate Director, Regulatory Affairs (Strategy, Hematology Oncology)](https://feeny.ai/job/senior-manager-associate-director-regulatory-affairs-strategy-hematology-zsgdf1qycbew) — Brisbane California, United States - [Senior Administrative Assistant, R&ED](https://feeny.ai/job/senior-administrative-assistant-r-ed-nurix-brisbane-california-9k9rhmyvd955) — Brisbane California, United States - [Senior Director, Quality Control](https://feeny.ai/job/senior-director-quality-control-nurix-brisbane-california-d4hqe06vb3t7) — Brisbane California, United States - [Associate Director, Chemical Engineering](https://feeny.ai/job/associate-director-chemical-engineering-nurix-brisbane-california-6gbpc8ben8eh) — Brisbane California, United States - [Senior Analyst, FP&A](https://feeny.ai/job/senior-analyst-fp-a-nurix-brisbane-california-g7qxkkvsfwbf) — Brisbane California, United States - [Medical Director / Senior Medical Director](https://feeny.ai/job/medical-director-senior-medical-director-nurix-brisbane-california-wkgs5dx1e7eq) — Brisbane California, United States - [Medical Director / Senior Medical Director](https://feeny.ai/job/medical-director-senior-medical-director-nurix-brisbane-california-57ydhjmqgfm6) — Brisbane California, United States