--- title: 'Research Leader (DMPK), Cambridge, MA at Isomorphic Labs' canonical: 'https://feeny.ai/job/research-leader-dmpk-cambridge-ma-isomorphic-labs-cambridge-pfx6zhwy5fj1' type: 'job' last_seen: '2026-09-08' --- # Research Leader (DMPK), Cambridge, MA at Isomorphic Labs - **Company:** Isomorphic Labs - **Location:** Cambridge, MA - **Posted:** 2026-09-03 - **Last confirmed live:** 2026-09-08 - **Apply:** https://job-boards.greenhouse.io/isomorphiclabs/jobs/6140840004 ## Job description Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. ## About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI. ## About the DMPK and Quantitative Pharmacology team The DMPK and Quantitative Pharmacology team, part of the Preclinical Development group, accelerates the delivery of high quality drug candidates by developing innovative and creative AI-first solutions. By applying our domain expertise and through collaboration with the entirety of our world-class drug discovery disciplines and ML researchers, we ensure that drug-like properties are at the heart of our drug design engine. We shape the development of state-of-the-art ADME and toxicology predictive models. We rethink drug discovery from Hit ID to first-in-human (FIH) trials by optimising the context of use of these models. ## Your impact At Isomorphic Labs, DMPK Leads drive the DMPK strategy of drug discovery projects to deliver high quality clinical candidates whilst using and contributing to the optimisation of state-of-the-art computational and AI ADME models. As part of the Drug Design and Medical Research team and through close collaboration with the Technology teams, you will be supporting the business alongside world leading AI/ML Drug Design Platform teams. You will collaborate to deliver scientific expertise and strategic direction to drive both improvements in the Platform and apply this to real drug design projects. If you are a skilled and ambitious scientist looking to take the next step in your career, joining Isomorphic Labs will lift you out of your comfort zone and provide you with an amazing opportunity for personal growth and development. ## What you will do - Design and implement stage-appropriate DMPK strategies with AI-first approach, integrating quantitative pharmacology and overall project strategies. - Design screening cascade and mechanistic experiments to support project progression in a data-driven manner. - Integrate DMPK, PD and toxicological data to extract decision-making information, including dose and safety window predictions. - Define Quantitative Pharmacology strategy in collaboration with Pharmacology Leads. - Optimise the use of Iso’s datasets to address fundamental DMPK questions and advance the field. - Optimise molecule design based on physico-chemistry and biotransformation knowledge in collaboration with Chemistry Leads. - Maintain knowledge of state-of-the-art technologies and methods to increase confidence in human PK prediction. - Author DMPK sections of regulatory documents. - Embrace and champion a culture of inclusion and continuous professional development. ## Skills and qualifications Essential: - PhD in either Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject. - 7-10+ years’ professional experience in a DMPK role, operating within a biotech or pharma setting, solving small molecule DMPK-related problems in drug discovery with a track record of working collaboratively to deliver high quality candidates. - Practical experience developing DMPK and quantitative pharmacology packages to support early clinical development, including authoring and reviewing regulatory documents, ideally in oncology or immunology. - Experience of partnering closely with Preclinical and Clinical teams. - In depth knowledge of biotransformation. - In depth knowledge of PK modelling and scaling of ADME properties. Nice to have: - Experience with peptides and other new modalities. - Advanced knowledge of PK/PD modelling. - Good understanding of machine learning techniques. - Familiarity with Python and R. Culture and values We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. Creating an extraordinary company We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. Hybrid working It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our [privacy policy](https://www.isomorphiclabs.com/applicant-and-candidate-privacy-policy). >> [Click to view other open roles at Isomorphic Labs](https://www.isomorphiclabs.com/work-with-us#current-job-openings) ## About Isomorphic Labs ## Company Overview - **One-liner**: Isomorphic Labs is an AI-driven drug discovery company building on AlphaFold to accelerate the design of novel therapeutics and solve disease at digital speed. - **Entity Type**: Private (Series B) - **Headquarters**: London, United Kingdom (with an office in Lausanne, Switzerland) - **Founded**: 2021 - **Founders**: Sir Demis Hassabis, PhD (CEO) ## Core Business - Primary industry/industries: Biotechnology, AI-powered Drug Discovery, Healthcare - Target customers: B2B (pharmaceutical and biotech partners such as Johnson & Johnson) - Mission or purpose statement: "To one day solve all disease with the help of AI." ## Products & Services - **Isomorphic Labs Drug Design Engine**: A suite of predictive and generative AI models that go beyond AlphaFold to model complex biological phenomena, design novel molecules, anticipate drug performance, and accelerate scientific discovery at digital speed. - **Research Collaborations**: Strategic partnerships with major pharmaceutical companies (e.g., Johnson & Johnson) to co-develop drug candidates across multiple therapeutic areas. ## Market Standing - **Valuation/Market Cap**: Not publicly disclosed (recent Series B completed in February 2025) - **Key Metric**: Total Funding — Series B investment round announced February 2025 (amount not disclosed); prior funding from Alphabet as a subsidiary - **Notable Investors/Partners**: Alphabet (parent company, including Google DeepMind and Google Cloud); Johnson & Johnson (research collaboration) - **Growth Signals**: Expansion into Lausanne, Switzerland (new office); continued hiring across AI, science, and engineering roles; building on Nobel-winning AlphaFold technology; partnerships with top-tier pharma ## Competitive Advantages - **Frontier AI Access**: Sits within the Alphabet ecosystem alongside Google DeepMind, providing unique access to cutting-edge AI research and AGI development. - **AlphaFold Foundation**: Built directly on the Nobel Prize-winning AlphaFold system, giving the company a massive head start in computational biology. - **Interdisciplinary Team**: Combines world-class drug discovery experts with machine learning specialists in a high-velocity, high-trust culture. - **Ethical Framework**: Deeply integrates responsible AI development and ethical considerations into drug discovery. ## Strategic Focus - Current priorities: Scaling the Drug Design Engine, expanding partnerships with pharma, building out the Lausanne office, and advancing multiple drug discovery programs toward clinical candidates. - Long-term direction: Realizing the promise of "digital biology" to transform how medicines are discovered and developed, with the ultimate goal of solving all disease. ## Why Work Here - **Culture**: Described as "high-velocity, high-trust" — defined by urgency, curiosity, and collaboration. Core values: Brave, Determined, Together, Thoughtful. - **Remote/Hybrid**: Hybrid working model is supported; specific policies discussed during recruitment. - **Perks**: Generous employee benefits, development opportunities, access to frontier AGI research, and a mission-driven environment focused on world-changing impact. - **Engineering Culture**: Interdisciplinary teams working at the intersection of AI, biology, and medicine; emphasis on continuous learning and innovation. - **Team**: Led by a Nobel laureate (Demis Hassabis) and staffed by leaders from DeepMind, academia, and pharma. ## Sources 1. [isomorphiclabs.com](https://www.isomorphiclabs.com/) 2. [isomorphiclabs.com/careers](https://www.isomorphiclabs.com/careers) 3. [isomorphiclabs.com/life-at-iso](https://www.isomorphiclabs.com/life-at-iso) 4. [isomorphiclabs.com/work-with-us](https://www.isomorphiclabs.com/work-with-us) 5. [isomorphiclabs.com/our-team](https://www.isomorphiclabs.com/our-team) ## Other roles at Isomorphic Labs - [Research Engineer (LLM Performance), London](https://feeny.ai/job/research-engineer-llm-performance-london-isomorphic-labs-london-28vn5v8wjp0g) — London, United Kingdom - [Team Coordinator, President Team, London](https://feeny.ai/job/team-coordinator-president-team-london-isomorphic-labs-london-9sntj7e5pjdp) — London, United Kingdom - [Talent Partner (Data), London](https://feeny.ai/job/talent-partner-data-london-isomorphic-labs-london-zyewt22y3rpz) — London, United Kingdom - [Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA](https://feeny.ai/job/research-leader-senior-scientist-computational-drug-design-cambridge-ma-bb4k9g76qsc9) — Cambridge, MA - [Senior Clinical Trial Manager, Cambridge, MA](https://feeny.ai/job/senior-clinical-trial-manager-cambridge-ma-isomorphic-labs-cambridge-367f9rxca8wq) — Cambridge, MA - [Program Manager, People Team, London](https://feeny.ai/job/program-manager-people-team-london-isomorphic-labs-london-tkcwz4p4ggnp) — London, United Kingdom - [Clinical Contracts Manager, Cambridge, MA](https://feeny.ai/job/clinical-contracts-manager-cambridge-ma-isomorphic-labs-cambridge-ctd4bzcwfhn1) — Cambridge, MA - [Director, Translational Medicine, Oncology, Cambridge, MA](https://feeny.ai/job/director-translational-medicine-oncology-cambridge-ma-isomorphic-labs-cambridge-bppat880d43c) — Cambridge, MA - [Director of Nonclinical Safety, Cambridge, MA](https://feeny.ai/job/director-of-nonclinical-safety-cambridge-ma-isomorphic-labs-cambridge-x2j3qdpbc08w) — Cambridge, MA - [Director of Clinical Pharmacology, Cambridge, MA](https://feeny.ai/job/director-of-clinical-pharmacology-cambridge-ma-isomorphic-labs-cambridge-arfkhjrafr5q) — Cambridge, MA