--- title: 'Research Scientist I/II, Purification Sciences at Iambic Therapeutics, Inc' canonical: 'https://feeny.ai/job/research-scientist-i-ii-purification-sciences-iambic-therapeutics-inc-san-diego-bbfkrw5by7v1' type: 'job' last_seen: '2026-09-16' --- # Research Scientist I/II, Purification Sciences at Iambic Therapeutics, Inc - **Company:** Iambic Therapeutics, Inc - **Location:** San Diego, CA - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-09-09 - **Last confirmed live:** 2026-09-16 - **Apply:** https://jobs.ashbyhq.com/iambic-therapeutics/35fa46c2-1cd5-4222-88f5-987e7bf26db7 ## Job description ## JOB SUMMARY We are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within our drug discovery team. This scientist will provide scientific and technical expertise in preparative SFC and LC purification, as well as high-throughput compound QC, supporting medicinal chemistry and high-throughput experimentation (HTE) platform. A key focus of this role will be SFC-based purification, including method development, optimization, and application to diverse and challenging chemical matter. The ideal candidate will combine strong fundamentals in chromatographic separation science with hands-on expertise in analytical QC, instrument troubleshooting, automation, and high-throughput workflows. This scientist will work closely with HTE, medicinal chemistry and other discovery teams to rapidly deliver purified, well-characterized compounds and high-quality analytical data, supporting an AI-driven design–make–test–learn drug discovery cycle. This position will be based out of our San Diego Headquarters. ## KEY RESPONSIBILITIES - Develop and execute small-molecule purification strategies using preparative SFC and LC, with particular emphasis on SFC method development and optimization. - Independently solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale-up, and fraction collection. - Develop and support high-throughput compound QC workflows using LC/MS and related analytical techniques to assess compound identity, purity, and sample quality. - Collaborate with medicinal chemistry and HTE teams to establish fit-for-purpose purification and QC strategies and rapidly deliver high-quality compounds. - Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting, including root-cause analysis of chromatography, fluidics, hardware, and software issues. - Provide hands-on support for SFC, LC, and LC/MS platforms, including maintenance, system optimization, and vendor coordination. - Develop and improve automated and high-throughput purification and QC workflows, integrating sample handling, purification, fraction processing, analytical characterization, and data management. - Evaluate and implement new chromatography, analytical, automation, and informatics technologies to expand throughput, capacity, and operational efficiency. ## QUALIFICATIONS - Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 0-5 years of relevant experience; or a MS with 7+ years / BS with 9+ years of relevant experience. - Strong hands-on expertise in small-molecule chromatographic purification and method development, preferably in a pharmaceutical, biotechnology, CRO, or drug discovery environment. - Demonstrated expertise in preparative SFC, including method development, optimization, and troubleshooting; preparative LC experience is strongly preferred. - Strong understanding of chromatographic separation science and demonstrated ability to independently solve complex purification problems. - Strong instrument troubleshooting skills, including experience diagnosing chromatography, fluidics, hardware, software, and workflow issues. - Strong understanding of medicinal chemistry and small-molecule drug discovery, with the ability to translate project needs into effective purification and analytical strategies. - Excellent scientific problem-solving, communication, and collaboration skills. ## PREFERRED QUALIFICATIONS - Experience with high-throughput LC/MS analysis and compound QC, including purity and identity assessment, is strongly preferred. - Experience with automation, high-throughput workflows, and informatics/data-management systems is highly desirable. - Experience with Agilent, Shimadzu, or comparable analytical and purification platforms is a plus. ## ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at [iambic.ai](http://iambic.ai). ## MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. ## PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play. ## About Iambic Therapeutics, Inc ## Company Overview - **One-liner**: Iambic Therapeutics is a clinical‑stage biotechnology company that uses an AI‑driven platform to discover and develop novel small‑molecule medicines for oncology and other diseases. - **Entity Type**: Private (late‑stage venture‑backed) - **Headquarters**: San Diego, California, United States - **Founded**: 2020 - **Founders**: Not explicitly named in available sources; leadership includes a Co‑Founder & CEO and a Co‑Founder & CTO. ## Core Business - **Primary industries**: Biotechnology, AI‑powered drug discovery, oncology therapeutics - **Target customers**: B2B partnerships with pharmaceutical companies (e.g., Bayer) and, ultimately, patients through a wholly‑owned pipeline of clinical‑stage candidates - **Mission**: *“Better technology for better medicines”* – using machine learning and automation to transform the creation of new therapeutics ## Products & Services - **Enchant Platform**: A multi‑modal transformer AI that breaks down data barriers between preclinical and clinical R&D, enabling rapid molecular design. - **NeuralPLexer**: A co‑folding AI technology that predicts protein‑ligand structures to guide drug design. - **Automated High‑Throughput Experimentation**: AI‑driven robotics that generate new biological data from novel molecular designs on a weekly cadence. - **IAM1363** (HER2 inhibitor): A highly selective, brain‑penetrant tyrosine kinase inhibitor for HER2‑driven cancers; currently in Phase 1b clinical studies. - **IAM‑C1** (CDK2/4 dual inhibitor): A potential first‑in‑class selective inhibitor for HR+/HER2‑ metastatic breast cancer (preclinical). - **IAM‑K1** (KIF18A inhibitor): A potential best‑in‑class allosteric inhibitor for triple‑negative breast cancer, ovarian cancer, and other solid tumors (preclinical). - **Undisclosed programs**: Additional wholly‑owned candidates across multiple target classes and mechanisms. ## Market Standing - **Valuation**: Not publicly disclosed - **Key Metric**: **Total funding** – $330.8 M (including a $100 M Series B in Oct 2023, a $50 M Series B extension in Apr 2024 led by EXOR N.V. and Mubadala Capital, and a $127.8 M venture round in Nov 2025) - **Notable Investors/Partners**: EXOR N.V., Mubadala Capital, Nexus Venture, Bayer (collaboration in AI drug discovery), and a Scientific Advisory Board including Nobel Laureate Frances Arnold (Caltech) - **Growth Signals**: - Headcount of **117** (64.5 % year‑over‑year growth) - Active job postings: **18** (+200 % quarterly, +50 % yearly) - Pipeline advanced from program launch to IND in **2 years** (vs. 6‑year industry average for IAM1363) - Broad platform applicability demonstrated across orthosteric, allosteric, and protein‑protein interaction modalities ## Competitive Advantages - **Speed**: AI‑driven platform can deliver development candidates to clinical trials in roughly one‑third the industry average time. - **Selectivity & Differentiated Profiles**: IAM1363 shows > 5000‑fold selectivity against EGFR, avoiding EGFR‑driven toxicity; IAM‑C1 targets CDK2/4 with a novel selectivity profile. - **Broad Platform Applicability**: Platform has produced leads across diverse protein classes and mechanisms (orthosteric, allosteric, PPI modulators). - **Integration of AI and Drug Hunting**: Tightly integrated team of AI experts and seasoned drug hunters, with a culture of “audacity” that tackles hard chemistry problems. ## Strategic Focus - Advancing the clinical pipeline: IAM1363 Phase 1b, preparing IAM‑C1 and IAM‑K1 for IND‑enabling studies. - Expanding platform partnerships (e.g., Bayer collaboration). - Scaling the organization: actively hiring in ML science, computational chemistry, medicinal chemistry, and clinical operations. - Exploring new therapeutic areas and target classes through the Enchant and NeuralPLexer technologies. ## Why Work Here - **Culture**: Values of **Respect**, **Collaboration**, and **Audacity** – cross‑functional teamwork with resilience and optimism; a flat, high‑trust environment. - **Work Model**: Based in La Jolla/San Diego, CA; the company emphasizes on‑site collaboration for drug‑discovery and lab‑based roles; remote/hybrid policy not explicitly stated. - **Team Growth**: Rapidly scaling (headcount +64 % YoY) with a strong pipeline of open roles in ML, computational chemistry, drug product development, and clinical operations. - **Cutting‑Edge Work**: Opportunity to work at the intersection of frontier AI (large multimodal models, agentic data pipelines) and real‑world drug discovery that reaches patients. - **Leadership & Mentorship**: Advisory board includes Nobel laureate and former NVIDIA AI director; close integration of AI and biology. ## Sources 1. [iambic.ai](https://www.iambic.ai/) – Homepage, platform, and corporate overview 2. [iambic.ai/about](https://www.iambic.ai/about) – Leadership, advisory board, investors 3. [iambic.ai/pipeline](https://www.iambic.ai/pipeline) – Pipeline details (IAM1363, IAM‑C1, IAM‑K1) 4. [iambic.ai/careers](https://www.iambic.ai/careers) – Careers page, values, open positions 5. [linkedin.com/company/iambic-ai](https://www.linkedin.com/company/iambic-ai) – Company stats (headcount 117, $3.4M revenue, $330.8M funding, funding rounds, employee growth) ## Other roles at Iambic Therapeutics, Inc - [Associate Director, Procurement](https://feeny.ai/job/associate-director-procurement-iambic-therapeutics-inc-san-diego-qcw4jt4y5w2k) — San Diego, CA - [Sr Manager, FP&A - Discovery R&D](https://feeny.ai/job/sr-manager-fp-a-discovery-r-d-iambic-therapeutics-inc-san-diego-sznt8xkbx741) — San Diego, CA - [Director, Compensation, Benefits and HR Systems](https://feeny.ai/job/director-compensation-benefits-and-hr-systems-iambic-therapeutics-inc-san-diego-nkd5b8fqk3mh) — San Diego, CA - [Associate Medical Director/Medical Director](https://feeny.ai/job/associate-medical-director-medical-director-iambic-therapeutics-inc-united-nrtdmj0ywpmb) — United States - [Senior Associate Scientist I/II, Purification Sciences](https://feeny.ai/job/senior-associate-scientist-i-ii-purification-sciences-iambic-therapeutics-inc-7gpy6fbbe0br) — San Diego, CA - [Director/Senior Director, Immunology](https://feeny.ai/job/director-senior-director-immunology-iambic-therapeutics-inc-san-diego-pc8aedpavc67) — San Diego, CA - [Software Engineer — Agentic data pipelines](https://feeny.ai/job/software-engineer-agentic-data-pipelines-iambic-therapeutics-inc-united-states-z1afztyyenvn) — United States - [Principal Medical Writer](https://feeny.ai/job/principal-medical-writer-iambic-therapeutics-inc-united-states-p7p8wv9kdmyd) — United States - [Sr Manager, Quality Systems & Compliance](https://feeny.ai/job/sr-manager-quality-systems-compliance-iambic-therapeutics-inc-united-states-vsh166q5vj7e) — United States - [Research Scientist I/II, Bioanalytical Sciences & Assay Development](https://feeny.ai/job/research-scientist-i-ii-bioanalytical-sciences-assay-development-iambic-z1xnw171hxqv) — San Diego, CA