--- title: 'Research Scientist II/Senior Research Scientist, Medicinal Chemistry at Iambic Therapeutics, Inc' canonical: 'https://feeny.ai/job/research-scientist-ii-senior-research-scientist-medicinal-chemistry-iambic-0qhfd46bny8y' type: 'job' last_seen: '2026-11-11' --- # Research Scientist II/Senior Research Scientist, Medicinal Chemistry at Iambic Therapeutics, Inc - **Company:** Iambic Therapeutics, Inc - **Location:** San Diego, CA - **Employment:** full-time - **Posted:** 2026-11-06 - **Last confirmed live:** 2026-11-11 - **Apply:** https://jobs.ashbyhq.com/iambic-therapeutics/517a437c-9810-402e-800b-4b593f3b3970 ## Job description ## POSITION We seek a motivated, detail-oriented, experienced and creative chemist to join our Discovery team at Iambic Therapeutics in San Diego, CA. The role will entail managing external research support, coordinating with the medicinal chemistry and HTE team to facilitate compound library campaigns, and drug discovery efforts. Candidate should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. This position will be based in our San Diego Headquarters. ## KEY RESPONSIBILITIES - Manage a team of FTEs/FFS teams at external CROs to drive molecular discovery efforts aimed to deliver intermediates, final targets, and reference compounds. - Support proposal development, scope definition, purchase orders, change orders, resource and FTE planning, budgeting, and commercial alignment throughout the project lifecycle. - Develop and manage integrated project plans, timelines, milestones, priorities, resources, action items, and deliverables to ensure effective and on-time execution. - Identify delivery risks, assess potential impacts, escalate critical issues, and drive resolution to maintain project momentum - Act as a liaison between Iambic, CROs, and other external collaborators - Communicate project updates clearly and effectively to the broader team and key stakeholders - Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork ## QUALIFICATIONS - Ph.D. in Organic Chemistry with 3+ years of Pharma/bio-tech drug discovery experience. - Strong foundation in modern organic synthetic methods as exemplified by peer-reviewed publication track record. - Ability to thrive in a fast-paced, highly collaborative, and dynamic research environment. - Strong written and verbal communication skills; able to clearly convey technical results to vendors, colleagues and cross-functional partners. - Prior expertise in CRO management; demonstrated examples of problem solving within tight timelines. - Experience in managing vendor relationships and performance, exemplified by eliminating obstacles to maximize the value of external workflows. - Highly organized and detail-oriented. ## ABOUT IAMBIC THERAPEUTICS Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at [iambic.ai](http://iambic.ai). ## MISSION & VALUES Our mission is to make better technology for better medicines. Three values guide how we work: - Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity. - Innovative. We are creative and find new solutions that deliver impact. - Collaborative. We respect one another and partner with integrity. We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow. ## PAY AND BENEFITS The pay range for this role is listed above. Actual pay depends on factors including experience, skills, and location. Eligible employees in the U.S. receive company-paid medical coverage, flexible spending accounts, voluntary life insurance, 401(k) matching and flexible time off. We are in a brand-new state-of-the art facility in beautiful San Diego with a community gym, dining, and easy access to great places to live and play. ## EQUAL OPPORTUNITY Iambic is an equal opportunity employer. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran or military status, or any other characteristic protected by law. ## About Iambic Therapeutics, Inc ## Company Overview - **One-liner**: Iambic Therapeutics is a clinical‑stage biotechnology company that uses an AI‑driven platform to discover and develop novel small‑molecule medicines for oncology and other diseases. - **Entity Type**: Private (late‑stage venture‑backed) - **Headquarters**: San Diego, California, United States - **Founded**: 2020 - **Founders**: Not explicitly named in available sources; leadership includes a Co‑Founder & CEO and a Co‑Founder & CTO. ## Core Business - **Primary industries**: Biotechnology, AI‑powered drug discovery, oncology therapeutics - **Target customers**: B2B partnerships with pharmaceutical companies (e.g., Bayer) and, ultimately, patients through a wholly‑owned pipeline of clinical‑stage candidates - **Mission**: *“Better technology for better medicines”* – using machine learning and automation to transform the creation of new therapeutics ## Products & Services - **Enchant Platform**: A multi‑modal transformer AI that breaks down data barriers between preclinical and clinical R&D, enabling rapid molecular design. - **NeuralPLexer**: A co‑folding AI technology that predicts protein‑ligand structures to guide drug design. - **Automated High‑Throughput Experimentation**: AI‑driven robotics that generate new biological data from novel molecular designs on a weekly cadence. - **IAM1363** (HER2 inhibitor): A highly selective, brain‑penetrant tyrosine kinase inhibitor for HER2‑driven cancers; currently in Phase 1b clinical studies. - **IAM‑C1** (CDK2/4 dual inhibitor): A potential first‑in‑class selective inhibitor for HR+/HER2‑ metastatic breast cancer (preclinical). - **IAM‑K1** (KIF18A inhibitor): A potential best‑in‑class allosteric inhibitor for triple‑negative breast cancer, ovarian cancer, and other solid tumors (preclinical). - **Undisclosed programs**: Additional wholly‑owned candidates across multiple target classes and mechanisms. ## Market Standing - **Valuation**: Not publicly disclosed - **Key Metric**: **Total funding** – $330.8 M (including a $100 M Series B in Oct 2023, a $50 M Series B extension in Apr 2024 led by EXOR N.V. and Mubadala Capital, and a $127.8 M venture round in Nov 2025) - **Notable Investors/Partners**: EXOR N.V., Mubadala Capital, Nexus Venture, Bayer (collaboration in AI drug discovery), and a Scientific Advisory Board including Nobel Laureate Frances Arnold (Caltech) - **Growth Signals**: - Headcount of **117** (64.5 % year‑over‑year growth) - Active job postings: **18** (+200 % quarterly, +50 % yearly) - Pipeline advanced from program launch to IND in **2 years** (vs. 6‑year industry average for IAM1363) - Broad platform applicability demonstrated across orthosteric, allosteric, and protein‑protein interaction modalities ## Competitive Advantages - **Speed**: AI‑driven platform can deliver development candidates to clinical trials in roughly one‑third the industry average time. - **Selectivity & Differentiated Profiles**: IAM1363 shows > 5000‑fold selectivity against EGFR, avoiding EGFR‑driven toxicity; IAM‑C1 targets CDK2/4 with a novel selectivity profile. - **Broad Platform Applicability**: Platform has produced leads across diverse protein classes and mechanisms (orthosteric, allosteric, PPI modulators). - **Integration of AI and Drug Hunting**: Tightly integrated team of AI experts and seasoned drug hunters, with a culture of “audacity” that tackles hard chemistry problems. ## Strategic Focus - Advancing the clinical pipeline: IAM1363 Phase 1b, preparing IAM‑C1 and IAM‑K1 for IND‑enabling studies. - Expanding platform partnerships (e.g., Bayer collaboration). - Scaling the organization: actively hiring in ML science, computational chemistry, medicinal chemistry, and clinical operations. - Exploring new therapeutic areas and target classes through the Enchant and NeuralPLexer technologies. ## Why Work Here - **Culture**: Values of **Respect**, **Collaboration**, and **Audacity** – cross‑functional teamwork with resilience and optimism; a flat, high‑trust environment. - **Work Model**: Based in La Jolla/San Diego, CA; the company emphasizes on‑site collaboration for drug‑discovery and lab‑based roles; remote/hybrid policy not explicitly stated. - **Team Growth**: Rapidly scaling (headcount +64 % YoY) with a strong pipeline of open roles in ML, computational chemistry, drug product development, and clinical operations. - **Cutting‑Edge Work**: Opportunity to work at the intersection of frontier AI (large multimodal models, agentic data pipelines) and real‑world drug discovery that reaches patients. - **Leadership & Mentorship**: Advisory board includes Nobel laureate and former NVIDIA AI director; close integration of AI and biology. ## Sources 1. [iambic.ai](https://www.iambic.ai/) – Homepage, platform, and corporate overview 2. [iambic.ai/about](https://www.iambic.ai/about) – Leadership, advisory board, investors 3. [iambic.ai/pipeline](https://www.iambic.ai/pipeline) – Pipeline details (IAM1363, IAM‑C1, IAM‑K1) 4. [iambic.ai/careers](https://www.iambic.ai/careers) – Careers page, values, open positions 5. [linkedin.com/company/iambic-ai](https://www.linkedin.com/company/iambic-ai) – Company stats (headcount 117, $3.4M revenue, $330.8M funding, funding rounds, employee growth) ## Other roles at Iambic Therapeutics, Inc - [Sr Manager, Enterprise Business Systems](https://feeny.ai/job/sr-manager-enterprise-business-systems-iambic-therapeutics-inc-san-diego-j2cv8nxyypq5) — San Diego, CA - [Associate Director/Director, FP&A](https://feeny.ai/job/associate-director-director-fp-a-iambic-therapeutics-inc-san-diego-z28z0y19xya6) — San Diego, CA - [Sr Manager, FP&A - Discovery R&D](https://feeny.ai/job/sr-manager-fp-a-discovery-r-d-iambic-therapeutics-inc-san-diego-sznt8xkbx741) — San Diego, CA - [Director, IP Counsel](https://feeny.ai/job/director-ip-counsel-iambic-therapeutics-inc-san-diego-492xa6xt2p79) — San Diego, CA - [Corporate Counsel, Commercial](https://feeny.ai/job/corporate-counsel-commercial-iambic-therapeutics-inc-san-diego-ww25hgtsp3t5) — San Diego, CA - [IT Support Specialist](https://feeny.ai/job/it-support-specialist-iambic-therapeutics-inc-san-diego-g98wd14jdssg) — San Diego, CA - [Sr Associate Scientist I or II, Medicinal Chemistry](https://feeny.ai/job/sr-associate-scientist-i-or-ii-medicinal-chemistry-iambic-therapeutics-inc-san-7zek78ek4h8y) — San Diego, CA - [Principal Scientist, Medicinal Chemistry](https://feeny.ai/job/principal-scientist-medicinal-chemistry-iambic-therapeutics-inc-san-diego-et7kjjyvc1yv) — San Diego, CA - [Principal / AD / Director, Agentic AI](https://feeny.ai/job/principal-ad-director-agentic-ai-iambic-therapeutics-inc-san-diego-1g1gksks4q51) — San Diego, CA - [Software Engineer I/II - Scientific Computing](https://feeny.ai/job/software-engineer-i-ii-scientific-computing-iambic-therapeutics-inc-boston-2vn970jxspag) — Boston, MA