---
title: 'Scientist, Drug Metabolism and Pharmacokinetics (DMPK) at Kardigan'
canonical: 'https://feeny.ai/job/scientist-drug-metabolism-and-pharmacokinetics-dmpk-kardigan-south-san-x3c0x3gmm3r7'
type: 'job'
last_seen: '2026-09-12'
---

# Scientist, Drug Metabolism and Pharmacokinetics (DMPK) at Kardigan

- **Company:** Kardigan
- **Location:** South San Francisco California, United States
- **Compensation:** $135k–$160k
- **Posted:** 2026-09-03
- **Last confirmed live:** 2026-09-12
- **Apply:** https://job-boards.greenhouse.io/kardigan/jobs/5409487008

## Job description

## About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Position Title: Scientist, Drug Metabolism and Pharmacokinetics (DMPK)

Department: Discovery Research

Reports To: Principal Scientist, DMPK

Location: South San Francisco, CA – On-site 4 days per week (Mon to Thurs)

Job Overview

Kardigan is looking for a highly motivated and detail-oriented DMPK Scientist to join our dynamic research team. This role offers a unique opportunity to contribute to both early-stage discovery and later-stage development by generating high-quality ADME/PK data to support our small molecule drug pipeline. The ideal candidate will bring hands-on expertise in bioanalysis, in vitro assay development, and mass spectrometry, along with a collaborative spirit and a passion for scientific excellence.

Essential Duties and Responsibilities

Key Responsibilities will include lab-based duties, but are not limited to the following:

- Develop in vitro assays and independently generate high quality data to support drug discovery and development
- Perform bioanalysis of structurally diversified small molecules for in vitro assays and develop fit-for-purpose sample preparation protocols and analytical methods by liquid chromatography and mass spectrometry
- Execute, analyze, and interpret in vitro drug metabolism assays to understand the ADME properties of small molecules in supporting discovery and development programs
- Culturing, testing, and validating cell or assay systems and ensuring cleanliness of labs
- Bioanalysis of pharmacokinetic samples and determination of pharmacokinetic parameters
- Maintain good documentation practices including laboratory notebooks, protocols, and reports writing; present data in team/project meetings as necessary
- Maintain and manage research databases, ensuring data integrity, accuracy, and accessibility
- Develop and document assay protocols for chemistry, biology, and DMPK studies
- Upload, organize, and QC assay data, ensuring accuracy and consistency

## Qualifications and Preferred Skills

- Highly motivated individual has a Ph.D. in pharmaceutical sciences, chemistry, bioanalysis, or biomedical science related fields with 0 – 3 years of experience or with at least 5 years (M.S. degree) or 8 years (B.S. degree) industrial/ academia experience.
- Demonstrate excellent verbal and technical communication, independent thinking, with the ability to interpret results, determine next steps and present data.
- Ability to work in a team oriented, innovative and fast-paced environment focusing on discovery and development of new drugs for treatment of cardiac diseases.
- Experience as a project representative is a plus.
- Expertise and experience in one or more of the following areas are required:
- Experienced in development of LC-MS-based analytical methods and sample preparation for small molecule analysis. Proficient in operation, maintenance and troubleshooting for high end scientific instrumentation, including general liquid handling equipment, Thermo Orbitrap Q-Exactive, Exploris 240 HRAMS, Sciex or Thermo triple-quad mass specs is highly desired.
- Hands-on experience in culturing primary and recombinant cell lines, developing cell-based and in vitro drug metabolism assays.
- Prior experience and knowledge in drug metabolism assays (i.e. metabolic stability assays in liver microsomes and hepatocytes, protein binding, cytochrome P450 inhibition assays and bioanalysis of PK samples), PK modeling programs such Phoenix Winnonlin, SimCyp and DMPK concepts to support ADME studies are a plus.
- Experience with research databases (e.g., CDD Vault)

Exact Compensation may vary based on skills, experience and location.

Pay range $135,000—$160,000 USD

## About Kardigan

## Company Overview
- **One-liner**: Kardigan is a publicly traded biopharmaceutical company developing targeted cardiovascular therapies with the aim of transforming treatment from symptom management toward functional cures.
- **Entity Type**: Public (ticker not available from provided sources; IPO closed as per company announcement)
- **Headquarters**: South San Francisco, California, United States (with additional offices in Princeton, New Jersey and Chicago, Illinois)
- **Founded**: Year not specified in available sources
- **Founders**: Tassos Gianakakos (Co-Founder, CEO & Chair), Dr. Jay Edelberg (Co-Founder & Chief Medical Officer), Dr. Bob McDowell (Co-Founder & Scientific Adviser), Brianne Puglisi (Co-Founder)

## Core Business
- **Primary industry**: Biopharmaceuticals – cardiovascular drug discovery and development
- **Target customers**: B2B / B2G – healthcare providers, hospitals, payers, and patients; the company develops prescription medicines for serious cardiovascular conditions
- **Mission or purpose statement**: “To make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.” ([kardigan.bio](https://www.kardigan.bio/))

## Products & Services
- **Tonlamarsen**: A Phase 2/3 candidate for acute severe hypertension (ASH) and uncontrolled hypertension. Positive Phase 2 data presented as a late-breaker at ACC.26 and simultaneously published in JACC. ([kardigan.bio](https://www.kardigan.bio/))
- **Danicamtiv**: A Phase 3 candidate for genetic dilated cardiomyopathy (DCM), targeting the underlying inherited cardiac muscle disease. ([kardigan.bio](https://www.kardigan.bio/))
- **Calcific Aortic Valve Stenosis (CAVS) Program**: A late-stage clinical program addressing calcium deposition that stiffens the aortic valve. ([kardigan.bio](https://www.kardigan.bio/))
- **Prolaio Subsidiary**: An AI and real‑world data platform integrated into Kardigan to generate insights, inform clinical trial design, and reduce time/cost of drug development. ([kardigan.bio](https://www.kardigan.bio/about-us/))
- **Cardiac Intelligence Platform**: A discovery and translational research engine that uses real‑world patient data, AI, and deep cardiovascular expertise to identify disease drivers and design targeted therapies. ([kardigan.bio](https://www.kardigan.bio/))

## Market Standing
- **Valuation/Market Cap**: Not disclosed in provided sources
- **Key Metric**: Public company (IPO closed); annual revenue not disclosed
- **Notable Investors/Partners**: Not explicitly listed in provided sources; company built on the team’s track record from MyoKardia (acquired by Bristol Myers Squibb for $13.1B in 2020)
- **Growth Signals**:
  - Positive Phase 2 pivotal data for Tonlamarsen in hypertension, presented at ACC.26 and published in JACC
  - Three late‑stage clinical programs (CAVS, ASH, DCM) running in parallel
  - Active job postings across 210+ roles in clinical operations, data science, manufacturing, and corporate strategy, indicating scaling ([job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan))
  - Integration of Prolaio’s AI platform to accelerate R&D

## Competitive Advantages
- **Leadership expertise**: CEO Tassos Gianakakos previously scaled MyoKardia from startup to a $13.1B acquisition; the team includes veterans from MyoKardia, Sanofi, BMS, and Merck.
- **Parallel pipeline strategy**: Multiple late‑stage programs targeting distinct cardiovascular diseases (valve, hypertension, cardiomyopathy) de‑risks development and creates data synergies.
- **Cardiac Intelligence platform**: Proprietary combination of real‑world data, AI, and deep biological insight to move beyond symptom management toward modifying underlying disease.
- **Focus on functional cures**: Each program aims to alter the course of disease rather than merely treat symptoms, creating potential for breakthrough efficacy.

## Strategic Focus
- **Advance late‑stage clinical trials**: Continue Phase 2/3 studies for Tonlamarsen, Danicamtiv, and CAVS while preparing for potential regulatory submissions.
- **Expand platform capabilities**: Leverage Prolaio’s AI and real‑world evidence to design smarter, faster trials and discover new drug targets.
- **Build commercial infrastructure**: Growing corporate strategy, medical affairs, and manufacturing teams in South San Francisco, Princeton, and Chicago signals preparation for launch.

## Why Work Here
- **Culture**: “Everything we do starts with patients – and it’s powered by people.” Emphasis on collaboration, purpose‑driven work, and achieving the impossible together. Mission‑oriented environment focused on curing cardiovascular disease. ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Work model**: Roles are listed for South San Francisco, Princeton, NJ, and Chicago, IL; likely on‑site/hybrid given the lab and clinical development nature. Not purely remote.
- **Benefits**:
  - Competitive salaries and annual bonus program
  - Comprehensive medical, dental, and vision coverage
  - 401(k) plan, life and disability insurance
  - Flexible spending and health savings accounts
  - Commuter benefits, cellphone allowance
  - Paid holidays and time off
  - Employee assistance program ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Engineering & data science culture**: Active recruitment for data analytics, AI, and clinical data science roles; Executive Director of Data, AI & Collaboration Services is an open position, reflecting a strong tech‑driven R&D approach.

## Sources
1. [kardigan.bio](https://www.kardigan.bio/) – Company homepage and pipeline descriptions
2. [kardigan.bio/about-us](https://www.kardigan.bio/about-us/) – About Us, mission, and Prolaio integration
3. [kardigan.bio/job-openings](https://www.kardigan.bio/job-openings/) – Careers page with benefits and open roles
4. [kardigan.bio/leadership](https://www.kardigan.bio/leadership/) – Leadership team and co‑founder backgrounds
5. [job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan) – Detailed job listings (32+ postings)

## Other roles at Kardigan

- [Senior Director, Product Strategy](https://feeny.ai/job/senior-director-product-strategy-kardigan-princeton-new-jersey-zrx68wcapady) — Princeton New Jersey, United States
- [Sr. Director, Clinical Trial Optimization](https://feeny.ai/job/sr-director-clinical-trial-optimization-kardigan-princeton-new-jersey-05t1jx6jawfw) — Princeton New Jersey, United States
- [Director, Demand/Supply Planning](https://feeny.ai/job/director-demand-supply-planning-kardigan-south-san-francisco-jcz16k67hq5r) — South San Francisco, CA
- [Sr. Executive Assistant - Contract to Hire](https://feeny.ai/job/sr-executive-assistant-contract-to-hire-kardigan-south-san-francisco-s62w5nabntfw) — South San Francisco, CA
- [Director, Clinical Trial Liaison West](https://feeny.ai/job/director-clinical-trial-liaison-west-kardigan-united-states-t8xmqj8mg16m) — United States
- [Senior Director, CMC Regulatory](https://feeny.ai/job/senior-director-cmc-regulatory-kardigan-princeton-new-jersey-74vt09gwp1cj) — Princeton New Jersey, United States
- [Senior Director, CMC Regulatory](https://feeny.ai/job/senior-director-cmc-regulatory-kardigan-south-san-francisco-california-xjzf831d0r9n) — South San Francisco California, United States
- [Head of Medical Affairs](https://feeny.ai/job/head-of-medical-affairs-kardigan-princeton-rq45s28mr31y) — Princeton, NJ
- [Director, Product Quality Lead](https://feeny.ai/job/director-product-quality-lead-kardigan-south-san-francisco-california-united-ft71es75vxe9) — South San Francisco California United States Princeton New Jersey, United States
- [Director, GCP Inspection Readiness and Audits Strategy](https://feeny.ai/job/director-gcp-inspection-readiness-and-audits-strategy-kardigan-princeton-new-4wfzyb6yt6zs) — Princeton New Jersey, United States