--- title: 'Scientist II at 4D Molecular Therapeutics' canonical: 'https://feeny.ai/job/scientist-ii-4d-molecular-therapeutics-emeryville-ycsqtraqg94b' type: 'job' last_seen: '2026-11-08' --- # Scientist II at 4D Molecular Therapeutics - **Company:** 4D Molecular Therapeutics - **Location:** Emeryville, CA - **Work type:** hybrid - **Posted:** 2026-11-03 - **Last confirmed live:** 2026-11-08 - **Apply:** https://4dmoleculartherapeutics.com/careers/?gh_jid=4750032005 ## Job description Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF biologics (aflibercept and anti-VEGF-C) with a single intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration and the second indication is diabetic macular edema, which are both in Phase 3 development. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery. We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our Core Values drive the way we work together: - Dare to Cure - Break Boundaries - Beyond Yourself - Prepare & Execute Relentlessly Join us in creating the future of genetic medicine. ## GENERAL SUMMARY This Scientist II role is in the Biomarkers & Immunology department and supports biomarker measurements, and clinical pharmacology deliverables by developing novel bioanalytical methods and providing analysis and interpretation of key bioanalytical datasets. Working closely with cross-functional teams (e.g., Early-Stage Product Development, Project Management, Clinical Operations, and Clinical Development), these deliverables inform key program decisions. The Scientist II position in Biomarkers & Immunology department will be responsible for execution of gene expression assays, molecular biology, ligand binding assays, cell culture activities, histology workflows and sample processing.  This Scientist II role may also contribute to management of assays performed externally at CROs. The Scientist II will be expected to work in a collaborative and flexible manner supporting other assays/workflows including biobank, safety and lab maintenance activities. In addition to hands on technical expertise this position will be required to summarize experimental data in presentations and datasets, maintain an up-to-date laboratory notebook and keep up with literature and scientific knowledge in the areas of gene therapy and bioanalytics. This position reports to the Sr. Director, Biomarkers & Immunology, and supports 4DMT’s mission and portfolio of targeted genetic medicines. ## MAJOR DUTIES & RESPONSIBILITIES: - Develop and execute Immunogenicity, PK/PD, and biomarker assays for preclinical and clinical use across multiple therapeutic areas (e.g., ophthalmology, pulmonology, CNS). - Molecular biology experimental execution (ie nucleic acid/ddPCR/plasmid and vector construction/molecular cloning) - Ligand binding/protein assay experimental execution (ie MSD/ELISA) - Cell culture activities and sample preparation to support diverse experimental workflows - Review and interpret bioanalytical datasets for quality, trends, and consistency; summarize findings for study teams and contribute to data summaries. - Histology sample preparation and IHC/ISH experimental execution - Effective data summary and presentation to internal teams ## QUALIFICATIONS: Education: - Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field - PhD in a relevant scientific discipline with 5+ years of industry experience; OR - Master's degree with 7-8+ years of industry or related experience; OR - Bachelor's degree with 9-11+ years of industry or related experience Experience: - AAV Vector experience - Cell culture, sample preparation - Experience with PCR, qPCR, and droplet digital PCR; RNA-seq; and tissue culture of primary cells and established cell lines. - Bioanalytical and/or biomarker assay development experience - Working knowledge of clinical pharmacology concepts (PK/PD, exposure metrics, dose selection, exposure–response) and experience translating study objectives into bioanalytical strategy (e.g., sampling strategy, assay performance characteristics), data generation plans, and interpretation for biologics and/or gene therapies - Molecular biology: qPCR, ddPCR, plasmid and vector construction, molecular cloning, and other nucleic acid manipulations - Ligand binding assays, cell-based assays - Familiarity with ligand binding assays and LC-MS - Experience in testing large sample sets in an organized and efficient manner - Ability to adapt to changing priorities and requests - Excellent communication skills with internal 4D colleagues and external audiences - Excellent data summary/presentation skills Travel: <5% Physical Requirements and Working Conditions: - Physical Requirements - Lifting up to 20 lbs, bending, lifting, twisting, ability to wear Personal Protective Equipment such as lab coat, goggles/glasses, and nitrile gloves - Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $140,000 - $155,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities ## About 4D Molecular Therapeutics ## Company Overview - **One-liner**: 4D Molecular Therapeutics is a late-stage clinical biotechnology company inventing and developing customized genetic medicines using a proprietary vector evolution platform to treat large-market diseases. - **Entity Type**: Public (NASDAQ: FDMT) - **Headquarters**: Emeryville, California, United States - **Founded**: 2013 - **Founders**: David Kirn, MD (Co-Founder, President, and CEO) ## Core Business - **Primary industry**: Biotechnology / Genetic Medicine / Gene Therapy - **Target customers**: B2B (partnerships with other biopharma companies) and B2C (patients with retinal and pulmonary diseases) - **Mission or purpose statement**: "To unlock the full potential of genetic medicines for large market diseases" by harnessing directed evolution to invent customized and enhanced vectors for transformative products. ## Products & Services - **4D-150**: A clinical-stage genetic medicine candidate for retinal vascular diseases (wet age-related macular degeneration and diabetic macular edema). It is designed as a single, routine, low-dose intravitreal injection that provides multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C). Currently in Phase 3 clinical trials (4FRONT-1 and 4FRONT-2) for wet AMD and Phase 1/2 for DME. - **4D-710**: An investigational genetic medicine candidate for cystic fibrosis lung disease. It uses the A101 vector for aerosol delivery of a corrective CFTR transgene (CFTR∆R) and is designed for patients ineligible for or who have discontinued CFTR modulator therapy. Currently in Phase 1/2. - **4D-175**: A preclinical candidate for geographic atrophy (a form of dry AMD) using the R100 vector to deliver a shortened form of human complement factor H (sCFH) to restore normal complement regulation. - **4D-725**: A preclinical candidate for alpha-1 antitrypsin (A1AT) lung disease using the A101 vector for aerosol delivery. ## Market Standing - **Valuation/Market Cap**: $756.4 million (as of latest data from LinkedIn) - **Key Metric**: Annual Revenue of $85.2 million (as of latest data from LinkedIn) - **Notable Investors/Partners**: The company is publicly traded (IPO in 2020). Key partnerships are sought for pipeline candidates like 4D-175 and 4D-725. - **Growth Signals**: The company is a late-stage biotech with two Phase 3 trials (4FRONT-1 and 4FRONT-2) for its lead candidate 4D-150 in wet AMD, and a Phase 1/2 trial for 4D-710 in cystic fibrosis. The company has a presence in Ecuador, France, and India. LinkedIn followers grew 24.7% year-over-year. ## Competitive Advantages - **Proprietary Vector Platform (Therapeutic Vector Evolution)**: The company uses directed evolution to create customized and proprietary AAV vectors (e.g., R100 for retina, A101 for lung) that are optimized for specific tissues and routes of administration, which is a significant differentiator from standard gene therapy approaches. - **Large-Market Focus**: Unlike many gene therapy companies targeting ultra-rare diseases, 4DMT is focused on large-market indications (wet AMD, DME, cystic fibrosis) with high unmet need, offering a potentially massive commercial opportunity. - **Durable, Single-Dose Therapies**: Their products are designed to provide multi-year efficacy from a single injection, which could dramatically reduce treatment burden for patients compared to current standard-of-care (e.g., frequent eye injections for wet AMD). ## Strategic Focus - **Advancing Late-Stage Pipeline**: The primary focus is executing the Phase 3 programs for 4D-150 in wet AMD and progressing 4D-710 in cystic fibrosis. - **Expanding Indications**: The company is exploring 4D-150 for diabetic macular edema (DME) and seeking partnerships to advance 4D-175 (geographic atrophy) and 4D-725 (A1AT deficiency). - **Platform Expansion**: Continuing to leverage the Therapeutic Vector Evolution platform to develop new genetic medicines for other large-market diseases. ## Why Work Here - **Mission-Driven Culture**: The company is deeply committed to "daring to cure" and unlocking the potential of genetic medicine for patients with devastating diseases. Core values include "Dare to Cure," "Break Boundaries," "Prepare & Execute Relentlessly," and "Beyond Yourself." - **Innovative Science**: Employees work on cutting-edge science at the intersection of gene therapy, vector engineering, and clinical development, tackling some of the biggest challenges in medicine. - **Collaborative Environment**: The company emphasizes teamwork, internal and external collaboration, and a culture that empowers innovation. - **Location & Perks**: Based in Emeryville, CA (San Francisco Bay Area). The company offers a competitive benefits package and a dynamic, collaborative environment. - **Diversity & Inclusion**: 4DMT champions diversity, equity, and inclusion through an employee-led initiative called "4Diversity," which partners with charitable organizations and focuses on social equity. - **Work Authorization**: Candidates must be authorized to work in the U.S. The company does not sponsor new nonimmigrant visa status petitions but welcomes candidates who require transfers or extensions. ## Sources 1. [4dmoleculartherapeutics.com](https://4dmoleculartherapeutics.com/) 2. [4dmoleculartherapeutics.com - About](https://4dmoleculartherapeutics.com/about/) 3. [4dmoleculartherapeutics.com - Careers](https://4dmoleculartherapeutics.com/careers/) 4. [4dmoleculartherapeutics.com - Pipeline](https://4dmoleculartherapeutics.com/pipeline/) 5. 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