---
title: 'Scientist II, Functional Bioassays & High Throughput Screening at Generate Biomedicines'
canonical: 'https://feeny.ai/job/scientist-ii-functional-bioassays-high-throughput-screening-generate-ajjehf28b7v6'
type: 'job'
last_seen: '2026-10-30'
---

# Scientist II, Functional Bioassays & High Throughput Screening at Generate Biomedicines

- **Company:** Generate Biomedicines
- **Location:** Somerville, MA
- **Compensation:** $114k–$150k
- **Posted:** 2026-10-20
- **Last confirmed live:** 2026-10-30
- **Apply:** https://generatebiomedicines.com/open-positions?gh_jid=4723337006

## Job description

The Role:

The Functional Bioassays team is seeking a Scientist II to develop, optimize, and execute functional assays across Generate’s therapeutic portfolio. This bench-focused role will generate high-quality data to guide protein design and program decisions, including AI/ML-enabled design cycles.

The scientist will design, optimize, and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze results; and support automation integration across programs. Work may include ion-channel, GPCR, ADC-related, and other functional assay platforms as portfolio needs evolve.

Approximately 80–90% of this role will be laboratory-based. The scientist will collaborate with colleagues across Therapeutics, Technology, and cross-functional program teams to deliver well-controlled data for iterative design-build-test-learn cycles.

This role is suited to a hands-on scientist with experience in functional assay development and high-throughput screening who can take ownership of experiments, communicate results clearly, and adapt to changing program needs.

Here's how you will contribute:

- Design, optimize, and implement high-throughput screening-compatible cell-based and biochemical assays, integrating automation where appropriate.
- Plan and execute plate-based high-throughput screening campaigns, analyze results, and interpret experimental datasets.
- Communicate findings to program teams to inform AI/ML-enabled design cycles, program decisions, and therapeutic optimization.
- Support high-throughput functional assay work across multiple therapeutic programs, with potential focus areas including ion channels, GPCRs, and ADC-related assays.
- Apply and expand expertise in novel functional assay technologies, including ion-channel and GPCR assays, as program needs evolve.
- Conduct experiments with attention to detail, scientific rigor, and adherence to established protocols.
- Troubleshoot assay performance, instrumentation, reagents, and workflows in partnership with senior scientists and Automation colleagues.
- Maintain accurate, timely, and well-organized records in electronic laboratory notebooks and other data systems.
- Prepare clear summaries of results for team discussions, program updates, and cross-functional meetings.
- Coordinate experiments with colleagues across Functional Bioassays, Automation, Biology, Protein Sciences, Data Science, and program teams.
- Follow laboratory safety practices, sample-handling requirements, data-integrity expectations, and Generate’s scientific standards.

The Ideal Candidate will have:

- PhD in cell biology, pharmacology, immunology, biochemistry, bioengineering, molecular biology, or a related discipline, with approximately 2+ years of industry or postdoctoral experience; or MS with approximately 5+ years of relevant industry or academic research experience; or BS with approximately 7+ years of relevant industry or academic research experience.
- Hands-on experience with cell-based, biochemical, and functional assays in an academic, biotech, pharmaceutical, or related research setting.
- Strong technical foundation in mammalian cell culture and plate-based assay workflows.
- Experience with plate-based assay technologies such as ELISA, HTRF, AlphaLISA, luminescence or fluorescence assays, flow cytometry, or similar methods.
- Experience designing, optimizing, and executing high-throughput screening in 384- or 1536-well formats for small molecules, biologics, or both, with appropriate controls and replicates, sound data quality, and clear documentation.
- Ability to recognize assay-performance or data-quality issues, investigate likely causes, and contribute to troubleshooting.
- Ability to work effectively in a fast-paced, matrixed research environment where priorities may shift across programs.
- Strong organizational skills and the ability to manage multiple experiments or workstreams.
- Ability to analyze and present data at scale using tools such as Spotfire, Dotmatics, ScreenWorks, Harmony, iQue Forecyt, or similar platforms.
- Strong written and verbal communication skills, including the ability to summarize results, observations, and next steps clearly.
- Collaborative working style, accountability, curiosity, and adaptability when learning new assay formats, therapeutic areas, and technologies.

## Preferred Qualifications

- Experience with ion-channel assays or related functional readouts, such as patch clamp, membrane-potential, thallium-flux assays, or electrophysiology workflows.
- Experience with GPCR assays, including reporter, calcium-flux, cAMP, IP-one, beta-arrestin, or other pathway-based functional assays.
- Experience with ADC, image-based internalization, targeted protein degradation, immune-cell, or cytotoxicity assay formats.
- Experience with organoid-based screening workflows.
- Experience working with primary cells, engineered cell lines, or stable cell-line generation.
- Experience with laboratory automation systems such as HighRes, Beckman Biomek i5/i7, Hamilton, EL406, Multidrop, or equivalent liquid-handling platforms.
- Interest in applying functional biology to AI/ML-enabled therapeutic discovery.

Who Will Love This Job:

This is an opportunity to join Generate’s Functional Bioassays team at a time of significant portfolio growth. As a Scientist II, you will play a hands-on role generating functional data that advances new therapeutic programs and supports rapid design-build-test-learn cycles. You will work on diverse biology, learn new assay platforms, collaborate across disciplines, and build expertise in assay development, high-throughput screening, automation, and drug discovery in a highly collaborative environment.

About Generate:Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

## #LI-RT1

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range $114,000—$150,000 USD

## About Generate Biomedicines

## Company Overview
- **One-liner**: Generate Biomedicines is a clinical-stage generative biology company pioneering the use of machine learning to design and develop protein-based medicines on demand.
- **Entity Type**: Public (ticker: GBIO)
- **Headquarters**: Somerville, Massachusetts, USA (Boynton Yards and Andover locations)
- **Founded**: 2018
- **Founders**: Gevorg Grigoryan, Daria Hazuda, and others

## Core Business
- **Primary industry**: Biotechnology / Drug Discovery & Development
- **Target customers**: B2B (pharmaceutical partners) and patients (via clinical programs)
- **Mission statement**: "We don’t discover medicines—we design them," with a belief that speed is a moral obligation to patients.

## Products & Services
- **[Generate Platform™]**: An integrated computational and biohardware innovation stack that uses generative biology to design proteins with defined biological intent. It can generate up to a billion designed variants per cycle with cycle times as fast as ~8 days.
- **[GB-0895 (Anti-TSLP Antibody)]**: A next-generation anti-TSLP monoclonal antibody for severe asthma and COPD, currently in global Phase 3 trials. Designed for ultra-high affinity (106 fM binding, 20x improvement over tezepelumab) and an extended half-life (98 days, longest known among TSLP-targeting therapies), enabling twice-yearly subcutaneous dosing.
- **[GB-5267 (MUC-16 Armored CAR-T)]**: A cell therapy candidate for metastatic ovarian cancer, expected to enter Phase 1 in 1H26.
- **[GB-4362 (Free MMAE Toxin Neutralizer)]**: A first-in-class neutralizer designed for combination with MMAE-based antibody-drug conjugates (ADCs), with Phase 1 initiation in bladder cancer expected 1H26.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed; IPO in February 2026 raised net proceeds of approximately $370 million.
- **Key Metric**: $221.5 million cash balance at YE 2025, plus ~$370 million from IPO (early 2026).
- **Notable Investors/Partners**: Strategic collaborations with Amgen, Novartis, MD Anderson Cancer Center, and Roswell Park Comprehensive Cancer Center.
- **Growth Signals**: 5 clinical-stage programs enabled by the platform; initiated global Phase 3 studies for GB-0895; operating out of 140k+ square feet of lab and office space; has studied millions of proteins and generated 42,000 proteins built and tested.

## Competitive Advantages
- **Fully integrated computational-biohardware loop**: Machine learning drives generative design, which feeds directly into high-throughput experimentation (including proprietary CryoEM with four of the best microscopes in the world), and results continuously train the AI system — a "living feedback loop" that compounds over time.
- **Multimodal platform**: Can generate candidates across antibodies, CAR-T, and other protein modalities from a single core technology, enabling a pipeline that covers both immunology and oncology.
- **Record speed and scale**: Capable of generating up to a billion designed variants in ~8-day cycles, dramatically reducing the time and cost traditionally associated with drug discovery.
- **First-mover in next-gen anti-TSLP**: First known next-generation anti-TSLP antibody to enter the clinic (GB-0895) with a differentiated half-life profile that could enable twice-yearly dosing, a significant competitive edge in a large market.

## Strategic Focus
- **Clinical execution**: Advancing GB-0895 through global Phase 3 trials in severe asthma (with data in 2H27/1H28) and initiating late-stage development in COPD.
- **Pipeline expansion**: Moving GB-5267 (CAR-T) and GB-4362 (ADC neutralizer) into Phase 1 in 2026, expanding the platform's therapeutic scope.
- **Platform scaling**: Continuing to refine the generative biology engine to unlock new modalities and therapeutic areas, while deepening existing strategic collaborations with major pharma partners.
- **Organizational growth**: Building out the team across computational, wet-lab, clinical, and operational functions to support the growing pipeline.

## Why Work Here
- **Mission-driven**: The company is explicit that "speed is not just a competitive advantage—it’s a moral obligation." Employees are directly involved in designing drugs rather than discovering them, with a focus on getting treatments to patients faster.
- **Interdisciplinary culture**: The company emphasizes true integration across machine learning, biological engineering, and medicine. As stated on their site, "We are a close-knit group of cross-disciplinary experts... each conversant in one another’s fields, working together to create a new one."
- **Cutting-edge technology**: Access to unique computational and biohardware infrastructure, including "the four best CryoEM microscopes in the world" and a high-throughput experimental loop that powers AI training in real-time.
- **Values-driven leadership**: Explicit leadership behaviors include "value the knowledge we gain more than the knowledge we have," "bring creativity, tenacity, and ingenuity to every challenge," and "hold oneself and others to an obligation to dissent."
- **Hybrid/office policy**: Not explicitly stated, but the company operates large physical facilities in Somerville and Andover, MA, and offers free parking, monthly subway passes, or subsidized commuter rail passes, suggesting a significant on-site expectation.
- **Comprehensive benefits**: Competitive pay, employee stock option plan, health/vision/dental insurance, long- and short-term disability, life insurance, EAP, retirement savings, paid parental/adoption/caregiver leave, free weekly lunch, and stocked kitchen.
- **Growth trajectory**: As a newly public company with a cash-rich balance sheet and multiple catalysts over the next 12–24 months, the company offers significant career growth potential for those who want to be part of building a "transcendent company" that redefines an industry.

## Sources
1. [generatebiomedicines.com](https://generatebiomedicines.com/)
2. [generatebiomedicines.com/careers](https://generatebiomedicines.com/careers)
3. [generatebiomedicines.com/about-us](https://generatebiomedicines.com/about-us)
4. [investors.generatebiomedicines.com](https://investors.generatebiomedicines.com/)
5. [Non-Confidential Overview (April 2026)](https://investors.generatebiomedicines.com/wp-content/uploads/2026/04/Generate-Biomedicines-Non-Confidential-Overview_April-2026-1.pdf)

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