---
title: 'Scientist, In Vivo Pharmacology at Serif Biomedicines, Inc.'
canonical: 'https://feeny.ai/job/scientist-in-vivo-pharmacology-serif-biomedicines-inc-cambridge-ss8e62xdrcqp'
type: 'job'
last_seen: '2026-11-04'
---

# Scientist, In Vivo Pharmacology at Serif Biomedicines, Inc.

- **Company:** Serif Biomedicines, Inc.
- **Location:** Cambridge, MA
- **Posted:** 2026-10-29
- **Last confirmed live:** 2026-11-04
- **Apply:** https://job-boards.greenhouse.io/serif/jobs/8923272002

## Job description

Company Summary:

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

We are looking for an experienced scientist to join the in vivo pharmacology group at Serif. This position will report to the head of pharmacology and will focus on executing preclinical studies in rodent models, including humanized mouse models, to support exploratory and therapeutic programs, both internally and in collaboration with CROs. This is a hands-on role that involves close collaboration with  multi-disciplinary teams in a fast-paced, highly collaborative environment.

Key Responsibilities:

- Execute and oversee in vivo efficacy, biodistribution, PK/PD in rodent models including humanized mice, xenograft, syngeneic, and transgenic mouse models relevant to platform and therapeutic programs.
- Contribute to study designs, study planning, and resource allocation of in vivo studies by working in close collaboration with head of Pharmacology
- Perform animal procedures including blood collection, necropsy, tissue harvest, and homogenization, cell isolation, and test article administration through multiple routes, including I.M, S.C, I.V, I.P.

Author protocols for rodent studies and contribute to NHP protocols as needed and oversee/conduct in vivo rodent studies at contract vivariums and/or CROs.

- Establish and maintain strong relationships with vivarium and external CRO to ensure high quality and timely execution of studies.
- Perform dose calculations and prepare dosing formulations for rodent and NHP studies. Coordinate shipment of test articles to CROs and the receipt of samples, ensuring timely communication with stakeholders.
- Ensure study compliance with IACUC protocols, and company policies.
- Maintain accurate experimental records, study protocols and reports.
- Demonstrate scientific and technical expertise to advance in vivo studies through familiarity with scientific literature.
- Proactively recognize and develop creative solutions for emerging technical and scientific issues.
- Analyze relevant tolerability endpoints and effectively communicate results to stakeholders.

Required Qualifications:

- M.S with 10+ or B.S with 12+ years industry experience, respectively. Level will be based on experience and demonstrated scope.
- Proficient hands-on experience in mouse models of immunology, oncology and transgenic reporter models. Experience with IVIS acquisition and analysis preferred.
- Experience in writing IACUC protocols required. Familiarity with NHP protocols preferred.
- Experience performing in-vivo procedures in rodents, including dose preparation and administration of therapeutics and sample collection (blood, tissues etc.) and processing required
- Strong organizational, communication and interpersonal skills.
- Ability to thrive in a fast-paced, and rapidly growing biotech environment with changing priorities.
- Work independently and collaboratively in a multidisciplinary team environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future. Privacy Notice for Applicants: When you apply for a role at Serif Biomedicines, Inc., a Flagship Pioneering portfolio company, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

## About Serif Biomedicines, Inc.

## Company Overview
- **One-liner**: Serif Biomedicines is pioneering Modified DNA as a new class of genetic medicine, using nucleic acid chemistry, synthetic biology, delivery science, and AI to create programmable, durable, and redosable DNA therapeutics.
- **Entity Type**: Private (Founded by Flagship Pioneering)
- **Headquarters**: Cambridge, MA, USA
- **Founded**: 2026 (public launch in April 2026)
- **Founders**: Originated at Flagship Pioneering; Founding team includes Jacob (Jake) Rubens, PhD (CEO), Matt Kennedy, PhD (CSO), and others.

## Core Business
- **Primary industry**: Biotechnology / Genetic Medicines
- **Target customers**: B2B (pharma/biotech partnerships) and B2G (therapeutic development for rare diseases and immune programming)
- **Mission**: To build a future where DNA becomes the source code for medicines that can be tailored across diseases and scaled for global impact.

## Products & Services
- **Modified DNA Platform**: A proprietary technology that chemically modifies DNA to minimize innate immunogenicity during delivery into cells. Once inside the nucleus, the Modified DNA reverts to unmodified DNA, enabling transcription into therapeutic RNA and proteins. This platform combines the best features of mRNA and gene therapy while mitigating their limitations (durability, redosability, cell-specific expression).
- **mRNA Co-factors**: Delivered alongside Modified DNA, these transiently express proteins that enhance nuclear entry and gene expression.
- **AI-Enabled Design-Build-Test-Learn Cycle**: Integrates AI to optimize DNA and mRNA co-factor sequences and lipid nanoparticle (LNP) formulations by learning from massive datasets.
- **Therapeutic Pipeline**: Initial drug discovery programs focused on rare diseases and immune programming.

## Market Standing
- **Valuation/Market Cap**: Not disclosed (private, Flagship Pioneering portfolio company)
- **Key Metric**: Total Funding — Not publicly disclosed (launched with Flagship Pioneering backing; no specific funding round announced)
- **Notable Investors/Partners**: Flagship Pioneering (originator and primary backer); Board includes Noubar Afeyan (Flagship CEO), John Maraganore (founding CEO of Alnylam), Andrew Allen (CEO of Tessera Therapeutics), and others.
- **Growth Signals**: Public launch in April 2026 with significant press coverage; presenting data at ASGCT 2026; actively hiring across multiple R&D functions (Protein Engineering, LNP Process & Development, Immunology, Bioanalytics, Molecular Biology).

## Competitive Advantages
- **Novel Platform Technology**: Serif is the first company to establish Modified DNA as a therapeutic modality, creating a new category of genetic medicine that combines the durability of gene therapy with the redosability and programmability of mRNA.
- **Flagship Pioneering Backing**: Originated and funded by Flagship, a top-tier biotech venture creation firm with a track record of building category-defining companies (Moderna, Tessera, etc.).
- **Integrated Capability Stack**: Combines nucleic acid chemistry, synthetic biology, delivery science (LNPs), and AI/ML for optimization — a full-stack approach to genetic medicine.
- **Strong IP & Scientific Team**: Leadership includes veterans from Flagship, Alnylam, and Tessera, with deep expertise in nucleic acid discovery, development, and delivery.

## Strategic Focus
- **Initial Therapeutic Areas**: Rare diseases and immune programming, where Modified DNA’s durability, redosability, and cell-specific expression offer clear advantages.
- **Platform Expansion**: Building scalable manufacturing processes and AI-driven design cycles to enable broad therapeutic application across diseases.
- **Talent Acquisition**: Actively hiring across R&D functions to build out the platform and pipeline.

## Why Work Here
- **Pioneering Science**: Opportunity to work on a first-in-class technology that could redefine genetic medicine — comparable to the early days of mRNA therapeutics.
- **Flagship Ecosystem**: Access to the resources, network, and expertise of Flagship Pioneering, one of the most successful biotech incubators.
- **Culture**: Described as a team of scientists, engineers, and company builders united by a mission to create a new foundational biotechnology. Emphasis on collaboration and innovation.
- **Location**: Cambridge, MA — a global hub for biotech and life sciences.
- **Growth Stage**: Early-stage (just launched in April 2026), offering significant impact and career growth potential for early hires.
- **Work Policy**: Not explicitly stated, but typical for early-stage biotech in Cambridge — likely on-site or hybrid.

## Sources
1. [serifbiomedicines.com](https://serifbiomedicines.com)
2. [serifbiomedicines.com/team](https://serifbiomedicines.com/team)
3. [serifbiomedicines.com/science](https://serifbiomedicines.com/science)
4. [flagshippioneering.com](https://www.flagshippioneering.com/companies/serif-biomedicines)
5. [job-boards.greenhouse.io/serif](https://job-boards.greenhouse.io/serif/jobs/8511741002)

## Other roles at Serif Biomedicines, Inc.

- [Senior Scientist, LNP Formulations](https://feeny.ai/job/senior-scientist-lnp-formulations-serif-biomedicines-inc-cambridge-e6as2tmxztgp) — Cambridge, MA
- [Associate Scientist, Bioanalytical Assays](https://feeny.ai/job/associate-scientist-bioanalytical-assays-serif-biomedicines-inc-cambridge-7e493d7k67nb) — Cambridge, MA
- [Senior Scientist, Analytical Development and Quality Control](https://feeny.ai/job/senior-scientist-analytical-development-and-quality-control-serif-biomedicines-1ewhtadm3tmg) — Cambridge, MA
- [Laboratory Operations Associate](https://feeny.ai/job/laboratory-operations-associate-serif-biomedicines-inc-cambridge-stbt1pbzxjn6) — Cambridge, MA
- [Scientist, In Vivo Pharmacology](https://feeny.ai/job/scientist-in-vivo-pharmacology-flagship-pioneering-inc-cambridge-fv3h21qm8e66) — Cambridge, MA