---
title: 'Scientist, mRNA Analytical Development at NewLimit'
canonical: 'https://feeny.ai/job/scientist-mrna-analytical-development-newlimit-south-san-francisco-e26js8ad15e6'
type: 'job'
last_seen: '2026-11-06'
---

# Scientist, mRNA Analytical Development at NewLimit

- **Company:** NewLimit
- **Location:** South San Francisco, CA
- **Posted:** 2026-10-20
- **Last confirmed live:** 2026-11-06
- **Apply:** https://job-boards.greenhouse.io/newlimit/jobs/6230292004

## Job description

## About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

We are seeking a Scientist to establish and grow NewLimit's mRNA analytical testing suite. In this role, you will lead the development of analytical methods to characterize our DNA templates and mRNAs. The assays you build will drive mRNA process development efforts as our programs advance toward the clinic.

This is a hands-on, lab-based role within Technical Operations that will interface with Delivery Sciences, research teams, and external CDMOs. It is ideal for an analytical scientist who enjoys building from the ground up and wants to expand their scope.

## What you'll do

As a member of our team, you will:

Build the analytical suite

- Develop and establish analytical methods for DNA template and mRNA drug substance release and characterization
- Lead studies to evaluate method robustness, specificity, sensitivity, precision, accuracy, and linearity, and set phase-appropriate performance criteria
- Act as the mRNA analytical lead for CMC program teams
- Evaluate emerging analytical technologies to expand our internal testing capabilities

Run and maintain the assays

- Perform routine testing of DNA templates and mRNA materials to support process development and research programs
- Investigate unexpected impurities, degradation, and atypical results
- Maintain instruments, reference standards, assay controls, and critical reagents

Documentation and collaboration

- Author method protocols and technical development reports
- Support method transfer and qualification at CDMOs
- Present experiment results at team meetings
- Manage the outsourcing of advanced analytical techniques to CROs, as needed

## Requirements

- Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience
- Experience with assay development and qualification across a broad range of mRNA analytical methods
- Hands-on experience executing and troubleshooting HPLC separations (e.g., IP-RP-HPLC, SEC), capillary electrophoresis, and plate based assays for impurity quantification (e.g. qPCR, ELISA)
- Ability to independently design, execute, and troubleshoot experiments
- Ability to analyze and present complex data sets
- Strong technical writing skills
- Excellent communication and organizational skills

## Nice to have

- Understanding of the analytical method lifecycle and phase-appropriate method qualification
- Experience with sequencing workflows and data analysis, including Sanger and Oxford Nanopore Technologies
- Experience developing cell-based potency assays
- Experience with LC-MS assays for evaluating poly(A) tail length and capping efficiency
- Experience transferring analytical methods to CDMOs

## Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site

Salary Range: $120,000-155,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers

*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

## About NewLimit

## Company Overview
- **One-liner**: NewLimit is a biotechnology company developing epigenetic reprogramming medicines to radically extend human healthspan by reversing cellular aging.
- **Entity Type**: Private (Series B)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2022
- **Founders**: Jacob Kimmel (Co-founder & President), Brian Armstrong (Co-founder), Blake Byers (Co-founder)

## Core Business
- **Primary industry/industries**: Biotechnology, Epigenetic Reprogramming, Longevity Therapeutics, Drug Discovery
- **Target customers**: B2B (pharmaceutical partners, clinical development), B2C (ultimately patients with age-related diseases)
- **Mission or purpose statement**: To radically extend human healthspan by creating the first medicines that reverse cellular aging at the epigenetic level.

## Products & Services
- **Discovery Engine**: An AI-powered platform that designs epigenetic payloads to make old cells look and act young. It tests thousands of designs simultaneously using genomics and retrains models iteratively on new data.
- **Therapeutics (Pipeline)**: Medicines focused on restoring youthful function in the liver, immune system, and vasculature. Initial programs target diseases resembling accelerated aging, with the goal of restoring youthful metabolism, energy levels, resilience to disease, and cognition.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed
- **Key Metric**: Total Funding of **$215M** (across three rounds); Annual Revenue estimated at **$12.8M** [linkedin.com](https://linkedin.com/company/newlimit)
- **Notable Investors/Partners**: Kleiner Perkins (led Series B), Valor Equity Partners, Quiet Capital, S32, Duke University Management Company, Liberty Mutual Investments, Fred Ehrsam, Elad Gil, Joe Lonsdale, Eric Schmidt, Garry Tan, Brian Armstrong, Blake Byers [newlimit.com](https://www.newlimit.com/company)
- **Growth Signals**: 44 employees (+40.5% YoY), 12 active job postings (+100% YoY), LinkedIn followers grew 157.6% in the past year, and the company closed a $130M Series B in May 2025 led by Kleiner Perkins [linkedin.com](https://linkedin.com/company/newlimit).

## Competitive Advantages
- **Proprietary AI Platform**: A frontier intelligence system that designs, tests, and retrains models on epigenetic reprogramming at unprecedented scale.
- **Scientific Moats**: Deep expertise in epigenetic reprogramming (a validated but complex mechanism for reversing cellular age); a team with backgrounds from Calico, UCSF, and Stanford.
- **Founding Team & Backing**: Co-founded by Brian Armstrong (CEO of Coinbase) and Blake Byers (early investor in OpenAI, Anthropic, Neuralink), providing deep capital access and a culture of ambitious, long-term execution.

## Strategic Focus
- **Current priorities**: Advancing pipeline programs into the clinic (Head of Clinical Development role is open); scaling the Discovery Engine; building the team across computational biology, immunology, and manufacturing.
- **Direction for growth**: Transition from a discovery-stage R&D company to a clinical-stage therapeutics company; generating large revenue streams to fund the mission; expanding into new cell types and disease areas.

## Why Work Here
- **Culture**: "Not for the faint of heart" — a high-performance, mission-focused team. No pure management roles; everyone executes. Values include safety then speed, clear communication, inherent optimism, independent thinking, and top talent in every seat [newlimit.com](https://www.newlimit.com/careers).
- **Remote/Hybrid/Office**: Likely on-site/hybrid given the lab-based nature of the work (headquarters in South San Francisco).
- **Notable Perks**: Competitive salaries, comprehensive health benefits (medical, dental, vision), equity packages, 401(k) with up to 4% match, generous parental leave, 20 days PTO + 15 holidays, free EV charging [newlimit.com](https://www.newlimit.com/careers).
- **Engineering Culture**: Strong emphasis on computational biology, machine learning, and functional genomics. The team spans both wet-lab and dry-lab disciplines, with a focus on building scalable methods and iterative data-driven discovery.

## Sources
1. [NewLimit Website](https://www.newlimit.com/)
2. [NewLimit Careers Page](https://www.newlimit.com/careers)
3. [NewLimit Company Page](https://www.newlimit.com/company)
4. [NewLimit Team Page](https://www.newlimit.com/team)
5. [NewLimit LinkedIn Page](https://www.linkedin.com/company/newlimit)

## Other roles at NewLimit

- [Group Lead, Immunology](https://feeny.ai/job/group-lead-immunology-newlimit-south-san-francisco-wfjbzx3hytgf) — South San Francisco, CA
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- [Senior/Research Associate, mRNA Engineering](https://feeny.ai/job/senior-research-associate-mrna-engineering-newlimit-south-san-francisco-h10v20kcztq2) — South San Francisco, CA
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- [Scientist, Metabolism](https://feeny.ai/job/scientist-metabolism-newlimit-south-san-francisco-5k9gbm6gpcwn) — South San Francisco, CA
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- [Senior Manager, Lab Operations](https://feeny.ai/job/senior-manager-lab-operations-newlimit-south-san-francisco-2s9yfb1zrv9n) — South San Francisco, CA
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