---
title: 'Scientist, mRNA Downstream Purification at NewLimit'
canonical: 'https://feeny.ai/job/scientist-mrna-downstream-purification-newlimit-south-san-francisco-2a496dgy9747'
type: 'job'
last_seen: '2026-11-06'
---

# Scientist, mRNA Downstream Purification at NewLimit

- **Company:** NewLimit
- **Location:** South San Francisco, CA
- **Posted:** 2026-10-20
- **Last confirmed live:** 2026-11-06
- **Apply:** https://job-boards.greenhouse.io/newlimit/jobs/6230305004

## Job description

## About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

We are seeking a Scientist to lead downstream process development for the mRNA Engineering team. In this role, you will design, optimize, and scale purification processes for mRNA drug substance.

This is a hands-on, lab-based role that spans program process development and platform engineering. It is ideal for a scientist who enjoys solving purification challenges and scaling processes in a dynamic, fast-paced environment.

## What you'll do

As a member of our team, you will:

Develop downstream purification processes

- Design, execute, and analyze process development studies for mRNA purification
- Act as the downstream lead for CMC program teams
- Help design and implement automated downstream workflows for high-throughput purification of research-grade mRNA
- Support execution of research-grade mRNA production runs for discovery and preclinical studies, as needed
- Support process scale-up from bench to pilot scale, as needed
- Evaluate emerging purification technologies and chromatography resins

Support tech transfer and CDMO manufacturing

- Perform tech transfer of downstream processes to CDMOs
- Act as person in plant during CDMO manufacturing runs
- Support process troubleshooting and deviation investigations at CDMOs

Documentation and collaboration

- Maintain organized experimental records in Electronic Lab Notebooks
- Author development SOPs and technical development reports
- Present experiment results at team meetings

## Requirements

- Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience
- Hands-on experience developing downstream purification processes for nucleic acids or other biologics
- Hands-on experience with tangential flow filtration (TFF)
- Experience operating ÄKTA chromatography systems
- Ability to independently design, execute, and troubleshoot experiments
- Ability to analyze and present complex data sets
- Strong technical writing skills
- Excellent communication and organizational skills

## Nice to have

- Experience with traditional nucleic acid purification methods (e.g., desalting, precipitation, size-exclusion)
- Experience with plasmid DNA purification
- Experience with Design of Experiments (DoE) and statistical data analysis
- Experience implementing automated or high-throughput purification workflows
- Experience with process transfer to CDMOs
- General understanding of cGMP and phase-appropriate process development
- Familiarity with mRNA analytics such as HPLC, CGE, and dsRNA ELISA

## Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site

Salary Range: $120,000-155,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers

*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

## About NewLimit

## Company Overview
- **One-liner**: NewLimit is a biotechnology company developing epigenetic reprogramming medicines to radically extend human healthspan by reversing cellular aging.
- **Entity Type**: Private (Series B)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2022
- **Founders**: Jacob Kimmel (Co-founder & President), Brian Armstrong (Co-founder), Blake Byers (Co-founder)

## Core Business
- **Primary industry/industries**: Biotechnology, Epigenetic Reprogramming, Longevity Therapeutics, Drug Discovery
- **Target customers**: B2B (pharmaceutical partners, clinical development), B2C (ultimately patients with age-related diseases)
- **Mission or purpose statement**: To radically extend human healthspan by creating the first medicines that reverse cellular aging at the epigenetic level.

## Products & Services
- **Discovery Engine**: An AI-powered platform that designs epigenetic payloads to make old cells look and act young. It tests thousands of designs simultaneously using genomics and retrains models iteratively on new data.
- **Therapeutics (Pipeline)**: Medicines focused on restoring youthful function in the liver, immune system, and vasculature. Initial programs target diseases resembling accelerated aging, with the goal of restoring youthful metabolism, energy levels, resilience to disease, and cognition.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed
- **Key Metric**: Total Funding of **$215M** (across three rounds); Annual Revenue estimated at **$12.8M** [linkedin.com](https://linkedin.com/company/newlimit)
- **Notable Investors/Partners**: Kleiner Perkins (led Series B), Valor Equity Partners, Quiet Capital, S32, Duke University Management Company, Liberty Mutual Investments, Fred Ehrsam, Elad Gil, Joe Lonsdale, Eric Schmidt, Garry Tan, Brian Armstrong, Blake Byers [newlimit.com](https://www.newlimit.com/company)
- **Growth Signals**: 44 employees (+40.5% YoY), 12 active job postings (+100% YoY), LinkedIn followers grew 157.6% in the past year, and the company closed a $130M Series B in May 2025 led by Kleiner Perkins [linkedin.com](https://linkedin.com/company/newlimit).

## Competitive Advantages
- **Proprietary AI Platform**: A frontier intelligence system that designs, tests, and retrains models on epigenetic reprogramming at unprecedented scale.
- **Scientific Moats**: Deep expertise in epigenetic reprogramming (a validated but complex mechanism for reversing cellular age); a team with backgrounds from Calico, UCSF, and Stanford.
- **Founding Team & Backing**: Co-founded by Brian Armstrong (CEO of Coinbase) and Blake Byers (early investor in OpenAI, Anthropic, Neuralink), providing deep capital access and a culture of ambitious, long-term execution.

## Strategic Focus
- **Current priorities**: Advancing pipeline programs into the clinic (Head of Clinical Development role is open); scaling the Discovery Engine; building the team across computational biology, immunology, and manufacturing.
- **Direction for growth**: Transition from a discovery-stage R&D company to a clinical-stage therapeutics company; generating large revenue streams to fund the mission; expanding into new cell types and disease areas.

## Why Work Here
- **Culture**: "Not for the faint of heart" — a high-performance, mission-focused team. No pure management roles; everyone executes. Values include safety then speed, clear communication, inherent optimism, independent thinking, and top talent in every seat [newlimit.com](https://www.newlimit.com/careers).
- **Remote/Hybrid/Office**: Likely on-site/hybrid given the lab-based nature of the work (headquarters in South San Francisco).
- **Notable Perks**: Competitive salaries, comprehensive health benefits (medical, dental, vision), equity packages, 401(k) with up to 4% match, generous parental leave, 20 days PTO + 15 holidays, free EV charging [newlimit.com](https://www.newlimit.com/careers).
- **Engineering Culture**: Strong emphasis on computational biology, machine learning, and functional genomics. The team spans both wet-lab and dry-lab disciplines, with a focus on building scalable methods and iterative data-driven discovery.

## Sources
1. [NewLimit Website](https://www.newlimit.com/)
2. [NewLimit Careers Page](https://www.newlimit.com/careers)
3. [NewLimit Company Page](https://www.newlimit.com/company)
4. [NewLimit Team Page](https://www.newlimit.com/team)
5. [NewLimit LinkedIn Page](https://www.linkedin.com/company/newlimit)

## Other roles at NewLimit

- [Group Lead, Immunology](https://feeny.ai/job/group-lead-immunology-newlimit-south-san-francisco-wfjbzx3hytgf) — South San Francisco, CA
- [Scientist, mRNA Analytical Development](https://feeny.ai/job/scientist-mrna-analytical-development-newlimit-south-san-francisco-e26js8ad15e6) — South San Francisco, CA
- [Senior/Research Associate, mRNA Engineering](https://feeny.ai/job/senior-research-associate-mrna-engineering-newlimit-south-san-francisco-h10v20kcztq2) — South San Francisco, CA
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- [Scientist, Metabolism](https://feeny.ai/job/scientist-metabolism-newlimit-south-san-francisco-5k9gbm6gpcwn) — South San Francisco, CA
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- [Senior Manager, Lab Operations](https://feeny.ai/job/senior-manager-lab-operations-newlimit-south-san-francisco-2s9yfb1zrv9n) — South San Francisco, CA
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