---
title: 'Scientist-Principal Scientist, Protein Design & Structure at Superluminal Medicines, Inc.'
canonical: 'https://feeny.ai/job/scientist-principal-scientist-protein-design-structure-superluminal-medicines-jf2p40h4fwng'
type: 'job'
last_seen: '2026-09-09'
---

# Scientist-Principal Scientist, Protein Design & Structure at Superluminal Medicines, Inc.

- **Company:** Superluminal Medicines, Inc.
- **Location:** Boston, MA
- **Posted:** 2026-06-01
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/superluminalrx/jobs/5234812008

## Job description

About Superluminal Medicines:

Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.

Position Summary

We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership.

## Key Responsibilities

- Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
- Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
- Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
- Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
- Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications

- Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master’s or bachelor’s degree in a related field with commensurate industry experience.
- Deep knowledge of GPCR biology and membrane protein structure-function relationships.
- Proven expertise in molecular biology (cloning, construct design, mutagenesis).
- Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).
- Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
- Excellent communication, interpersonal, and leadership skills.

## Preferred Qualifications

- Experience with structural biology methods (data collection and processing for Cryo-EM).
- Experience in laboratory automation in protein sciences & purification.
- Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

Benefits:

Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance.

Equal Opportunity Statement:

Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

## About Superluminal Medicines, Inc.

## Company Overview
- **One-liner**: Superluminal Medicines is a drug discovery company integrating AI/ML, protein dynamics, and structural biology to rapidly develop small molecule therapeutics targeting challenging G protein-coupled receptors (GPCRs) for cardiometabolic diseases and obesity.
- **Entity Type**: Private (Convertible Note financing round; total funding $158M as of 2026)
- **Headquarters**: Boston, Massachusetts, United States (15 Necco Street, 4th Floor)
- **Founded**: 2022
- **Founders**: Not publicly disclosed

## Core Business
- **Primary Industry**: Biotechnology / Drug Discovery & Development
- **Target Customers**: B2B partnerships with large pharmaceutical companies (e.g., Eli Lilly) and, ultimately, patients with cardiometabolic conditions and obesity
- **Mission / Purpose**: “Revolutionizing the speed and accuracy of how medicine is created” by combining generative biology and chemistry with AI-driven computational methods.

## Products & Services
- **Hyperloop™ Platform**: An integrated drug discovery platform that merges structure-based drug discovery, machine learning, proprietary big data infrastructure, and experimental validation to generate candidate-ready small molecule compounds targeting GPCRs. (SaaS/internal tool – not sold externally)
- **Pipeline – MC4R Agonist**: A selective, biased MC4R agonist advancing to IND-enabling studies for the treatment of obesity.
- **Other pipeline programs**: Undisclosed GPCR targets for cardiometabolic diseases, developed in collaboration with Eli Lilly.

## Market Standing
- **Valuation**: Not publicly available
- **Key Metric**: Total funding raised – $158M (CB Insights estimate)
- **Notable Investors/Partners**: Eli Lilly and Company (collaborator and equity investor), RA Capital Management, Insight Partners, Gaingels, NVentures (NVIDIA’s venture arm)
- **Growth Signals**:
  - Announced a multi-target collaboration with Eli Lilly worth up to $1.3B in upfront, near-term, milestone payments, equity investment, and tiered royalties.
  - Biased MC4R agonist moving into IND-enabling studies.
  - Active hiring: 5+ open positions in Machine Learning, Protein Design, Computational Chemistry, HR, and Finance.

## Competitive Advantages
- **Hyperloop Platform**: Combines deep biology/chemistry expertise with AI and proprietary big data in a single, rapid iteration cycle – enabling candidate-ready compounds at unprecedented speed.
- **GPCR Focus**: Specialization in the most challenging GPCR targets, a proven class for drug development but historically difficult to modulate selectively.
- **Big Pharma Backing**: Strategic collaboration with Eli Lilly provides significant funding, validation, and potential for rapid clinical development.

## Strategic Focus
- Advance the MC4R agonist and other pipeline candidates through IND-enabling studies and into clinical trials.
- Expand the Hyperloop platform’s application to additional GPCR targets and disease areas beyond cardiometabolic indications.
- Leverage AI/ML and structural biology to compress traditional drug discovery timelines from years to months.

## Why Work Here
- **Culture**: Core values emphasize urgency (speed to patients), resilience, collaboration, transparency, and compassion. The team describes the environment as inclusive, collaborative, and supportive.
- **Work Policy**: Primarily onsite at a brand-new lab space in Boston’s Seaport area (Lilly Gateway Labs). Remote/hybrid flexibility is not explicitly stated.
- **Benefits**: 100% employer-paid health/dental/vision insurance, equity participation, 401k, unlimited paid time off, and a subsidy for parking or mass transit.
- **Engineering & Science Culture**: Opportunities to work at the intersection of AI/ML, computational chemistry, and structural biology in a well-funded, fast-moving biotech startup with direct pharma partnerships.

## Sources
1. [superluminalrx.com](https://www.superluminalrx.com/about/)
2. [superluminalrx.com](https://www.superluminalrx.com/careers/)
3. [cbinsights.com](https://www.cbinsights.com/company/superluminal-medicines)
4. [job-boards.greenhouse.io](https://job-boards.greenhouse.io/superluminalrx)

## Other roles at Superluminal Medicines, Inc.

- [Facilities Manager](https://feeny.ai/job/facilities-manager-superluminal-medicines-inc-boston-8nq8khwhqgzr) — Boston, MA
- [Director, Technical Accounting & External Financial Reporting](https://feeny.ai/job/director-technical-accounting-external-financial-reporting-superluminal-49bbyadb2w2t) — Boston, MA
- [Director, Financial Planning & Analysis (FP&A)](https://feeny.ai/job/director-financial-planning-analysis-fp-a-superluminal-medicines-inc-boston-bjw8mawtvpp1) — Boston, MA
- [Research Associate/ Senior Research Associate, Discovery Biology](https://feeny.ai/job/research-associate-senior-research-associate-discovery-biology-superluminal-m37r6n23bkv2) — Boston, MA
- [Senior Scientist - Principal Scientist, Computational Chemistry](https://feeny.ai/job/senior-scientist-principal-scientist-computational-chemistry-superluminal-amgvtc3fygv1) — Boston, MA