---
title: 'Scientist/Senior Scientist, High-Throughput Screening at Until'
canonical: 'https://feeny.ai/job/scientist-senior-scientist-high-throughput-screening-until-san-francisco-e4xp9jk9s8wk'
type: 'job'
last_seen: '2026-11-02'
---

# Scientist/Senior Scientist, High-Throughput Screening at Until

- **Company:** Until
- **Location:** San Francisco, CA
- **Compensation:** $165k–$185k
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-10-22
- **Last confirmed live:** 2026-11-02
- **Apply:** https://jobs.lever.co/until/7506d899-6fb9-4a65-b5e3-bba25e087da9

## Job description

Until is a moonshot company building a “pause button” for biology. Our near-term focus is organ-scale reversible cryopreservation: preserving donated organs at subzero temperatures without ice formation, then rewarming them uniformly for transplant. By solving this grand challenge, we’re laying the foundation for whole-body reversible cryopreservation, giving patients a bridge to future cures.

To achieve our goal, we are assembling an interdisciplinary team to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware.

We envision a future where no transplantable organ is lost to logistics, and no terminal diagnosis is final because patients can safely wait for future medicine to arrive.

## About the Role

We are seeking a Scientist/Senior Scientist, High-Throughput Screening to manage the day-to-day execution of our cryoprotectant screening program. You will be responsible for improving an established screening workflow, increasing throughput, identifying less-toxic formulations, and advancing our understanding of how cryoprotectants affect cell viability and function.

Working closely with assay scientists, biologists, and automation engineers, you will integrate primary cells and iPSC-derived models into scalable screening workflows. You will develop mechanism-of-action assays, investigate cellular mechanisms of toxicity. This role combines hands-on experimental work, team coordination, and responsibility for delivering screening milestones that support organ-scale reversible cryopreservation.

You Will

- Coordinate the screening team’s day-to-day work, plan experiments, mentor team members, and ensure timely delivery of screening milestones.

- Manage and improve the screening workflow from cell-culture readiness and HTS assay execution through data analysis, quality control, and interpretation.

- Increase screening throughput and reproducibility in partnership with automation engineers while maintaining biological relevance and data quality.

- Design and execute functional assays to characterize cellular responses following cryoprotectant exposure.

- Develop and validate mechanism-of-action assays to identify drivers of toxicity and guide the design of less-toxic formulations.

- Improve the integration of renal, cardiac, and hepatic cell models using primary cells or iPSC-derived cells into the screening pipeline.

- Use chromatography and mass spectrometry to assess the purity of compounds used in cryoprotectant screening.

- Analyze multiparametric datasets, prioritize findings for follow-up, and communicate actionable recommendations to colleagues developing cryoprotectant formulations.

You Are

- Trained at the PhD level in Toxicology, Pharmacology, Cell Biology, Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, or a related field, or bring equivalent expertise through at least four years of relevant experience managing research projects end to end.

- Experienced in independently designing, executing, and improving cell-based high-throughput screening workflows.

- Skilled in assay development using primary cells or iPSC-derived cells, with experience in at least one renal, cardiac, or hepatic model.

- Experienced in developing mechanistic assays and translating screening results into testable hypotheses about cellular toxicity.

- Comfortable working hands-on with plate-based assays, imaging, flow cytometry, and analytical chemistry methods such as HPLC, LC-MS, or GC-MS for compound purity assessment.

- Experienced in quantitative analysis of screening data, including quality control, statistical interpretation, and analysis of multiple experimental readouts.

- Able to coordinate and mentor a scientific team, manage interdependent workflows, and take responsibility for experimental execution and outcomes.

- Collaborative, receptive to diverse perspectives, and comfortable adapting priorities in a fast-paced, mission-driven research environment.

## Preferred Qualifications

- Experience scaling automated screening workflows in close partnership with lab automation engineers.

- Experience integrating iPSC-derived cells or advanced 3D models into high-throughput screening pipelines.

- Experience with high-content imaging, transcriptomics, or other approaches that connect cellular phenotypes to mechanisms of toxicity.

- Proficiency in Python or R for analysis, visualization, and interpretation of complex screening datasets.

- Experience relating compound purity measurements to biological assay results.

## Benefits

- Generous medical, dental and vision insurance coverage

- Flexible time off and paid holidays

- Competitive compensation package, including salary and equity

- Access to a 401(k) retirement savings plan

- FSA and commuter benefits

- Daily lunch and dinners, plus a variety of snacks

- Monthly learning stipend

- On-site fitness center

- Quarterly team social budget

As an equal opportunity employer, Until is committed to providing employment opportunities to all individuals. All applicants for positions at Until will be treated without regard to race, color, ethnicity, religion, sex, gender, gender identity and expression, sexual orientation, national origin, disability, age, marital status, veteran status, pregnancy, or any other basis prohibited by applicable law.

## About Until

## Company Overview
- **One-liner**: Until is building reversible cryopreservation technology to bank whole human organs, extending viability from hours to weeks or months, with the long-term goal of whole-body cryopreservation.
- **Entity Type**: Private (Privately Held)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2025
- **Founders**: Laura Deming (CEO, Co-founder) and Hunter Davis Ozawa (CSO, Co-founder)

## Core Business
- Primary industry/industries: Biotechnology Research, Cryopreservation, Organ Preservation, Hibernation Science
- Target customers: Organ procurement organizations, transplant hospitals, and ultimately patients waiting for organ transplants (B2B with healthcare institutions)
- Mission or purpose statement: "Pressing pause on biological time, for those who need it most." The company aims to solve the organ procurement and matching problem by making donated organs last long enough to reach any patient in need.

## Products & Services
- **Reversible Cryopreservation for Whole Organs**: A technology that cools organs to -130°C using biocompatible cryoprotectants, then rewarms them without damage, turning hours of viability into weeks or months.
- **Cryoprotectant Discovery Engine**: A platform combining physics simulations and machine learning to screen over 250,000 candidate molecules for cryoprotective formulations that stay within a "Biocompatibility Budget" – preventing ice formation without harming cells.
- **Hibernation Research**: Exploratory work on inducing reversible metabolic arrest (hibernation-like states) in organisms, with potential applications in organ preservation and future whole-body suspension.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (private company, founded 2025)
- **Key Metric**: Total Funding – Not disclosed; headcount of 53 employees (as of early 2026) with 9.5% monthly growth and 29 active job postings.
- **Notable Investors/Partners**: Not publicly listed. The company is co-founded by Laura Deming, a noted longevity and biotech investor (founder of the Longevity Fund), which may signal strong investor connections.
- **Growth Signals**: Rapid hiring (29 open roles for a 53-person team, +31.8% quarterly job posting growth), high-throughput screening scale (2,903 formulations tested in Q2 2026 alone), and public progress on cryoprotectant discovery.

## Competitive Advantages
- **Combination of Physics Simulation and ML**: Their discovery engine screens millions of molecules in silico before wet-lab validation, dramatically accelerating cryoprotectant development.
- **Biocompatibility Budget Framework**: A novel approach that distributes cryoprotectant toxicity across multiple mechanisms, avoiding the single-dose toxicity that has stymied the field for 50 years.
- **Focus on Whole Organs (not just cells)**: Extending cryopreservation from small samples (IVF, stem cells) to whole human organs – a much harder problem with massive clinical impact.
- **Talent Philosophy**: "Proof of work" culture that hires for demonstrated ability over credentials, with fast promotion for those who earn it.

## Strategic Focus
- **Immediate**: Scale up cryoprotectant discovery and validation to achieve reversible cryopreservation of a whole human organ (likely a kidney or heart) within the next few years.
- **Medium-term**: De-risk and build the foundation for whole-body reversible cryopreservation, enabling "a bridge to future cures" for patients with currently incurable conditions.
- **Talent Acquisition**: Aggressively hiring scientists, engineers, and operations staff across physics, biology, chemistry, and engineering disciplines to accelerate R&D.

## Why Work Here
- **Work Environment**: On-site in San Francisco (HQ). The work spans "the edge of physics, biology, and engineering" – from quantum-level simulations to handling real organs. Culture emphasizes "hard problems", rigor, and speed.
- **Culture**: Flat hierarchy, promotion on merit, "proof of work" over credentials. Team includes people from top universities and self-taught scientists alike.
- **Benefits**: Comprehensive medical/dental/vision, 401(k) via Guideline, unlimited PTO, paid parental and disability leave, on-site fitness center, catered lunch and dinner, plus snacks.
- **Engineering & Science**: Opportunity to work on cutting-edge cryobiology, nanotech, polymer chemistry, and high-throughput automation. The company uses AI tools in hiring but makes final human decisions.

## Sources
1. [untillabs.com/careers](https://www.untillabs.com/careers)
2. [untillabs.com](https://untillabs.com/)
3. [untillabs.com/our-team](https://www.untillabs.com/our-team)
4. [builtin.com/company/until-labs](https://builtin.com/company/until-labs)
5. [jobs.lever.co/until](https://jobs.lever.co/until)

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