---
title: 'Scientist/ Senior Scientist - Translational Cardiac Biology at Until'
canonical: 'https://feeny.ai/job/scientist-senior-scientist-translational-cardiac-biology-until-bay-area-4t7rwnr11n7h'
type: 'job'
last_seen: '2026-09-14'
---

# Scientist/ Senior Scientist - Translational Cardiac Biology at Until

- **Company:** Until
- **Location:** Bay Area
- **Compensation:** $120k–$180k
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-02-24
- **Last confirmed live:** 2026-09-14
- **Apply:** https://jobs.lever.co/until/b5c0ae67-cdad-4f30-ae55-0057030c9bab

## Job description

Until is a moonshot company building a “pause button” for biology. Our near-term focus is organ-scale reversible cryopreservation: preserving donated organs at subzero temperatures without ice formation, then rewarming them uniformly for transplant. By solving this grand challenge, we’re laying the foundation for whole-body reversible cryopreservation, giving patients a bridge to future cures.

To achieve our goal, we are assembling an interdisciplinary team to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware.

We envision a future where no transplantable organ is lost to logistics, and no terminal diagnosis is final because patients can safely wait for future medicine to arrive.

## About the Role

We are seeking a Scientist/Senior Scientist, Translational Cardiac Biology to join our team. You will be part of a multidisciplinary team that designs, builds, and characterizes new technologies that form the foundation of organ-scale reversible cryopreservation.

In this role, you will advance cryopreservation formulations by designing, executing, and analyzing high throughput experiments focused on cardiac biology and toxicology. You will establish novel approaches to characterize toxicity and permeability of new cryoprotectant solutions using cardiac cells (hiPSC-CMs, immortalized cells) and advanced 3D in vitro cardiac models. Your work will pioneer the use of predictive 2D and 3D models for toxicity assessment, helping enable human-sized organ preservation and bridging patients to future cures.

## Key Responsibilities

- Develop clinically translatable healthy in vitro models using primary/immortalized cardiac cells, including iPSC-derived cardiomyocytes
- Design and implement high throughput screening (HTS) experiments to characterize the viability and functional performance of cardiac cells using MEA, calcium imaging, impedance-based readouts
- Create and validate complex in vitro 3D cardiac models (e.g., organoids, engineered heart tissues, micro-tissues) to accurately assess cardiotoxicity and permeability of new cryoprotectant solutions
- Develop innovative approaches to characterize cardiotoxicity of new compounds and their interactions with healthy heart function, including functional endpoints such as contractility, electrophysiology, and calcium handling
- Apply plate-reader, flow cytometry based and/or genomics techniques such as GWAS, RNAseq, and FISH to inform and refine molecular discovery and in vitro models
- Collaborate closely with cross-functional teams to translate experimental findings into new cryoprotectant solutions for human-sized organ preservation
- Recruit and mentor team members and take on greater responsibility for experimental design and strategy as needed

## Who You Are

- PhD and/or Postdoc training in Cardiac Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, Pharmacology, Toxicology or a related field, or have an equivalent (4+ years) of industry experience leading research projects end-to-end
- Have a track record of scientific excellence and autonomy, with the ability to independently develop and carry out complex experiments in cardiac biology or a related therapeutic area
- Hands-on expertise in cell-based assay development, including experience with primary cells, iPSC-derived cell types, or 3D in vitro models
- Proven ability to design and execute high throughput screening workflows and analyze multiparametric datasets
- Bring a collaborative mindset and value diverse perspectives
- Thrive fast-paced environments with high sense of mission and urgency

## Nice to have

- Experience evaluating pharmacokinetics and pharmacodynamics, with the ability to apply these frameworks to cryoprotectant formulation development
- Experience with cardiac electrophysiology, contractility measurement, or calcium imaging techniques
- Publication record in peer-reviewed journals in cardiac biology, cryobiology, toxicology, or related fields

## Benefits

- Opportunity for outsized impact creating the future as an early team member
- Generous medical, dental, and vision insurance coverage for employees and their dependents
- Flexible time off and paid holidays
- Competitive compensation package, including salary and equity
- Access to a 401(k) retirement savings plan
- FSA and commuter benefits
- Subsidized lunch daily

As an equal opportunity employer, Until is committed to providing employment opportunities to all individuals. All applicants for positions at Until will be treated without regard to race, color, ethnicity, religion, sex, gender, gender identity and expression, sexual orientation, national origin, disability, age, marital status, veteran status, pregnancy, or any other basis prohibited by applicable law.

## About Until

## Company Overview
- **One-liner**: Until is building reversible cryopreservation technology to bank whole human organs, extending viability from hours to weeks or months, with the long-term goal of whole-body cryopreservation.
- **Entity Type**: Private (Privately Held)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2025
- **Founders**: Laura Deming (CEO, Co-founder) and Hunter Davis Ozawa (CSO, Co-founder)

## Core Business
- Primary industry/industries: Biotechnology Research, Cryopreservation, Organ Preservation, Hibernation Science
- Target customers: Organ procurement organizations, transplant hospitals, and ultimately patients waiting for organ transplants (B2B with healthcare institutions)
- Mission or purpose statement: "Pressing pause on biological time, for those who need it most." The company aims to solve the organ procurement and matching problem by making donated organs last long enough to reach any patient in need.

## Products & Services
- **Reversible Cryopreservation for Whole Organs**: A technology that cools organs to -130°C using biocompatible cryoprotectants, then rewarms them without damage, turning hours of viability into weeks or months.
- **Cryoprotectant Discovery Engine**: A platform combining physics simulations and machine learning to screen over 250,000 candidate molecules for cryoprotective formulations that stay within a "Biocompatibility Budget" – preventing ice formation without harming cells.
- **Hibernation Research**: Exploratory work on inducing reversible metabolic arrest (hibernation-like states) in organisms, with potential applications in organ preservation and future whole-body suspension.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (private company, founded 2025)
- **Key Metric**: Total Funding – Not disclosed; headcount of 53 employees (as of early 2026) with 9.5% monthly growth and 29 active job postings.
- **Notable Investors/Partners**: Not publicly listed. The company is co-founded by Laura Deming, a noted longevity and biotech investor (founder of the Longevity Fund), which may signal strong investor connections.
- **Growth Signals**: Rapid hiring (29 open roles for a 53-person team, +31.8% quarterly job posting growth), high-throughput screening scale (2,903 formulations tested in Q2 2026 alone), and public progress on cryoprotectant discovery.

## Competitive Advantages
- **Combination of Physics Simulation and ML**: Their discovery engine screens millions of molecules in silico before wet-lab validation, dramatically accelerating cryoprotectant development.
- **Biocompatibility Budget Framework**: A novel approach that distributes cryoprotectant toxicity across multiple mechanisms, avoiding the single-dose toxicity that has stymied the field for 50 years.
- **Focus on Whole Organs (not just cells)**: Extending cryopreservation from small samples (IVF, stem cells) to whole human organs – a much harder problem with massive clinical impact.
- **Talent Philosophy**: "Proof of work" culture that hires for demonstrated ability over credentials, with fast promotion for those who earn it.

## Strategic Focus
- **Immediate**: Scale up cryoprotectant discovery and validation to achieve reversible cryopreservation of a whole human organ (likely a kidney or heart) within the next few years.
- **Medium-term**: De-risk and build the foundation for whole-body reversible cryopreservation, enabling "a bridge to future cures" for patients with currently incurable conditions.
- **Talent Acquisition**: Aggressively hiring scientists, engineers, and operations staff across physics, biology, chemistry, and engineering disciplines to accelerate R&D.

## Why Work Here
- **Work Environment**: On-site in San Francisco (HQ). The work spans "the edge of physics, biology, and engineering" – from quantum-level simulations to handling real organs. Culture emphasizes "hard problems", rigor, and speed.
- **Culture**: Flat hierarchy, promotion on merit, "proof of work" over credentials. Team includes people from top universities and self-taught scientists alike.
- **Benefits**: Comprehensive medical/dental/vision, 401(k) via Guideline, unlimited PTO, paid parental and disability leave, on-site fitness center, catered lunch and dinner, plus snacks.
- **Engineering & Science**: Opportunity to work on cutting-edge cryobiology, nanotech, polymer chemistry, and high-throughput automation. The company uses AI tools in hiring but makes final human decisions.

## Sources
1. [untillabs.com/careers](https://www.untillabs.com/careers)
2. [untillabs.com](https://untillabs.com/)
3. [untillabs.com/our-team](https://www.untillabs.com/our-team)
4. [builtin.com/company/until-labs](https://builtin.com/company/until-labs)
5. [jobs.lever.co/until](https://jobs.lever.co/until)

## Other roles at Until

- [Senior / Staff Power Electronics Engineer](https://feeny.ai/job/senior-staff-power-electronics-engineer-until-bay-area-5y9bjz922v89) — Bay Area
- [Electrical Engineer / Applied Physicist](https://feeny.ai/job/electrical-engineer-applied-physicist-until-bay-area-kgcsag1hxzzk) — Bay Area
- [Mechanical Engineering, Design](https://feeny.ai/job/mechanical-engineering-design-until-bay-area-cbaa9hk1my9k) — Bay Area
- [Senior Scientist, Cardiac Preservation (Organ Perfusion)](https://feeny.ai/job/senior-scientist-cardiac-preservation-organ-perfusion-until-bay-area-b452rfthhqkp) — Bay Area
- [Research Associate (Organ Perfusion)](https://feeny.ai/job/research-associate-organ-perfusion-until-bay-area-0b1srem75ztf) — Bay Area
- [Research Assistant, Materials Chemistry (Nanoparticles)](https://feeny.ai/job/research-assistant-materials-chemistry-nanoparticles-until-bay-area-3m7hw2phjy84) — Bay Area
- [Head of Legal](https://feeny.ai/job/head-of-legal-until-bay-area-a15h6wha3f21) — Bay Area
- [Research Associate, Hibernation](https://feeny.ai/job/research-associate-hibernation-until-bay-area-a9jr1rkbe83f) — Bay Area
- [Physics and Engineering Technician](https://feeny.ai/job/physics-and-engineering-technician-until-bay-area-csevrzjywfzk) — Bay Area
- [Sr. Mechanical Engineer, Fluidics/Perfusion](https://feeny.ai/job/sr-mechanical-engineer-fluidics-perfusion-until-bay-area-fkstk4p7d9q0) — Bay Area