---
title: 'Senior Applied AI Bioinformatician at Sequencing'
canonical: 'https://feeny.ai/job/senior-applied-ai-bioinformatician-sequencing-united-states-m69tcssm87yh'
type: 'job'
last_seen: '2026-09-15'
---

# Senior Applied AI Bioinformatician at Sequencing

- **Company:** Sequencing
- **Location:** United States
- **Employment:** full-time
- **Work type:** remote
- **Posted:** 2026-08-11
- **Last confirmed live:** 2026-09-15
- **Apply:** https://jobs.gem.com/sequencing/am9icG9zdDpoTIA_5wbbHqeuO2iG_1R8

## Job description

The opportunity As Senior Applied AI Bioinformatician, you will discover and prove new genetically enabled capabilities for Sequencing’s products and broader intelligence layer. Reporting: This role reports to the Senior Director, AI & Emerging Technologies. This is a hands-on senior individual-contributor role for a genuinely strong bioinformatician who thinks and builds agentically. You will explore new ways to combine genetic data, scientific knowledge, retrieval tools, computational methods, and AI reasoning to create useful capabilities that are not possible today. Examples could include a new bioinformatics skill, a genomic retrieval or interpretation component, or an evidence-synthesis workflow that expands what Sequencing’s AI products can do. You will take promising ideas from scientific hypothesis through working prototype. For each proposed bioinformatics capability, you will define the user value, required data, underlying genetic premise, scientific uncertainty, evaluation plan, and evidence needed to advance, narrow, or stop the work. You will partner with Product and Engineering to turn validated ideas into scalable capabilities, while independent scientific evaluation remains a separate release safeguard. This is a 0-to-1 exploration role, not the ongoing owner of production model quality. Bioinformatics retains ownership of benchmark maintenance, independent scientific evaluation, ongoing quality monitoring, release readiness, and scientific reliability. Your job is to open new possibility space, prove or disprove ideas quickly, and hand off evidence-backed capabilities for independent evaluation and productionization.

## What you’ll own

- A portfolio of bounded exploratory projects that test new bioinformatics capabilities for Sequencing’s AI products and broader intelligence layer.
- Scientific hypotheses that connect a meaningful user need to a defensible genetic premise and an achievable computational approach.
- Hands-on prototypes combining genomic data, scientific literature and knowledge, retrieval or query tools, deterministic methods, and model reasoning.
- Explicit uncertainty boundaries, contraindications, data limitations, failure modes, and stop conditions for each proposed capability.
- Diagnosis of failures across source data, bioinformatics processing, retrieval and tool use, model reasoning, and orchestration during exploration and prototyping.
- Evidence packages that allow Product, Engineering, Bioinformatics, and independent evaluators to decide whether a capability should stop, be revised, or advance into independent evaluation.
- Clear handoffs to the AI Platform PM, Engineering, and Bioinformatics when a prototype has enough evidence to enter independent scientific evaluation and potential productionization.
- Ongoing awareness of Sequencing’s bioinformatics systems and capabilities through deep working partnership with the Bioinformatics team.
- Use of evaluation findings, customer questions, scientific developments, and production evidence as inputs to new hypotheses and prototype revisions, without owning the production quality loop.

## What you will not own

- Ongoing ownership of production model quality, benchmark datasets, independent scientific evaluation, release readiness, or production scientific reliability. These remain with Bioinformatics and the designated quality owner.
- Independent scientific evaluation or final validation of your own work.
- Production release approval for scientific accuracy or safety.
- General backend-engineering delivery that belongs in the separate AI Bioinformatics Engineering search.
- Broad Bioinformatics organizational leadership or people management.

## Who you are

- You have deep professional expertise in bioinformatics, computational genomics, statistical genetics, or a closely related field.
- You can evaluate the genetic premise, evidence quality, uncertainty, and limitations behind a proposed capability.
- You build hands-on with modern AI tools and can show how you have used models, agents, retrieval, tools, structured data, or computational pipelines to investigate or prototype scientific work.
- You understand that using AI is different from building a reliable AI system, and can explain validation, guardrails, failure handling, and human review.
- You can distinguish failures in data availability, bioinformatics processing, retrieval, model reasoning, and orchestration.
- You design reproducible experiments with explicit success criteria, negative controls, uncertainty, and advance or stop evidence.
- You communicate scientific complexity clearly to Product and Engineering without overstating confidence.
- You welcome independent review and can change course when evidence does not support a hypothesis.
- You are energized by 0-to-1 scientific exploration and evidence-backed handoffs, rather than ongoing ownership of production model quality.
- You are based in the United States and comfortable operating as a senior individual contributor in a fast-moving, fully remote environment. Helpful experience
- Consumer genomics, clinical genomics, variant interpretation, polygenic risk, pharmacogenomics, or genomic knowledge systems.
- Production LLM evaluation, retrieval-augmented generation, agentic systems, or scientific tool use.
- Translating research prototypes into reliable product or platform capabilities.
- Health-product safety, regulated environments, or scientific release governance.

## Benefits overview

- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential) Join Sequencing
- Redefine how people understand themselves through their DNA
- Build category-defining products alongside scientists, engineers, and innovators
- Contribute to technology that will improve and extend millions of lives
- Shape one of the most important emerging categories in AI and healthcare Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting joinus@sequencing.com.

## About Sequencing

## Company Overview
- **One-liner**: Sequencing is a genomics platform that provides clinical-grade whole genome sequencing, free lifetime DNA data storage, and AI-powered interpretation to deliver personalized health, wellness, and ancestry insights.
- **Entity Type**: Private (seed-stage; $5M total funding)
- **Headquarters**: Pasadena, California, United States
- **Founded**: 2017
- **Founders**: Brandon Colby, MD

## Core Business
- **Primary industry**: Biotechnology Research / Digital Health (genomics, bioinformatics, AI-driven health)
- **Target customers**: B2C (individuals seeking DNA insights), B2B (healthcare professionals, healthtech companies)
- **Mission**: To help everyone outsmart their genes by making genomic data accessible, actionable, and transformative for humanity.

## Products & Services
- **Clinical-Grade Whole Genome Sequencing (WGS)**: 30x coverage WGS service delivered via at-home DNA kit or direct lab partnership.
- **Free Lifetime DNA Data Storage**: Unlimited, secure storage of raw genetic data.
- **App & Report Marketplace**: Ecosystem of third-party and proprietary apps/reports for health, wellness, ancestry, and longevity.
- **AI-Powered Interpretation**: Proprietary algorithms and AI combine bioinformatics with machine learning to generate dynamic, actionable insights.
- **Personalized Health Reports**: Ongoing updates covering disease predisposition, medication response, carrier status, and wellness optimization.

## Market Standing
- **Valuation**: Not publicly disclosed
- **Key Metric**: Annual Revenue ~$8M (LinkedIn estimate); Total Funding $5M (seed rounds)
- **Notable Investors/Partners**: Lerer Hippeau (led $5M seed round in November 2022), plus additional undisclosed investors in subsequent rounds.
- **Growth Signals**: Claims to be the world’s largest provider of clinical-grade WGS by volume; global headcount of ~29 employees distributed across 5 countries; fully remote team; expanding AI and bioinformatics capabilities; hiring for senior roles across engineering, security, marketing, and product.

## Competitive Advantages
- **Scale & Data**: Largest base of clinical-grade whole genomes sequenced, providing a unique foundation for AI training and genomic intelligence.
- **Privacy & Storage**: Free, unlimited DNA data storage with strong emphasis on privacy (HIPAA compliance).
- **Marketplace Model**: Open ecosystem of DNA apps/reports that continuously add value for users.
- **AI-Native Platform**: Combines deterministic bioinformatics with AI reasoning to ensure scientifically accurate, explainable insights.
- **Clinical-Grade Quality**: 30x WGS ensures highest accuracy for actionable health decisions.

## Strategic Focus
- Building the lifelong home for every human genome – a trusted platform for storage, interpretation, and continuous value.
- Expanding the AI-native genomic intelligence layer to support prevention, longevity, and personalized care.
- Growing the developer and partner ecosystem around the Sequencing platform.
- Scaling B2B partnerships with healthcare providers and healthtech companies.
- Preparing for regulatory certifications (SOC 2, ISO 27001) to deepen enterprise trust.

## Why Work Here
- **Culture**: Fully remote, global team of doctors, scientists, engineers, and AI researchers with a mission-driven focus on genomics and health.
- **Work Environment**: Remote-first with offices in Pasadena, Los Angeles, and Sioux Falls; flexible for global time zones.
- **Perks & Engineering Culture**: Opportunity to work at the intersection of genomics, cloud infrastructure (AWS), and AI; emphasis on data privacy, security, and scientific rigor; employee rating 4.0/5.0 on Built In (compensation 4.0, culture 3.1).
- **Growth**: High-impact roles across bioinformatics engineering, AI/ML, security, and product management in a fast-growing startup.

## Sources
1. [sequencing.com](https://sequencing.com/about)
2. [builtin.com](https://builtin.com/company/sequencing-com)
3. [linkedin.com](https://www.linkedin.com/company/sequencing-com)
4. [sequencing.com](https://sequencing.com/knowledge-center/faqs/who-is-sequencing)
5. [builtin.com](https://builtin.com/company/sequencing-com/jobs)

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