--- title: 'Senior Associate Scientist, Bioanalytical Sciences at Alector' canonical: 'https://feeny.ai/job/senior-associate-scientist-bioanalytical-sciences-alector-south-san-francisco-2mm0qga432rr' type: 'job' last_seen: '2026-10-17' --- # Senior Associate Scientist, Bioanalytical Sciences at Alector - **Company:** Alector - **Location:** South San Francisco, CA - **Compensation:** $125k–$140k - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-09-02 - **Last confirmed live:** 2026-10-17 - **Apply:** https://jobs.lever.co/alector/af8ed468-f2ec-4daf-a1e3-6f7b5db52da3 ## Job description Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. This role is based at Alector’s headquarters in South San Francisco, CA. Regular onsite presence is essential given the combination of hands-on laboratory work, scientific leadership, and close collaboration with multidisciplinary teams We are seeking a Senior Associate Scientist, Bioanalytical Sciences to support bioanalytical assay development and execution across Alector’s nonclinical and clinical programs. You will be a hands-on laboratory scientist responsible for independently developing, optimizing, troubleshooting, and qualifying bioanalytical assays while also managing selected activities performed at external CROs. You will bring strong experience with ligand-binding assays for pharmacokinetic, immunogenicity and biomarker assessments, including independent, hands-on development of PK, anti-drug antibody (ADA) and/or biomarker assays in biological samples such as CSF, serum/plasma, and tissue lysates. You must also have direct bioanalytical experience supporting a range of therapeutic modalities, such as antibodies, bispecific antibodies, and/or conjugated siRNA/ASOs. This is an individual-contributor position with no people-management responsibilities. You will work closely with colleagues across Research, Toxicology, Clinical Development, and external partners to generate high-quality bioanalytical data that supports program decisions. ## Key Goals & Accountabilities - Independently develop PK, ADA and biomarker assays! Design, develop, optimize, troubleshoot, and qualify ligand-binding assays across biological matrices including CSF, serum/plasma, and tissue lysates. - Support diverse therapeutic modalities! Apply your bioanalytical expertise to antibodies, bispecific antibodies, conjugated siRNAs, and other emerging therapeutic approaches. - Stay hands-on in the laboratory! Plan and execute experiments using platforms such as ELISA and MSD, evaluate assay performance, investigate matrix effects and interference, and deliver reproducible, decision-ready data. - Manage external bioanalytical work! Coordinate assay transfer, validation, sample analysis, troubleshooting, data review, timelines, and study deliverables with CRO partners while maintaining scientific ownership and supporting work conducted in accordance with applicable GLP and regulatory expectations. - Help us work smarter! Integrate innovative technologies—including laboratory automation, AI, and large language models—to accelerate assay development, improve quality, and use resources more effectively! Required Qualifications - BS in Biology, Biochemistry, Pharmacology, Immunology, or a related scientific discipline with 5+ years of relevant biotechnology or pharmaceutical industry experience, or an MS in a related scientific discipline with 3+ years of relevant industry experience.Demonstrated ability to independently develop PK, ADA and/or biomarker assays in biological samples including CSF, serum/plasma, and tissue lysates. You have hands-on experience designing, developing, optimizing, troubleshooting, and qualifying assays rather than only executing established methods. - Direct bioanalytical experience supporting therapeutic modalities such as antibodies, bispecific antibodies, and/or conjugated siRNA is required. - Strong hands-on experience with ligand-binding assay platforms such as ELISA and MSD, including evaluation of sensitivity, selectivity, precision, matrix effects, drug tolerance, and assay interference. - Experience authoring and reviewing bioanalytical method protocols, qualification and validation plans, SOPs, data summaries, and technical reports. - Strong knowledge of GLP requirements and regulatory guidance from FDA, ICH, and EMA related to bioanalytical assay development, qualification, and validation. - Experience working with external CROs on assay transfer, validation, sample analysis, troubleshooting, and data review; strong experimental documentation and communication skills; and active use of large language models with a strong interest in evolving AI ## Preferred Qualifications - Experience developing neutralizing antibody assays or other immunogenicity assessments. - Experience supporting regulated bioanalytical method validation and sample analysis. - Experience with automated liquid- or sample-handling platforms such as Agilent Bravo, Hamilton or Tecan. - Experience in Gyrolab and fit-for-purpose biomarker assay qualification - Experience with Benchling, Watson LIMS, Graphpad Prism, Softmax Pro or comparable electronic laboratory and bioanalytical data systems. - Experience introducing new assay technologies, automation, or data-analysis approaches into laboratory workflows. Collaboration You will partner closely with colleagues across Research, Toxicology, Clinical Development, and other multidisciplinary teams. We expect you to communicate experimental results, assay limitations, risks, and recommendations clearly. We share knowledge openly, solve problems together, and adapt quickly as program needs evolve. At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together. Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. Review our Privacy Policy ## About Alector ## Company Overview - **One-liner**: Alector is a clinical-stage biopharmaceutical company developing immuno-neurology therapies to treat neurodegenerative diseases by targeting the brain’s immune system. - **Entity Type**: Public (NASDAQ: ALEC) - **Headquarters**: South San Francisco, California, United States - **Founded**: 2013 - **Founders**: Not publicly available on their website or in recent reports; co-founded by a team of scientific and industry veterans. ## Core Business - **Primary industry/industries**: Biotechnology / Immuno-Neurology - **Target customers**: B2B (partnerships with large pharma), but primarily focused on patients, healthcare providers, and clinical trial sites. - **Mission or purpose statement**: “To slow the progression of neurodegenerative diseases and to one day prevent their occurrence.” [alector.com](https://alector.com/about-us/our-mission/) ## Products & Services For each major offering: - **Therapeutic Pipeline (Multiple Programs)**: A portfolio of investigational therapies targeting frontotemporal dementia, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions. These are biologic drugs designed to remove toxic proteins, replace deficient proteins, and restore immune and nerve cell function. - **Alector Brain Carrier (ABC) Platform**: A proprietary technology designed to enhance brain penetration of therapeutics across the blood-brain barrier (BBB) using receptor-mediated transcytosis. This is an enabling platform technology, not a standalone product. - **Biomarker-Guided Development**: An internal capability for identifying and using diagnostic and pharmacodynamic biomarkers to select patient populations and track therapeutic impact in clinical trials. ## Market Standing - **Valuation/Market Cap**: As of early September 2026, Alector’s market cap is approximately **$1.2 billion** (based on recent trading data from Yahoo Finance). - **Key Metric**: Annual Revenue of **$21 million** (latest fiscal year); total funding to date (including IPO and follow-on offerings) is approximately **$1.1 billion** (sum of disclosed financings per SEC filings). - **Notable Investors/Partners**: Key institutional investors include **Fidelity**, **OrbiMed**, **Baker Bros. Advisors**, and **BVF Partners**. Strategic collaboration with **GSK** (GlaxoSmithKline) for the development of INHBE programs. - **Growth Signals**: Despite a 38.3% year-over-year reduction in headcount (85 employees as of mid-2025), the company has made significant clinical progress, including advancing its lead program to Phase 3 and expanding the ABC platform. Recent hires in clinical operations signal a push toward late-stage trials. ## Competitive Advantages - **Immuno-Neurology Focus**: Alector is a leader in the emerging field of immuno-neurology, targeting immune pathways directly in the brain rather than just neurons, which represents a novel approach distinct from competitors working on amyloid or tau alone. - **Alector Brain Carrier (ABC)**: A proprietary BBB-crossing platform that could be a significant differentiator, potentially applicable to many other therapeutic modalities beyond Alector’s own pipeline. This creates a potential partnership or licensing revenue stream. - **Human Genetics Foundation**: Their discovery approach is deeply rooted in human genetics, focusing on genetically validated targets, which reduces the risk of pursuing biologically irrelevant mechanisms. ## Strategic Focus - **Current priorities and direction for growth**: Alector is laser-focused on advancing its lead clinical programs toward regulatory milestones, particularly for frontotemporal dementia. The company is also investing in expanding the ABC platform’s utility, both internally and through partnerships. Cost discipline (headcount reduction is a recent signal) suggests a focus on extending cash runway into late-stage data readouts. ## Why Work Here - **Culture highlights**: Alector has been certified as a “Great Place to Work” since 2020 and was named one of the San Francisco Business Times’ “Best Places to Work” in 2023. The company emphasizes a culture of growth, feedback, and inclusivity. [alector.com](https://alector.com/culture-careers/) - **Remote/hybrid/office policy**: Hybrid model—regular on-site days for collaboration with flexibility for remote work. Headquarters in South San Francisco, CA. - **Notable perks or engineering culture**: Comprehensive benefits (medical, dental, vision, mental health), onsite gym and basketball court, 20 days PTO plus 10 holidays and a winter shutdown, 401(k) match, employee stock purchase plan, and peer mentorship programs. The company also offers a seminar series with visiting academics. ## Sources 1. [alector.com](https://alector.com/culture-careers/) — Company culture, benefits, and demographic data. 2. [alector.com](https://alector.com/about-us/our-mission/) — Mission statement. 3. [alector.com](https://alector.com/our-scientific-approach/) — Scientific approach, ABC platform, and biomarker strategy. 4. [linkedin.com](https://linkedin.com/company/alector) — Employee count, revenue, and location. 5. [jobs.lever.co/alector](https://jobs.lever.co/alector) — Current job openings and work model details. 6. Yahoo Finance / SEC Filings — Market cap and revenue data (cross-referenced via public filings). ## Other roles at Alector - [Scientist, Biology](https://feeny.ai/job/scientist-biology-alector-south-san-francisco-zq17fzwrscce) — South San Francisco, CA - [Senior Associate Scientist, Computational Biology](https://feeny.ai/job/senior-associate-scientist-computational-biology-alector-south-san-francisco-5ha25hazb6jg) — South San Francisco, CA - [Associate Director, Protein Sciences](https://feeny.ai/job/associate-director-protein-sciences-alector-south-san-francisco-31rfw6947pf6) — South San Francisco, CA - [Vice President, Clinical Development](https://feeny.ai/job/vice-president-clinical-development-alector-united-states-c849h987900w) — United States - [Associate Director, Clinical Project Management](https://feeny.ai/job/associate-director-clinical-project-management-alector-south-san-francisco-6y12fee2nf0j) — South San Francisco, CA - [People Operations Specialist (Temporary)](https://feeny.ai/job/people-operations-specialist-temporary-alector-south-san-francisco-rvx5447yfnzf) — South San Francisco, CA