---
title: 'Senior Associate Scientist, Biologics Downstream Process Development at Asimov'
canonical: 'https://feeny.ai/job/senior-associate-scientist-biologics-downstream-process-development-asimov-nesyzysj6bsz'
type: 'job'
last_seen: '2026-11-06'
---

# Senior Associate Scientist, Biologics Downstream Process Development at Asimov

- **Company:** Asimov
- **Location:** Boston, MA
- **Compensation:** $105k–$115k
- **Employment:** full-time
- **Posted:** 2026-10-26
- **Last confirmed live:** 2026-11-06
- **Apply:** https://jobs.ashbyhq.com/asimov/0b5c0e83-7b94-4b59-b6e7-37e1c745ed3b

## Job description

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We are seeking a Senior Associate Scientist, Biologics Downstream Process Development to join our team in Boston, MA and help push the boundaries of biopharmaceutical and gene therapy process development. This role is for a technical expert who will conduct bioprocess engineering for biologics, design complex experimental approaches to improve our workflows and systems, apply scaling principles to both upstream and downstream processing (with emphasis on downstream), and coordinate interdepartmental project efforts.

The successful candidate will work closely with Asimov’s synthetic biology, cell line development, and analytical development teams, along with interfacing with external partners. The role reports to the lead scientist for Downstream Process Development and is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.

About the Role:

- You will perform clarifications, downstream processing/purification, and product quality assessment with analytical tools.
- Be involved hands-on in projects that include bioreactor scale-up (2L+) process development, harvest, and downstream process development.
- Serve as a technical subject matter expert (SME) in at-scale process development for both internal and external projects.
- Represent the process development team on cross-functional projects, making decisions for process development activities and effectively communicating results, progress, and plans.
- Work together with the strategic alliance and commercial teams to technology transfer developed processes and early-look materials to external partners.
- Partner with the software team to develop integrated data platforms and analysis for streamlined data analysis.
- Author, review, and approve process development reports and technology transfer protocols.
- Organize and document experiments and data in an electronic lab notebook.

About You:

- You have a MS in Biological Engineering, Chemical Engineering, Cell Biology, Molecular Biology, or a related field with minimum of 4 years of relevant hands-on experience in bioprocessing or a Bachelors with minimum 6 years of hands-on industry experience.
- You have downstream purification experience, optimizing ProA and UF/DF steps. This role requires experience using chromatography systems and their HMI (i.e., AKTA/UNICORN). Additional experience on additional chromatography and polishing steps (e.g., IEX, HIC) is highly preferable.
- Mammalian (CHO) and/or viral vector process development is squarely in your wheelhouse.
- Knowledge and experience in the technology transfer of manufacturing processes and generation of GLP tox material is preferred.
- You are a creative problem solver and get excited about the opportunity to drive the creation of industry-disruptive technology.
- Being detail-oriented is not just a sound bite for you, it is part of your DNA. Keeping track of a bunch of moving parts is easy for you because you are highly organized. It is not your first time following a standardized workflow or pipeline.
- You are an expert in spreadsheets such as Google Sheets or Excel and ideally Spotfire, Google Apps Script (JavaScript) and/or BigQuery to facilitate data management and analysis.
- Experienced using DOE software to develop robust experiments.

We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

## About Asimov

## Company Overview
- **One-liner**: Asimov builds an integrated platform of cells, genes, and software to program living systems, enabling the design and manufacture of advanced therapies.
- **Entity Type**: Private (Series B, raised $175M in January 2023)
- **Headquarters**: Boston, Massachusetts, USA (with a second office in Boulder, Colorado)
- **Founded**: 2017
- **Founders**: Alec Nielsen (CEO), Chris Voigt, Doug Densmore, Raja Srinivas

## Core Business
- **Primary industry/industries**: Synthetic biology, biotechnology, therapeutics manufacturing
- **Target customers**: B2B – biotech startups, mid-size biotechs, and large pharmaceutical companies (partnered with over 25 companies)
- **Mission or purpose statement**: “To radically advance humanity’s ability to design living systems, enabling biological technologies with outsized societal benefit.”

## Products & Services
- **Design Software**: Cloud-based CAD platform to design, simulate, and optimize genetic systems in different cell types.
- **Genetic Parts Library**: Over 1,000 experimentally validated genetic parts (transposases, expression vectors, inducible systems, tissue-specific promoters, etc.).
- **Host Cell Lines**: Engineered, highly characterized GMP host cells for therapeutic production (CHO, HEK293, etc.) with regulatory documentation.
- **LV Edge**: Stable cell lines and software tools for lentiviral titers up to 1E9 TU/mL.
- **AAV Edge**: End-to-end payload design and production achieving titers up to 6E15 vg/L.
- **RNA Edge**: Sequence design through wet-lab validation in weeks.
- **CHO Edge**: Genetic tools and data-driven models delivering titers of 8–12 g/L across modalities.
- **Platform Transfer & Full Service**: Two engagement models – customers use the platform in-house, or Asimov performs cell line development and process development at its Boston lab.

## Market Standing
- **Valuation/Market Cap**: Not disclosed
- **Key Metric**: Total funding of $205M; annual revenue of ~$4.0M (LinkedIn estimate)
- **Notable Investors/Partners**: Andreessen Horowitz (seed lead), Horizons Ventures (Series A lead), CPP Investments (Series B lead), DARPA (research support). Partners include 25+ biotechs and pharma companies.
- **Growth Signals**: 95 employees (25.8% YoY growth); raised $200M in Series B (Jan 2023); launched AI-driven 4th generation CHO Edge System with increased titer guarantee; expanding into RNA and cell therapy tools.

## Competitive Advantages
- Only company offering an end-to-end platform that integrates mammalian synthetic biology, computer-aided design, and machine learning.
- Proprietary library of 1,000+ well-characterized genetic parts and GMP-banked host cells.
- “We use our own platform every day” – internal R&D teams validate improvements before releasing to customers.
- Strong regulatory support (GMP documentation for host cells) that de-risks therapeutic development.

## Strategic Focus
- Deepen AI/ML integration into genetic design and cell line development.
- Expand platform to cover more therapeutic modalities (cell therapy, RNA therapy, biologics).
- Scale partnerships with large pharma while continuing to support early-stage biotechs.
- Build out the “first CAD platform for biology” to transition genetic engineering into a fully-fledged engineering discipline.

## Why Work Here
- **Culture**: “A culture of recombination” – interdisciplinary team of biologists, engineers, and ML scientists. Values include mission first, urgency, continuous learning, thoughtful communication, and avoiding local optima.
- **Work model**: Hybrid – employees engage in a combination of remote and on-site work (Cambridge, MA and Boulder, CO).
- **Perks & growth**: Built In profile highlights career growth, compensation & benefits, work-life balance, and stability. The company is actively hiring across roles (Staff Software Engineer, Principal Scientist, Sr. Scientist, Associate Director).
- **Impact**: Work at the cutting edge of synthetic biology, directly contributing to the design and manufacture of life-saving therapies.

## Sources
1. [asimov.com](https://www.asimov.com/)
2. [asimov.com/about](https://www.asimov.com/about)
3. [LinkedIn](https://www.linkedin.com/company/asimov)
4. [Built In](https://builtin.com/company/asimov)
5. [Careers Page](https://jobs.ashbyhq.com/asimov)

## Other roles at Asimov

- [Principal Scientist, Lentiviral Vector Cell Line Development](https://feeny.ai/job/principal-scientist-lentiviral-vector-cell-line-development-asimov-boston-0p8n91rkhbwh) — Boston, MA
- [Senior Research Associate/Associate Scientist, Analytical Development (Contractor)](https://feeny.ai/job/senior-research-associate-associate-scientist-analytical-development-contractor-33d5zjt4mhr3) — Boston, MA
- [Scientist, Viral Vector Process Development](https://feeny.ai/job/scientist-viral-vector-process-development-asimov-boston-1qsqy03f8zyb) — Boston, MA
- [Scientist, Lentiviral Vector Cell Line Development](https://feeny.ai/job/scientist-lentiviral-vector-cell-line-development-asimov-boston-vhtpf4a8bt9m) — Boston, MA
- [Senior Scientist, Analytical Development](https://feeny.ai/job/senior-scientist-analytical-development-asimov-boston-9r1y790704fx) — Boston, MA
- [Principal Scientist, Biologics Cell Line Development](https://feeny.ai/job/principal-scientist-biologics-cell-line-development-asimov-boston-zc098zf7xer4) — Boston, MA