---
title: 'Senior Automation Engineer (Sr. Engineer II) at Generate Biomedicines'
canonical: 'https://feeny.ai/job/senior-automation-engineer-sr-engineer-ii-generate-biomedicines-somerville-93kdmjzrd1sd'
type: 'job'
last_seen: '2026-11-06'
---

# Senior Automation Engineer (Sr. Engineer II) at Generate Biomedicines

- **Company:** Generate Biomedicines
- **Location:** Somerville, MA
- **Compensation:** $140k–$180k
- **Posted:** 2026-11-03
- **Last confirmed live:** 2026-11-06
- **Apply:** https://generatebiomedicines.com/open-positions?gh_jid=4726447006

## Job description

The Role:

Generate:Biomedicines is seeking an experienced and highly motivated Senior Automation Engineer to join our team at the interface of lab instrumentation, integrated workcells, custom hardware, and protein therapeutics discovery.

This role will be central to sustaining and advancing Generate’s wet lab platform, with particular emphasis on automated workflows spanning DNA production, protein production, cell culture, and screening & validation assays. Just as importantly, this senior engineer will extend Generate’s capabilities beyond immediate automation support by building and integrating custom instrument capabilities into the wet lab ecosystem and leading adjacent engineering efforts where thoughtful hardware, fluidics, or systems integration can unlock better science.

The role serves as the automation engineering lead both as an individual contributor and the direct manager of automation engineers. The ideal candidate will bring strong expertise in liquid handling, workcell automation, scripting, wet lab agentic deployment, and method development, along with experience building, adapting, or integrating instrumentation in close partnership with scientists and the rest of the engineering team. This role is well-suited for someone who can execute at a high technical level while thinking end-to-end about building scalable support through training, documentation, AI, and handoff practices that increase scientist independence. As a central communicator in the lab, the role will be tasked with consistently identifying areas of the lab that can be enhanced with engineering solutions.

Here's how you will contribute:

- Design, build, and integrate custom instrument capabilities into Generate’s wet lab platform, including in-house-built hardware, fluidic systems, or related technologies into scientist-facing workflows.
- Own critical automation and instrumentation problems end-to-end, from method design and system improvement through live troubleshooting on active runs, vendor coordination, documentation, and knowledge transfer.
- Drive reliability, troubleshooting, and method development for DNA/protein production and assay/readout workflows on integrated workcells, while improving throughput, parallelization, and data quality across platform and pipeline programs.
- Partner closely with scientists to provide high-quality in-lab support, unblock experiments quickly, and identify new automation- or engineering-enabled capabilities that reduce timelines for production, scale-up, and future platform workflows.
- Identify and prioritize lab automation projects across the automation engineering team and seek out key stakeholders as collaborators
- Manage a team of automation engineers in both day-to-day activities and long-term projects providing guidance and proper resourcing to their efforts

The Ideal Candidate will have:

- BS + with 7+ years industry experience in lab automation and analytical & process instrumentation development, MS with 5+ years industry experience, or PhD in engineering, computer science, physics, chemistry, life sciences, or a related field.
- A proven track record of leadership within a wet lab and within an engineering team both via project management and direct reports
- Strong experience with liquid handlers and integrated workcells, including platforms such as Biomek, Tecan, Lynx, Hamilton, Opentrons, HighRes, Retisoft, and/or similar systems.
- Experience owning workflows end-to-end, from method design and execution through debugging, documentation, and operational support.
- A strong drive to proactively hand-off workflows to scientists in a way that improves adoption, increases autonomy, and effective use of automation tools.
- Exceptional communication skills and proactivity to facilitate interactions between scientists, engineers, lab operations, and other stakeholders that span a range of technical and scientific languages.
- Experience developing and/or deploying wet lab-facing agentic applications, e.g.  closed-loop experimental systems.
- Experience building, integrating, or supporting custom instrumentation, fluidic systems, and/or microfluidic devices in an R&D environment.

## Preferred Qualifications

- Experience supporting DNA production, protein production, protein purification, cell culture, functional & binding assays, and/or related molecular biology workflows at scale.
- Significant experience with HighRes, Retisoft, and/or other advanced scheduling and orchestration systems and integrated hardware environments.
- Experience supporting platform transfer, vendor coordination, user training, or expansion of methods across multiple instruments and lab locations.
- Experience working in a highly collaborative, matrixed research environment where automation, platform engineering, and discovery teams are tightly integrated.

Who Will Love This Job:

- You are motivated working in fast-paced and dynamic research environments, with a drive to frequently move out of your immediate comfort zone and learn new things.
- You like working in the lab and helping scientists succeed not only by solving urgent problems, but by building systems, habits, and training that empowers them.
- You enjoy translating across biology, engineering, software, and instrumentation, and you are energized by working on problems that span automation as well as broader wet lab engineering.
- You take a pragmatic, builder-oriented approach to method development and troubleshooting: moving fast, improving iteratively, and focusing on what will best unblock the science.
- You are a people person who genuinely wants to be a people manager: you enjoy coaching engineers, investing in their growth, and helping them build meaningful careers.

## About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

## #LI-HM1

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range $140,000—$180,000 USD

## About Generate Biomedicines

## Company Overview
- **One-liner**: Generate Biomedicines is a clinical-stage generative biology company pioneering the use of machine learning to design and develop protein-based medicines on demand.
- **Entity Type**: Public (ticker: GBIO)
- **Headquarters**: Somerville, Massachusetts, USA (Boynton Yards and Andover locations)
- **Founded**: 2018
- **Founders**: Gevorg Grigoryan, Daria Hazuda, and others

## Core Business
- **Primary industry**: Biotechnology / Drug Discovery & Development
- **Target customers**: B2B (pharmaceutical partners) and patients (via clinical programs)
- **Mission statement**: "We don’t discover medicines—we design them," with a belief that speed is a moral obligation to patients.

## Products & Services
- **[Generate Platform™]**: An integrated computational and biohardware innovation stack that uses generative biology to design proteins with defined biological intent. It can generate up to a billion designed variants per cycle with cycle times as fast as ~8 days.
- **[GB-0895 (Anti-TSLP Antibody)]**: A next-generation anti-TSLP monoclonal antibody for severe asthma and COPD, currently in global Phase 3 trials. Designed for ultra-high affinity (106 fM binding, 20x improvement over tezepelumab) and an extended half-life (98 days, longest known among TSLP-targeting therapies), enabling twice-yearly subcutaneous dosing.
- **[GB-5267 (MUC-16 Armored CAR-T)]**: A cell therapy candidate for metastatic ovarian cancer, expected to enter Phase 1 in 1H26.
- **[GB-4362 (Free MMAE Toxin Neutralizer)]**: A first-in-class neutralizer designed for combination with MMAE-based antibody-drug conjugates (ADCs), with Phase 1 initiation in bladder cancer expected 1H26.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed; IPO in February 2026 raised net proceeds of approximately $370 million.
- **Key Metric**: $221.5 million cash balance at YE 2025, plus ~$370 million from IPO (early 2026).
- **Notable Investors/Partners**: Strategic collaborations with Amgen, Novartis, MD Anderson Cancer Center, and Roswell Park Comprehensive Cancer Center.
- **Growth Signals**: 5 clinical-stage programs enabled by the platform; initiated global Phase 3 studies for GB-0895; operating out of 140k+ square feet of lab and office space; has studied millions of proteins and generated 42,000 proteins built and tested.

## Competitive Advantages
- **Fully integrated computational-biohardware loop**: Machine learning drives generative design, which feeds directly into high-throughput experimentation (including proprietary CryoEM with four of the best microscopes in the world), and results continuously train the AI system — a "living feedback loop" that compounds over time.
- **Multimodal platform**: Can generate candidates across antibodies, CAR-T, and other protein modalities from a single core technology, enabling a pipeline that covers both immunology and oncology.
- **Record speed and scale**: Capable of generating up to a billion designed variants in ~8-day cycles, dramatically reducing the time and cost traditionally associated with drug discovery.
- **First-mover in next-gen anti-TSLP**: First known next-generation anti-TSLP antibody to enter the clinic (GB-0895) with a differentiated half-life profile that could enable twice-yearly dosing, a significant competitive edge in a large market.

## Strategic Focus
- **Clinical execution**: Advancing GB-0895 through global Phase 3 trials in severe asthma (with data in 2H27/1H28) and initiating late-stage development in COPD.
- **Pipeline expansion**: Moving GB-5267 (CAR-T) and GB-4362 (ADC neutralizer) into Phase 1 in 2026, expanding the platform's therapeutic scope.
- **Platform scaling**: Continuing to refine the generative biology engine to unlock new modalities and therapeutic areas, while deepening existing strategic collaborations with major pharma partners.
- **Organizational growth**: Building out the team across computational, wet-lab, clinical, and operational functions to support the growing pipeline.

## Why Work Here
- **Mission-driven**: The company is explicit that "speed is not just a competitive advantage—it’s a moral obligation." Employees are directly involved in designing drugs rather than discovering them, with a focus on getting treatments to patients faster.
- **Interdisciplinary culture**: The company emphasizes true integration across machine learning, biological engineering, and medicine. As stated on their site, "We are a close-knit group of cross-disciplinary experts... each conversant in one another’s fields, working together to create a new one."
- **Cutting-edge technology**: Access to unique computational and biohardware infrastructure, including "the four best CryoEM microscopes in the world" and a high-throughput experimental loop that powers AI training in real-time.
- **Values-driven leadership**: Explicit leadership behaviors include "value the knowledge we gain more than the knowledge we have," "bring creativity, tenacity, and ingenuity to every challenge," and "hold oneself and others to an obligation to dissent."
- **Hybrid/office policy**: Not explicitly stated, but the company operates large physical facilities in Somerville and Andover, MA, and offers free parking, monthly subway passes, or subsidized commuter rail passes, suggesting a significant on-site expectation.
- **Comprehensive benefits**: Competitive pay, employee stock option plan, health/vision/dental insurance, long- and short-term disability, life insurance, EAP, retirement savings, paid parental/adoption/caregiver leave, free weekly lunch, and stocked kitchen.
- **Growth trajectory**: As a newly public company with a cash-rich balance sheet and multiple catalysts over the next 12–24 months, the company offers significant career growth potential for those who want to be part of building a "transcendent company" that redefines an industry.

## Sources
1. [generatebiomedicines.com](https://generatebiomedicines.com/)
2. [generatebiomedicines.com/careers](https://generatebiomedicines.com/careers)
3. [generatebiomedicines.com/about-us](https://generatebiomedicines.com/about-us)
4. [investors.generatebiomedicines.com](https://investors.generatebiomedicines.com/)
5. [Non-Confidential Overview (April 2026)](https://investors.generatebiomedicines.com/wp-content/uploads/2026/04/Generate-Biomedicines-Non-Confidential-Overview_April-2026-1.pdf)

## Other roles at Generate Biomedicines

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