---
title: 'Senior Business Systems Architect at 4D Molecular Therapeutics'
canonical: 'https://feeny.ai/job/senior-business-systems-architect-4d-molecular-therapeutics-united-states-0jycx224r9tk'
type: 'job'
last_seen: '2026-09-13'
---

# Senior Business Systems Architect at 4D Molecular Therapeutics

- **Company:** 4D Molecular Therapeutics
- **Location:** United States
- **Work type:** hybrid
- **Posted:** 2026-08-10
- **Last confirmed live:** 2026-09-13
- **Apply:** https://4dmoleculartherapeutics.com/careers/?gh_jid=4722670005

## Job description

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery

## GENERAL SUMMARY

4DMT is seeking a Senior Business Systems Architect to serve as a hands-on, business-facing technology leader and trusted IT partner supporting our G&A functions, including Procurement, Legal, Finance & Accounting, Human Resources, and Facilities. This role configures, optimizes, supports, and applies AI and automation to the G&A application portfolio, enabling compliant, scalable business processes that support 4DMT’s commercialization objectives.

A successful candidate will be a hands-on G&A Solutions Architect who personally combines enterprise application and integration build skills, AI innovation, stakeholder engagement, and governance discipline to enable scalable growth and commercial readiness.  Open to remote or hybrid candidates that are geographically based on the West Coast.

## MAJOR DUTIES & RESPONSIBILITIES:

Business Partnership

- Serve as the day-to-day IT point of contact and trusted advisor to G&A stakeholders.
- Translate business requirements into practical, scalable, well-documented solutions.
- Run hands-on process improvement initiatives and maximize value from existing platforms.
- Drive user adoption through training, communication, and change management in partnership with the Business Process Owner (BPO).

Enterprise Applications Support and Solution

- Act as the functional and technical owner for applications used across the G&A ecosystem, with primary day-to-day responsibility for the Procurement, CLM, and finance platforms in use; scope will shift as new G&A applications are implemented.
- Perform configuration, enhancements, UAT, security administration, and release/regression testing.
- Coordinate with outsourced remote MSP on day-to-day basis – ticket triage, backlog prioritization, SLA tracking, and escalation.
- Support the underlying business processes end-to-end from IT, technology and compliance standpoint, including contract lifecycle management, procurement, supplier data management, spend management, inventory management, and reporting
- Partner with stakeholders to evaluate and pilot new business technologies supporting future growth.

AI, Automation & Digital Transformation

- Identify and build opportunities to leverage AI, Copilot, and workflow automation.
- Implement automation solutions that measurably improve efficiency and user experience.
- Evaluate emerging technologies to modernize manual processes in partnership with business users, collaboratively with other IT team members.

Integration, Compliance & Governance

- Serve collaboratively as application SME and partner for the design, build and maintenance of enterprise integrations on modern integration platforms.
- Execute IT SOX, ITGC, audit, security, and SDLC/change management requirements, including evidence preparation and walkthrough support.
- Ensure solutions meet compliance, scalability, and operational standards while balancing efficiencies.

## QUALIFICATIONS:

Education:

- Bachelor’s degree in Information Technology, Business Systems or equivalent

Experience:

- 8–12 years of hands-on enterprise business systems experience.
- Demonstrated delivery of efficiency gains using AI technologies and tools.
- Strong administration and implementation experience across G&A platforms, including:
- Procurement / P2P (Coupa)
- Contract lifecycle management (Ironclad or equivalent)
- Legal spend / matter management (Brightflag or equivalent) - preferred, not required.
- ERP – NetSuite or comparable (financials and inventory) - preferred, not required.
- Expert knowledge of procurement, sourcing, supply chain, inventory, supplier onboarding, legal operations, and related controls.
- Experience with SaaS integrations, APIs, middleware, and workflow automation platforms (such as Workato) - preferred, not required.
- MSP partnership and accountability for outsourced or offshore application support.
- Strong understanding of evidential SOX, ITGC, audit controls, and governance requirements.
- Experience supporting cross-functional business application integrations.
- Strong reporting, analytics, and process design capabilities.
- Familiarity with the Microsoft Azure framework, including Power Platform.
- Excellent stakeholder management, workload management and service delivery skills.
- Proven capability to work independently with full task ownership and minimal supervision.
- Consultative, results-oriented customer-focused mindset
- Strong analytical and problem-solving capabilities.
- Strong execution, follow-through, and prioritization skills across concurrent initiatives.
- High ownership, accountability, and attention to detail and documentation.
- Collaborative team player who thrives in a fast-paced semi-structured environment.
- Curiosity and passion for AI, automation, and continuous improvement.

Other Qualifications/Skills:

- Professional Certifications in Enterprise Platforms (Coupa, Ironclad, etc.) – preferred, not mandatory
- ITIL, TOGAF, or similar technology governance / architecture certification preferred.
- Hands-on business systems SME with Coupa and CLM expertise.
- Proven success delivering AI-enabled process improvements.
- Comfortable working directly with auditors, offshore/remote support teams, and business process owners.
- Able to balance assigned strategic projects, day-to-day support, and compliance responsibilities without losing hands-on depth and details.

Physical Requirements and Working Conditions:

- Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
- Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Base salary compensation range: $167,000 - $183,000 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

## About 4D Molecular Therapeutics

## Company Overview
- **One-liner**: 4D Molecular Therapeutics is a late-stage clinical biotechnology company inventing and developing customized genetic medicines using a proprietary vector evolution platform to treat large-market diseases.
- **Entity Type**: Public (NASDAQ: FDMT)
- **Headquarters**: Emeryville, California, United States
- **Founded**: 2013
- **Founders**: David Kirn, MD (Co-Founder, President, and CEO)

## Core Business
- **Primary industry**: Biotechnology / Genetic Medicine / Gene Therapy
- **Target customers**: B2B (partnerships with other biopharma companies) and B2C (patients with retinal and pulmonary diseases)
- **Mission or purpose statement**: "To unlock the full potential of genetic medicines for large market diseases" by harnessing directed evolution to invent customized and enhanced vectors for transformative products.

## Products & Services
- **4D-150**: A clinical-stage genetic medicine candidate for retinal vascular diseases (wet age-related macular degeneration and diabetic macular edema). It is designed as a single, routine, low-dose intravitreal injection that provides multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C). Currently in Phase 3 clinical trials (4FRONT-1 and 4FRONT-2) for wet AMD and Phase 1/2 for DME.
- **4D-710**: An investigational genetic medicine candidate for cystic fibrosis lung disease. It uses the A101 vector for aerosol delivery of a corrective CFTR transgene (CFTR∆R) and is designed for patients ineligible for or who have discontinued CFTR modulator therapy. Currently in Phase 1/2.
- **4D-175**: A preclinical candidate for geographic atrophy (a form of dry AMD) using the R100 vector to deliver a shortened form of human complement factor H (sCFH) to restore normal complement regulation.
- **4D-725**: A preclinical candidate for alpha-1 antitrypsin (A1AT) lung disease using the A101 vector for aerosol delivery.

## Market Standing
- **Valuation/Market Cap**: $756.4 million (as of latest data from LinkedIn)
- **Key Metric**: Annual Revenue of $85.2 million (as of latest data from LinkedIn)
- **Notable Investors/Partners**: The company is publicly traded (IPO in 2020). Key partnerships are sought for pipeline candidates like 4D-175 and 4D-725.
- **Growth Signals**: The company is a late-stage biotech with two Phase 3 trials (4FRONT-1 and 4FRONT-2) for its lead candidate 4D-150 in wet AMD, and a Phase 1/2 trial for 4D-710 in cystic fibrosis. The company has a presence in Ecuador, France, and India. LinkedIn followers grew 24.7% year-over-year.

## Competitive Advantages
- **Proprietary Vector Platform (Therapeutic Vector Evolution)**: The company uses directed evolution to create customized and proprietary AAV vectors (e.g., R100 for retina, A101 for lung) that are optimized for specific tissues and routes of administration, which is a significant differentiator from standard gene therapy approaches.
- **Large-Market Focus**: Unlike many gene therapy companies targeting ultra-rare diseases, 4DMT is focused on large-market indications (wet AMD, DME, cystic fibrosis) with high unmet need, offering a potentially massive commercial opportunity.
- **Durable, Single-Dose Therapies**: Their products are designed to provide multi-year efficacy from a single injection, which could dramatically reduce treatment burden for patients compared to current standard-of-care (e.g., frequent eye injections for wet AMD).

## Strategic Focus
- **Advancing Late-Stage Pipeline**: The primary focus is executing the Phase 3 programs for 4D-150 in wet AMD and progressing 4D-710 in cystic fibrosis.
- **Expanding Indications**: The company is exploring 4D-150 for diabetic macular edema (DME) and seeking partnerships to advance 4D-175 (geographic atrophy) and 4D-725 (A1AT deficiency).
- **Platform Expansion**: Continuing to leverage the Therapeutic Vector Evolution platform to develop new genetic medicines for other large-market diseases.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "daring to cure" and unlocking the potential of genetic medicine for patients with devastating diseases. Core values include "Dare to Cure," "Break Boundaries," "Prepare & Execute Relentlessly," and "Beyond Yourself."
- **Innovative Science**: Employees work on cutting-edge science at the intersection of gene therapy, vector engineering, and clinical development, tackling some of the biggest challenges in medicine.
- **Collaborative Environment**: The company emphasizes teamwork, internal and external collaboration, and a culture that empowers innovation.
- **Location & Perks**: Based in Emeryville, CA (San Francisco Bay Area). The company offers a competitive benefits package and a dynamic, collaborative environment.
- **Diversity & Inclusion**: 4DMT champions diversity, equity, and inclusion through an employee-led initiative called "4Diversity," which partners with charitable organizations and focuses on social equity.
- **Work Authorization**: Candidates must be authorized to work in the U.S. The company does not sponsor new nonimmigrant visa status petitions but welcomes candidates who require transfers or extensions.

## Sources
1. [4dmoleculartherapeutics.com](https://4dmoleculartherapeutics.com/)
2. [4dmoleculartherapeutics.com - About](https://4dmoleculartherapeutics.com/about/)
3. [4dmoleculartherapeutics.com - Careers](https://4dmoleculartherapeutics.com/careers/)
4. [4dmoleculartherapeutics.com - Pipeline](https://4dmoleculartherapeutics.com/pipeline/)
5. [LinkedIn - 4D Molecular Therapeutics](https://www.linkedin.com/company/4d-molecular-therapeutics-llc)

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