---
title: 'Senior Clinical Trial Manager at Atrium Therapeutics'
canonical: 'https://feeny.ai/job/senior-clinical-trial-manager-atrium-therapeutics-san-diego-qanrknbqna2s'
type: 'job'
last_seen: '2026-11-06'
---

# Senior Clinical Trial Manager at Atrium Therapeutics

- **Company:** Atrium Therapeutics
- **Location:** San Diego, CA
- **Compensation:** $171k–$189k
- **Employment:** full-time
- **Work type:** remote
- **Posted:** 2026-10-12
- **Last confirmed live:** 2026-11-06
- **Apply:** https://jobs.lever.co/atrium-therapeutics/ede193fd-055e-421e-ad2a-8b1b34a064a0

## Job description

Atrium is a biopharmaceutical company pioneering delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies. Our proprietary technology leverages the targeted RNA delivery platform initially designed at Avidity, which combines the tissue selectivity of mAbs and other targeted delivery ligands with the precision of oligonucleotides. This unique combination is designed to allow selective targeting of the underlying genetic drivers of disease that were previously undruggable. Through targeted, non-viral delivery of siRNA to cardiac tissues, our approach has the potential to overcome key limitations of nonspecific viral and nanoparticle-based delivery systems, including challenges related to tissue specificity, immunogenicity, and redosing.

Job Summary: The Senior Clinical Trial Manager is a senior leader accountable for overall clinical study operations including CRO and vendor management, development of project plans, budget, and resource management.  They will lead the development of study operational plans and provide input into other functional area plans and processes as needed. They will provide oversight of the CRO, vendors and sites as well as ensure compliance with GCP and regulatory guidelines. This position will work cross-functionally with clinical development, legal, finance, regulatory affairs, quality assurance, and IT, as needed. Job Responsibilities:

- Performs job with minimal supervision
- Acts as the clinical operations representative in a variety of cross-functional teams
- Collaborates with the program Clinical Operations Lead to develop and manage study level timelines and budgets in accordance with corporate, department, and project goals, working closely with internal leadership and CROs
- Independently manage clinical study vendors
- Establish key deliverables and KPIs in management of CRO and vendors
- Collaborate with CRO to identify and develop training needs for site staff, CRAs, and vendors specific to the study protocol and processes, including presenting these at Investigator Meetings and Kick-off meetings
- Oversee, support and track all submissions and approvals to Competent Authorities and IRB/Ethics Committees in conjunction with regulatory departments and CRO, as applicable
- Develop clinical monitoring strategies for assuring study timelines are met and assuring quality deliverables
- Responsible for management and/or oversight of eTMF structure, plans and quality.
- Manage study activities including, but not limited to, investigator selection, drug supply projections, study start-up, subject recruitment & retention, data collection, and database locks, study drug accountability and study closeout.
- Actively contribute to technical and study design discussions, providing input toward clinical trial outlines, protocols, informed consent forms, and clinical study reports.
- Lead and/or collaborate with functional team members to draft/revise, finalize, and implement project plans, study-specific training, system builds, CRF designs, UATs.
- Identify issues and risks with cross functional teams and service providers; develop and present proposed solutions and provide oversight of timely resolution in a collaborative approach.
- Collaborate with data management (internal or CRO vendor) and CRAs to ensure data quality and compliance with data cleaning timelines
- May perform clinical data review of patient profiles, data listings and summary tables, including query generation
- Leads and/or contributes to department process improvements/initiatives and SOPs
- Provide direction and mentoring to junior team members.
- Escalate pertinent CRA performance and site compliance issues when necessary
- May have line management responsibilities
- Performs other duties as assigned by management Education & Experience Requirements:
- Bachelor’s degree required, preferably in the Life Sciences or equivalent
- Minimum of 8-10 years of experience in clinical operations is required
- Experience managing a CRO as well as a complex study in a previous Clinical Trial Manager (or equivalent) position is required
- Global Clinical Trial experience in Phase I-III
- Experience in Rare Disease required, cardiovascular a plus
- Inspection readiness and inspection experience is a plus
- Exceptional attention to detail and organizational skills
- Excellent communication (oral and written), analytical, and project management skills
- Ability to develop and maintain strong, collaborative relationships with key internal and external stakeholders
- Ability to multi-task well, to deal well with conflict and obstacles, and to work in a fast-paced environment
- Ability to quickly learn and use technical applications with preferred experience using smart sheets/MS Excel or equivalent and the ability to manage budgets and forecast
- Prior auditing experience preferred
- Prior experience working as a Clinical Research Associate (CRA) preferred
- In depth knowledge of ICH/GCP, regulatory guidelines/directives, and drug development and clinical research processes
- Team leadership experience within a cross-functional matrix environment
- Ability to travel for meetings and conferences nationally and globally, approximately 10%-15%

What we Provide:

- The base salary range for this role is $171,000-$189,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
- Atrium offers competitive compensation and benefits which include stock options, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and unlimited of time off including summer & winter breaks
- A commitment to learning and development which includes a variety of programming internally developed by and for Atrium employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

## About Atrium Therapeutics

## Company Overview
- **One-liner**: Atrium Therapeutics is a biopharmaceutical company pioneering the delivery of RNA therapeutics directly to the heart muscle to transform the standard of care for people living with cardiomyopathies.
- **Entity Type**: Private (startup stage, not yet publicly traded; no funding rounds publicly disclosed)
- **Headquarters**: San Diego, California, United States
- **Founded**: 2026
- **Founders**: Not explicitly listed; the company was formed by a team of former executives from Avidity Biosciences and other biotech firms, led by CEO Kathleen Gallagher.

## Core Business
- **Primary industry**: Biotechnology – RNA therapeutics for cardiovascular diseases (precision cardiology).
- **Target customers**: Patients with rare cardiomyopathies (PLN cardiomyopathy, PRKAG2 syndrome), healthcare providers, and payers (B2B/B2C through drug development and eventual commercialization).
- **Mission statement**: “Pioneer the delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies.”

## Products & Services
- **ATR 1072**: Development candidate for PRKAG2 syndrome (rare cardiomyopathy). Preclinical/early clinical stage.
- **ATR 1086**: Development candidate for PLN (phospholamban) cardiomyopathy. Preclinical/early clinical stage.
- **Undisclosed pipeline**: Two additional research-stage targets in rare cardiomyopathies.
- **Technology Platform**: Proprietary RNA delivery platform based on the clinically validated AOC (Antibody-Oligonucleotide Conjugate) technology, originally designed at Avidity Biosciences. Combines the tissue selectivity of monoclonal antibodies with the precision of oligonucleotides to deliver siRNA directly to cardiac tissue, overcoming challenges with immunogenicity, cytotoxicity, and redosing limitations.

## Market Standing
- **Valuation/Market Cap**: Not disclosed (private company; no public funding rounds reported).
- **Key Metric**: Headcount of 41 employees (as of mid-2026), with 5.7% monthly growth; 28 employees recruited from Avidity Biosciences.
- **Notable Investors/Partners**: No specific investors or partnerships disclosed publicly. The company’s “Investors” page is a placeholder.
- **Growth Signals**: Founded in 2026; rapid team building with deep expertise from Avidity, Ionis, Biogen, etc.; two lead candidates in development for high‑unmet‑need cardiomyopathies; 4,200+ LinkedIn followers with +4.2% monthly growth.

## Competitive Advantages
- **Proprietary cardiac RNA delivery platform** that targets heart muscle with high specificity – a key differentiator from viral and nanoparticle delivery systems.
- **Clinically validated technology** originally developed at Avidity Biosciences, reducing technical risk.
- **Focus on underserved rare cardiomyopathies** with no approved therapies (PLN, PRKAG2), offering potential for rapid regulatory pathways (orphan drug designation).
- **Experienced leadership team** with track record in RNA therapeutics, rare disease drug development, and commercialization (Akcea, Ionis, Biogen, Avidity).

## Strategic Focus
- **Advance two lead candidates** (ATR 1072, ATR 1086) through preclinical and into clinical trials.
- **Expand the pipeline** with additional undisclosed targets in rare cardiomyopathies.
- **Build out the organization**, particularly in translational medicine, process development, and quality assurance (as evidenced by current job postings).
- **Leverage the AOC platform** to potentially address broader cardiac indications beyond the initial rare disease focus.

## Why Work Here
- **Cutting‑edge science**: Opportunity to work on a novel RNA delivery platform with the potential to transform cardiology.
- **Small, agile team** (~41 employees) allows for high impact and visibility across functions.
- **Founding team from Avidity Biosciences** brings deep domain expertise and a proven track record in RNA therapeutics.
- **Location**: Onsite roles in San Diego, California (Science Center Drive), a major biotech hub.
- **Current open roles** include:
  - Scientist II, Translational Medicine (San Diego, onsite)
  - Senior Director, AOC Process Development & Manufacturing – Oligonucleotide (San Diego)
  - Senior Director, Head of Quality Assurance (San Diego)
  - Manager, Accounting (from LinkedIn)
- **Culture**: The company’s website emphasizes a commitment to patients with high unmet need, a collaborative environment, and a passion for precision medicine.
- **Perks**: Not explicitly stated, but typical biotech early‑stage includes equity, competitive compensation, and the chance to shape a young company’s culture.

## Sources
1. [Atrium Therapeutics - Homepage](https://atriumtherapeutics.com/)
2. [Atrium Therapeutics - About Page](https://atriumtherapeutics.com/about/)
3. [Atrium Therapeutics - Investors Page](https://investors.atriumtherapeutics.com/overview)
4. [Atrium Therapeutics - Careers Page](https://atriumtherapeutics.com/careers/)
5. [LinkedIn - Atrium Therapeutics](https://www.linkedin.com/company/atrium-therapeutics)

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