---
title: 'Senior Clinical Trial Manager at Definium Therapeutics'
canonical: 'https://feeny.ai/job/senior-clinical-trial-manager-definium-therapeutics-remote-wvrjhsw19grb'
type: 'job'
last_seen: '2026-10-27'
---

# Senior Clinical Trial Manager at Definium Therapeutics

- **Company:** Definium Therapeutics
- **Location:** Remote
- **Compensation:** $160k–$190k
- **Work type:** remote
- **Posted:** 2026-10-23
- **Last confirmed live:** 2026-10-27
- **Apply:** https://job-boards.greenhouse.io/definiumtherapeutics/jobs/6232666004

## Job description

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

The Senior CTM role sits within the Clinical Operations Department at Definium Therapeutics and provides site and/or country level management as well as vendor/external service provider oversight and management.  As a Senior CTM, this role may be assigned as the Clinical Operational Trial Lead on a clinical trial, with oversight by the Senior Director/Executive Director of Clinical Operations within the organization. The role provides operational oversight at the site level and/or country level (for larger late phase trials) and is responsible for oversight and management of external service providers/vendors, ensuring high-quality deliverables, within agreed upon timelines and budget, and in alignment with all the applicable SOPs and regulatory requirements. The Senior CTM, if assigned as the Clinical Operations Trial Lead for a trial, is responsible and accountable for ensuring successful cross-functional delivery of the trial, with scope from draft protocol synopsis to availability of the Clinical Study Report (CSR) and applicable disclosure of the trial results. The Senior CTM, whether managing site/country and vendors or as the Clinical Operational Trial Lead, will ensure ongoing inspection readiness, data integrity and overall data quality according to and in compliance with corporate and project/program Standard Operating Procedures (SOPs), Good Clinical Practice (GCP)/International Conference on Harmonization (ICH) guidelines and other applicable federal (FDA) and state regulations.

The Senior CTM role will assist in the development and review of Clinical Operations Department SOPs, Plans and Systems build.  In addition, will lead process improvement initiates, create processes not currently in place, including the creation of site/trial management tools.  For outsourced trials to a CRO, this role will serve as a key liaison with oversight and delivery of the transferred obligations and responsibilities.

Responsibilities:

- Utilize Definium’s or CRO systems (when outsourced) to review Monitoring Visit Reports, monitoring visit scheduling, monitoring metrics, protocol deviations, issues, and action items to ensure data quality
- Serve as Sponsor contact for external service providers/vendors with overall responsibility ensuring deliverables are executed with high quality and within timelines and budget
- Oversees and tracks CRO/Vendor partners to ensure that patient enrollment and data collection are completed in accordance with study timelines and objectives; escalates risk to timelines and budget as needed
- Maintain therapeutic knowledge and familiarity with clinical protocol(s) and project(s) as appropriate
- Work with CRO/Vendors to revise scope of service agreements, budgets, plans and detailed timelines, and ensure that performance expectations are met
- Oversight of CRO monitoring team activities and deliverables
- Assist QA with site audits
- Review and contribute to study protocols, changes in eCRF design, laboratory manuals, monitoring guidelines, pharmacy manuals, informed consent forms, and other study-related documents/plans
- Perform financial management, including review and approval of site contracts and budgets, as well as CRO/Vendor invoices and accruals with oversight by the Senior Director of Clinical Operations
- Assist in tracking and coordination of trial related materials, including investigational product, clinical trial and laboratory samples, etc.
- Organize and manage site round-table meetings and site recruitment meetings
- Participate in the development, review and implementation of departmental SOPs, systems and processes
- Provides oversight of external service providers used for the trial for both in-house and outsourced studies; responsible to ensure selection, and set up, including scope of work (SOW) and specifications are in line with protocol requirements, budget, and timelines
- Ensures that the trial team operates in a constant state of inspection-readiness. Collaborate with Quality liaisons to ensure quality oversight of assigned trial utilizing the available tools
- Ensures trial team members have received the appropriate trial-specific training needed for their function; in collaboration with the study clinician, ensures appropriate trial-specific training is given to trial team members and/or to the CRO

## REQUIREMENTS:

- BS degree or equivalent required, preferably in Life Sciences (e.g., Biology, Chemistry, Biochemistry, Nursing, Pharmacy)
- Minimum of 6 years clinical trial experience in the pharmaceutical industry or CRO
- Experience with managing clinical trials or prior experience in a senior CRA role, ideally in the psychiatric space
- Willingness and ability to travel up to 20% of the time, defined by business needs
- This position requires strong organizational skills, attention to detail, and the ability to work effectively in a fast-paced and dynamic environment
- Requires clinical research operational knowledge, project planning/management, communication, and presentation skills. Must have the ability to manage all aspects of execution of a clinical trial. Experience managing teams in a virtual environment is required.
- Experience in vendor management strongly preferred
- Must possess excellent leadership skills and proven ability to foster team productivity and cohesiveness

Individual compensation within the range is determined based on factors such as relevant skills, experience, qualifications, scope of the role, and other legitimate business considerations.  In addition to base salary, this role may be eligible for bonus and equity opportunities. We also offer a comprehensive benefits package including health insurance, 401(k) with company match, flexible time off and additional wellness benefits and perks.  Learn more about our benefits on our Careers page.

The anticipated base salary range for this position is: $160,000—$190,000 USD

## About Definium Therapeutics

## Company Overview
- **One-liner**: Definium Therapeutics is a clinical-stage biopharmaceutical company applying scientific rigor to psychedelic medicine to develop accessible treatments for psychiatric disorders.
- **Entity Type**: Public (NASDAQ: DFTX)
- **Headquarters**: Not specified in available sources; the company operates as a remote-first organization.
- **Founded**: 2019 (originally as MindMed)
- **Founders**: Not publicly available in provided sources.

## Core Business
- **Primary Industry**: Biotechnology / Psychiatric drug development (psychedelic medicine)
- **Target Customers**: Patients with major depressive disorder (MDD), generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and autism spectrum disorder (ASD); also healthcare providers and payers.
- **Mission/Purpose**: “Unlock healing at scale” by harnessing the full therapeutic potential of psychedelic medicine through precise, evidence-based science.

## Products & Services
- **DT120 ODT (Lysergide/LSD D-Tartrate Oral Disintegrating Tablet)**: Investigational drug for GAD, MDD, and PTSD. Currently in four Phase 3 trials (Voyage, Panorama, Emerge, Ascend) and a fifth planned for PTSD. FDA Breakthrough Therapy Designation for GAD. No adjunctive psychotherapy required.
- **DT402 (R(-)-MDMA)**: R-enantiomer of MDMA selected for serotonergic properties with a potentially superior tolerability profile. In Phase 2a study for social communication challenges in autism spectrum disorder.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (publicly listed on NASDAQ as DFTX as of 2026, but recent market cap not provided in search results).
- **Key Metric**: Pre-revenue clinical-stage company; total funding history not disclosed in available sources.
- **Notable Investors/Partners**: Not disclosed in provided sources.
- **Growth Signals**:
  - Five Phase 3 trials ongoing or planned for DT120 ODT.
  - FDA Breakthrough Therapy Designation for DT120 in GAD.
  - Phase 2a trial initiated for DT402 in ASD.
  - Full results from Phase 2b GAD trial published in JAMA (2025).
  - Strong intellectual property with issued patents covering formulation, manufacturing, and treatment.

## Competitive Advantages
- **Proprietary Formulations**: Pharmaceutically optimized ODT for LSD (DT120) and novel R-enantiomer of MDMA (DT402) with potential improved tolerability.
- **Scientific Rigor**: Standalone drug studies without psychotherapy, enabling clearer efficacy and safety data.
- **Regulatory Momentum**: FDA Breakthrough Therapy Designation and multiple IND clearances.
- **Experienced Management Team**: Proven track record in developing and commercializing CNS therapies.
- **Comprehensive IP Strategy**: Patents covering drug formulations, methods of manufacture, and treatment use.

## Strategic Focus
- **Late-Stage Pipeline Advancement**: Completing Phase 3 trials for GAD and MDD, initiating PTSD trial.
- **Pipeline Expansion**: Advancing DT402 for ASD and exploring additional neuropsychiatric indications.
- **Commercial Readiness**: Building infrastructure (hiring VP of Sales, Senior Director of Field VEOR, etc.) to support potential future launch.
- **Data Generation**: Generating high-quality evidence to support regulatory submissions and differentiation.

## Why Work Here
- **Remote-First Culture**: “You can live anywhere in the country you’re employed in” (remote-first workforce).
- **Comprehensive Benefits**: 100% paid medical, dental, vision for employees and dependents; FSA/HSA; life and disability insurance.
- **Wellness & Time Off**: Annual wellness allowance, flexible PTO, company-wide shutdowns for rest.
- **Family Support**: Paid parental leave for birthing and non-birthing parents, 2-week return-to-work transition.
- **Financial Wellness**: Competitive compensation, 401(k) with employer match, employee equity (new hire grants and refreshes), Employee Stock Purchase Plan (ESPP) with discount.
- **Mission-Driven Work**: Opportunity to contribute to groundbreaking treatments in psychedelic psychiatry with a science-driven, collaborative team.

## Sources
1. [definiumtx.com](https://definiumtx.com/) – Company overview and pipeline details
2. [definiumtx.com](https://definiumtx.com/story/) – Company history, leadership, and strategic milestones
3. [definiumtx.com](https://definiumtx.com/careers/) – Careers page with benefits and remote-first policy
4. [definiumtx.com](https://definiumtx.com/research-development/) – Research and development pipeline details
5. [linkedin.com](https://www.linkedin.com/company/definiumtherapeutics) – LinkedIn company page

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