---
title: 'Senior Data Scientist at Probably Genetic'
canonical: 'https://feeny.ai/job/senior-data-scientist-probably-genetic-san-francisco-gsgj1tcdngah'
type: 'job'
last_seen: '2026-09-09'
---

# Senior Data Scientist at Probably Genetic

- **Company:** Probably Genetic
- **Location:** San Francisco, CA
- **Compensation:** $180k–$230k
- **Employment:** full-time
- **Work type:** hybrid
- **Posted:** 2026-06-03
- **Last confirmed live:** 2026-09-09
- **Apply:** https://jobs.ashbyhq.com/probablygenetic/38b04bbc-0526-44f6-9502-07772f3a1164

## Job description

## About Probably Genetic

Probably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible. We are a tight-knit group of hard-working, ambitious problem solvers united by a mission greater than ourselves. We do well by doing right by patients. We are developing some of the most cutting-edge solutions in healthcare, and our roadmap is packed with innovations in bioinformatics, AI, and drug development. We have built a lean, all-star team to help us bring our vision to life, and we want you to be a part of it. Probably Genetic has raised multiple rounds of funding from Silicon Valley’s best investors, including Threshold, Khosla, and Y Combinator, and offer competitive salaries, comprehensive benefits, and meaningful early stage equity.

## About the role

We are looking for a Senior Data Scientist who will own some of the most consequential diagnostic AI in rare disease: building, validating, and operationalizing the models that help us find and diagnose patients who have never had a name for their disease, powering the analytical rigor behind our testing programs, and shaping how we use data to make smarter product decisions.

## What you will do

- Own the end-to-end development, validation, and operationalization of PG's predictive diagnostic AI models — from feature engineering through production deployment – that power program eligibility decisions and clinical decisions for patients
- Run prospective testing experiments: apply diagnostic models to undiagnosed patients, coordinate testing, and track outcomes to continuously improve model performance
- Build and maintain PG's synthetic patient data pipeline, a critical deliverable for our research programs, and key input to our own model development lifecycle
- Optimize our patient intake experience using NLP and multimodal data analysis to determine which questions to ask, in what order, to maximize data quality and conversion
- Own API usage and cost optimization across PG's AI stack, including prompt engineering, model evaluation, and ongoing performance monitoring
- Conduct ad hoc strategic analyses that inform product prioritization, causality assessment, and generate customer-facing program insights
- Establish MLOps infrastructure: model monitoring, drift detection, API observability, and lightweight but durable operational processes
- Have the freedom to conduct blue sky research initiatives aimed at creating value from our data
- Work with Data Engineering to build a robust, scalable data foundation that supports all of the above

## Who you are

We are looking for a few specific things that will help you succeed in this role:

- 7+ years of experience in data science, machine learning engineering, or a closely related field
- Strong Python proficiency and fluency across the core data science stack: pandas, NumPy, scikit-learn, PySpark, and SQL
- Demonstrated end-to-end ML experience: you have taken models from problem definition through feature engineering, validation, deployment, and monitoring in a production environment
- Experience with NLP techniques and applying language models to real-world problems
- Comfort with prompt engineering and evaluating external AI API performance (e.g., OpenAI)
- A track record of operating with high ownership in lean, fast-moving environments where you have had to build structure as much as execute within it
- Strong analytical communication skills — you can translate complex model outputs and data findings into clear, actionable narratives for technical and non-technical audiences alike

Some things that are not required, but you will learn on the job:

- Experience with Databricks or similar lakehouse/ML platform environments
- Familiarity with synthetic data generation techniques
- Domain knowledge in healthcare, rare disease, genomics, or clinical research
- Experience with MLOps tooling and building observability infrastructure from scratch
- Exposure to biopharma or insurance analytics use cases

As with all new hires at Probably Genetic, you will also need to be:

- A good person. We work with some of the most marginalized populations on the planet and empathy is key
- Patient-focused and motivated to have a lasting, positive impact on humanity
- Comfortable in a fast-paced, often ambiguous environment with rapid change
- Action-oriented and excited to build a company from the ground up

The salary range for this role is $180,000-$230,000 annually. Actual compensation offered will depend on several factors including but not limited to: work experience, education, skill level, and/or other business and organizational needs.

What we offer at Probably Genetic:

- An engaging and supportive team all on a mission to improve lives
- Fair and equitable compensation with competitive early-stage equity grants
- Generous Flexible Time off policy, that we actually use
- Parental Leave Benefits (12 weeks for both birthing and non-birthing)
- Hybrid, flexible work with high-trust and autonomy
- A bright, inviting, pet-friendly office in Downtown SF near transit
- Company-sponsored team lunch every Thursday
- A “work from anywhere” policy, up to 4 weeks a year
- Regular team retreats in exciting destinations
- Health Benefits including medical, dental, vision, therapy, FSA, and 401k
- And so much more!

Probably Genetic is committed to fostering a welcoming and inclusive work environment for people of all genders, sexuality, ethnicity, socioeconomic background and life experiences. We urge candidates of all backgrounds to apply. If you require specific accommodations as you interview or consider working with us, please let us know.

## About Probably Genetic

## Company Overview
- **One-liner**: Probably Genetic uses AI and at-home genetic testing to help diagnose rare genetic diseases and connect patients to treatments, while powering drug development with real-world data.
- **Entity Type**: Private (Seed-stage; Y Combinator Winter 2019 batch)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2019 (per Y Combinator; company website states 2018 – conflicting reports)
- **Founders**: Lukas Lange (CEO & Co-Founder)

## Core Business
- **Primary industry**: Healthcare / Genetic Testing / Biotechnology
- **Target customers**: B2B (drug developers, patient advocacy groups, clinical labs) and B2C (patients with undiagnosed rare diseases and their caregivers)
- **Mission**: "We develop AI to diagnose 200+ million patients living with genetic disease to help them access the treatments they need and catalyze drug development."

## Products & Services
- **Probably Genetic Platform (Patient Intelligence Platform)**: End-to-end system that identifies undiagnosed patients via an AI-powered symptom checker, ships at-home saliva or cheek swab kits, provides genetic counseling, and delivers clinical-grade reports. The platform is used by drug developers to discover and engage eligible patients for clinical trials and sponsored testing programs. (SaaS + Services)
- **Free Sponsored Testing Programs**: Offered in partnership with pharmaceutical companies and patient advocacy groups, allowing eligible patients to access genetic testing at no cost.

## Market Standing
- **Valuation**: Not publicly available
- **Key Metric**: Total Funding – USD 11.2 million (as of latest LinkedIn data) across multiple rounds (Pre-Seed led by Y Combinator, Seed, and Angel Round in 2022)
- **Notable Investors/Partners**: Y Combinator, Threshold, Khosla Ventures; partnered with 50+ patient advocacy groups (e.g., NORD, Global Genes)
- **Growth Signals**:
  - 200,000+ patients have used the platform
  - >6x year-over-year revenue growth (self-reported)
  - Profitable (stated on Y Combinator jobs page)
  - Team size: 17 (Y Combinator) vs. 12 (LinkedIn, showing -21.4% YoY headcount decline – conflicting reports)
  - Global reach: services offered internationally

## Competitive Advantages
- Proprietary AI models trained on a large, growing dataset of rare disease phenotypes and genotypes
- Direct-to-consumer at-home testing removes barriers for undiagnosed patients
- CLIA-Certified & CAP-accredited lab; HIPAA-compliant data handling
- Strong integration with drug developer workflows (patient identification, consent, data sharing)

## Strategic Focus
- Expand the dataset and refine AI algorithms to improve diagnostic accuracy for more rare diseases
- Deepen partnerships with pharmaceutical companies to launch new sponsored testing programs
- Scale patient outreach globally, especially in underserved regions
- Advance bioinformatics and machine learning capabilities to accelerate drug development

## Why Work Here
- Mission-driven culture: "We do well by doing right by patients"
- Tight-knit, ambitious team united by a challenging problem
- Remote/hybrid policy: San Francisco headquarters with remote options within the US
- Competitive salaries ($150K–$190K for senior engineering roles) plus meaningful equity
- Notable perks: "Incredible team retreats to places like Barbados, the Alps, Mexico, Costa Rica, and Portugal"
- Y Combinator backing with a profitable, high-growth trajectory

## Sources
1. [probablygenetic.com](https://www.probablygenetic.com/)
2. [probablygenetic.com/about](https://www.probablygenetic.com/about-probably-genetic)
3. [ycombinator.com](https://www.ycombinator.com/companies/probably-genetic)
4. [ycombinator.com/jobs](https://www.ycombinator.com/companies/probably-genetic/jobs)
5. [linkedin.com](https://www.linkedin.com/company/probablygenetic)

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