--- title: 'Senior Development Scientist I at Freenome' canonical: 'https://feeny.ai/job/senior-development-scientist-i-freenome-brisbane-q9tqegw3c6c4' type: 'job' last_seen: '2026-09-07' --- # Senior Development Scientist I at Freenome - **Company:** Freenome - **Location:** Brisbane, CA - **Work type:** onsite - **Posted:** 2026-08-18 - **Last confirmed live:** 2026-09-07 - **Apply:** https://job-boards.greenhouse.io/freenome/jobs/8691772002 ## Job description About this opportunity: At Freenome, we are seeking a Senior Development Scientist I to help grow the Freenome Genomics Late Development team. You will develop, optimize, verify, and validate clinical-grade assay technologies for Freenome's multiomic platform, advancing our mission to detect cancer earlier. Working across manual and automated workflows, you will collaborate with cross-functional teams to develop and transfer robust NGS-based assays into a regulated, high-throughput production environment. You are passionate about developing life saving diagnostics using NGS technologies, and you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer. The role reports to the Senior Manager of Genomics Development. This role will be an onsite role based in our Brisbane, California headquarters. What you’ll do: - Apply knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA, including genome-wide and targeted approaches. - Oversee and lead mission-critical experiments to optimize, characterize, verify, and validate NGS-based assays, owning scientific strategy, experimental design, planning, timelines, execution, and delivery. - Design and execute high-impact experiments, generate detailed documentation, perform data analysis, create summary presentations, and present results cross-functionally. - Troubleshoot complex technical challenges, identify root causes, and drive process improvements to assay performance and laboratory workflows. - Drive project planning and prioritization by defining milestones, identifying and mitigating risks, and adapting to evolving program needs. - Build productive working relationships and partner cross-functionally with computational scientists, engineers, and clinical laboratory team members to transition development protocols into clinical production, including automation, validation experiments, and SOP development. - Document product development requirements and author study protocols and reports. Diligently apply current Good Laboratory and Documentation Practices (cGLP, cGDP) to maintain high standard of scientific rigor and quality. Must haves: - PhD in molecular biology, biochemistry, genetics, or a related field with at least 4 years of professional experience in the life sciences, or a Bachelors or Masters degree with at least 10 years of professional experience. Prior experience in clinical diagnostics and/or working in a start-up environment is preferred. - Experience designing and leading the execution of verification and validation studies for IVD assays in a regulated clinical laboratory environment (GLP). - Extensive hands-on experience in Next-gen sequencing (NGS) based automated assay development including extraction, library preparation, target capture, and sequencing. Experience working with automated platforms and liquid handlers. - Extensive hands-on experience in nucleic acid preparation, amplification, and quantification (DNA/RNA extraction and purification, PCR, qPCR, Qubit, Fragment Analyzer, Tapestation). Experience in working with ctDNA/cfDNA as an analyte in NGS workflows. - Proven track record of designing, planning, and executing successful experiments, including performing independent data analysis and giving effective scientific presentations. - High attention to detail and ability to record accurate and detailed observations, assess impact, and lead independent troubleshooting investigations. - Excellent written and verbal communication. Proactive communicator with ability to foster collaboration in a multidisciplinary team. - Flexible and highly motivated to learn new skills and comfortable adapting to changing priorities. - Experience providing technical mentorship and training to other scientists and research associates to contribute to a culture of technical excellence and continuous improvement. Nice to haves: - Experience in working with with methylated ctDNA/cfDNA as an analyte in NGS workflows. - Familiarity with scientific programming or data analysis tools such as Python or R, and experience contributing to publications, patents, or other scientific innovations. Benefits and additional information: The US target range of our base salary rate for new hires is $140,250 - $200,025. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.  Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ [freenome.com/job-openings/](http://freenome.com/job-openings/) for additional company information. Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Applicants have rights under Federal Employment Laws. - https://www.dol.gov/agencies/whd/posters/fmla - https://www.dol.gov/agencies/ofccp/posters - https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act California applicants please review the CCPA Notice at Collection here: - https://www.freenome.com/ccpa-privacy-notice-for-freenome-california-job-applicants/ ## #LI-ONSITE ## About Freenome ## Company Overview - **One-liner**: Freenome is a biotechnology company developing blood-based multi-omics tests powered by machine learning to detect cancer in its earliest, most treatable stages. - **Entity Type**: Private (Late Stage) – raised over $2B in total funding; stock symbol FRNM (NASDAQ) is associated with a related SPAC entity but the operating company remains privately held [linkedin.com] - **Headquarters**: Brisbane, California, United States - **Founded**: 2014 - **Founders**: Riley Ennis (Co-Founder and Chief Product Officer) and others [freenome.com] ## Core Business - **Primary industry**: Biotechnology / Early Cancer Detection - **Target customers**: B2B (health systems, insurers, employers) and B2C (patients via healthcare providers) - **Mission**: To create tools that empower everyone to prevent, detect, and treat their disease, starting with early cancer detection. ## Products & Services - **Freenome Multi-Omics Blood Test (Colorectal Cancer)**: A next-generation blood test that uses a multi-omics platform (cell-free DNA, methylation, proteins, etc.) combined with machine learning to detect early-stage colorectal cancer and advanced adenomas. Type: Diagnostic test (IVD) – currently under clinical validation and regulatory review [freenome.com]. ## Market Standing - **Valuation / Market Cap**: Not publicly disclosed (private). Total funding of $2.07B (LinkedIn estimate) or $1.428B (CB Insights); conflicting reports reflect different counting methods [linkedin.com], [cbinsights.com] - **Key Metric (Funding)**: Most recent round – $75M corporate round (Nov 2025) led by Roche, plus $254M venture round (Feb 2024) also led by Roche [linkedin.com] - **Notable Investors**: Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis, American Cancer Society’s BrightEdge Ventures, Exact Sciences [linkedin.com], [freenome.com] - **Growth Signals**: - Blood-based test included in updated American Cancer Society colorectal cancer screening guideline - Appointed industry veteran Rob Guigley as Chief Commercial Officer (2025) - Ongoing clinical programs for multiple cancer types - Employee headcount of 304 with 22 active job postings (as of mid-2025) [linkedin.com] ## Competitive Advantages - **Multi-omics + AI platform**: Combines multiple biological signals (DNA methylation, fragmentomics, proteins) with proprietary machine learning algorithms to achieve high sensitivity and specificity for early-stage cancer. - **Strong clinical program**: Rigorous multi-site studies and partnerships with leading health systems (e.g., Kaiser Permanente). - **Deep investor backing**: Long-term support from top healthcare investors and strategic partners (Roche, Exact Sciences) provides capital and commercial pathways. - **First-mover in multi-cancer blood screening**: Focus on colorectal cancer as first indication, with potential to expand to other cancers. ## Strategic Focus - **Clinical validation & regulatory approval**: Completing pivotal studies and preparing FDA submission for colorectal cancer test. - **Commercial launch preparation**: Building commercial team (hiring Strategic Account Executives, VP Revenue Cycle Management) and establishing relationships with payers and health systems. - **Platform expansion**: Extending multi-omics technology to additional cancer types (lung, pancreatic, etc.) through research programs. ## Why Work Here - **Mission-driven culture**: Employees are motivated by the opportunity to “outpace cancer” and make a tangible impact on patient lives. Values include integrity, empathy, trust, servant leadership, and striving for greatness [freenome.com]. - **Equity ownership**: Every U.S. full-time employee receives equity packages, aligning personal success with company milestones [freenome.com/careers]. - **Competitive benefits**: Comprehensive medical plans, wellness programs, generous PTO, 12 paid holidays, annual bonus opportunities, and market-based salaries [freenome.com/careers]. - **Collaborative environment**: Cross-functional teams across clinical, scientific, and business domains; emphasis on respect and inclusion [freenome.com/careers]. - **Work model**: Likely office-based in Brisbane, CA (hybrid flexibility not explicitly stated). The company has a physical lab and office presence. - **Engineering & science culture**: Opportunity to work with state-of-the-art multi-omics data, machine learning, and clinical trial design. The team includes senior ML scientists, computational biologists, and software engineers. ## Sources 1. [freenome.com](https://www.freenome.com/) – Company overview, leadership, values, products 2. [freenome.com/careers](https://www.freenome.com/careers/) – Benefits, culture, job openings 3. [linkedin.com/company/freenome](https://www.linkedin.com/company/freenome) – Employee count, revenue estimate, funding rounds, investor list, recent hires and departures 4. [cbinsights.com/company/freenome](https://www.cbinsights.com/company/freenome) – Funding total, company description, patent activity ## Other roles at Freenome - [Help Desk Specialist (Contractor)](https://feeny.ai/job/help-desk-specialist-contractor-freenome-brisbane-ypj66zndzpfp) — Brisbane, CA - [Senior Bioinformatics Research Engineer](https://feeny.ai/job/senior-bioinformatics-research-engineer-freenome-brisbane-jqm79zg6pz00) — Brisbane, CA - [Senior Research Associate](https://feeny.ai/job/senior-research-associate-freenome-brisbane-tsgfk8fbvpav) — Brisbane, CA - [Computational Biologist](https://feeny.ai/job/computational-biologist-freenome-remote-989vnftsd0w5) - [Staff Computational Biologist](https://feeny.ai/job/staff-computational-biologist-freenome-remote-9yh259vcdkp1) - [Strategic Account Executive (South)](https://feeny.ai/job/strategic-account-executive-south-freenome-remote-yr0frzr784de) - [Senior Director, Real World Data (RWD)](https://feeny.ai/job/senior-director-real-world-data-rwd-freenome-remote-djm04bx8qkbm) - [Vice President, Product Management](https://feeny.ai/job/vice-president-product-management-freenome-brisbane-sk773jd0f1tq) — Brisbane, CA - [Research Associate I/II](https://feeny.ai/job/research-associate-i-ii-freenome-brisbane-b2v3jsj88dmn) — Brisbane, CA - [Research Scientist I/II](https://feeny.ai/job/research-scientist-i-ii-freenome-brisbane-t4ngtdsjkvhc) — Brisbane, CA