--- title: 'Senior Director, Biometrics at Prime Medicine' canonical: 'https://feeny.ai/job/senior-director-biometrics-prime-medicine-cambridge-5b24s6r19ew4' type: 'job' last_seen: '2026-09-10' --- # Senior Director, Biometrics at Prime Medicine - **Company:** Prime Medicine - **Location:** Cambridge, MA - **Compensation:** $263k–$292k - **Posted:** 2026-07-08 - **Last confirmed live:** 2026-09-10 - **Apply:** https://job-boards.greenhouse.io/primemedicine/jobs/6111419004 ## Job description Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit [www.primemedicine.com](http://www.primemedicine.com/). Reports To: VP of Clinical Development Position Summary Prime Medicine is seeking an experienced Senior Director, Biometrics to serve as the senior biostatistics leader for the organization while providing strategic and operational leadership for the broader Biometrics function, including Clinical Data Management, in support of our gene editing clinical programs. This individual will provide statistical expertise across Prime’s clinical portfolio, including input on study design, protocol development, dose-escalation strategy, interim analyses, regulatory interactions, and submission planning. In parallel, the individual will build and lead an integrated Biometrics function by providing strategic oversight and line management of Clinical Data Management while partnering closely with Clinical Development, Clinical Operations, Regulatory Affairs, Medical Writing, Translational Medicine and other functions. This role requires both strategic vision and hands-on oversight, particularly in a lean, fast-moving biotech environment.  Although responsible for the broader Biometrics function, this position is first and foremost a senior biostatistics leadership role requiring deep expertise in clinical trial design, statistical methodology, regulatory interactions, and quantitative decision-making across clinical development.  This is a high visibility role with significant influence on clinical development decisions. ## Key Responsibilities Biometrics Strategy & Leadership - Provide overall biometrics leadership across Prime Medicine’s clinical programs, spanning: - Biostatistics - Data Management - Statistical programming (via vendors) - Define and implement biometrics strategies appropriate for early- and mid-stage gene therapy development, including: - Study design and statistical approaches - Endpoint selection and estimands - Data standards and quality frameworks - Serve as the primary biometrics representative on cross-functional program and study teams. Lead Biostatistician Responsibilities Function as the lead statistician across Prime's clinical development portfolio, providing scientific and strategic statistical leadership from protocol concept through regulatory submission. - Provide strategic input into: - Clinical trial design - Sample size and power considerations - Randomization and statistical analysis plans (SAPs) - As needed, data extraction and compilation for publications and external presentation activities - Review, approve, and oversee key statistical deliverables, including: - SAPs - Interim and final analyses, including supporting SRC and DMC outputs - Clinical Study Reports (statistical sections) - Support regulatory interactions by contributing to: - IND/CTA submissions - Health authority briefing packages - Responses to regulatory questions related to study design and analyses Data Management Oversight Provide strategic leadership and line management for the Clinical Data Management function, ensuring close integration between data management and statistical activities. - Oversee data management strategy and execution, including: - CRF design and database build - Data cleaning, validation, and lock - Data standards (e.g., CDISC/SDTM/ADaM expectations) - Ensure data quality, integrity, and inspection readiness across all clinical programs. - Provide input into protocol development and study start-up activities to ensure efficient data collection - Partner with Clinical Operations and vendors to proactively identify and resolve data-related risks. Vendor Management & Operational Execution - Lead vendor selection, onboarding, and governance for biometrics-related CROs and service providers. - Provide active oversight of vendor performance, timelines, quality, and budgets. - Ensure clear scopes of work, deliverable expectations, and communication pathways. - Act as the escalation point for biometrics-related issues and drive timely resolution. - Ensure biometrics deliverables are aligned with clinical, regulatory, and program objectives. - Contribute to inspection readiness activities and support audits as needed. Function Building & Future Growth - Establish scalable biometrics SOPs/processes, standards, and best practices appropriate for a growing organization. - Contribute to longer-term planning for internal capability development, including future team growth as the pipeline expands. - Mentor and guide internal team members or matrixed contributors as applicable. ## Qualifications Required - Advanced degree in Statistics, Biostatistics, Mathematics, or a related quantitative field. - 10+ years of experience in biometrics (biostatistics and/or data management) within biotech or pharmaceutical development. - Demonstrated experience supporting clinical development programs, including regulatory submissions, ideally with experience supporting early-phase (FIH) through later stage programs. - Experience serving as the lead statistician for clinical studies and regulatory submissions. - Strong understanding of clinical trial design, statistical principles, and data management practices especially in rare disease and/or gene and cell therapies. - Proven experience leading biometrics through CRO/vendor models. - Deep familiarity with regulatory expectations (FDA, EMA, ICH) related to biometrics. - Experience leading or managing Clinical Data Management is strongly preferred but is not required. - Excellent leadership, communication, and cross-functional collaboration skills. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together. U.S. Pay Range $263,000—$292,000 USD Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law. ## About Prime Medicine ## Company Overview - **One-liner**: Prime Medicine is a biotechnology company using prime editing, a next-generation gene editing technology, to “search and replace” disease-causing genetic mutations and restore normal gene function. - **Entity Type**: Public (NASDAQ: PRME, IPO October 2022) - **Headquarters**: Cambridge, Massachusetts, United States - **Founded**: 2019 - **Founders**: David Liu, PhD (Scientific Founder); Andrew Anzalone, MD, PhD (Co-founder) ## Core Business - **Primary industry**: Biotechnology / Gene Editing Therapeutics - **Target customers**: Patients with genetic diseases; partners include pharmaceutical companies (e.g., Bristol Myers Squibb) and foundations (e.g., Cystic Fibrosis Foundation) - **Mission**: “To bring the promise of gene editing to patients” and ultimately “cure, halt, and prevent genetic diseases, providing lifelong benefit to patients.” ## Products & Services - **Prime Editing Platform**: A proprietary gene editing technology that acts like a “DNA word processor” to precisely replace faulty DNA sequences without causing double-strand breaks. Designed to address ~90% of known disease-causing mutations. - **PM359** (Phase 1/2): Ex vivo prime editing therapy for p47phox Chronic Granulomatous Disease (CGD). Received FDA RMAT designation and orphan drug designation. - **PM577a** (Phase 1/2): In vivo prime editing therapy for H1069Q-mutated Wilson Disease. Clinical trial application cleared in New Zealand. - **Alpha-1 Antitrypsin Deficiency (AATD)**: Discovery-stage liver program using LNP delivery. - **Cystic Fibrosis**: Discovery program supported by Cystic Fibrosis Foundation (up to $15M), using PASSIGE™ technology. - **Ex vivo CAR-T** (collaboration with Bristol Myers Squibb): Strategic license and broad collaboration to develop and commercialize ex vivo T-cell prime editor products. ## Market Standing - **Valuation/Market Cap**: $777.8 million (as of mid-2026, per LinkedIn data) - **Key Metric**: Annual revenue $4.6 million; total funding raised ~$1.02 billion (including post-IPO equity) - **Notable Investors/Partners**: ARCH Venture Partners, F-Prime, Bristol-Myers Squibb (corporate round $55M in 2024), Google Ventures (post-IPO equity $5M in 2025), Cystic Fibrosis Foundation - **Growth Signals**: - Clinical data for PM359 published in *The New England Journal of Medicine*; RMAT designation from FDA. - Headcount of 154 (down 29.4% YoY, likely reflecting strategic refocusing). - Active job postings: 7 (as of mid-2026), with recent uptick in quarterly postings (+40%). ## Competitive Advantages - **Prime Editing differentiation**: Unlike CRISPR, prime editing does not require double-strand DNA breaks, enabling more precise and predictable edits with fewer unwanted modifications. - **Broad applicability**: Can theoretically correct ~90% of known disease-causing mutations across many organs and cell types. - **Strong IP and scientific foundation**: Co-invented by David Liu (Broad Institute), a pioneer in gene editing. ## Strategic Focus - **Advancing lead programs** (PM359 for CGD, PM577a for Wilson Disease) through clinical development and regulatory approvals. - **Expanding pipeline** in liver, lung, hematology/immunology/oncology via internal research and strategic partnerships (e.g., BMS for CAR-T). - **Leveraging delivery technologies** (LNP, AAV, ex vivo electroporation) to enable both in vivo and ex vivo applications. ## Why Work Here - **Mission-driven culture**: Opportunity to shape the future of gene editing and directly impact patients with genetic diseases. - **Collaborative environment**: Emphasis on diversity of viewpoints, scientific curiosity, and passion for patient outcomes. - **Location**: Headquarters in Cambridge, MA – a hub for biotech innovation. Presence also in India. - **Career development**: Roles span research, clinical, technical development, finance, HR, and informatics. Recent job postings include AI & Informatics Engineer, Senior Scientist, and Director of People & Culture. - **Perks & culture**: Not explicitly detailed, but the company values “dedicated, scientifically curious individuals” and offers the chance to work with a world-class scientific team. ## Sources 1. [primemedicine.com](https://primemedicine.com/) 2. [primemedicine.com/about/](https://primemedicine.com/about/) 3. [primemedicine.com/careers/](https://primemedicine.com/careers/) 4. [primemedicine.com/pipeline/](https://primemedicine.com/pipeline/) 5. [linkedin.com/company/prime-medicine](https://www.linkedin.com/company/prime-medicine) ## Other roles at Prime Medicine - [Medical Director, Clinical Development](https://feeny.ai/job/medical-director-clinical-development-prime-medicine-cambridge-mez51gt08bys) — Cambridge, MA - [Senior Quality Engineering Specialist](https://feeny.ai/job/senior-quality-engineering-specialist-prime-medicine-cambridge-yearqxvgjzt1) — Cambridge, MA - [Informatics Engineer](https://feeny.ai/job/informatics-engineer-prime-medicine-cambridge-t211ebww167m) — Cambridge, MA - [Senior Scientist / Senior Engineer, LNP Process Development](https://feeny.ai/job/senior-scientist-senior-engineer-lnp-process-development-prime-medicine-h2ma4d77ffav) — Cambridge, MA - [Senior Scientist, mRNA Design & Platform Innovation](https://feeny.ai/job/senior-scientist-mrna-design-platform-innovation-prime-medicine-cambridge-hma82924aerh) — Cambridge, MA