---
title: 'Senior Director, Clinical Development at Definium Therapeutics'
canonical: 'https://feeny.ai/job/senior-director-clinical-development-definium-therapeutics-remote-0vw2y4y2rj0z'
type: 'job'
last_seen: '2026-10-13'
---

# Senior Director, Clinical Development at Definium Therapeutics

- **Company:** Definium Therapeutics
- **Location:** Remote
- **Work type:** remote
- **Posted:** 2026-02-19
- **Last confirmed live:** 2026-10-13
- **Apply:** https://job-boards.greenhouse.io/definiumtherapeutics/jobs/5808053004

## Job description

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

The Sr. Director, Clinical Development will play a key role in the design and execution of ongoing and new clinical studies and contribute to the clinical development plan for one or more programs. The position will successfully lead and/or serve as the clinical science representative on one or more clinical studies (US and/or global) to deliver high quality data for registration. The position requires the ability to partner with Clinical Operations, Clinical Pharmacology, Regulatory, Early Development, Medical Affairs, Commercial and other stakeholders to deliver clinical programs for registration and launch. The successful candidate will have direct and recent experience in late phase clinical development, and in CRO and KOL interactions.

Responsibilities:

- Provides clinical science leadership within assigned teams or programs
- Manage the design, planning and execution of clinical trial program(s) as needed with minimal guidance
- Is able to play a leadership role in subject matter expertise when interacting with global health authorities
- Has deep familiarity with registration submission strategies and can manage the Clinical needs for all submissions as needed
- Leads the study design, implementation and execution of clinical trials on assigned programs. Is responsible for the preparation of clinical study synopses and serves as a major contributor to the writing of protocols/major amendments, the design of data collection systems, the interpretation of clinical data, and the preparation of final clinical study reports
- Works cooperatively with project team members to provide clinical development expertise and leadership
- Responsible for identifying and cultivating relationships with relevant national and international thought leaders to further project goals
- In partnership with Regulatory Affairs and Project Management, oversee and ensure the quality, coordination and timeliness of clinical sections of IND's, Investigator Brochures, CTA's, ISS', ISE's and clinical expert reports, including writing and editing
- Responsible for providing or supervising medical monitoring activities for all human clinical trials including support of adverse event reporting and safety management
- Responsible for ongoing benefit/risk assessment, monitoring adherence to protocols, helping in the investigation of protocol deviations and providing leadership for monitoring activities related to execution of the protocol or program
- Provides medical/clinical information for inclusion in reports submitted to regulatory authorities and supports the authoring of regulatory documents
- Develops relationships with investigators and external organizations and experts to optimize study design and executions

Requirements:

- Doctoral level degree (PhD, MD, PharmD, PsyD) required
- 8+ years of relevant clinical development experience
- Experience in CNS development (Psychiatry or neurology) strongly preferred
- Possess strong knowledge of the clinical development process
- Possess a solid understanding of the pharmaceutical industry, company competition and commercial side of business
- Experience in small molecule development
- Experienced in data review and analysis, presentations (internal and external) and regulatory writing (IND, CTD sections)
- Experience building strong relationships within cross-functional groups to achieve results
- Proven ability to identify and solve relevant problems related to clinical development
- Experience in clinical research for psychiatry, addiction psychiatry, and addiction medicine programs, strongly preferred.
- Background and proven relevant experience in engaging with clinical trial strategy and trial management
- Understanding of the drug development process including technical, business, and regulatory issues.
- IND experience strongly preferred
- Diplomacy and professionalism, ability to build positive relationships both with company leadership and external experts
- Able to command respect from peers and subordinates, capable of highly independent work as well as being a team player and role model
- Excellent interpersonal, verbal and written communication skills
- Proven ability to work remotely and with remote internal and external interdisciplinary teams
- Problem-solving and strategic planning skills
- Excited by innovative ideas in clinical research space
- Self-motivated, resourceful with a ‘get the job done’ attitude in a fast-paced team environment

Other Skills:

- Excellent writing and communication skills
- Managerial skills a plus
- Ability to handle obstacles and roadblocks by anticipating challenges and preparing well thought out arguments and contingencies
- Proven track record of garnering support for projects and recommendations through on-going collaboration, open and influential communications and commitment to improvement/change

Special Working Conditions:

Ability to travel as required, including international travel. Average 10-20%, reaching 50% or more in some months

The starting base pay range for this position is $247,649.00 - $298,800.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

- 100% paid health benefits including Medical, Dental and Vision for you and your dependents
- 401(k) program with company match and vesting after the turn of the first month after your start date
- Flexible time off
- Generous parental leave and some fun fringe perks!

## About Definium Therapeutics

## Company Overview
- **One-liner**: Definium Therapeutics is a clinical-stage biopharmaceutical company applying scientific rigor to psychedelic medicine to develop accessible treatments for psychiatric disorders.
- **Entity Type**: Public (NASDAQ: DFTX)
- **Headquarters**: Not specified in available sources; the company operates as a remote-first organization.
- **Founded**: 2019 (originally as MindMed)
- **Founders**: Not publicly available in provided sources.

## Core Business
- **Primary Industry**: Biotechnology / Psychiatric drug development (psychedelic medicine)
- **Target Customers**: Patients with major depressive disorder (MDD), generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and autism spectrum disorder (ASD); also healthcare providers and payers.
- **Mission/Purpose**: “Unlock healing at scale” by harnessing the full therapeutic potential of psychedelic medicine through precise, evidence-based science.

## Products & Services
- **DT120 ODT (Lysergide/LSD D-Tartrate Oral Disintegrating Tablet)**: Investigational drug for GAD, MDD, and PTSD. Currently in four Phase 3 trials (Voyage, Panorama, Emerge, Ascend) and a fifth planned for PTSD. FDA Breakthrough Therapy Designation for GAD. No adjunctive psychotherapy required.
- **DT402 (R(-)-MDMA)**: R-enantiomer of MDMA selected for serotonergic properties with a potentially superior tolerability profile. In Phase 2a study for social communication challenges in autism spectrum disorder.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (publicly listed on NASDAQ as DFTX as of 2026, but recent market cap not provided in search results).
- **Key Metric**: Pre-revenue clinical-stage company; total funding history not disclosed in available sources.
- **Notable Investors/Partners**: Not disclosed in provided sources.
- **Growth Signals**:
  - Five Phase 3 trials ongoing or planned for DT120 ODT.
  - FDA Breakthrough Therapy Designation for DT120 in GAD.
  - Phase 2a trial initiated for DT402 in ASD.
  - Full results from Phase 2b GAD trial published in JAMA (2025).
  - Strong intellectual property with issued patents covering formulation, manufacturing, and treatment.

## Competitive Advantages
- **Proprietary Formulations**: Pharmaceutically optimized ODT for LSD (DT120) and novel R-enantiomer of MDMA (DT402) with potential improved tolerability.
- **Scientific Rigor**: Standalone drug studies without psychotherapy, enabling clearer efficacy and safety data.
- **Regulatory Momentum**: FDA Breakthrough Therapy Designation and multiple IND clearances.
- **Experienced Management Team**: Proven track record in developing and commercializing CNS therapies.
- **Comprehensive IP Strategy**: Patents covering drug formulations, methods of manufacture, and treatment use.

## Strategic Focus
- **Late-Stage Pipeline Advancement**: Completing Phase 3 trials for GAD and MDD, initiating PTSD trial.
- **Pipeline Expansion**: Advancing DT402 for ASD and exploring additional neuropsychiatric indications.
- **Commercial Readiness**: Building infrastructure (hiring VP of Sales, Senior Director of Field VEOR, etc.) to support potential future launch.
- **Data Generation**: Generating high-quality evidence to support regulatory submissions and differentiation.

## Why Work Here
- **Remote-First Culture**: “You can live anywhere in the country you’re employed in” (remote-first workforce).
- **Comprehensive Benefits**: 100% paid medical, dental, vision for employees and dependents; FSA/HSA; life and disability insurance.
- **Wellness & Time Off**: Annual wellness allowance, flexible PTO, company-wide shutdowns for rest.
- **Family Support**: Paid parental leave for birthing and non-birthing parents, 2-week return-to-work transition.
- **Financial Wellness**: Competitive compensation, 401(k) with employer match, employee equity (new hire grants and refreshes), Employee Stock Purchase Plan (ESPP) with discount.
- **Mission-Driven Work**: Opportunity to contribute to groundbreaking treatments in psychedelic psychiatry with a science-driven, collaborative team.

## Sources
1. [definiumtx.com](https://definiumtx.com/) – Company overview and pipeline details
2. [definiumtx.com](https://definiumtx.com/story/) – Company history, leadership, and strategic milestones
3. [definiumtx.com](https://definiumtx.com/careers/) – Careers page with benefits and remote-first policy
4. [definiumtx.com](https://definiumtx.com/research-development/) – Research and development pipeline details
5. [linkedin.com](https://www.linkedin.com/company/definiumtherapeutics) – LinkedIn company page

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