---
title: 'Senior Director, Clinical Development at Tango Therapeutics'
canonical: 'https://feeny.ai/job/senior-director-clinical-development-tango-therapeutics-boston-hsrsdbmhcjgw'
type: 'job'
last_seen: '2026-10-13'
---

# Senior Director, Clinical Development at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $274k–$412k
- **Posted:** 2026-06-29
- **Last confirmed live:** 2026-10-13
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/7786013003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

The Senior Director, Clinical Development will provide medical and scientific leadership for Tango’s oncology development programs, driving clinical strategy from early-stage development through registration. Reporting to the President, Research & Development, this individual will lead cross-functional clinical teams, shape development plans, oversee study execution and medical monitoring, and serve as a key partner to investigators, regulators, and senior leadership.

This highly visible role combines strategic leadership with hands-on clinical development responsibilities and offers the opportunity to directly influence the advancement of innovative precision oncology therapies for patients. The Senior Director will build and maintain strong relationships with investigators, key opinion leaders (KOLs), and external partners while ensuring the successful execution of clinical studies and overall program objectives.

Your Role:

- Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering with cross-functional teams to create and implement comprehensive clinical development plans
- Provide leadership to the clinical team and serve as the medical and scientific expert for development programs
- Design, author, and oversee the development of study protocols, protocol amendments, investigator brochures, and other key clinical documents in compliance with project plans, global regulations, ICH/GCP guidelines, and Good Medical Practice
- Serve as the primary clinical lead for study investigators and key opinion leaders, building strong relationships that support program success and scientific advancement
- Lead clinical contributions to regulatory submissions, including INDs, CTAs, NDA/MAA filings, and interactions with Health Authorities
- Act as Medical Monitor and/or oversee external Medical Monitors for company-sponsored clinical trials, ensuring appropriate medical oversight and patient safety
- Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation
- Partner closely with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences to ensure integrated and efficient execution of development programs
- Analyze and interpret clinical trial data and communicate findings through regulatory submissions, scientific publications, medical congress presentations, and internal governance reviews
- Lead responses to questions from Health Authorities, Ethics Committees, and Institutional Review Boards, ensuring consistency and scientific rigor
- Contribute to portfolio strategy, development planning, and broader organizational initiatives as needed
- Perform additional responsibilities as required to support the advancement of Tango’s clinical programs

What You Bring:

- MD required; board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred
- 5+ years of clinical development experience within the biotechnology and/or pharmaceutical industry, including experience leading oncology development programs
- Demonstrated experience in the design, execution, interpretation, and reporting of oncology clinical trials involving targeted therapies, small molecules, and/or immuno-oncology agents
- Experience supporting or leading late-stage clinical development programs, NDA/BLA/MAA submissions, and Health Authority interactions
- Strong understanding of the biological and translational sciences underlying modern oncology drug development, including molecular biology, cancer genetics, immunology, and precision medicine approaches
- Proven ability to lead and influence cross-functional teams within a matrixed organization
- Excellent strategic thinking, organizational, and project leadership skills, with the ability to balance high-level planning and hands-on execution
- Strong problem-solving skills and the ability to identify innovative approaches to advance development programs and organizational objectives
- Exceptional communication and presentation skills, including the ability to engage effectively with senior leadership, investigators, KOLs, and regulatory agencies
- Demonstrated leadership capabilities with a collaborative, team-oriented, and results-driven approach
- Flexible, resourceful, and entrepreneurial mindset with the ability to thrive in a dynamic and fast-paced biotechnology environment

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Salary range $274,400—$411,600 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Executive Director, Commercial Law/Commercial Contracts](https://feeny.ai/job/executive-director-commercial-law-commercial-contracts-tango-therapeutics-boston-4rgpv55eb66w) — Boston, MA
- [Director, Intellectual Property](https://feeny.ai/job/director-intellectual-property-tango-therapeutics-boston-pesyhn9k10dj) — Boston, MA
- [Senior Clinical Data Manager](https://feeny.ai/job/senior-clinical-data-manager-tango-therapeutics-boston-xk614h7zhf91) — Boston, MA
- [Manager, GMP Quality](https://feeny.ai/job/manager-gmp-quality-tango-therapeutics-boston-70t57986x902) — Boston, MA
- [Executive Director, Commercial Strategy & Execution](https://feeny.ai/job/executive-director-commercial-strategy-execution-tango-therapeutics-boston-y7x7vkeeenkd) — Boston, MA
- [Head of Marketing & Sales](https://feeny.ai/job/head-of-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Head of Insights & Analytics](https://feeny.ai/job/head-of-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA
- [Executive Director, FP&A](https://feeny.ai/job/executive-director-fp-a-tango-therapeutics-boston-kph81hnp4jvk) — Boston, MA
- [Associate Director, Pharmacovigilance Scientist](https://feeny.ai/job/associate-director-pharmacovigilance-scientist-tango-therapeutics-boston-5cgk3mmdsprr) — Boston, MA