---
title: 'Senior Director, Clinical Operations at Vir Biotechnology'
canonical: 'https://feeny.ai/job/senior-director-clinical-operations-vir-biotechnology-san-francisco-s9fmzy3axqz1'
type: 'job'
last_seen: '2026-11-07'
---

# Senior Director, Clinical Operations at Vir Biotechnology

- **Company:** Vir Biotechnology
- **Location:** San Francisco, CA
- **Posted:** 2026-10-22
- **Last confirmed live:** 2026-11-07
- **Apply:** https://job-boards.greenhouse.io/virbiotechnologyinc/jobs/4746522005

## Job description

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.

Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.

## THE OPPORTUNITY

Vir Biotechnology is seeking an experienced Senior Director of Clinical Operations to provide portfolio-level strategic and operational leadership for multiple complex global oncology programs. This individual will be accountable for translating clinical development strategy into executable operational plans, delivering studies against timelines, budgets, quality standards, and decision-critical milestones, and proactively identifying and resolving risks that could affect program objectives. The role will serve as a hands-on leader across study execution, program governance, alliance management, operational excellence, and oncology portfolio growth.

You will establish the operational strategy for assigned programs and provide effective sponsor oversight of CROs, clinical sites, laboratories, and specialty vendors. As a key member of cross-functional program and study teams, you will provide operational leadership from protocol concept and country and site strategy through database lock, study closeout, and regulatory submission support. You will also lead Clinical Operations initiatives that strengthen portfolio governance, resource planning, process improvement, SOP development, inspection readiness, and scalable operating capabilities.

This role is based at our San Francisco headquarters, with an expectation of working in the office at least three days per week.

## WHAT YOU'LL DO

- Oversee the tactical implementation of clinical development plans for multiple global oncology trials, with accountability for delivery against timelines, budgets, quality standards, and milestones
- Provide strategic and operational leadership for first-in-human, dose-escalation, dose-optimization, backfill, combination, and expansion-cohort oncology studies, including rapid cohort activation, fit-for-purpose safety oversight, intensive pharmacokinetic and biomarker sampling, and timely delivery of data to support dose, indication, and portfolio decisions.
- Partner closely with Clinical Development, Translational Medicine, Clinical Pharmacology, Medical Monitoring, Biometrics, Regulatory Affairs, Safety, Clinical Supply, and other functions to align operational and clinical objectives and ensure consistency across assigned studies
- Translate program strategy into an integrated operational plan encompassing country and site strategy,, start-up and enrollment assumptions, patient and site engagement, vendor and CRO selection, resourcing, budget, clinical supply interfaces, data-delivery milestones, and scenario-based risk mitigation.
- Provide effective Sponsor oversight of CROs and ancillary vendors through clear governance, performance metrics, issue escalation, quality and risk review, financial oversight, and documented accountability for timely corrective and preventive actions.
- Implement and oversee risk-based quality management plans, sponsor-oversight activities, and inspection-readiness strategies across all assigned studies
- Drive Clinical Operations excellence by serving as the Clinical Operations subject matter expert for assigned clinical studies and leading cross-functional initiatives, including KPI tracking, process improvement, and oversight to ensure adherence to protocols, project plans, and GCP requirements
- Partner with senior leadership to foster a highly desirable work environment that attracts and retains high-performing Clinical Operations professionals
- Build, lead, and develop a high-performing Clinical Operations team through effective management, coaching, and professional development of direct reports
- Mentor junior Clinical Operations colleagues and contribute to building organizational capabilities that support a growing oncology portfolio
- Develop company SOPs, guidelines, and efficient systems in collaboration with the Clinical Operations team to enhance departmental effectiveness and ensure compliance with applicable FDA regulations and current ICH GCP guidelines
- Represent Clinical Operations on program, study, governance, and portfolio planning teams, providing clear operational recommendations, scenario analyses, risk assessments, and escalation of decisions required to protect program timelines and objectives.
- Serve as the operational lead for alliance and co-development programs, representing Clinical Operations in joint governance forums and facilitating cross-company operational alignment
- Lead Clinical Operations planning for emerging oncology assets transitioning from preclinical development into the clinic, including first-in-human operational strategy, country and site assessment, vendor and systems readiness, initial budget and resource assumptions, and execution planning aligned with regulatory submission and study-start milestones.

## WHO YOU ARE AND WHAT YOU BRING

- Bachelor’s degree in life sciences or a related field and 15+ years of clinical development experience in the biotechnology or pharmaceutical industry
- Significant experience overseeing complex global oncology clinical trials, with deep expertise in early-phase oncology development
- Demonstrated experience leading first-in-human and early-development oncology trials, including dose-escalation, backfill, expansion, signal-seeking, and dose-optimization studies
- Experience supporting development of novel oncology modalities, such as T-cell engagers, bispecific antibodies, immuno-oncology therapies, cell therapies, cytokine-based therapies, or related platforms
- Demonstrated expertise in global study start-up, country and site feasibility, investigator engagement, enrollment forecasting and optimization, and recruitment planning across academic and community oncology networks, including strategies for biomarker-selected populations, competing trials, screen failure, and complex referral pathways.
- Strong understanding of clinical trial design and execution, including operational considerations in oncology studies
- Extensive knowledge of FDA, EMA, ICH GCP, and other global regulatory requirements.
- Experience managing CROs and vendors across global clinical development programs
- Experience supporting regulatory inspections, audits, and inspection readiness activities
- Demonstrated ability to balance strategic leadership with hands-on execution, make timely decisions with incomplete or evolving data, and resolve complex operational issues in a fast-paced, resource-conscious biotechnology environment.
- Proven ability to influence cross-functional program strategy and drive timely decisions in a fast-paced biotechnology environment
- Experience contributing to departmental initiatives, process improvements, and operational excellence programs
- Ability to travel domestically and internationally as needed.

## #LI-AS1

#LI-Hybride

## WHO WE ARE AND WHAT WE OFFER

The expected salary range for this position is $235,500 to $329,000 per year. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.

Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office.

Applicants must currently be authorized to work for any employer in the U.S.  We are unable to sponsor or take over sponsorship of an employment Visa at this time.

All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics.

This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.  Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.

Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

For hires based in the United States, Vir Biotechnology, participates in [E-Verify](https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf).

[Candidate Privacy Notice](https://www.vir.bio/candidate-notice/)

## About Vir Biotechnology

## Company Overview
- **One-liner**: Vir Biotechnology is a clinical-stage immunology company focused on engineering powerful antibody-based medicines to treat infectious diseases and cancer.
- **Entity Type**: Public (Ticker: VIR)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2016
- **Founders**: Not publicly available (the company was formed with founding investments from ARCH Venture Partners, the Bill & Melinda Gates Foundation, and others)

## Core Business
- **Primary Industry**: Biotechnology (Immunology, Infectious Disease, Oncology)
- **Target Customers**: Patients with serious infectious diseases (e.g., chronic hepatitis delta, COVID-19, Ebola) and specific cancers; the company's customers are effectively patients and healthcare systems, with revenue coming from partnerships and product sales.
- **Mission/Purpose**: "Power the immune system to transform lives" by delivering potentially transformative medicines for patients with high unmet medical needs.

## Products & Services
- **Next-Generation Antibody Platform**: A proprietary platform that enables the rapid discovery, optimization, and advancement of antibody candidates for infectious diseases.
- **PRO-XTEN® Protease-Releasable Masking Technology**: A platform (exclusive rights for oncology and infectious disease) used to engineer conditionally activated antibodies that are designed to be safer and more effective in treating cancer. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.
- **Pipeline Programs**: The company’s pipeline includes leading programs in chronic hepatitis delta virus (HDV) and strategically expanding into oncology. They have demonstrated their ability to discover and develop antibody-based medicines for COVID-19 and Ebola.

## Market Standing
- **Valuation/Market Cap**: Market cap fluctuates with stock price. As of recent reporting, it is in the range of several billion USD. For the most current figure, refer to financial data providers.
- **Key Metric**: As a public company, key metrics include R&D spending, cash position, and pipeline progress. The company had significant revenue from its COVID-19 antibody partnership (sotrovimab) but is now focused on advancing its pipeline.
- **Notable Investors/Partners**: Founding investors include ARCH Venture Partners and the Bill & Melinda Gates Foundation. Key partners include Alnylam Pharmaceuticals and Sanofi (via the Amunix/PRO-XTEN platform).
- **Growth Signals**: The company is actively expanding its oncology pipeline, appointing an SVP of Oncology and a Vice President of Clinical Research-Oncology. It continues to hire across R&D, regulatory, and business development, signaling a phase of growth and pipeline advancement.

## Competitive Advantages
- **Deep Immunology Expertise**: The company has a world-class team with deep knowledge of immunology and antibody engineering.
- **Dual-Platform Strategy**: Combining a powerful antibody discovery platform with the PRO-XTEN® masking technology gives it a unique ability to create both potent and safer therapies.
- **Proven Track Record**: Successfully developed and brought to market a COVID-19 antibody (sotrovimab) and an Ebola treatment (mAb114) on an accelerated timeline, demonstrating execution capability.
- **Focus on Unmet Needs**: Concentrates on diseases with limited treatment options, such as chronic hepatitis delta and hard-to-treat cancers.

## Strategic Focus
- **Infectious Disease Foundation**: Continuing to advance its core programs in infectious diseases, with a leading program in chronic hepatitis delta.
- **Strategic Oncology Expansion**: Building a robust oncology pipeline using its antibody and PRO-XTEN® platforms, with a focus on indications with high unmet need.
- **Pipeline Acceleration**: Leveraging its platforms to rapidly identify, optimize, and advance candidates from concept to clinic.
- **Building for the Long Term**: The company is strategically building its capabilities and team to become a multi-product, multi-indication biotech.

## Why Work Here
- **Mission-Driven**: Employees are directly contributing to developing transformative medicines for patients with serious diseases.
- **World-Class Team**: Opportunity to work alongside industry-leading scientists, clinicians, and business leaders in the U.S. and Europe.
- **Commitment to Fair Pay**: The company has an "unwavering commitment to fair pay" with a rigorous, proactive approach to compensation based on skills and experience. U.S. salary ranges are shared internally for transparency.
- **Generous Benefits**: Includes health benefits and wellness program, unaccrued time off with structured holidays, on-site paid parking, lunch, and transit spending account (in the U.S.).
- **Workplace Culture**: The company emphasizes "Virtues" over values and a culture of urgency and impact.
- **Locations**: Primarily San Francisco, CA, with some remote options for specific roles (e.g., Regulatory Writer). European offices are also part of the company.

## Sources
1. [vir.bio](https://www.vir.bio/)
2. [vir.bio/careers](https://www.vir.bio/careers/)
3. [job-boards.greenhouse.io/virbiotechnologyinc](http://job-boards.greenhouse.io/virbiotechnologyinc)
4. [vir.bio/about/strategy](https://www.vir.bio/about/strategy/)

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