---
title: 'Senior Director, Global Program Development Lead - DMD/Neuromuscular at REGENXBIO'
canonical: 'https://feeny.ai/job/senior-director-global-program-development-lead-dmd-neuromuscular-regenxbio-xbereeg0zrc8'
type: 'job'
last_seen: '2026-09-14'
---

# Senior Director, Global Program Development Lead - DMD/Neuromuscular at REGENXBIO

- **Company:** REGENXBIO
- **Location:** Rockville, MD
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-01-30
- **Last confirmed live:** 2026-09-14
- **Apply:** https://jobs.lever.co/regenxbio/5646ccfd-dfe7-4968-820e-a03c35dc0936

## Job description

## Who we are

REGENXBIO is an exceptional place to work. You'll have the opportunity to collaborate with some of the best and the brightest people, touch amazing science, and be a part of extraordinary plans. Our core values: Trust, Accountability, Perseverance, and Innovation drive everything we do. We aim to bring these values to life every day with all that we do, and we believe that what we do matters - to patients, to their families, and to their communities.

The opportunity

As a Senior Director, Global Program Development Lead (PDL), you will be in a highly visible leadership role that sits at the center of the cross-functional program team, to shape a compelling strategic direction, set ambitious priorities, and drive disciplined execution, in partnership with senior leadership.  Leveraging deep expertise in drug development and commercialization, along with a forward-looking perspective and strong operational mindset, you will ensure the program team operates with clarity, rigor, and urgency while fostering collaboration and high performance. Accountable for cross-functional outputs, you'll guide the program’s path forward by anticipating opportunities, mitigating risks, cultivating strategic options, and driving decision-making amid complexity and uncertainty to achieve long-term program success.

## What you'll be doing

- Lead overall program strategy, accountable for an integrated Program Development Strategy, Target Product Profile (TPP), and lifecycle management plan aligned with corporate objectives and long-term portfolio goals to maximize asset value.
- Drive cross-functional strategic integration, ensuring scientific rigor and emerging clinical data, competitive intelligence, and evolving market dynamics inform program direction and critical decisions.
- Identify key development challenges and define strategic options across functions, including timelines, budgets, risks, and trade-offs, enabling timely, high-quality decision-making.
- Support business development activities, including opportunity assessment and due diligence; represent the program on Joint Steering Committees for partnered assets.
- Maintain external perspective and scientific credibility through engagement with KOLs, patient advocacy groups, and other external experts.
- Evolving and maturing the program’s external communications strategy in partnership with key groups, including the elements of scientific messaging, competitive positioning, and stakeholder alignment.
- Drive cross-functional program execution within a matrix organization, ensuring high-quality, on-time deliverables while aligning priorities and resources to maximize program value and proactively resolve critical challenges.
- Anticipate operational and strategic risks, establish contingency plans, and pressure-test assumptions, timelines, and budgets to maintain program agility and informed decision-making.
- Serve as the primary liaison between the Core Team and governance committees, presenting program materials with clear, data-driven recommendations and actionable options to support timely approvals.
- Build, influence, and sustain high-performing teams, guiding complex, high-stakes decisions without direct authority.
- Lead cross-functional teams to deliver high-impact program outcomes, challenging assumptions, timelines, and budgets while developing alternative scenarios to mitigate risk and maximize value.
- Own the quality, integrity, and timeliness of team outputs, ensuring company-level decisions are informed by robust, high-caliber data; set pace and priorities to achieve milestones in a highly competitive landscape.
- Serve as the program spokesperson, aligning stakeholders and communicating strategy, progress, and decisions clearly across internal and external audiences.
- Inspire innovation, scientific rigor, and creative problem-solving, fostering a culture of collaboration, continuous improvement, and boundary-less thinking.
- Coach and develop team members to achieve peak performance, cultivating accountability, skill growth, and collective achievement.
- Lead with pragmatism and clarity through ambiguity, charting the path forward and driving complex drug development decisions in fast-paced, dynamic environments.
- Travel up to 20%
- It is imperative that REGENXBIO employees embody our core values by working collaboratively, building strong relationships and using clear communication to meet shared objectives.

## What we're looking for

- Bachelor’s degree required; advanced degree (MS, PhD, MBA) in life sciences or healthcare field preferred.
- Proven leader with 8+ years in pharmaceutical industry leadership, with a strong track record driving drug development programs through pivotal stages to commercialization; product launch and early commercialization experience is a strong plus.
- Strong understanding of drug development and commercialization processes, ideally within rare disease or gene therapy
- Deep knowledge of neuromuscular diseases is highly desirable.
- The ability to work well under intense pressure, tight timelines, and in rapidly changing situations
- Evidence of an entrepreneurial spirit and a capacity to find creative solutions to unexpected hurdles
- Interacts effectively across teams with supporting REGENXBIO functions and disciplines using influencing, communication and relationship building skills
- Commitment to anticipate, influence and direct change
- Excellent listening and collaboration skills

Why should you apply?

By joining REGENXBIO, you will have the opportunity to be a part of a growing company, with an incredible team, who is passionate about developing novel AAV gene therapies for patients in need.

We offer a comprehensive and competitive benefit & compensation package which includes market-competitive salaries, an annual bonus program, education assistance, retirement plan with employer match, stock options at all levels, summer hours and more! The estimated compensation range for this role is $235,000 to $335,000 annually. The actual salary offered to the final candidate depends on a number of factors such as relevant work experience, skills, education, and years of experience.

In addition, professional development is important to us.  By joining our team, you’ll have the opportunity to be exposed to challenging projects and have access to development resources to help you grow personally and professionally.

## About REGENXBIO

## Company Overview
- **One-liner**: REGENXBIO is a clinical-stage biotechnology company developing one-time gene therapies for rare and retinal diseases using its proprietary AAV vector platform.
- **Entity Type**: Public (NASDAQ: RGNX)
- **Headquarters**: Rockville, Maryland, United States
- **Founded**: 2008 (founded as a company; operations began in 2009)
- **Founders**: Not publicly listed as individual founders; the company was spun out from the gene therapy research of the University of Pennsylvania and licensed its NAV Technology Platform from the university.

## Core Business
- **Primary industry**: Biotechnology – Gene Therapy (AAV-based)
- **Target customers**: B2B (pharma partners like AbbVie, Nippon Shinyaku) and B2G (regulatory agencies, clinical trial sites); ultimate customers are patients with rare and retinal diseases (Duchenne muscular dystrophy, MPS I, MPS II, wet AMD, diabetic retinopathy).
- **Mission or purpose statement**: “To improve lives through the curative potential of gene therapy.” [regenxbio.com](https://www.regenxbio.com/culture-careers/)

## Products & Services
- **NAV® Technology Platform**: Proprietary AAV vector gene delivery platform (including AAV8 and AAV9) used for internal programs and licensed to partners (e.g., Novartis for ZOLGENSMA®).
- **ABBV-RGX-314** (in collaboration with AbbVie): Investigational one-time gene therapy for wet age-related macular degeneration (wet AMD) and diabetic retinopathy (DR). In pivotal clinical trials.
- **RGX-202** (Duchenne muscular dystrophy): Phase I/II/III AFFINITY DUCHENNE® trial; pivotal phase expected to support BLA submission in 2026 using accelerated approval pathway. [ir.regenxbio.com](https://ir.regenxbio.com/static-files/92731f97-50e3-4285-b793-d2cdc99611aa)
- **RGX-121** (MPS II – Hunter syndrome): In partnership with Nippon Shinyaku; late-stage development.
- **RGX-111** (MPS I – Hurler syndrome): In partnership with Nippon Shinyaku; clinical development.
- **Manufacturing**: In-house cGMP production facility (REGENXBIO Manufacturing Innovation Center – RMIC) in Rockville, MD, operational since mid-2022.

## Market Standing
- **Valuation/Market Cap**: $447.8 million (as of recent data). [linkedin.com](https://linkedin.com/company/regenx)
- **Key Metric**: Annual Revenue $170.4 million (primarily from license and collaboration revenue). [linkedin.com](https://linkedin.com/company/regenx)
- **Notable Investors/Partners**:
    - AbbVie (collaboration for ABBV-RGX-314)
    - Nippon Shinyaku (partnerships for RGX-121 and RGX-111)
    - Novartis (licensee for ZOLGENSMA® using NAV vectors)
- **Growth Signals**:
    - Headcount: 296 employees (+1.3% YoY). [linkedin.com](https://linkedin.com/company/regenx)
    - BLA submission for RGX-202 targeted for 2026.
    - RMIC facility operational since 2022, enabling scalable clinical and commercial manufacturing.
    - Scholarly output: 160 works, 7,337 citations, field-weighted citation impact of 2.6 (highly influential). [linkedin.com](https://linkedin.com/company/regenx)

## Competitive Advantages
- **Proprietary NAV Technology Platform**: Exclusive rights to a large portfolio of AAV vectors (including AAV8 and AAV9), the foundation for multiple approved and investigational gene therapies. [ir.regenxbio.com](https://ir.regenxbio.com/static-files/92731f97-50e3-4285-b793-d2cdc99611aa)
- **End-to-end capabilities**: Integrated in-house R&D, preclinical development, clinical development, and cGMP manufacturing.
- **Proven platform**: Thousands of patients have been treated with AAV vectors from the NAV platform (including via Novartis’ ZOLGENSMA®).
- **Late-stage pipeline**: Multiple programs in pivotal or near-pivotal trials (RGX-202, ABBV-RGX-314) with clear regulatory pathways.

## Strategic Focus
- **Near-term**: Advance RGX-202 toward BLA submission in 2026; continue pivotal trials for ABBV-RGX-314 in wet AMD and diabetic retinopathy.
- **Long-term**: Expand pipeline in retinal, neuromuscular, and neurodegenerative diseases; leverage RMIC for commercial-scale manufacturing; deepen partnerships with AbbVie and Nippon Shinyaku.
- **Platform expansion**: Ongoing research to expand NAV vector capabilities and develop new AAV-based therapies.

## Why Work Here
- **Mission-driven culture**: “Patient-focused, driven by results, fosters collaboration.” Core values emphasize accountability, innovation, and serving patients with limited therapeutic options. [regenxbio.com](https://www.regenxbio.com/culture-careers/)
- **Impactful work**: Opportunity to work on one-time gene therapies that could fundamentally alter the course of devastating diseases.
- **Growth & stability**: Public company with late-stage pipeline, strong partnerships, and a clear path to commercialization.
- **Location & facilities**: Headquarters in Rockville, MD, with a state-of-the-art cGMP manufacturing facility (RMIC) on site.
- **Work policy**: Not explicitly stated as remote/hybrid; positions appear to be on-site (based on job listings in Rockville and field-based Medical Science Liaison roles).
- **Perks**: Comprehensive and competitive benefits for employees and families. [regenxbio.com](https://www.regenxbio.com/culture-careers/)
- **Engineering & science culture**: High scholarly output and citation impact; emphasis on cross-functional collaboration between research, manufacturing, and clinical teams.
- **Recruitment note**: REGENXBIO warns of fraudulent job offers; all applications go through their official Lever portal. [regenxbio.com](https://www.regenxbio.com/culture-careers/)

## Sources
1. [regenxbio.com – Culture & Careers](https://www.regenxbio.com/culture-careers/)
2. [linkedin.com – REGENXBIO company page](https://linkedin.com/company/regenx)
3. [ir.regenxbio.com – 10-K Filing (Business Overview)](https://ir.regenxbio.com/static-files/92731f97-50e3-4285-b793-d2cdc99611aa)
4. [ir.regenxbio.com – Investor Overview](https://ir.regenxbio.com/investor-overview)
5. [jobs.lever.co – REGENXBIO careers](https://jobs.lever.co/regenxbio)

## Other roles at REGENXBIO

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- [Associate Director, Data & Information Architecture](https://feeny.ai/job/associate-director-data-information-architecture-regenxbio-rockville-b0m5vrmrm33p) — Rockville, MD
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