--- title: 'Senior Director, Information Technology at Maze Therapeutics' canonical: 'https://feeny.ai/job/senior-director-information-technology-maze-therapeutics-south-san-francisco-gzknm40mvm03' type: 'job' last_seen: '2026-09-13' --- # Senior Director, Information Technology at Maze Therapeutics - **Company:** Maze Therapeutics - **Location:** South San Francisco, CA - **Posted:** 2026-09-09 - **Last confirmed live:** 2026-09-13 - **Apply:** http://www.mazetx.com/careers/?gh_jid=8788021002 ## Job description The Position As our Senior Director, Information Technology, you’ll report to the SVP, Technology & Business Operations and lead the strategy, operations, security, and evolution of Maze’s enterprise technology environment. This is a role for a leader who can balance strategy with hands-on execution. You’ll lead our internal IT team while evolving our operating model with Managed Service Providers (MSPs) and strategic partners to deliver reliable, secure, and responsive technology services. As Maze advances its clinical programs and prepares for increasingly complex global development, you’ll ensure our technology environment can scale with the business. You’ll partner across Clinical, Quality, Regulatory, Finance, Legal, HR, Research, Informatics, and other functions to modernize how we work, strengthen cybersecurity, improve the employee technology experience, and help expand the use of AI and automation across the company. This position is based in our South San Francisco headquarters and requires onsite presence a minimum of three days per week. The Impact You’ll Have Lead Technology Strategy and Operations - Develop and execute Maze’s enterprise IT strategy and roadmap aligned with business growth, clinical development, security, and compliance needs. - Lead the delivery of enterprise IT services, including Microsoft 365, identity and access management, endpoints, networking, cloud services, business applications, and end-user support. - Modernize the employee technology experience, including onboarding, access provisioning, support, and authentication. - Establish meaningful service levels, operational metrics, and performance expectations that drive accountability and continuous improvement. - Own IT financial planning and investment prioritization, balancing business value, risk, employee experience, scalability, and cost. Evolve Our IT Operating Model and Build a High-Performing Organization - Lead Maze’s transition to an effective MSP-enabled operating model across end-user support and infrastructure. - Establish clear roles, accountability, service expectations, and ways of working between internal IT leaders, MSPs, and strategic technology partners. - Lead, coach, and develop Maze’s IT leadership team, building trust, collaboration, and shared accountability across IT Operations, Infrastructure, and Helpdesk. - Manage vendor performance, service quality, escalation, cost, and continuous improvement while ensuring Maze retains ownership of technology strategy, security, risk, and business outcomes. - Create a service-oriented culture where internal teams and external partners operate as one IT organization focused on delivering an exceptional employee experience. - Remain close enough to the technology and operations to identify issues, remove roadblocks, and guide the team effectively. Strengthen Cybersecurity and Compliance - Develop and execute Maze’s cybersecurity strategy and multi-year roadmap, maturing capabilities across identity, endpoints, networks, SaaS applications, data protection, monitoring, third-party risk, and incident response. - Improve Maze’s ability to proactively identify, assess, and mitigate cybersecurity risks. - Maintain strong disaster recovery, business continuity, and incident response capabilities. - Support SOX, GDPR, audits, access controls, and applicable GxP and computer system validation requirements. Partner with the Business - Build trusted partnerships across Clinical Development, Quality, Regulatory, Finance, Legal, HR, Research, Drug Discovery, and Technical Operations. - Establish a proactive IT business-partnership model that anticipates functional needs, identifies opportunities to improve how teams work, and translates those needs into the technology roadmap. - Support the technology needs of global clinical development and external partners, including CROs and other service providers. - Partner with business owners on the selection and implementation of critical platforms, including clinical, quality, and document-management systems. - Translate business needs into practical, scalable technology solutions. Advance AI and Automation - Help lead the continued evolution of AI@Maze, enabling secure and responsible use of enterprise AI. - Partner with Informatics, Data Science, Legal, and business teams on AI governance, architecture, security, and adoption. - Evaluate enterprise AI platforms and opportunities to connect approved AI tools with internal Maze information such as SharePoint. - Identify opportunities to automate routine work and improve productivity across the company. As a Senior Director, we also expect you to demonstrate the following Maze Leadership Competencies: - Communication and Influence - Role models clear communication and open two-way conversations. - Reinforces an environment where people feel heard and their opinions are valued. - Inspires followership despite differing initial opinions. - Teamwork and Collaboration - Champions collaboration and connection across Maze. - Establishes team norms and expectations. - Seeks opportunities to spotlight team and individual contributions. - Execution and Results - Develops recommendations to seize opportunities and mitigate obstacles that could impact long-term success. - Coaches others on resource management and delegation. - Aligns work to Maze’s strategy, mission, and vision. - Develop Others and Self - Develops staff capabilities to take on greater responsibility. - Encourages staff to pursue meaningful stretch goals. - Identifies ways to strengthen inclusive leadership. ## What We’re Looking For - 15+ years of progressive IT experience, including 5+ years in technology leadership. - Experience in biotechnology, pharmaceutical, life sciences, or another highly regulated environment; clinical-stage and public-company experience strongly preferred. - Demonstrated success leading enterprise IT in a cloud-first, SaaS-based environment. - Experience managing MSPs and strategic technology partners. - Strong cybersecurity, business continuity, disaster recovery, and compliance experience. - Familiarity with SOX, GDPR, GxP, GAMP 5, and computer system validation. - Experience supporting enterprise applications, identity and access management, endpoint management, networking, and end-user services. - Experience improving operations through automation and emerging technologies, including AI. - Strong business judgment, communication skills, and ability to partner effectively with senior leaders and cross-functional teams. - Demonstrated ability to lead through change while remaining hands-on when needed. What Sets You Apart You’re a technology leader who enjoys building strong teams, improving operations, and solving business problems. You can move comfortably between strategy and execution, know how to get the best from MSPs without outsourcing accountability, and believe IT should be a trusted partner that makes the company more secure, productive, and effective. You bring curiosity about emerging technologies and AI, balanced with strong judgment around security, privacy, compliance, and business value. ## About Maze Therapeutics Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease. Our People Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. Our Core Values Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. Stand True – Our integrity is foundational; it guides us no matter the obstacle. The expected annual salary range for employees located in the San Francisco Bay Area is $270,000-330,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. #LI-Hybrid ## About Maze Therapeutics ## Company Overview - **One-liner**: Maze Therapeutics is a clinical-stage biopharmaceutical company developing small molecule precision medicines for common diseases, primarily kidney disease, by leveraging human genetics and its proprietary Compass platform. - **Entity Type**: Public (NASDAQ: MAZE) - **Headquarters**: South San Francisco, California, United States - **Founded**: 2018 - **Founders**: Not publicly listed as individual founders; the company was established by a team of geneticists and industry veterans. ## Core Business - **Primary industry/industries**: Biotechnology / Biopharmaceuticals (Precision Medicine) - **Target customers**: B2B (partners and investors), B2C (patients with APOL1-mediated kidney disease, chronic kidney disease, and phenylketonuria) - **Mission or purpose statement**: "Harnessing the power of genetics to transform the lives of patients" by translating genetic insights into effective precision medicines. ## Products & Services - **MZE829 (Lead Program)**: An oral, small molecule, dual-mechanism APOL1 inhibitor for the treatment of APOL1-mediated kidney disease (AMKD). Recently reported positive topline Phase 2 HORIZON trial data. - **MZE782 (SLC6A19 Inhibitor)**: A precision medicine in development for chronic kidney disease (CKD) and phenylketonuria (PKU), currently in clinical trials. - **Maze Compass™ Platform**: A proprietary platform that leverages variant functionalization to link genetic variants to disease pathways, enabling the discovery and design of precision medicines. - **Other Pipeline Programs**: Several additional programs in drug discovery targeting renal, cardiovascular, and metabolic diseases. ## Market Standing - **Valuation/Market Cap**: Approximately **$1.48 Billion** (as of mid-2026, per CB Insights market cap data). - **Key Metric**: **Total Raised** (including IPO): **$496 Million**. The company also announced a **$150 Million registered offering** in 2026. - **Notable Investors/Partners**: Key investors include **Third Rock Ventures**, **Gilead Sciences**, **Genentech**, **Denali Therapeutics**, and **Calico Life Sciences** (as top talent sources and likely institutional backers). The company went public via a PIPE/IPO structure. - **Growth Signals**: - Positive topline data from the Phase 2 HORIZON trial of MZE829 (announced March 2026). - Three clinical-stage programs and several discovery-stage programs. - Active job postings increased by **120% year-over-year**. - Headcount of approximately 150 employees (based on LinkedIn data showing ~150 total employees). ## Competitive Advantages - **Proprietary Compass Platform**: A unique, data-driven platform that functionally validates genetic variants, giving Maze a differentiated ability to identify and target disease-causing pathways that are often overlooked. - **Focus on Common Diseases**: Unlike many precision medicine companies that focus on rare diseases, Maze targets large, unmet medical needs (e.g., chronic kidney disease), which represents a massive market opportunity. - **Strong Genetic Foundation**: The company’s entire strategy is built on robust human genetic evidence, reducing the risk of late-stage clinical failures and increasing the probability of success. - **Experienced Leadership Team**: The team includes veterans from leading biotech and pharma companies (Gilead, Genentech, Amgen), providing deep industry expertise in drug development and commercialization. ## Strategic Focus - **Advance Lead Programs**: Primary focus is on progressing MZE829 through Phase 2/3 trials for APOL1-mediated kidney disease and advancing MZE782 for CKD and PKU. - **Expand Pipeline**: Leveraging the Compass platform to identify and develop additional precision medicines for renal, cardiovascular, and metabolic diseases. - **Clinical Data Generation**: Delivering key clinical readouts to support regulatory filings and potential partnerships. - **Commercial Preparation**: Building the infrastructure and team (e.g., Senior Director, Talent Acquisition; Senior Director, Pharmaceutical Development) to prepare for potential late-stage success and launch. ## Why Work Here - **Mission-Driven Culture**: The company is deeply committed to "harnessing the power of genetics to transform the lives of patients," with core values of "Impact Obsessed," "Stand True" (integrity), and "Further Together" (teamwork and resilience). - **Supportive Work Environment**: Maze promotes a culture that encourages "vision, initiative, and the development of talent," with a "stimulating atmosphere where people enjoy coming to work." - **Comprehensive Benefits**: Offers "comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of employees and their families." - **Equal Opportunity Employer**: Committed to diversity and non-discrimination. - **Growth Trajectory**: As a public clinical-stage company with positive clinical data and a 120% increase in job postings year-over-year, there are significant opportunities for career growth and impact. - **Location**: Based in South San Francisco (a major biotech hub), though specific remote/hybrid policy is not publicly detailed. ## Sources 1. [mazetx.com](https://mazetx.com/) 2. [mazetx.com](https://mazetx.com/about-us/) 3. [mazetx.com](https://mazetx.com/careers/) 4. [cbinsights.com](https://www.cbinsights.com/company/maze-therapeutics) 5. [linkedin.com](https://www.linkedin.com/company/mazetx) ## Other roles at Maze Therapeutics - [Manager, Chemical Development](https://feeny.ai/job/manager-chemical-development-maze-therapeutics-south-san-francisco-8x7qw5qcxd7k) — South San Francisco, CA - [Trial Master File Sr. Manager, Clinical Operations](https://feeny.ai/job/trial-master-file-sr-manager-clinical-operations-maze-therapeutics-south-san-qyae6d13b97b) — South San Francisco, CA - [Senior Project Manager, Clinical Operations](https://feeny.ai/job/senior-project-manager-clinical-operations-maze-therapeutics-south-san-francisco-tdcv9cmr2ey2) — South San Francisco, CA - [Director, Clinical Business Operations](https://feeny.ai/job/director-clinical-business-operations-maze-therapeutics-south-san-francisco-asppwh94sg0p) — South San Francisco, CA - [Oversight Director, Clinical Operations](https://feeny.ai/job/oversight-director-clinical-operations-maze-therapeutics-south-san-francisco-qxwr1q6bq364) — South San Francisco, CA - [Director, Clinical Operations](https://feeny.ai/job/director-clinical-operations-maze-therapeutics-south-san-francisco-8bfjmd3vbqe7) — South San Francisco, CA - [Director, Medical Writing](https://feeny.ai/job/director-medical-writing-maze-therapeutics-south-san-francisco-8ar22n6wfbe9) — South San Francisco, CA - [Senior Medical Director](https://feeny.ai/job/senior-medical-director-maze-therapeutics-south-san-francisco-p9vqa6q3dn5f) — South San Francisco, CA - [Director, Data Management](https://feeny.ai/job/director-data-management-maze-therapeutics-south-san-francisco-g2r1x3jr1v40) — South San Francisco, CA