--- title: 'Senior Director, Real World Data (RWD) at Freenome' canonical: 'https://feeny.ai/job/senior-director-real-world-data-rwd-freenome-remote-djm04bx8qkbm' type: 'job' last_seen: '2026-09-07' --- # Senior Director, Real World Data (RWD) at Freenome - **Company:** Freenome - **Location:** Remote - **Work type:** remote - **Posted:** 2026-07-24 - **Last confirmed live:** 2026-09-07 - **Apply:** https://job-boards.greenhouse.io/freenome/jobs/8649444002 ## Job description About this opportunity: As the Senior Director of Real World Data (RWD), you will be accountable for defining, developing, and implementing our RWD strategy, platform, and data pipeline to transform diverse real-world datasets into regulatory-grade, research-ready assets that drive our clinical development, evidence generation, digital health products and product offerings. You will play a key role informing regulatory decisions, improving clinical trial efficiency, evaluating and implementing AI/agentic workflows to strengthen our RWD platform and help bridge the gap between clinical research and medical practice to improve patient outcomes and advance our vision of a world without disease. The Senior Director will lead all informatics aspects of developing and maintaining a “regulatory-grade” RWD pipeline.  Specifically, the Senior Director will lead the RWD Informatics team in turning electronic health records (EHR), claims, imaging, and other RWD sources into research-ready datasets accessible by our biostatisticians,computational scientists and other end users while ensuring data quality, operational efficiency, and scalability. These efforts will contribute to developing and commercializing a portfolio of early cancer detection products — based on both clinical and multiomics data — and digital health solutions that will enable payers, providers, and patients to catch cancers early when curative intervention is most achievable. The role reports to the Chief Product Officer. This role will be a Remote role. What you’ll do: - Lead the operations and continuous improvement of our RWD curation pipeline, managing internal and external resources as needed. Evaluate and integrate agentic workflows and AI to ensure accuracy, augment the interpretability and quality, and drive efficiencies across our RWD efforts.  This includes: - Designing and implementing processes, analytical methods, and AI tools to integrate a variety of RWD sources. - Preparing data for analysis, including data cleaning and mapping. - Ensuring “regulatory-grade” data quality where required. - Developing a scalable unstructured data curation operation, leveraging automation as much as possible and only transiently leveraging manual techniques with a roadmap towards eliminating these steps as appropriate. - Create a comprehensive, multi-year strategy for the acquisition, management, curation, and use of RWD to support regulatory submissions, clinical evidence generation, health economics and outcomes research (HEOR), and commercial efforts such as patient identification and care navigation. - Architect, build, and maintain a robust, efficient, and scalable RWD platform and pipeline capable of ingesting, linking, harmonizing, and curating large, complex, and disparate real-world datasets such as Electronic Health Records (EHRs), claims data, imaging, and registries of structured and unstructured data. - Lead clinical data analyses to support product strategy, development and commercialization to improve Freenome’s access to RWD and enhance future product offerings for HCOs. - Serve as the RWD expert, proactively collaborating with Clinical Development, Biostatistics, Regulatory Affairs, Medical Affairs, Engineering, Science and Product and Commercial teams to ensure the RWD pipeline meets diverse end-user needs, clinical, scientific and commercial objectives. - Contribute to defining the strategic direction of Freenome's data initiatives, in partnership with senior leadership and cross-functional teams. - Support data acquisition by conducting technical due diligence, facilitating data acquisition agreements and defining data delivery specifications and lead data product implementation efforts into Freenome’s platforms with strategic partners and customers. - Oversee the translation of raw RWD datasets into research-ready, regulatory-grade datasets, following OMOP or other industry-standard models, suitable for rigorous statistical analysis and real-world evidence (RWE) generation. - Foster a quality mindset through data quality checks, governance policies, and standard operating procedures (SOPs) to ensure the integrity, privacy, security, and traceability of all RWD assets to meet regulatory requirements. - Develop the team, building technical and leadership capabilities and coaching for high-performance proficiency. - Directly lead a team of clinical informaticists and data analysts through clear direction and priorities and hands-on management to enable focused execution in alignment with company objectives. - Manage the RWD department budget, ensuring efficient resource utilization and allocation of expenditures. - Build and maintain a culture of collaboration and inclusivity both within RWD and cross-functionally across Freenome. Must haves: - Master’s or Ph.D. in Biostatistics, Epidemiology, Health Informatics, Computer Science, or a related quantitative field. - At least 12 years of progressive experience in clinical informatics, including experience with: - EHR, claims, other structured and unstructured RWD, and molecular data. - Applying RWD to device, therapeutic and/or software product development. - RWD across multiple disease areas, including oncology. - At least 10 years of experience building and leading high-performing, multi-disciplinary teams. - Demonstrated success operating within a matrixed organization and proactively collaborating with teams of internal and external partners to guide product delivery from concept to completion. - Passion for getting in the trenches, leading by example, and scaling technical platforms and teams. - Excellent written and verbal communicator with strong stakeholder management capabilities and problem-solving skills. - Experience leading data modeling, terminology normalization, data curation and/or unstructured data abstraction via natural language processing (NLP). - Deep knowledge of ontologies commonly used by health systems and payers (ICD-10, HCPCS, CPT, LOINC, RxNorm). - Experience with Python, R, and/or SQL. Nice to haves: - Experience supporting real-world evidence FDA submissions or payer/guideline dossiers. - Clinical background (MD, NP, RN, or similar) and/or degree in health informatics. - Experience with cloud-based data storage and processing environments (e.g. AWS, Azure, GCP). - Experience working directly with health systems or data vendors on data licensing and ingestion projects. Benefits and additional information: The US target range of our base salary rate for new hires is $236,300 - $335,475. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.  Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ [freenome.com/job-openings/](http://freenome.com/job-openings/) for additional company information. Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Applicants have rights under Federal Employment Laws. - https://www.dol.gov/agencies/whd/posters/fmla - https://www.dol.gov/agencies/ofccp/posters - https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act California applicants please review the CCPA Notice at Collection here: - https://www.freenome.com/ccpa-privacy-notice-for-freenome-california-job-applicants/ ## #LI-REMOTE ## About Freenome ## Company Overview - **One-liner**: Freenome is a biotechnology company developing blood-based multi-omics tests powered by machine learning to detect cancer in its earliest, most treatable stages. - **Entity Type**: Private (Late Stage) – raised over $2B in total funding; stock symbol FRNM (NASDAQ) is associated with a related SPAC entity but the operating company remains privately held [linkedin.com] - **Headquarters**: Brisbane, California, United States - **Founded**: 2014 - **Founders**: Riley Ennis (Co-Founder and Chief Product Officer) and others [freenome.com] ## Core Business - **Primary industry**: Biotechnology / Early Cancer Detection - **Target customers**: B2B (health systems, insurers, employers) and B2C (patients via healthcare providers) - **Mission**: To create tools that empower everyone to prevent, detect, and treat their disease, starting with early cancer detection. ## Products & Services - **Freenome Multi-Omics Blood Test (Colorectal Cancer)**: A next-generation blood test that uses a multi-omics platform (cell-free DNA, methylation, proteins, etc.) combined with machine learning to detect early-stage colorectal cancer and advanced adenomas. Type: Diagnostic test (IVD) – currently under clinical validation and regulatory review [freenome.com]. ## Market Standing - **Valuation / Market Cap**: Not publicly disclosed (private). Total funding of $2.07B (LinkedIn estimate) or $1.428B (CB Insights); conflicting reports reflect different counting methods [linkedin.com], [cbinsights.com] - **Key Metric (Funding)**: Most recent round – $75M corporate round (Nov 2025) led by Roche, plus $254M venture round (Feb 2024) also led by Roche [linkedin.com] - **Notable Investors**: Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis, American Cancer Society’s BrightEdge Ventures, Exact Sciences [linkedin.com], [freenome.com] - **Growth Signals**: - Blood-based test included in updated American Cancer Society colorectal cancer screening guideline - Appointed industry veteran Rob Guigley as Chief Commercial Officer (2025) - Ongoing clinical programs for multiple cancer types - Employee headcount of 304 with 22 active job postings (as of mid-2025) [linkedin.com] ## Competitive Advantages - **Multi-omics + AI platform**: Combines multiple biological signals (DNA methylation, fragmentomics, proteins) with proprietary machine learning algorithms to achieve high sensitivity and specificity for early-stage cancer. - **Strong clinical program**: Rigorous multi-site studies and partnerships with leading health systems (e.g., Kaiser Permanente). - **Deep investor backing**: Long-term support from top healthcare investors and strategic partners (Roche, Exact Sciences) provides capital and commercial pathways. - **First-mover in multi-cancer blood screening**: Focus on colorectal cancer as first indication, with potential to expand to other cancers. ## Strategic Focus - **Clinical validation & regulatory approval**: Completing pivotal studies and preparing FDA submission for colorectal cancer test. - **Commercial launch preparation**: Building commercial team (hiring Strategic Account Executives, VP Revenue Cycle Management) and establishing relationships with payers and health systems. - **Platform expansion**: Extending multi-omics technology to additional cancer types (lung, pancreatic, etc.) through research programs. ## Why Work Here - **Mission-driven culture**: Employees are motivated by the opportunity to “outpace cancer” and make a tangible impact on patient lives. Values include integrity, empathy, trust, servant leadership, and striving for greatness [freenome.com]. - **Equity ownership**: Every U.S. full-time employee receives equity packages, aligning personal success with company milestones [freenome.com/careers]. - **Competitive benefits**: Comprehensive medical plans, wellness programs, generous PTO, 12 paid holidays, annual bonus opportunities, and market-based salaries [freenome.com/careers]. - **Collaborative environment**: Cross-functional teams across clinical, scientific, and business domains; emphasis on respect and inclusion [freenome.com/careers]. - **Work model**: Likely office-based in Brisbane, CA (hybrid flexibility not explicitly stated). The company has a physical lab and office presence. - **Engineering & science culture**: Opportunity to work with state-of-the-art multi-omics data, machine learning, and clinical trial design. The team includes senior ML scientists, computational biologists, and software engineers. ## Sources 1. [freenome.com](https://www.freenome.com/) – Company overview, leadership, values, products 2. [freenome.com/careers](https://www.freenome.com/careers/) – Benefits, culture, job openings 3. [linkedin.com/company/freenome](https://www.linkedin.com/company/freenome) – Employee count, revenue estimate, funding rounds, investor list, recent hires and departures 4. [cbinsights.com/company/freenome](https://www.cbinsights.com/company/freenome) – Funding total, company description, patent activity ## Other roles at Freenome - [Help Desk Specialist (Contractor)](https://feeny.ai/job/help-desk-specialist-contractor-freenome-brisbane-ypj66zndzpfp) — Brisbane, CA - [Senior Bioinformatics Research Engineer](https://feeny.ai/job/senior-bioinformatics-research-engineer-freenome-brisbane-jqm79zg6pz00) — Brisbane, CA - [Senior Development Scientist I](https://feeny.ai/job/senior-development-scientist-i-freenome-brisbane-q9tqegw3c6c4) — Brisbane, CA - [Senior Research Associate](https://feeny.ai/job/senior-research-associate-freenome-brisbane-tsgfk8fbvpav) — Brisbane, CA - [Computational Biologist](https://feeny.ai/job/computational-biologist-freenome-remote-989vnftsd0w5) - [Staff Computational Biologist](https://feeny.ai/job/staff-computational-biologist-freenome-remote-9yh259vcdkp1) - [Strategic Account Executive (South)](https://feeny.ai/job/strategic-account-executive-south-freenome-remote-yr0frzr784de) - [Vice President, Product Management](https://feeny.ai/job/vice-president-product-management-freenome-brisbane-sk773jd0f1tq) — Brisbane, CA - [Research Associate I/II](https://feeny.ai/job/research-associate-i-ii-freenome-brisbane-b2v3jsj88dmn) — Brisbane, CA - [Research Scientist I/II](https://feeny.ai/job/research-scientist-i-ii-freenome-brisbane-t4ngtdsjkvhc) — Brisbane, CA