---
title: 'Senior Director, US Medical Lead LC-FAOD and MPSs at Ultragenyx Pharmaceutical'
canonical: 'https://feeny.ai/job/senior-director-us-medical-lead-lc-faod-and-mpss-ultragenyx-pharmaceutical-e9cazv3hfwnx'
type: 'job'
last_seen: '2026-09-14'
---

# Senior Director, US Medical Lead LC-FAOD and MPSs at Ultragenyx Pharmaceutical

- **Company:** Ultragenyx Pharmaceutical
- **Location:** United States
- **Compensation:** $271k–$334k
- **Work type:** remote
- **Posted:** 2026-08-18
- **Last confirmed live:** 2026-09-14
- **Apply:** https://job-boards.greenhouse.io/ultragenyxpharmaceutical/jobs/4725352005?gh_jid=4725352005

## Job description

Why Join Us?

Be a hero for our rare disease patients

At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won’t go – challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them.

Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth – so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.

If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team.

Position Summary:

ultraimpact – Make a difference for those who need it most

Ultragenyx is seeking an accomplished medical affairs leader, motivated by working in a highly scientific, innovative, and fast-paced environment, and driven to lead the future of rare disease medicine. This exceptional leader must have deep scientific knowledge, strong business acumen, and exemplary communication skills. The Senior Director will play a key medical leadership role in the LC-FAOD and MPS franchises for the US region, supporting assets with distinct lifecycle management cycles.

Work Model:

Remote: Officially documented as working full-time from home, with travel to Ultragenyx's offices or other locations on occasion as needed.

Responsibilities:

- Serve as the medical lead for LC-FAOD, MPS VII and MPS IIIA, accountable for the regional pull-through of the global medical strategy, and the development and timely execution of US tactical plans aligned to brand strategy and lifecycle priorities
- Serve as the UX111 US medical launch team, accountable for developing and leading the execution of a robust medical launch plan, partnering closely with the Field Medical and Gene Therapy Treatment Teams.  Provide clear directions to teams to ensure successful execution of the launch plan
- Accountable to define and deliver meaningful strategic goals that demonstrate measurable impact on medical affairs and business outcomes
- Lead and/or implement US data generation activities aligned to the integrated evidence plan/US medical needs and provide medical leadership for associated evidence dissemination activities
- Build and maintain strong relationships with key opinion leaders (KOLs); integrate insights into strategic planning and lead collaborations on priority initiatives, such as advisory boards, QTC connect meetings and payer education as needed
- Provide deep disease area and product expertise, ensuring accurate and consistent communication of clinical and scientific data
- Lead US conference strategy, including the delivery of scientific education symposia and other educational events that advance HCP knowledge and understanding of assigned programs
- Collaborate closely with the US field medical team, supporting the full cycle of strategic insights generation through to action
- Ensure development of impactful scientific resources (slide decks, FAQs, educational materials) for use by US field teams
- Represent US medical and serve as an active contributor to the Global Medical Strategy Team on all assigned programs, ensuring that US insights inform global strategy
- Provide medical and scientific expertise for promotional and non-promotional materials/medical affairs review committees, ensuring scientific accuracy, strategic alignment, suitability for use and compliant with US regulations
- Collaborate effectively with the Global Medical team and other cross-functional partners, including all commercialization functions, patient advocacy, clinical development, HEOR, diagnostics, scientific communications and publications and regulatory

Requirements:

- MD with specialty training in metabolic genetics, with rare disease expertise, or PhD with substantial, relevant experience in the LC-FAOD and MPSs
- At least five years’ experience in pharmaceutical/biotechnology industry, including US medical affairs
- Demonstrated ability to develop and execute medical launch strategies in the US market is highly preferred
- Proven leadership skills, including ability to navigate ambiguous situations and collaborate with cross functional teams on complex initiatives to drive alignment and decision-making
- High aptitude for attention to detail, commitment to high-quality work, and sense of passion and urgency to achieve goals and improve the lives of patients
- Proven ability to take initiative and drive successful execution of complex projects
- Highly analytical and strategic thinker with the ability to identify interdependencies, consider medical implications, and understand broader program and organizational goals
- Excellent communication skills, with the ability to articulate scientific and strategic concepts in both written documents and verbal presentations
- Proactive, highly organized and manages shifting priorities in rapidly changing environment
- Willingness and ability to travel up to 15% of the time

#LI-CS1 #LI-Remote The typical annual salary range for this full-time position is listed below. This range reflects the characteristics of the job, such as required skills and qualifications and is based on the office location noted in this job posting. The range may also be adjusted based on applicant's geographic location.

This position is eligible for annual bonus and equity incentives. Actual individual pay is determined by demonstrated experience and internal equity alignment.

Pay Range $270,500—$334,100 USD

Full Time employees across the globe enjoy a range of benefits, including, but not limited to:

- Generous vacation time and public holidays observed by the company
- Volunteer days
- Long term incentive and Employee stock purchase plans or equivalent offerings
- Employee wellbeing benefits
- Fitness reimbursement
- Tuition sponsoring
- Professional development plans
- Benefits vary by region and country

Ultragenyx Pharmaceutical is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status, and any other status or classification protected by applicable federal, state, and/or local laws. Reasonable accommodation will be provided for all protected statuses or classifications protected by applicable law, including individuals with disabilities, disabled veterans, for pregnancy, childbirth, and related medical conditions, and based on sincerely held religious beliefs. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, you may contact Talent Acquisition by emailing us at talentacquisition@ultragenyx.com.

See our [CCPA Employee and Applicant Privacy Notice](https://www.ultragenyx.com/CCPA-Notice/).

See our [Privacy Policy](https://www.ultragenyx.com/privacy-policy/).

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation.  Inquiries on developing a recruiting relationship with us, may be directed to: [talentacquisition@ultragenyx.com](http://mailto:talentacquisition@ultragenyx.com/).

## About Ultragenyx Pharmaceutical

## Company Overview
- **One-liner**: Ultragenyx Pharmaceutical is a biopharmaceutical company dedicated to developing and commercializing first-ever treatments for rare and ultra-rare genetic diseases with high unmet medical need.
- **Entity Type**: Public (NASDAQ: RARE)
- **Headquarters**: Novato, California, United States
- **Founded**: 2010
- **Founders**: Emil D. Kakkis, M.D., Ph.D.

## Core Business
- **Primary industry/industries**: Biotechnology research; rare disease therapeutics (metabolic, bone, endocrine, muscle, and central nervous system disorders).
- **Target customers**: B2B (healthcare providers, payers, government agencies) and B2C (patients and patient advocacy groups).
- **Mission or purpose statement**: “Transform the lives of those living with rare diseases” (ultragenyx.com).

## Products & Services
- **Crysvita (burosumab)**: Approved for X-linked hypophosphatemia (XLH) – a biologic therapy.
- **Dojolvi (triheptanoin)**: Approved for long-chain fatty acid oxidation disorders (LC-FAOD) – a small molecule.
- **Mepsevii (vestronidase alfa)**: Approved for mucopolysaccharidosis VII (Sly syndrome) – an enzyme replacement therapy.
- **Evinacumab-dgnb (non-U.S. rights)**: Approved by FDA and EMA for homozygous familial hypercholesterolemia; marketed outside the U.S. under a partnership with Regeneron.
- **Pipeline**: A diverse portfolio across multiple modalities – gene therapies, antisense oligonucleotides (ASOs), mRNA therapies – targeting ultra-rare diseases in bone, endocrine, metabolic, muscle, and CNS categories (ultragenyx.com).

## Market Standing
- **Valuation/Market Cap**: ~$3.3 billion (as of June 2026, per LinkedIn company page and market data).
- **Key Metric**: Annual revenue of $673 million (most recent fiscal year); total funding of $1.55 billion (including Series A, post-IPO equity, and debt).
- **Notable Investors/Partners**:
  - Investors: Ontario Municipal Employees Retirement System (led $400M post-IPO debt in 2025), multiple venture and institutional investors.
  - Partners: Kyowa Hakko Kirin, Daiichi Sankyo, Mereo BioPharma, Regeneron (non-U.S. commercial rights for evinacumab).
- **Growth Signals**:
  - One of the largest and most diverse pipelines in rare disease.
  - Awarded “Best Place to Work” by BioSpace (2020, 2021) and recognized by Deloitte’s Fast 500.
  - Active job postings: 21 openings as of mid-2026 (LinkedIn), though headcount declined 1.9% YoY to 1,247 employees.
  - Recent news: Ultragenyx Reports Inducement Grant Under Nasdaq Listing Rule 5 (June 2026).

## Competitive Advantages
- **Ultra-rare focus**: Targets diseases with no approved therapies, creating first-ever treatments and building significant regulatory and commercial expertise.
- **Multi-modality platform**: Expertise across biologics, small molecules, gene therapies, ASOs, and mRNA – reducing risk and expanding addressable disease space.
- **Global infrastructure**: Operations in 20 countries (including Brazil, Switzerland, Mexico, Japan) and commercial presence in North America, Europe, Latin America, and Asia.

## Strategic Focus
- **Commercial expansion**: Hiring for Commercial and Medical Affairs teams to support growing product portfolio.
- **Gene therapy manufacturing**: Building a new gene therapy manufacturing facility in the Boston area to scale production for pipeline candidates.
- **Pipeline advancement**: Continued clinical development of gene therapies, ASOs, and mRNA programs for ultra-rare indications.

## Why Work Here
- **Culture**: Described as “inclusive, generous, curious, and humble,” with a strong emphasis on purpose and patient impact. Named a top workplace by BioSpace and Deloitte.
- **Benefits**: Comprehensive coverage starting on day one for all regular full-time employees; includes robust health, retirement, and wellness programs.
- **Work environment**: Hybrid/office model with multiple U.S. hubs (Novato, Brisbane, Boston area) and international offices. Employer rating on LinkedIn: 3.3/5 (324 reviews) with culture rated 3.5, compensation 4.0, and work-life balance 3.2.
- **Career development**: Internships, seasonal co-ops, and postdoctoral programs; strong alumni pipeline to top biopharma companies (Genentech, BioMarin, Vertex, Amgen).

## Sources
1. [ultragenyx.com](https://www.ultragenyx.com/)
2. [ultragenyx.com – Join Our Team](https://www.ultragenyx.com/join-our-team/)
3. [ultragenyx.com – Current Opportunities](https://www.ultragenyx.com/join-our-team/current-opportunities/)
4. [LinkedIn Company Page](https://www.linkedin.com/company/ultragenyx)
5. [talent.ultragenyx.com](https://talent.ultragenyx.com/)
6. [Greenhouse Careers Page](https://job-boards.greenhouse.io/ultragenyxpharmaceutical)

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