---
title: 'Senior Fullstack Engineer at Orchestra Bio'
canonical: 'https://feeny.ai/job/senior-fullstack-engineer-orchestra-bio-san-francisco-ef6twv02mxwc'
type: 'job'
last_seen: '2026-09-07'
---

# Senior Fullstack Engineer at Orchestra Bio

- **Company:** Orchestra Bio
- **Location:** San Francisco, CA
- **Employment:** full-time
- **Work type:** hybrid
- **Posted:** 2025-10-09
- **Last confirmed live:** 2026-09-07
- **Apply:** https://jobs.ashbyhq.com/orchestra-bio/a4a1f2b7-16e0-49b4-b123-d8bab1fd6939

## Job description

## ABOUT ORCHESTRA

Orchestra helps companies navigate the journey from discovery to medicine by connecting science, operations, and finance in an intelligent platform. We're on a mission to make every R&D dollar count.

Developing new medicines is a societal imperative to improve human health and reduce medical costs. Brilliant science needs effective management to develop breakthrough medicines that reach patients. We aim to bring the same level of sophistication to scientific development that modern tools brought to software development. While software teams can ship updates daily, R&D organizations face unique challenges: years long development cycles, complex interdependencies, and high-stakes decisions that can make or break billion dollar programs.

Founded by early Benchling leaders, we just emerged from stealth with $20M in funding from 8VC, Andreessen Horowitz, Insight Partners, Definition, and Haystack to transform how biotech companies operate. Our customers are working on society's most important challenges, including neurodegeneration, cancer, metabolic disease, and biomanufacturing. We're looking for engineers who are excited about building software that helps scientific organizations operate more effectively.

## THE ROLE

We're seeking a Senior Fullstack Engineer to join our growing team in San Francisco. You'll work with our team to create complex but intuitive products to manage R&D.

## CHALLENGES YOU'LL TACKLE

Complex Decision Making: Build interactive tools that help organizations model different paths to market for their discoveries, assessing complex trade offs between time, money, and technical risk. Our users need to understand how decisions today affect their programs years into the future.

Organizational Alignment: Create intuitive interfaces that help diverse teams (scientists, program managers, executives) understand how their work connects to broader company goals. This includes designing clear ways to visualize complex dependencies and communicate progress across teams.

Scientific Operations: Design interfaces that scientists and researchers use daily to manage their studies, track progress, and coordinate with their teams. This requires crafting experiences that empower rather than get in the way of work.

AI Powered R&D Management: Leverage LLMs to help teams generate and evaluate scenarios, infer scientific progress and risks from unstructured data, and surface critical insights from across their R&D portfolio.

## WHAT SETS YOU APART

Complexity: You understand how to build software for complex, interconnected domains where changes in one area cascade across multiple dimensions. You're excited about creating systems that handle the unique challenges of long term, high stakes R&D programs.

Agency: You're drawn to environments where you can shape both the technical architecture and product direction. You enjoy the responsibility of building foundational systems that will scale, balancing the speed needed at an early stage company with the craftsmanship required for complex, mission critical software.

Curiosity: You're genuinely curious about how breakthrough products are developed and excited about building software that helps scientific organizations operate more effectively. You want your technical work to contribute to bringing medicines and other innovations to market.

## QUALIFICATIONS

## REQUIRED

- 6-8 years of frontend or fullstack engineering experience
- Deep expertise in React and modern JavaScript/TypeScript
- Strong understanding of frontend architecture
- Excellent communication skills and ability to collaborate with product and design
- Proven track record of working effectively in small, fast-moving engineering teams

## PREFERRED

- Experience building sophisticated data visualization UIs
- Background in high domain complexity
- Track record of mentoring other engineers

## About Orchestra Bio

## Company Overview
- **One-liner**: Orchestra Bio provides an agentic operations platform that unifies scientific, operational, and financial planning to reduce the complexity of drug development for life sciences R&D organizations.
- **Entity Type**: Private (Seed Stage)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2022
- **Founders**: Ashoka Rajendra (CEO), Andy Xu (CTO)

## Core Business
- **Primary Industry**: Life Sciences R&D Management / Enterprise Software for Biotech
- **Target Customers**: B2B; biotech companies, CROs, CDMOs, and biopharma partners; R&D leadership, program managers, and scientific teams
- **Mission**: To reduce the operational complexity of developing medicines by providing an intelligent management system for life sciences R&D.

## Products & Services
- **Orchestra Platform**: An agentic operations platform that acts as both a system of record and a system of intelligence. It unifies scientific, operational, and financial context into one environment, enabling teams to build centralized roadmaps, automate operations, and run scenario analyses for drug development decisions. The platform is built on a multi-stage intelligence arc: Unified Planning, Intelligent Operations, and Decision Support.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (Private company)
- **Key Metric**: Raised a $20M Seed round in 2024 from top-tier investors.
- **Notable Investors/Partners**: Andreessen Horowitz, 8VC, Insight Partners, Definition, Haystack.
- **Growth Signals**: Headcount grew ~5.9% YoY to 12 employees; LinkedIn followers grew 37.2% yearly; active job postings increased 200% year-over-year; launched a partnership with BiotechTV at JPM in early 2026.

## Competitive Advantages
- **First-of-its-kind platform**: Orchestra is described as the first platform to unify scientific, operational, and financial context into a single intelligent environment for life sciences R&D.
- **Deep domain expertise**: Founded by engineers, operators, and scientists with firsthand experience in biotech and enterprise software, giving them a unique understanding of the operational burden facing scientific teams.
- **Agentic AI approach**: The platform uses a multi-stage intelligence arc (Unified Planning, Intelligent Operations, Decision Support) to continuously interpret data, acting as both a system of record and a system of intelligence.

## Strategic Focus
- **Product-led growth**: Building a platform that serves as the "operating system for scientific progress," targeting both individual biotechs and the broader collaboration network (CROs, CDMOs, partners).
- **Talent acquisition**: Actively hiring senior engineering talent (Senior Fullstack, Backend, and Platform Engineers) to scale the product and team.
- **Partnership development**: Recently launched a partnership with BiotechTV at JPM, signaling a push for industry visibility and ecosystem integration.

## Why Work Here
- **Mission-driven work**: Employees directly contribute to accelerating the pace of scientific discovery by solving operational challenges for drug development teams.
- **High-impact, early-stage environment**: As a seed-stage company with 12 employees, new hires will have significant ownership and influence over the product and culture.
- **Strong technical team**: The engineering team includes alumni from top tech companies like Apple, Stripe, and Benchling, indicating a high-caliber peer group.
- **Remote/Hybrid Policy**: Not explicitly stated, but the company has two offices in San Francisco, suggesting a preference for in-person or hybrid collaboration.
- **Culture**: The company emphasizes building at the intersection of biotech, intelligence systems, and enterprise tooling, offering a unique challenge for engineers and operators who want to directly accelerate scientific discovery.

## Sources
1. [orchestra.bio](https://orchestra.bio/)
2. [orchestra.bio/about](https://orchestra.bio/about)
3. [LinkedIn](https://www.linkedin.com/company/orchestrabio)
4. [Simplify Jobs](https://simplify.jobs/c/OrchestraBio)
5. [Ashby Careers Page](https://jobs.ashbyhq.com/orchestra-bio)

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