---
title: 'Senior IT Operations Engineer at Profluent'
canonical: 'https://feeny.ai/job/senior-it-operations-engineer-profluent-emeryville-58byesg33whn'
type: 'job'
last_seen: '2026-10-18'
---

# Senior IT Operations Engineer at Profluent

- **Company:** Profluent
- **Location:** Emeryville, CA
- **Compensation:** $167k–$206k
- **Work type:** hybrid
- **Posted:** 2026-09-17
- **Last confirmed live:** 2026-10-18
- **Apply:** https://job-boards.greenhouse.io/profluent/jobs/5427027008

## Job description

Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.

## The Role

The Senior IT Operations Engineer is responsible for the design, deployment, and day-to-day management of the company's entire IT infrastructure. This role owns everything from workstation provisioning and identity/access management to network architecture, cloud environments, backups, and end-user support. The ideal candidate is a hands-on generalist who can move fluidly between strategic infrastructure planning and hands-on troubleshooting, ensuring a secure, reliable, and well-documented technology environment across the organization. This position is reporting to the Director of Security, Compliance & IT.

## Key Responsibilities

- Google Workspace & Productivity Applications
- Administer and support Google Workspace (Gmail, Drive, Calendar, Admin Console) and other Google office applications.
- Manage user accounts, groups, shared drives, permissions, and organizational units.
- Configure security policies, DLP rules, and third-party app integrations within Workspace.
- Rippling Platform Administration
- Manage employee onboarding and offboarding workflows end to end.
- Configure and maintain rule sets, policies, and automation within Rippling.
- Build and maintain deployment scripting for automated device and software provisioning.
- Administer Mobile Device Management (MDM) policies, compliance rules, and app deployment.
- Endpoint Security
- Deploy, configure, and maintain SentinelOne (or equivalent) endpoint anti-virus/EDR across all devices.
- Monitor threat alerts, investigate incidents, and coordinate remediation.
- Network Infrastructure (Meraki)
- Plan, deploy, and optimize Meraki wireless, switching, and security appliances.
- Design and maintain VLAN segmentation, Air-cabbed Lab network, firewall rules, and network security policies.
- Monitor network performance and proactively resolve connectivity issues.
- Physical Access control, Remote Access & Identity Security
- Plan, develop, implement, and maintain keycard access control to office and lab environments.
- Configure and secure VPN solutions for remote access.
- Implement and manage Multi-Factor Authentication (MFA) across systems and applications.
- Collaboration & Cloud Platforms
- Administer Slack workspace settings, integrations, and user access.
- Manage and support cloud environments including GCP and Oracle Cloud infrastructure.
- Storage & Backup
- Maintain Synology NAS systems for storage, file sharing, and backup.
- Implement and test backup/disaster recovery procedures to ensure data integrity.
- Workstation & Device Lifecycle Management
- Prepare, image, and deploy Mac and Windows workstations for new hires and refresh cycles.
- Plan, oversee, and manage system inventory.
- Provide troubleshooting and technical support for hardware and software issues.
- Manage Microsoft WSUS for patch management and Microsoft Office application deployment.
- Conferencing & Collaboration Equipment
- Set up, maintain, and troubleshoot audio/video conferencing equipment in meeting spaces.
- Software & License Management
- Oversee procurement, deployment, and lifecycle of software applications and licensing.
- Maintain an accurate inventory of software licenses and ensure compliance.

## Qualifications

- Bachelor Degree in Information Technology
- 8+ years in a similar IT Operations role; at least 2-3 years in a high-growth startup or solo environment.
- Proven track record and experience in transitioning off an external MSP or managing a solo IT environment at a high-growth startup.
- Profound knowledge of Google Workspace and Google office applications.
- Experience in supporting SOC 2 Type 2 efforts, collecting and providing evidence and log records, review and reporting cadence.
- Hands-on experience with Rippling (or comparable HRIS/IT platform) for onboarding, rules, deployment scripting, and MDM.
- Experience with endpoint protection platforms such as SentinelOne.
- Strong knowledge of Meraki networking (wireless, VLAN, firewall/security).
- Experience configuring and securing VPN and MFA solutions.
- Familiarity with Slack and Jira administration.
- Working knowledge of cloud platforms, particularly GCP and Oracle Cloud.
- Experience with Synology NAS storage and backup systems.
- Proficiency preparing, deploying, and troubleshooting both Mac and Windows workstations.
- Experience with Microsoft WSUS and Microsoft Office application deployment and support.
- Experience setting up and maintaining audio/video conferencing systems.
- Strong understanding of software license management and compliance.
- Excellent problem-solving skills and ability to manage multiple priorities independently.
- Strong communication skills, a customer-service and healthy security mindset.

## Preferred Skills

- Relevant certifications (e.g., CompTIA, Meraki/Cisco, Google Workspace Administrator, Microsoft certifications).
- Experience in a fast-growing or multi-office environment.
- Demonstrates a highly collaborative approach to problem-solving by analyzing challenges and presenting multiple viable solutions to key stakeholders.
- Scripting/automation experience (e.g., Bash, PowerShell, or similar) to support deployment workflows.

## What We Offer

- High-growth opportunity with meaningful impact on the future of protein design
- Competitive compensation package with equity participation
- 401(k) with a strong employer match
- Comprehensive benefits including health/dental/vision insurance
- Generous PTO policy and commitment to work-life balance
- Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire. Hiring Salary Range $167,000—$205,900 USD

NOTICE TO STAFFING AND SEARCH FIRMS: Profluent does not accept unsolicited candidate submissions. We ask that agencies refrain from sending resumes to our careers inbox, hiring managers, or any Profluent employee. Any resume submitted without a signed agreement and an active search request from our Talent team will be treated as the property of Profluent, and no placement fee will be owed.

## About Profluent

## Company Overview
- **One-liner**: Profluent is an AI-first protein design company that develops deep generative models to design and validate novel, functional proteins for biomedicine, agriculture, and other industries.
- **Entity Type**: Private (Series B; total funding $150M)
- **Headquarters**: Emeryville, California, United States
- **Founded**: 2022
- **Founders**: Ali Madani (CEO), Alexander Meeske

## Core Business
- **Primary industries**: Biotechnology, Artificial Intelligence, Genetic Medicine
- **Target customers**: B2B – pharmaceutical companies, biotech firms, agricultural companies, and research institutions
- **Mission statement**: "Decode the language of life with AI" – using AI to author new biology and create solutions that transform medicine, agriculture, and beyond.

## Products & Services
- **OpenCRISPR**: The world's first AI-designed gene editor, made open-source to accelerate genome editing research. Based on a novel nuclease generated by Profluent's generative AI.
- **AI Protein Design Platform**: A proprietary platform that writes proteins from scratch or by reimagining natural scaffolds, enabling rapid design of proteins for therapeutic, industrial, and agricultural applications.
- **Partnerships (e.g., Eli Lilly)**: Collaborations to develop AI-designed recombinases for genetic medicine, with deal value up to $2.25 billion.

## Market Standing
- **Valuation / Market Cap**: Not publicly available
- **Key Metric (Total Funding)**: $150M raised across multiple rounds (Seed $9M in 2022, Venture Round $35M in 2024, Series B $106M in 2025)
- **Notable Investors**: Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, Convergent Ventures
- **Growth Signals**: 
  - Headcount grew 78.4% YoY (53 employees as of mid-2026)
  - Published generative AI research in Nature (July 2025)
  - Secured a landmark partnership with Eli Lilly (up to $2.25B in milestones)
  - LinkedIn followers grew 67.8% in the past year (11,906 followers)

## Competitive Advantages
- **Pioneering AI-first protein design**: One of the few companies translating large language models (LLMs) to biology, with demonstrated ability to create functional gene editors from scratch.
- **Open-source gene editing**: OpenCRISPR-1 provides a freely available AI-designed nuclease, establishing thought leadership and potential ecosystem lock-in.
- **Cross-disciplinary team**: Combines top ML talent (from Salesforce, Meta, Amazon) with leading biologists (from CRISPR pioneers, UCSF, Harvard, Arc Institute).
- **Published in top journals**: Nature publication validates the scientific rigor of their approach.

## Strategic Focus
- Advance AI-designed recombinases for in vivo gene editing through the Lilly partnership
- Expand platform to design enzymes, antibodies, and industrial proteins
- Continue open-source releases to drive adoption and attract top research talent
- Scale headcount across ML, biology, and bioinformatics functions

## Why Work Here
- **Culture & Mission**: Opportunity to work at the frontier of AI and biology, authoring new proteins that can transform medicine and agriculture. Team culture emphasizes curiosity, societal impact, and breakthrough science.
- **Work Policy**: Hybrid – most roles require 2-3 days on-site at the Emeryville, CA headquarters. Some lab-based roles (e.g., in vivo pharmacology, LNP formulation) are fully on-site.
- **Team mix**: Diverse backgrounds spanning ML science, structural biology, software engineering, and drug discovery. Flat structure with direct access to founders and top domain experts.
- **Notable perks**: Backed by top-tier investors; highly collaborative environment; opportunities to publish and release open-source work.
- **Growth trajectory**: Fast-growing company (78% headcount increase in last year) with substantial funding runway and a high-profile pharma partnership, offering strong career progression.

## Sources
1. [profluent.bio](https://www.profluent.bio/)
2. [Greenhouse Jobs at Profluent](http://job-boards.greenhouse.io/profluent)
3. [LinkedIn Company Page](https://www.linkedin.com/company/profluent-bio)
4. [CB Insights Profile](https://www.cbinsights.com/company/profluent-bio)

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