---
title: 'Senior Laboratory Director, Oncology at BillionToOne'
canonical: 'https://feeny.ai/job/senior-laboratory-director-oncology-billiontoone-menlo-park-x3315y8ak0dj'
type: 'job'
last_seen: '2026-09-09'
---

# Senior Laboratory Director, Oncology at BillionToOne

- **Company:** BillionToOne
- **Location:** Menlo Park, CA
- **Posted:** 2026-09-01
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/billiontoone/jobs/4729471005

## Job description

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

BillionToOne is seeking a Senior Laboratory Director, Oncology to lead and own the daily operations of our high-complexity oncology clinical laboratory. Reporting to the SVP of Laboratory Operations, this person owns oncology laboratory operations end to end, with accountability for quality, turnaround time, capacity, cost, and regulatory compliance. This is a full-time, onsite role (2 to 3 days/week) in Menlo Park, CA.

Responsibilities:

- Lead, build, and scale the oncology laboratory organization (technologists, supervisors, and operations managers), including headcount planning, hiring, and competency management.
- Own the oncology laboratory operating budget and P&L, including COGS, operating expenses, and capital equipment planning.
- Drive operational performance against turnaround-time (TAT), throughput, capacity, and quality targets; implement process improvements and automation to scale.
- Lead laboratory scale-up, new-assay and instrument onboarding, inspection readiness, and vendor and capital procurement.
- Provide technical oversight of somatic variant interpretation and oncology report sign-out from Northstar liquid biopsy assays, ensuring accuracy and timeliness.
- Troubleshoot technical issues across oncology workflows (liquid biopsy sample prep, NGS library preparation, sequencing, and data analysis).
- Ensure compliance with CLIA, CAP, and NYSDOH standards; oversee Non-Conforming Events, CAPAs, and documentation of SOPs, validations, QC records, competencies, proficiency testing, and report archives.
- Collaborate with bioinformatics, R&D, and medical affairs on assay development and interpretation guidelines; serve as a subject-matter expert on oncology variant interpretation (AMP/CAP/NYS guidelines).

Qualifications:

- Doctoral degree (PhD, MD, or equivalent) in genetics, molecular biology, or a related field, with board certification (ABMGG, ABP in Molecular Genetic Pathology, or equivalent).
- Valid or eligible for California Clinical Laboratory Director license (CGMB, CGMBS, MD/DO licensure) and New York State CoQ in oncology testing.
- 7+ years in a regulated clinical laboratory environment (CLIA/CAP/NYSDOH), with at least 4 years in molecular oncology testing including NGS.
- Proven leadership developing, validating, and implementing oncology assays (e.g., somatic mutation panels, methylation), with deep knowledge of cancer genomics (tumor heterogeneity, somatic driver mutations, targeted therapies).
- Experience with variant interpretation databases (COSMIC, OncoKB, ClinVar), IGV and BAM file review, and molecular tumor boards; proficiency with LIMS and oncology bioinformatics tools.
- Strong analytical, communication, and organizational skills, with a track record of leading teams in high-growth environments.

Benefits And Perks:

- Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
- Open, transparent culture that includes weekly Town Hall meetings
- The ability to indirectly or directly change the lives of hundreds of thousands patients
- Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
- Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
- Supplemental fertility benefits coverage
- Retirement savings program including a 4% Company match
- Increase paid time off with increased tenure
- Latest and greatest hardware (laptop, lab equipment, facilities)
- Daily on-site lunches provided from top eateries
- A variety of perks on campus (state of the art gym, restaurant)
- Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $471,554 per year, including a base pay range of $246,525 - $267,962 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. For more information about how we protect your information, we encourage you to review our [Privacy Policy](https://billiontoone.com/privacy-policy/).

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

[Unity Complete™](https://www.unityscreen.com/) is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. [Unity Confirm™](https://www.unityscreen.com/webinars/confirm-gc) enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology. Our [Northstar®](https://www.northstaronc.com/) liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at[billiontoone.com](https://www.billiontoone.com)

## About BillionToOne

## Company Overview
- **One-liner**: BillionToOne is a precision diagnostics company that uses a proprietary molecular counting platform to improve disease detection through non-invasive prenatal screening and liquid biopsy for cancer.
- **Entity Type**: Private; raised over $699M in funding across multiple rounds (Series A, B, C, debt)
- **Headquarters**: Menlo Park, California, United States
- **Founded**: 2016
- **Founders**: Oguzhan Atay, PhD; David Tsao, PhD

## Core Business
- **Primary industry**: Precision molecular diagnostics / Biotechnology
- **Target customers**: Healthcare providers, hospitals, clinics, oncologists, and prenatal care specialists (B2B); ultimately serves patients (B2C)
- **Mission or purpose statement**: "To remove the fear of the unknown by providing molecular diagnostics that are accurate, fast, and accessible."

## Products & Services
- **Northstar Select®**: A pan-cancer liquid biopsy test that guides therapy selection by identifying actionable genomic alterations from a single blood draw.
- **Northstar Response®**: A complementary liquid biopsy test for real-time treatment response monitoring, detecting resistance and tracking tumor dynamics earlier than imaging.
- **PrenatalUnity Complete®**: The first non-invasive prenatal test (NIPT) that uses cell-free DNA to assess fetal risk for recessive conditions and aneuploidy from a single maternal blood sample at 9+ weeks.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed for private company; See "Funding" below.
- **Key Metrics**:
  - **Annual Revenue**: $305.1M (as of most recent estimate) [linkedin.com](https://www.linkedin.com/company/billiontoone)
  - **Total Funding**: $699.1M [linkedin.com](https://www.linkedin.com/company/billiontoone)
  - **Headcount**: 616 employees (+44% YoY growth) [linkedin.com](https://www.linkedin.com/company/billiontoone)
- **Funding Rounds**:
  - Seed Round (2017): $2.4M led by e2vc
  - Series A (2020): $15M led by Neotribe Ventures, Hummingbird Ventures
  - Series B (2021): $55M led by Hummingbird Ventures
  - Series C (2022): $48.5M
  - Debt Financing (2022): $35M led by Bridge Bank
- **Notable Investors/Partners**: Hummingbird Ventures, Neotribe Ventures, Bridge Bank
- **Growth Signals**:
  - 44% headcount growth year-over-year
  - Operating in 5 countries (US, Philippines, Australia, Canada, UK)
  - 117 active job postings; job postings up 112.7% year-over-year
  - Recent announcement of collaboration (specific partner undisclosed in search results) [billiontoone.com](https://www.billiontoone.com/)
  - New lab location coming to Austin, TX

## Competitive Advantages
- **Proprietary technology platform** (Quantitative Counting Templates / smNGS) that counts DNA molecules at the single-base-pair level, enabling direct measurement of sparse disease-causing DNA fragments from blood.
- **Distinctive product portfolio**: Only NIPT to assess recessive conditions AND aneuploidy from a single maternal blood sample; pan-cancer liquid biopsy covering therapy selection and response monitoring.
- **Strong hiring from top competitors**: Talent sourced from Exact Sciences (28), Myriad Genetics (26), Invitae (23), Natera (20), Guardant Health (19), GRAIL (11)—indicating strong industry reputation and intense competition for talent.

## Strategic Focus
- Expanding liquid biopsy capabilities for oncology (therapy selection and real-time monitoring).
- Scaling prenatal screening to include more conditions from a single blood draw.
- Geographic expansion (new lab in Austin, TX; presence in Canada, Australia, UK, Philippines).
- Continued hiring and headcount growth across all departments (Medical: 23%, Sales: 18%, Research: 9%, Technical: 7%).

## Why Work Here
- **Culture**: Described as "open, transparent culture" with weekly town halls. The company emphasizes values including "Patient-Centered," "Creative & Innovative," "Profoundly Impactful," "Internally Motivated & Passionate," "Rational & Deliberate," and "Kindly Inquisitive & Collaborative." [billiontoone.com](https://www.billiontoone.com/careers)
- **Work model**: Hybrid—on-site at state-of-the-art labs and collaborative workspaces in Menlo Park, CA (HQ) and Union City, CA; also offers remote positions.
- **Notable perks**:
  - 16 weeks 100% paid family & parental leave
  - Multiple medical plans; employee premiums 100% covered on select plans, dependents up to 80%
  - 401(k) with up to 4% company match, immediate vesting
  - Daily catered lunches from local eateries, fully stocked kitchens
  - Onsite gyms with classes, weights, pools, saunas, climbing walls
  - Free WiFi-enabled shuttle connecting BART, Caltrain, and San Francisco
  - Pet-friendly offices
  - Fertility and family support benefits
  - Generous PTO that increases with tenure
- **Career development**: Twice-yearly performance reviews; internal training programs including a Post-Baccalaureate CGMBS Training Program (CDPH-approved, ASCP prep); People Leader Development workshops
- **Engineering culture**: Employees work on cutting-edge molecular diagnostics, integrating software, bioinformatics, and wet-lab science. Senior Software Engineer and Product Management Intern roles are currently open. [job-boards.greenhouse.io](https://job-boards.greenhouse.io/billiontoone)

## Sources
1. [BillionToOne Official Site](https://www.billiontoone.com/)
2. [BillionToOne About Page](https://www.billiontoone.com/about)
3. [BillionToOne Careers Page](https://www.billiontoone.com/careers)
4. [BillionToOne Open Positions (Greenhouse)](https://job-boards.greenhouse.io/billiontoone)
5. [BillionToOne LinkedIn Company Profile](https://www.linkedin.com/company/billiontoone)

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