---
title: 'Senior Manager, Clinical Operations - GI at Iterative Health'
canonical: 'https://feeny.ai/job/senior-manager-clinical-operations-gi-iterative-health-cambridge-massachusetts-715v1vveqtdq'
type: 'job'
last_seen: '2026-09-11'
---

# Senior Manager, Clinical Operations - GI at Iterative Health

- **Company:** Iterative Health
- **Location:** Cambridge Massachusetts United States New York New York, United States
- **Compensation:** $140k–$165k
- **Posted:** 2026-08-25
- **Last confirmed live:** 2026-09-11
- **Apply:** https://job-boards.greenhouse.io/iterativehealth/jobs/4707490006

## Job description

Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes.

We built a leading performance-driven network of 100+ sites across the US, Europe, India, and Australia, conducting research directly in the communities where care is delivered across gastrointestinal, hepatology, obesity, and cardiology. By combining deep clinical trial expertise with cutting-edge AI, we connect sponsors' scientific ambitions with high-performing research teams that expedite and expand access to novel therapeutics for patients in need. Today, Iterative Health is headquartered in Cambridge, Massachusetts, and New York City with 250+ employees world-wide.

As the Senior Manager, Clinical Operations- GI at Iterative Health you will serve as a strategic advisor to sponsors, CROs, and research sites, translating operational challenges into scalable solutions that improve study execution, accelerate activation timelines, and drive patient recruitment performance. By combining deep clinical research expertise with a consultative approach, this individual will help strengthen sponsor relationships, elevate site performance across the network, and contribute directly to Iterative Health's mission of bringing innovative therapies to patients faster.

As Iterative Health continues to expand its Site Network and partnerships with sponsors and CROs, operational excellence has become a critical differentiator. This role sits at the center of those relationships, helping ensure studies are launched efficiently, sites are set up for success, and sponsors receive the insights and partnership needed to achieve their clinical development goals. In particular, this role will own and scale the site activation process across the organization. This role is responsible for driving on-time site activations within SLAs, proactively identifying and resolving blockers, and improving activation workflows to increase speed, predictability, and efficiency.

This is a highly visible, customer-facing role with the opportunity to influence study strategy, shape operational best practices, and drive measurable impact across a growing portfolio of clinical trials.

Where You’ll Drive Impact

Study Activation Ownership & Execution

- Own the end-to-end site activations, managing timelines, dependencies, and risks across multiple concurrent sites and trials
- Help teams prioritize tasks and ensure milestones are met within defined SLAs
- Maintain activation plans, status tracking, and documentation, escalating risks and delays proactively

Sponsor & CRO Partnership

- Serve as the primary operational partner to sponsors, CROs, and sites throughout the trial lifecycle
- Lead and support sponsor, CRO, and partner meetings by providing clinical operations expertise, actionable insights, and strategic recommendations.
- Build strong relationships with key stakeholders and ensure alignment on study goals, performance metrics, and operational priorities.
- Proactively communicate study risks, mitigation plans, and escalation strategies
- Facilitate educational sessions, webinars, and customer forums to strengthen engagement and share best practices.
- Travel as needed to customer sites, investigator meetings, conferences, and sponsor engagements (up to 15%).

Study Performance & Operational Excellence

- Monitor study performance metrics and own activation-specific reporting, including time-to-activation, SLA performance, and root causes of delays
- Build and maintain dashboards that provide clear stakeholder visibility
- Use data to inform prioritization, process improvements, and resourcing decisions
- Identify operational gaps affecting site activation, enrollment, and execution, and collaborate cross-functionally to address them
- Advocate for site needs and serve as a subject matter expert in clinical research operations
- Collaborate cross-functionally to implement solutions that improve site performance and study outcomes.
- Partner with sponsors and CROs to streamline processes and optimize site activation timelines.
- Performs related duties as requested

## What You Bring to the Team

- Bachelor's degree or equivalent combination of education and experience.
- 8+ years of experience supporting Phase II-IV sponsor-funded clinical trials.
- Deep understanding of clinical trial operations, including study startup, feasibility, regulatory processes, protocol execution, and GCP requirements.
- Experience working directly with sponsors, CROs, investigative sites, and cross-functional stakeholders.
- Demonstrated ability to manage multiple priorities, navigate ambiguity, and drive projects to successful completion.
- Strong analytical, communication, and stakeholder management skills.
- Comfort adopting and leveraging new technologies and operational tools.
- Willingness to travel up to 30%.

## Preferred Qualifications

- Experience in GI & Hepatology clinical research.
- Prior project or program management experience.
- 5+ years of experience as a Clinical Research Associate (CRA) or Clinical Research Coordinator (CRC), or 3+ years leading clinical operations teams.
- Experience with CTMS platforms, with RealTime CTMS strongly preferred.
- Experience working in a high-growth or startup environment.
- Experience presenting to sponsors, CRO leadership, and executive stakeholders.

## How We Work

- Collaborative and low-ego team environment
- High ownership and accountability culture
- Fast-paced and highly iterative growth environment
- Open communication and continuous learning mindset
- Mission-driven organization focused on improving patient outcomes
- Comfortable navigating evolving business priorities and opportunities

## Benefits That Support You

We believe great teams do their best work when they feel supported — professionally and personally.

- Hybrid work environment with in-office collaboration two days per week in either our NYC or Boston office
- Comprehensive medical, dental, and vision coverage, with up to 80% of premiums covered by Iterative Health
- Mental health and wellness support through Spring Health
- Health HSA or FSA options, and commuter FSA contributions supported by Iterative Health
- Unlimited PTO, 12 company holidays, and a company-wide shutdown between Christmas and New Years
- 401(k) program with a company match of up to 3% (up to $3,000 annually)
- Weekly in-office lunch benefit every Tuesday
- 100% company-paid short-term and long-term disability coverage
- Annual wellness and professional development stipend to support your health and growth
- And more!

New York pay range $140,000—$165,000 USD

At Iterative Health, we’re actively working towards creating an environment that is representative of the diversity of patients our technology serves. We are focused on building an equitable and inclusive culture, and by extension, hiring process. If you require any accommodations to make the application process or interviewing experience more accessible to you, please contact CandidateAccommodations@iterative.health.

## About Iterative Health

## Company Overview
- **One-liner**: Iterative Health is a healthcare technology and services company that accelerates clinical research by combining AI-powered tools with a performance-driven global site network, focusing on GI, Hepatology, Obesity, and Cardiology therapies.
- **Entity Type**: Private (Series C)
- **Headquarters**: Cambridge, Massachusetts, United States (also New York, New York)
- **Founded**: 2017
- **Founders**: Jonathan Ng, MBBS (Founder & CEO)

## Core Business
- **Primary industry/industries**: Healthcare technology, clinical research services, artificial intelligence
- **Target customers**: B2B – sponsors (pharma/biotech), CROs, and community-based provider networks (clinical research sites)
- **Mission or purpose**: “To accelerate clinical research to bring life-changing therapies to patients sooner, transforming care through expertise and proven results.”

## Products & Services
- **AI-Powered Clinical Trial Platform**: Software that streamlines site selection, patient enrollment, and operational workflows, reducing burden and accelerating trial timelines.
- **Performance-Driven Site Network**: A global network of elite community-based research sites with deep expertise in GI, Hepatology, Obesity, and Cardiology, enabling faster activation and high enrollment.
- **Site Enablement Services**: Operational support, training, and technology to help sites grow their research programs and improve performance.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed (private company)
- **Key Metric**: Total Funding – $264 million (including $77 million Series C closed May 2026)
- **Notable Investors/Partners**: Partners include GI Alliance, One GI, and US Heart & Vascular (USHV). Specific investors not named in provided materials, but Series C led by investors noted in Business Wire (May 14, 2026).
- **Growth Signals**: 
  - Raised $77M Series C in May 2026 to accelerate clinical research.
  - Acquired cardiology research sites from NextStage Clinical Research (April 2026), expanding into cardiology.
  - Presented expanded trial performance data at Digestive Disease Week 2026, demonstrating consistent outperformance of industry benchmarks at double the scale.

## Competitive Advantages
- **Deep Therapeutic Focus**: Specialized expertise in GI, Hepatology, Obesity, and Cardiology allows for tailored site selection and patient recruitment that generalist CROs cannot match.
- **AI Integration**: Proprietary AI tools that enhance site selection, pre-screening, and operational efficiency, reducing time-to-market for sponsors.
- **Embedded Community Network**: Sites are integrated into community care settings, giving access to diverse patient populations and enabling faster, more representative enrollment.
- **Performance Track Record**: Proven ability to activate sites faster and achieve industry-leading enrollment metrics, as validated by DDW 2026 data.

## Strategic Focus
- **Scale the Site Network**: Continue acquiring and onboarding high-performing community sites, particularly in cardiology and other adjacent therapeutic areas.
- **Deepen AI Capabilities**: Invest in machine learning and data science to further automate and optimize clinical trial operations.
- **Expand Sponsor Partnerships**: Leverage the combined technology and site network to become the preferred partner for sponsors seeking rapid, reliable trial execution.

## Why Work Here
- **Mission-Driven Culture**: Focus on accelerating life-changing therapies to patients; work directly impacts patient access and trial efficiency.
- **Values: G.R.I.T.**: The company emphasizes collaboration, curiosity, compassion, resilience, and innovation. Described as a “people-first team of builders.”
- **Benefits**: 75% paid company benefits, 401k with 3% company match, health insurance, life/STD/LTD, and paid time off plus company holidays.
- **Work Environment**: Hybrid/office presence in Cambridge, MA and New York, NY. Open roles span clinical operations, engineering, data science, finance, marketing, and more.
- **Growth Trajectory**: Company is well-funded (Series C, $264M total raised) and actively expanding through acquisitions and headcount, providing career advancement opportunities.

## Sources
1. [iterative.health](https://iterative.health/) – Company homepage, mission, partners, news
2. [iterative.health/about-us](https://iterative.health/about-us/) – Founding story, team, leadership
3. [iterative.health/iterative-health-careers](https://iterative.health/iterative-health-careers/) – Culture, benefits, values
4. [job-boards.greenhouse.io/iterativehealth](https://job-boards.greenhouse.io/iterativehealth) – Current job openings (35 roles)
5. [cbinsights.com](https://www.cbinsights.com/company/iterative-scopes) – Funding history, total raised, stage

## Other roles at Iterative Health

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- [Clinical Research Coordinator I -  Memphis, TN](https://feeny.ai/job/clinical-research-coordinator-i-memphis-tn-iterative-health-memphis-czn11v20anvp) — Memphis, TN
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- [Clinical Research Coordinator II - Mansfield, TX](https://feeny.ai/job/clinical-research-coordinator-ii-mansfield-tx-iterative-health-mansfield-rv0h9mancmjt) — Mansfield, TX
- [Research Site Manager](https://feeny.ai/job/research-site-manager-iterative-health-providence-7efmg6z2808r) — Providence, RI
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- [Clinical Research Coordinator II - Troy, MI](https://feeny.ai/job/clinical-research-coordinator-ii-troy-mi-iterative-health-troy-tve19pph0hqh) — Troy, MI
- [Clinical Research Coordinator I - Webster, TX](https://feeny.ai/job/clinical-research-coordinator-i-webster-tx-iterative-health-webster-3cdvktdfajh7) — Webster, TX
- [VP, US Site Management & Operations - GI](https://feeny.ai/job/vp-us-site-management-operations-gi-iterative-health-new-york-mzp6n6cw94dr) — New York, NY / Boston, MA / Dallas, TX