---
title: 'Senior Manager, Clinical Project Management (Project Delivery) at Immunome, Inc.'
canonical: 'https://feeny.ai/job/senior-manager-clinical-project-management-project-delivery-immunome-inc-4qv8cbmwxyhp'
type: 'job'
last_seen: '2026-09-05'
---

# Senior Manager, Clinical Project Management (Project Delivery) at Immunome, Inc.

- **Company:** Immunome, Inc.
- **Location:** Bothell Washington, United States
- **Compensation:** $175k–$200k
- **Posted:** 2026-09-02
- **Last confirmed live:** 2026-09-05
- **Apply:** https://job-boards.greenhouse.io/immunomeinc/jobs/5412991008

## Job description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Senior Manager, Clinical Project Management (Clinical Project Delivery CPD) provides hands-on operational management for the execution of one or more of Immunome’s clinical trials, supporting all aspects of cross-functional clinical trial delivery from planning and initiation through completion to ensure studies are executed on time, within budget, and in compliance with regulatory requirements and corporate objectives.

The Senior Manager acts as the primary point of accountability for study-level timelines, enrollment projections, budgets, and vendor performance for assigned trials.

The Senior Manager may support one or more studies and/or development programs under the guidance of an Associate Director or above.

## Responsibilities

Clinical Project Delivery

- Lead cross-functional facilitation of clinical study teams through the trial lifecycle.
- Own study-level timeline development, tracking, and reporting for assigned trials.
- Develop and maintain enrollment graphs and dashboards, ensuring accuracy and timely updates to inform decision-making.
- Monitor project delivery metrics (timelines, milestones, enrollment, budget adherence, vendor KPIs) and ensure corrective action when studies are at risk.
- Facilitate or support cross-functional planning, execution, and delivery of assigned clinical trials on time, within budget, and to quality standards.
- Help the clinical study team (CST) identify operational risks and implement mitigation strategies to ensure successful trial delivery.

Clinical Operations

- Champion a culture of accountability, collaboration, and continuous improvement.
- May contribute to functional and/or departmental initiatives.
- May mentor new or junior team members.

Vendor Management

- Manage CRO and Central lab relationships and oversight for assigned studies.
- Initiate vendor identification, selection, contracting, and onboarding activities in support of Finance, Legal, and clinical study teams.
- Manage and monitor vendor performance against contractual obligations, operational timelines, and quality and performance metrics.
- Support vendor governance meetings, oversight activities, issue escalation, and resolution to ensure timely and effective trial execution.

Quality Assurance and Regulatory Compliance

- Ensure adherence to ICH-GCP, FDA, EMA, and global regulatory requirements for assigned trials.
- Work with Quality Assurance and the CST to support and ensure ongoing inspection- readiness and implement corrective actions as needed.
- Help ensure data integrity and consistent trial conduct across assigned trials.

Cross-Functional Collaboration

- Align cross-functionally on program objectives and study execution plans, including Clinical Site & Trial Operations, Clinical Field Monitoring & Trial Operations, and Clinical Development Systems.
- Work with cross-functional teams to identify and mitigate study delivery risks.
- Provide study-level operational input into program-level discussions and decisions.
- Support regulatory submissions (INDs, NDAs, BLAs) and health authority interactions as needed for assigned studies.

Budget and Resource Management

- Work with Finance to support management and forecasting of study-level budgets, including change orders, ensuring alignment with corporate priorities and program timelines.
- Maintain financial oversight for vendor and study-related activities with strict oversight of Change Orders and Change Notifications.
- Track and report on budget adherence for assigned studies.

## Qualifications

- Bachelor’s degree plus a minimum of 6 years of clinical project management or clinical trial experience in the biotechnology or pharmaceutical industry, or an equivalent combination of education and experience.
- A minimum of 3 years of sponsor experience.
- Demonstrated experience managing or supporting clinical trial vendors, including CROs and central labs.
- Working knowledge and experience in study timeline development, enrollment forecasting and tracking methodologies, and trial risk management.
- Experience managing or supporting complex clinical trials in a pharmaceutical or biotech environment.
- Demonstrated experience supporting or managing Trial Master Files.

Knowledge and Skills

- Strong working knowledge of clinical development, trial design, and global regulatory frameworks (ICH-GCP, FDA, and EMA).
- Experience managing CROs and other vendors across the trial lifecycle.
- Solid project management skills; PMP Certification a plus.
- Ability to effectively work cross-functionally and build relationships with stakeholders without direct authority.
- Strong and effective communication, negotiation, and interpersonal skills.
- Detail-oriented with an analytical approach to problem-solving.
- Ability to prioritize and manage multiple tasks and projects in a fast-paced, dynamic environment.
- Highly professional, adaptable, and accountable.

Washington State Pay Range $175,000—$199,577 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: [E-Verify Participation Poster](https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk) | https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e | https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u.

## About Immunome, Inc.

## Company Overview
- **One-liner**: Immunome is a clinical-stage oncology company developing first-in-class and best-in-class targeted cancer therapies, with a primary focus on antibody-drug conjugates (ADCs).
- **Entity Type**: Public (Nasdaq: IMNM)
- **Headquarters**: Bothell, Washington, United States
- **Founded**: The company was formed through a merger of Morphimmune and Immunome in October 2023.
- **Founders**: The company is led by Clay Siegall, Ph.D. (Chairman, CEO, and President), who co-founded Seagen. The original Immunome entity was founded earlier, but the current company structure dates to the 2023 merger.

## Core Business
- Primary industry/industries: Biotechnology, Oncology, Drug Discovery & Development
- Target customers: Patients with cancer, healthcare providers, and clinical trial sites. The company is a B2B/B2C entity in the healthcare and life sciences space.
- Mission or purpose statement: "Our mission is to improve outcomes for cancer patients by advancing and expanding a portfolio of first-in-class and best-in-class therapeutic candidates." [immunome.com](https://immunome.com/)

## Products & Services
- **Varegacestat (formerly AL102)**: A late-clinical stage gamma secretase inhibitor for the treatment of desmoid tumors. The company submitted a New Drug Application (NDA) to the U.S. FDA in April 2026. [investors.immunome.com](https://investors.immunome.com/)
- **IM-1021**: A ROR1-targeted antibody-drug conjugate (ADC) currently in a Phase 1 trial.
- **IM-3050**: A FAP-targeted radioligand which received IND clearance in Q1 2025.
- **Preclinical ADC Pipeline (IM-1617, IM-1340, IM-1335)**: ADCs pursuing undisclosed targets with expression in multiple solid tumors. IM-1617 had its first patient dosed in a Phase 1 trial in June 2026. [investors.immunome.com](https://investors.immunome.com/)

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the search results. As a public company, this fluctuates. (Check recent filings for current data).
- **Key Metric**: The company is pre-revenue (clinical-stage) and has raised significant capital. Since the 2023 merger, CEO Clay Siegall has raised $355 million in equity financings. [immunome.com](https://immunome.com/about/)
- **Notable Investors/Partners**: The company is publicly traded. Key leadership previously worked at Seagen (acquired by Pfizer for $43 billion).
- **Growth Signals**: The company is rapidly advancing its pipeline. Key milestones include the NDA submission for varegacestat, first patient dosed for IM-1617, and positive Phase 3 data presented at ASCO 2026. The company currently lists 32 open positions on its careers page, indicating strong hiring momentum. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)

## Competitive Advantages
- **World-Class Leadership**: The executive team, led by Seagen co-founder Clay Siegall, has deep experience in designing, developing, and commercializing blockbuster ADCs (ADCETRIS, PADCEV, TIVDAK, TUKYSA). [immunome.com](https://immunome.com/about/)
- **Proprietary ADC Platform**: A systematic, data-driven process for optimizing antibodies, linkers, and payloads to create differentiated ADCs. [immunome.com](https://immunome.com/)
- **Near-Term Catalyst**: The NDA submission for varegacestat provides a potential near-term commercial opportunity.
- **Strong Financial Backing**: Raised $355M in equity since the merger, providing a solid runway for pipeline advancement.

## Strategic Focus
- **Advancing the Pipeline**: The primary focus is on executing clinical trials for varegacestat (Phase 3), IM-1021 (Phase 1), and IM-3050 (Phase 1), and advancing preclinical ADCs into the clinic.
- **Regulatory Filing**: Successfully navigating the FDA NDA submission and potential approval for varegacestat.
- **Discovery & Expansion**: Using their ADC discovery platform to generate new candidates and identify and acquire targeted oncology assets to expand the portfolio. [immunome.com](https://immunome.com/about/)

## Why Work Here
- **Mission-Driven**: The work directly impacts the lives of cancer patients, with a stated goal of developing transformative therapies. [immunome.com](https://immunome.com/about/)
- **High-Impact Team**: Opportunity to work with "some of the brightest and most experienced minds in ADC development," including leaders who have brought multiple drugs to market. [immunome.com](https://immunome.com/careers/)
- **Growth Stage**: With 32 open roles, the company is in a rapid growth phase, offering significant career advancement opportunities. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)
- **Comprehensive Benefits**: Includes 100% company-paid medical premiums for employees, a 401(k) with employer match, paid parental leave, and a week-long winter break. [immunome.com](https://immunome.com/careers/)
- **Location & Culture**: Based in Bothell, WA. The company describes a culture of "innovative, collaborative environment where employees are empowered to do their best work." [immunome.com](https://immunome.com/careers/)

## Sources
1. [Immunome Official Website](https://immunome.com/)
2. [Immunome About Page](https://immunome.com/about/)
3. [Immunome Investor Relations](https://investors.immunome.com/)
4. [Immunome Careers Page](https://immunome.com/careers/)
5. [Immunome Jobs on Greenhouse](http://job-boards.greenhouse.io/immunomeinc)

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