--- title: 'Senior Manager, Drug Substance Manufacturing Upstream at Ultragenyx Pharmaceutical' canonical: 'https://feeny.ai/job/senior-manager-drug-substance-manufacturing-upstream-ultragenyx-pharmaceutical-avf8j7sg57qn' type: 'job' last_seen: '2026-11-09' --- # Senior Manager, Drug Substance Manufacturing Upstream at Ultragenyx Pharmaceutical - **Company:** Ultragenyx Pharmaceutical - **Location:** Bedford, MA - **Compensation:** $160k–$197k - **Posted:** 2026-11-06 - **Last confirmed live:** 2026-11-09 - **Apply:** https://job-boards.greenhouse.io/ultragenyxpharmaceutical/jobs/4751190005?gh_jid=4751190005 ## Job description Why Join Us? Be a hero for our rare disease patients At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won’t go – challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them. Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth – so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work. If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team. Position Summary: ultrafocused – Work together to fearlessly uncover new possibilities The Upstream Manufacturing Manager will report to the Sr. Director of Upstream Manufacturing. The role will be responsible for the supervision of a shift of 5 manufacturing technicians and Associates on a rotating pitman (every other weekend off) 12 hour schedule (7am-7pm). The roles primary focus will be on cell culture operations from vial thaw through to 2K operations for the production of viral particles for gene therapy products. Work Model: Core Lab & Ops: This role typically requires that the majority of the work be conducted on-site. Responsibilities: Quality Systems: - Act as Area Lead for internal/external Audits as required, including hosting tours. - Front room SME presenting for regulatory inspections. - Drive the manufacturing review of the completed batch records per the release plan. - Driver of all assigned quality system items (Deviations, CAPA, Change Control), SOPs, MBRs, Risk Assessments etc. Plant & Process: - Demonstrate ownership of the process to ensure that all resources (materials, personnel, documentation etc.) required for processing are available. - Identify any Continuous Improvements to the process/equipment and drive through to completion any projects to which may be assigned. - Ensure Business System Ownership (BSO) ownership of the equipment and facility is demonstrated at all times. Leadership: - Oversight and responsibility for technicians that report into the role, including compliance, training, safety and career development within Ultragenyx. - The Manager will also be assigned as a “project lead” on higher level initiatives and expected to drive projects to completion in a highly collaborative manner in a matrix environment. - Leader ensures a calm, strong and robust communications between all managers within Manufacturing and ensuring the appropriate dissemination of communications to support staff. Requirements: - Ideally, degree in Engineering or Scientific Discipline, equivalent education/experience could be considered. - Ability to be on call for Upstream MFG alarms off shift. - 10+ years leadership positions with direct reports ideally in Biologics environment running 24/7. - Experience with GMP manufacturing of viral vectors and/or biological processes. - Strong collaboration, team-working skills, and communication skills. Physical Demands/Work Environment/Safety Considerations: - Stand for extended periods of time with periodic stooping / bending / kneeling - Able to lift, push, pull up to 50lbs. - Climb ladders and stairs of various heights. - Work in a controlled environment requiring GxP gowning and wear protective clothing over the head, face, hands, feet, and body. This requires the ability to change clothes into appropriate gowning and personal protective equipment. - Certain tasks may require the use of a respirator; medical clearance will be required in advance. - Must remove all make-up, jewelry, and contact lenses while in the manufacturing environment. - Working in temperature-controlled environments (cold rooms). #LI-KJ1 #LI-Onsite The typical annual salary range for this full-time position is listed below. This range reflects the characteristics of the job, such as required skills and qualifications and is based on the office location noted in this job posting. The range may also be adjusted based on applicant's geographic location. This position is eligible for annual bonus and equity incentives. Actual individual pay is determined by demonstrated experience and internal equity alignment. Pay Range $159,500—$197,100 USD Full Time employees across the globe enjoy a range of benefits, including, but not limited to: - Generous vacation time and public holidays observed by the company - Volunteer days - Long term incentive and Employee stock purchase plans or equivalent offerings - Employee wellbeing benefits - Fitness reimbursement - Tuition sponsoring - Professional development plans - Benefits vary by region and country Ultragenyx Pharmaceutical is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status, and any other status or classification protected by applicable federal, state, and/or local laws. Reasonable accommodation will be provided for all protected statuses or classifications protected by applicable law, including individuals with disabilities, disabled veterans, for pregnancy, childbirth, and related medical conditions, and based on sincerely held religious beliefs. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, you may contact Talent Acquisition by emailing us at talentacquisition@ultragenyx.com. See our [CCPA Employee and Applicant Privacy Notice](https://www.ultragenyx.com/CCPA-Notice/). See our [Privacy Policy](https://www.ultragenyx.com/privacy-policy/). Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation.  Inquiries on developing a recruiting relationship with us, may be directed to: [talentacquisition@ultragenyx.com](http://mailto:talentacquisition@ultragenyx.com/). ## About Ultragenyx Pharmaceutical ## Company Overview - **One-liner**: Ultragenyx Pharmaceutical is a biopharmaceutical company dedicated to developing and commercializing first-ever treatments for rare and ultra-rare genetic diseases with high unmet medical need. - **Entity Type**: Public (NASDAQ: RARE) - **Headquarters**: Novato, California, United States - **Founded**: 2010 - **Founders**: Emil D. Kakkis, M.D., Ph.D. ## Core Business - **Primary industry/industries**: Biotechnology research; rare disease therapeutics (metabolic, bone, endocrine, muscle, and central nervous system disorders). - **Target customers**: B2B (healthcare providers, payers, government agencies) and B2C (patients and patient advocacy groups). - **Mission or purpose statement**: “Transform the lives of those living with rare diseases” (ultragenyx.com). ## Products & Services - **Crysvita (burosumab)**: Approved for X-linked hypophosphatemia (XLH) – a biologic therapy. - **Dojolvi (triheptanoin)**: Approved for long-chain fatty acid oxidation disorders (LC-FAOD) – a small molecule. - **Mepsevii (vestronidase alfa)**: Approved for mucopolysaccharidosis VII (Sly syndrome) – an enzyme replacement therapy. - **Evinacumab-dgnb (non-U.S. rights)**: Approved by FDA and EMA for homozygous familial hypercholesterolemia; marketed outside the U.S. under a partnership with Regeneron. - **Pipeline**: A diverse portfolio across multiple modalities – gene therapies, antisense oligonucleotides (ASOs), mRNA therapies – targeting ultra-rare diseases in bone, endocrine, metabolic, muscle, and CNS categories (ultragenyx.com). ## Market Standing - **Valuation/Market Cap**: ~$3.3 billion (as of June 2026, per LinkedIn company page and market data). - **Key Metric**: Annual revenue of $673 million (most recent fiscal year); total funding of $1.55 billion (including Series A, post-IPO equity, and debt). - **Notable Investors/Partners**: - Investors: Ontario Municipal Employees Retirement System (led $400M post-IPO debt in 2025), multiple venture and institutional investors. - Partners: Kyowa Hakko Kirin, Daiichi Sankyo, Mereo BioPharma, Regeneron (non-U.S. commercial rights for evinacumab). - **Growth Signals**: - One of the largest and most diverse pipelines in rare disease. - Awarded “Best Place to Work” by BioSpace (2020, 2021) and recognized by Deloitte’s Fast 500. - Active job postings: 21 openings as of mid-2026 (LinkedIn), though headcount declined 1.9% YoY to 1,247 employees. - Recent news: Ultragenyx Reports Inducement Grant Under Nasdaq Listing Rule 5 (June 2026). ## Competitive Advantages - **Ultra-rare focus**: Targets diseases with no approved therapies, creating first-ever treatments and building significant regulatory and commercial expertise. - **Multi-modality platform**: Expertise across biologics, small molecules, gene therapies, ASOs, and mRNA – reducing risk and expanding addressable disease space. - **Global infrastructure**: Operations in 20 countries (including Brazil, Switzerland, Mexico, Japan) and commercial presence in North America, Europe, Latin America, and Asia. ## Strategic Focus - **Commercial expansion**: Hiring for Commercial and Medical Affairs teams to support growing product portfolio. - **Gene therapy manufacturing**: Building a new gene therapy manufacturing facility in the Boston area to scale production for pipeline candidates. - **Pipeline advancement**: Continued clinical development of gene therapies, ASOs, and mRNA programs for ultra-rare indications. ## Why Work Here - **Culture**: Described as “inclusive, generous, curious, and humble,” with a strong emphasis on purpose and patient impact. Named a top workplace by BioSpace and Deloitte. - **Benefits**: Comprehensive coverage starting on day one for all regular full-time employees; includes robust health, retirement, and wellness programs. - **Work environment**: Hybrid/office model with multiple U.S. hubs (Novato, Brisbane, Boston area) and international offices. Employer rating on LinkedIn: 3.3/5 (324 reviews) with culture rated 3.5, compensation 4.0, and work-life balance 3.2. - **Career development**: Internships, seasonal co-ops, and postdoctoral programs; strong alumni pipeline to top biopharma companies (Genentech, BioMarin, Vertex, Amgen). ## Sources 1. [ultragenyx.com](https://www.ultragenyx.com/) 2. [ultragenyx.com – Join Our Team](https://www.ultragenyx.com/join-our-team/) 3. [ultragenyx.com – Current Opportunities](https://www.ultragenyx.com/join-our-team/current-opportunities/) 4. [LinkedIn Company Page](https://www.linkedin.com/company/ultragenyx) 5. [talent.ultragenyx.com](https://talent.ultragenyx.com/) 6. [Greenhouse Careers Page](https://job-boards.greenhouse.io/ultragenyxpharmaceutical) ## Other roles at Ultragenyx Pharmaceutical - [Key Account Manager](https://feeny.ai/job/key-account-manager-ultragenyx-pharmaceutical-greater-london-mp9xb7agphnn) — Greater London, United Kingdom - [UltraCare Liaison (Atlanta)](https://feeny.ai/job/ultracare-liaison-atlanta-ultragenyx-pharmaceutical-united-states-9bsg49pqe04j) — United States - [Manager, Drug Product Manufacturing](https://feeny.ai/job/manager-drug-product-manufacturing-ultragenyx-pharmaceutical-bedford-tmtndeam8yev) — Bedford, MA - [Senior Medical Science Manager North UK](https://feeny.ai/job/senior-medical-science-manager-north-uk-ultragenyx-pharmaceutical-united-kingdom-rd4ajn23t7z4) — United Kingdom - [UltraCare Liaison](https://feeny.ai/job/ultracare-liaison-ultragenyx-pharmaceutical-germany-b502ttkt7d2w) — Germany - [Senior Director, US Marketing, Inborn Errors of Metabolism](https://feeny.ai/job/senior-director-us-marketing-inborn-errors-of-metabolism-ultragenyx-qfhmhx57fftq) — United States