---
title: 'Senior Platform Engineer at Orchestra Bio'
canonical: 'https://feeny.ai/job/senior-platform-engineer-orchestra-bio-san-francisco-eyadecnehe79'
type: 'job'
last_seen: '2026-09-07'
---

# Senior Platform Engineer at Orchestra Bio

- **Company:** Orchestra Bio
- **Location:** San Francisco, CA
- **Employment:** full-time
- **Work type:** hybrid
- **Posted:** 2025-08-06
- **Last confirmed live:** 2026-09-07
- **Apply:** https://jobs.ashbyhq.com/orchestra-bio/a70ca727-2587-467e-a651-d30452b5de9c

## Job description

## ABOUT ORCHESTRA

Orchestra helps companies navigate the journey from discovery to medicine by connecting science, operations, and finance in an intelligent platform. We're on a mission to make every R&D dollar count.

Developing new medicines is a societal imperative to improve human health and reduce medical costs. Brilliant science needs effective management to develop breakthrough medicines that reach patients. We aim to bring the same level of sophistication to scientific development that modern tools brought to software development. While software teams can ship updates daily, R&D organizations face unique challenges: years long development cycles, complex interdependencies, and high-stakes decisions that can make or break billion dollar programs.

Founded by early Benchling leaders, we just emerged from stealth with $20M in funding from 8VC, Andreessen Horowitz, Insight Partners, Definition, and Haystack to transform how biotech companies operate. Our customers are working on society's most important challenges, including neurodegeneration, cancer, metabolic disease, and biomanufacturing. We're looking for engineers who are excited about building software that helps scientific organizations operate more effectively.

## THE ROLE

We're seeking a Senior Platform Engineer to join our growing team in San Francisco. You'll build and maintain the foundational infrastructure that powers Orchestra's intelligent R&D management platform, ensuring our systems can scale reliably as we help more companies bring breakthrough innovations to market.

## CHALLENGES YOU'LL TACKLE

Mission Critical Infrastructure: Design and maintain the cloud infrastructure that biotech companies depend on for managing billion dollar R&D programs. Build systems that handle sensitive scientific data, complex financial modeling, and AI workloads with the reliability and security these high stakes operations demand.

Scalable AI Operations: Create the platform infrastructure that powers our AI driven signals extraction from meeting transcripts, documents, and operational data. Design systems that can process unstructured data at scale while maintaining performance and cost efficiency as our customer base grows.

Developer Experience: Create tooling and infrastructure that enables our engineering team to ship features rapidly and reliably. Design CI/CD pipelines, monitoring systems, and development environments that help us maintain quality while moving at startup speed.

Security & Compliance: Implement infrastructure that meets the stringent requirements of biotech and pharmaceutical companies. Build towards SOC 2 compliance while maintaining the development velocity needed in a fast-growing startup environment.

## WHAT SETS YOU APART

Complexity: You understand how to build platform infrastructure for complex, data-intensive applications where reliability directly impacts scientific outcomes. You're excited about the technical challenges of supporting AI workloads, financial modeling, and secure data processing at scale.

Curiosity: You're genuinely curious about how breakthrough products are developed and excited about building infrastructure that helps scientific organizations operate more effectively. You want your platform work to contribute to bringing medicines and other innovations to market.

Agency: You're drawn to environments where you can shape both the technical infrastructure and operational practices. You enjoy the responsibility of building foundational systems that will scale, balancing the speed needed at an early stage company with the reliability required for mission critical software.

## QUALIFICATIONS

## REQUIRED

- 5+ years of platform/infrastructure engineering or SRE experience
- Strong expertise in cloud infrastructure (AWS/GCP/Azure) including IaC tools (Terraform, CloudFormation)
- Hands-on experience with monitoring and observability, implementing and running alerting systems and incident response
- Hands-on experience with CI/CD pipeline design, implementation and maintenance
- Collaborative mindset with proven track record of working effectively in small, fast-moving engineering teams

## PREFERRED

- SOC 2 compliance implementation experience: security controls, monitoring, audit preparation
- Performance optimization experience for data intensive applications
- AI-assisted development proficiency; leveraging tools to accelerate infrastructure work

## About Orchestra Bio

## Company Overview
- **One-liner**: Orchestra Bio provides an agentic operations platform that unifies scientific, operational, and financial planning to reduce the complexity of drug development for life sciences R&D organizations.
- **Entity Type**: Private (Seed Stage)
- **Headquarters**: San Francisco, California, United States
- **Founded**: 2022
- **Founders**: Ashoka Rajendra (CEO), Andy Xu (CTO)

## Core Business
- **Primary Industry**: Life Sciences R&D Management / Enterprise Software for Biotech
- **Target Customers**: B2B; biotech companies, CROs, CDMOs, and biopharma partners; R&D leadership, program managers, and scientific teams
- **Mission**: To reduce the operational complexity of developing medicines by providing an intelligent management system for life sciences R&D.

## Products & Services
- **Orchestra Platform**: An agentic operations platform that acts as both a system of record and a system of intelligence. It unifies scientific, operational, and financial context into one environment, enabling teams to build centralized roadmaps, automate operations, and run scenario analyses for drug development decisions. The platform is built on a multi-stage intelligence arc: Unified Planning, Intelligent Operations, and Decision Support.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (Private company)
- **Key Metric**: Raised a $20M Seed round in 2024 from top-tier investors.
- **Notable Investors/Partners**: Andreessen Horowitz, 8VC, Insight Partners, Definition, Haystack.
- **Growth Signals**: Headcount grew ~5.9% YoY to 12 employees; LinkedIn followers grew 37.2% yearly; active job postings increased 200% year-over-year; launched a partnership with BiotechTV at JPM in early 2026.

## Competitive Advantages
- **First-of-its-kind platform**: Orchestra is described as the first platform to unify scientific, operational, and financial context into a single intelligent environment for life sciences R&D.
- **Deep domain expertise**: Founded by engineers, operators, and scientists with firsthand experience in biotech and enterprise software, giving them a unique understanding of the operational burden facing scientific teams.
- **Agentic AI approach**: The platform uses a multi-stage intelligence arc (Unified Planning, Intelligent Operations, Decision Support) to continuously interpret data, acting as both a system of record and a system of intelligence.

## Strategic Focus
- **Product-led growth**: Building a platform that serves as the "operating system for scientific progress," targeting both individual biotechs and the broader collaboration network (CROs, CDMOs, partners).
- **Talent acquisition**: Actively hiring senior engineering talent (Senior Fullstack, Backend, and Platform Engineers) to scale the product and team.
- **Partnership development**: Recently launched a partnership with BiotechTV at JPM, signaling a push for industry visibility and ecosystem integration.

## Why Work Here
- **Mission-driven work**: Employees directly contribute to accelerating the pace of scientific discovery by solving operational challenges for drug development teams.
- **High-impact, early-stage environment**: As a seed-stage company with 12 employees, new hires will have significant ownership and influence over the product and culture.
- **Strong technical team**: The engineering team includes alumni from top tech companies like Apple, Stripe, and Benchling, indicating a high-caliber peer group.
- **Remote/Hybrid Policy**: Not explicitly stated, but the company has two offices in San Francisco, suggesting a preference for in-person or hybrid collaboration.
- **Culture**: The company emphasizes building at the intersection of biotech, intelligence systems, and enterprise tooling, offering a unique challenge for engineers and operators who want to directly accelerate scientific discovery.

## Sources
1. [orchestra.bio](https://orchestra.bio/)
2. [orchestra.bio/about](https://orchestra.bio/about)
3. [LinkedIn](https://www.linkedin.com/company/orchestrabio)
4. [Simplify Jobs](https://simplify.jobs/c/OrchestraBio)
5. [Ashby Careers Page](https://jobs.ashbyhq.com/orchestra-bio)

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