---
title: 'Senior Project Manager, Clinical Operations at Maze Therapeutics'
canonical: 'https://feeny.ai/job/senior-project-manager-clinical-operations-maze-therapeutics-south-san-francisco-tdcv9cmr2ey2'
type: 'job'
last_seen: '2026-09-13'
---

# Senior Project Manager, Clinical Operations at Maze Therapeutics

- **Company:** Maze Therapeutics
- **Location:** South San Francisco, CA
- **Posted:** 2026-08-13
- **Last confirmed live:** 2026-09-13
- **Apply:** http://www.mazetx.com/careers/?gh_jid=8697191002

## Job description

The Position

At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As Sr. Project Manager, Clinical Operations, you will play a critical role in driving operational excellence across our growing Clinical Operations organization. This position combines portfolio-level project management with strategic operational initiatives, partnering closely with Clinical Operations Study Leads, Oversight Directors, and cross-functional teams to support the successful execution of multiple clinical pharmacology studies, early-phase studies, Phase 2 studies, and Phase 3 development programs,

In this role, you will facilitate cross-functional planning and communication, coordinate complex study execution activities across the clinical portfolio, and oversee key Clinical Operations initiatives that strengthen organizational capabilities, improve processes, and drive operational excellence. As Maze continues to grow, you will partner with the Head of Clinical Operations to help establish scalable operational infrastructure, implement innovative technologies, and support initiatives that enable efficient, high-quality clinical trial execution across all stages of development.

This role is ideal for a highly organized, collaborative project manager who enjoys bringing structure to complex initiatives, driving accountability, and enabling teams to deliver ambitious clinical development goals.

The Impact You’ll Have

- Clinical Operations Project Management
- Partner with Clinical Operations Study Leads and Oversight Directors to coordinate project management activities across multiple Phase 1, clinical pharmacology, Phase 2, and Phase 3 studies, ensuring alignment of timelines, milestones, dependencies, and cross-functional deliverables.
- Develop and maintain integrated project plans, timelines, risk registers, and action trackers that support efficient study execution across the clinical portfolio.
- Monitor portfolio-wide study milestones, cross-study dependencies, operational risks, and key deliverables, proactively escalating issues and facilitating timely resolution.
- Coordinate cross-functional activities for Clinical Operations collaborating with Clinical Science, Biometrics, Data Management, Regulatory Affairs, Clinical Supply, Quality Assurance, and other functional teams.
- Develop project dashboards, status reports, and operational metrics that provide visibility into study execution, portfolio health, and organizational priorities.
- Cross-functional Leadership & Study Governance
- Partner with Clinical Operations Study Leads to coordinate, facilitate, and manage Study Execution Team (SET) meetings across multiple development programs.
- Develop meeting agendas, facilitate productive discussions, document decisions and action items, and drive accountability for follow-up activities.
- Coordinate governance meetings, operational reviews, leadership updates, and cross-functional planning sessions.
- Foster effective communication and collaboration across Clinical Operations, Clinical Science, Biometrics, Data Management, Regulatory Affairs, Clinical Supply, Quality Assurance, Finance, and other functional teams to ensure alignment on priorities and execution
- Strategic Clinical Operations Initiatives
- Oversee and coordinate cross-functional initiatives that strengthen Clinical Operations capabilities and improve organizational effectiveness.
- Manage implementation of strategic projects including:
- In-house eTMF implementation and governance
- Artificial intelligence (AI) initiatives
- Companion Diagnostic (CDx) operational workflows
- SOP development and revision working groups
- Inspection readiness initiatives
- Clinical Operations systems implementations (CTMS, eTMF, dashboards, etc.)
- Process improvement and organizational change initiatives
- Develop project plans, implementation strategies, communication plans, and timelines while tracking progress, risks, and dependencies.
- Support evaluation and implementation of innovative technologies, automation tools, and operational best practices.
- Operational Excellence
- Develop standardized project management tools, templates, meeting frameworks, and operational best practices that improve consistency and scalability across Clinical Operations.
- Identify opportunities to improve business processes, cross-functional collaboration, and operational efficiency.
- Collaborate with study teams to monitor key performance indicators (KPIs) that measure study execution, operational effectiveness, and organizational performance.
- Support onboarding of new Clinical Operations team members through development of training materials, tools, and operational resources.
- Champion continuous improvement initiatives that enhance execution, collaboration, and organizational effectiveness.
- Portfolio Planning & Communication
- Support Clinical Operations leadership with portfolio planning, and department prioritization.
- Prepare executive presentations, dashboards, reports, and meeting materials for leadership reviews and governance meetings.
- Coordinate communication plans for organizational initiatives, ensuring stakeholders remain informed and aligned.
- Maintain project documentation, lessons learned, and organizational knowledge to support continuous improvement and future planning.

As a Senior Project Manager, Clinical Operations, we also expect our leaders to demonstrate the following Leadership Competencies:

Leadership Competencies

- Communication and Influence
- Communicates the reasoning behind decisions to appropriate stakeholders.
- Promotes open communication with internal and external stakeholders.
- Fosters healthy and respectful debate.
- Teamwork and Collaboration
- Creates opportunities for team members to connect with others outside of team.
- Manages conflict effectively between teams.
- Openly values thoughts, opinions, and contributions of employees.
- Execution and Results
- Exercises astute judgment to make decisions with only the necessary amount of data.
- Supports team members in creating their own resolutions to challenges and problems.
- Works with others to reinforce process compliance, what good looks like, and risk mitigation.
- Develop Others and Self
- Articulates what good looks like throughout Maze.
- Pursues development activities for continuous improvement of self and team.

## What We’re Looking For

You might be the right fit for this role if you have:

- Bachelor's degree in Life Sciences or a related field.
- 6-8+ years of experience in Clinical Project Management, 8+ years in Clinical Operations, or related field, with specifically 6+ years of Clinical Project Management within biotech.
- Demonstrated experience managing complex cross-functional projects supporting multiple clinical studies or development programs.
- Strong understanding of clinical trial operations across early-phase, clinical pharmacology, Phase 2, and Phase 3 clinical development.
- Experience facilitating governance meetings, driving action items, managing timelines, and coordinating cross-functional teams.
- Experience overseeing operational improvement initiatives, business process implementation, or organizational change management is strongly preferred.
- Strong organizational skills with the ability to manage multiple priorities, competing deadlines, and cross-functional initiatives simultaneously.
- Excellent communication, facilitation, relationship-building, and problem-solving skills with the ability to influence without direct authority.
- Experience developing dashboards, project metrics, and executive-level reporting is preferred.
- Proficiency with project management tools (e.g., Smartsheet, Microsoft Project) and Microsoft Office applications.
- Experience with GCP-regulated clinical development environments and clinical systems (e.g., CTMS, eTMF, EDC) is preferred.

## About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $181,000 - $221,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

#LI-Hybrid

## About Maze Therapeutics

## Company Overview
- **One-liner**: Maze Therapeutics is a clinical-stage biopharmaceutical company developing small molecule precision medicines for common diseases, primarily kidney disease, by leveraging human genetics and its proprietary Compass platform.
- **Entity Type**: Public (NASDAQ: MAZE)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2018
- **Founders**: Not publicly listed as individual founders; the company was established by a team of geneticists and industry veterans.

## Core Business
- **Primary industry/industries**: Biotechnology / Biopharmaceuticals (Precision Medicine)
- **Target customers**: B2B (partners and investors), B2C (patients with APOL1-mediated kidney disease, chronic kidney disease, and phenylketonuria)
- **Mission or purpose statement**: "Harnessing the power of genetics to transform the lives of patients" by translating genetic insights into effective precision medicines.

## Products & Services
- **MZE829 (Lead Program)**: An oral, small molecule, dual-mechanism APOL1 inhibitor for the treatment of APOL1-mediated kidney disease (AMKD). Recently reported positive topline Phase 2 HORIZON trial data.
- **MZE782 (SLC6A19 Inhibitor)**: A precision medicine in development for chronic kidney disease (CKD) and phenylketonuria (PKU), currently in clinical trials.
- **Maze Compass™ Platform**: A proprietary platform that leverages variant functionalization to link genetic variants to disease pathways, enabling the discovery and design of precision medicines.
- **Other Pipeline Programs**: Several additional programs in drug discovery targeting renal, cardiovascular, and metabolic diseases.

## Market Standing
- **Valuation/Market Cap**: Approximately **$1.48 Billion** (as of mid-2026, per CB Insights market cap data).
- **Key Metric**: **Total Raised** (including IPO): **$496 Million**. The company also announced a **$150 Million registered offering** in 2026.
- **Notable Investors/Partners**: Key investors include **Third Rock Ventures**, **Gilead Sciences**, **Genentech**, **Denali Therapeutics**, and **Calico Life Sciences** (as top talent sources and likely institutional backers). The company went public via a PIPE/IPO structure.
- **Growth Signals**: 
    - Positive topline data from the Phase 2 HORIZON trial of MZE829 (announced March 2026).
    - Three clinical-stage programs and several discovery-stage programs.
    - Active job postings increased by **120% year-over-year**.
    - Headcount of approximately 150 employees (based on LinkedIn data showing ~150 total employees).

## Competitive Advantages
- **Proprietary Compass Platform**: A unique, data-driven platform that functionally validates genetic variants, giving Maze a differentiated ability to identify and target disease-causing pathways that are often overlooked.
- **Focus on Common Diseases**: Unlike many precision medicine companies that focus on rare diseases, Maze targets large, unmet medical needs (e.g., chronic kidney disease), which represents a massive market opportunity.
- **Strong Genetic Foundation**: The company’s entire strategy is built on robust human genetic evidence, reducing the risk of late-stage clinical failures and increasing the probability of success.
- **Experienced Leadership Team**: The team includes veterans from leading biotech and pharma companies (Gilead, Genentech, Amgen), providing deep industry expertise in drug development and commercialization.

## Strategic Focus
- **Advance Lead Programs**: Primary focus is on progressing MZE829 through Phase 2/3 trials for APOL1-mediated kidney disease and advancing MZE782 for CKD and PKU.
- **Expand Pipeline**: Leveraging the Compass platform to identify and develop additional precision medicines for renal, cardiovascular, and metabolic diseases.
- **Clinical Data Generation**: Delivering key clinical readouts to support regulatory filings and potential partnerships.
- **Commercial Preparation**: Building the infrastructure and team (e.g., Senior Director, Talent Acquisition; Senior Director, Pharmaceutical Development) to prepare for potential late-stage success and launch.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "harnessing the power of genetics to transform the lives of patients," with core values of "Impact Obsessed," "Stand True" (integrity), and "Further Together" (teamwork and resilience).
- **Supportive Work Environment**: Maze promotes a culture that encourages "vision, initiative, and the development of talent," with a "stimulating atmosphere where people enjoy coming to work."
- **Comprehensive Benefits**: Offers "comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of employees and their families."
- **Equal Opportunity Employer**: Committed to diversity and non-discrimination.
- **Growth Trajectory**: As a public clinical-stage company with positive clinical data and a 120% increase in job postings year-over-year, there are significant opportunities for career growth and impact.
- **Location**: Based in South San Francisco (a major biotech hub), though specific remote/hybrid policy is not publicly detailed.

## Sources
1. [mazetx.com](https://mazetx.com/)
2. [mazetx.com](https://mazetx.com/about-us/)
3. [mazetx.com](https://mazetx.com/careers/)
4. [cbinsights.com](https://www.cbinsights.com/company/maze-therapeutics)
5. [linkedin.com](https://www.linkedin.com/company/mazetx)

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