--- title: 'Senior Project Manager at Iovance Biotherapeutics' canonical: 'https://feeny.ai/job/senior-project-manager-iovance-biotherapeutics-philadelphia-544ts29ssrxz' type: 'job' last_seen: '2026-09-10' --- # Senior Project Manager at Iovance Biotherapeutics - **Company:** Iovance Biotherapeutics - **Location:** Philadelphia, PA - **Posted:** 2026-08-27 - **Last confirmed live:** 2026-09-10 - **Apply:** https://job-boards.greenhouse.io/iovancebiotherapeutics/jobs/5406391008 ## Job description Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. ## Overview The Senior Project Manager will play a key role in the development, management, and execution of Iovance’s manufacturing sites’ project portfolios in Philadelphia, PA, reporting to the Senior Director, Operational Excellence.  This experienced individual will shape project management processes and standards and provide guidance to less experienced project managers.  The role will be responsible for planning, leading, and managing the successful execution of complex cross-functional projects aligned with site and company objectives and priorities.  This role will also be responsible for establishing and reporting on key portfolio and project metrics in support of on time and within budget project deliverables. As a member of the Operational Excellence department, this individual will act as a change agent to instill a culture of continuous improvement and support building capabilities to enable individuals and teams to identify opportunities for improvement and independently implement solutions. Essential Functions and Responsibilities - Shape project management processes and standards and provide guidance to less experienced project managers. - Engage with senior leaders, sponsors, and stakeholders to ensure alignment of projects with organizational strategy. - Identify and mitigate risks at a portfolio level and develop strategies for risk management that affect multiple projects or the organization. - In collaboration with cross-functional teams, create, establish, and maintain integrated project plans. - Lead and facilitate complex cross-functional projects with minimal oversight through all life cycle phases: initiation and feasibility, planning and design, execution, and closing. - Deliver timely, high-quality output on multiple projects simultaneously by utilizing project management skills including clear project charters, timeline and budget management, data collection and analysis, and communication plans. Utilize escalation plans and countermeasures when outcomes, timelines, or budgets are at risk. - Identify interdependencies, critical path and at-risk activities, anticipate bottlenecks, and help remove barriers to progress against department or corporate goals. - Establish, monitor, and report on portfolio and project progress to senior leadership utilizing status / dashboard reports. - Act as a subject matter expert coaching all levels of the organization in project management concepts, best practices, and tool application to increase the capability of the business. - Build productive internal and external working relationships with stakeholders in a matrix organization. - Identify and initiate process improvements as appropriate. - Support the vision of Operational Excellence and act as a change agent to instill a continuous improvement culture throughout the organization. - Must adhere to Iovance Biotherapeutics’ core values, policies, procedures, and business ethics.Perform miscellaneous duties as assigned. Travel - May require travel based on business needs Required Education, Skills, and Knowledge - Bachelor’s degree in science, engineering, business, or other related field. - Project Management Professional or equivalent experience - 10+ years of industry and supervisory experience.  At least 8 years of experience managing and leading multiple complex projects effectively and efficiently in a matrix organization. - Ability to use predictive, agile and hybrid approaches to determine which way of working is best for each project. - Strong communication, interpersonal, influencing, change management, and people leadership skills. - Proactive, results oriented, self-starter with attention to detail and the ability to work both independently and collaboratively in a fast-paced setting. - Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities and ability to manage ambiguity. - Proficient with Microsoft Office (Excel, PowerPoint, and Outlook), Visio, and project management software including timeline visualization. Preferred Education, Skills, and Knowledge - Manufacturing experience, ideally in a Biopharmaceutical environment and/or Cell and Gene Therapy. - Change Management / Agent Training - Lean or Lean Six Sigma certification or training - Proficient with Smartsheet The physical demands described here represent those that an employee must meet to perform the essential functions of this job successfully. Reasonable accommodations may be made upon request to enable individuals to perform essential functions. Please contact Human Resources to request an accommodation. Physical Demands and Activities Required - Must be able to remain in a stationary position standing or sitting for prolonged periods of time. - Must be able to move about inside an office and exert up to 10 pounds of force occasionally or a negligible amount of force frequently or constantly to lift, carry, push, pull, or otherwise move objects. - Must have visual acuity to perform activities such as: preparing and analyzing data and figures, viewing a computer screen, and extensive reading. - This position requires repetitive motion, substantial movements (motions) of the wrist, hands, and/or fingers. - Must be able to communicate with others to exchange information. Mental - Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines Work Environment - This job works in a professional office environment and a manufacturing lab setting. - Potential exposure to latex, bleach, loud noise, lab equipment hazards, strong odors, and chemical/biochemical is possible. - Requires operating standard office equipment and keyboards. #LI-onsite The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time. Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer, our employees and applicants will be considered without regard to an individual’s race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities, please contact careers@iovance.com. By voluntarily providing information and clicking “Submit Application”, you explicitly consent to the collection and use of your personal information for the purposes described above and in our [Candidate Privacy Notice](https://www.iovance.com/privacy-policy/). ## About Iovance Biotherapeutics ## Company Overview - **One-liner**: Iovance Biotherapeutics is pioneering tumor infiltrating lymphocyte (TIL) cell therapies to develop personalized, one-time treatments for solid tumor cancers. - **Entity Type**: Public (NASDAQ: IOVA) - **Headquarters**: San Carlos, California, USA - **Founded**: 2007 (originally named Lion Biotechnologies, renamed Iovance Biotherapeutics in 2017) - **Founders**: Not publicly available (the company was formed through a merger and rebranding) ## Core Business - **Primary industry**: Biotechnology — Cell Therapy (Immuno-Oncology) - **Target customers**: B2B / B2G — Healthcare providers, clinical trial sites, and ultimately patients with advanced solid tumors (melanoma, non-small cell lung cancer, endometrial cancer, etc.) - **Mission or purpose statement**: To be the global leader in innovating, developing, and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer, harnessing the immune system to recognize and attack diverse cancer cells. ## Products & Services - **Lifileucel (IOV-009)**: A one-time, personalized TIL therapy for advanced melanoma. It is the first approved TIL therapy for a solid tumor (FDA approved in early 2024 under the brand name Amtagvi). - **IOV-LUN-202**: An investigational TIL therapy for advanced non-small cell lung cancer (NSCLC) currently in Phase 2 clinical trials. - **IOV-END-201**: An investigational TIL therapy for advanced endometrial cancer currently in Phase 2 clinical trials. - **IOV-4001**: A next-generation, gene-edited TIL therapy (using TALEN technology to inactivate PD-1 expression) for solid tumors, currently in preclinical/early clinical development. - **IOV-3001**: An engineered IL-2 therapy (licensed from Novartis) designed to support TIL therapy efficacy, currently in preclinical development. - **Cell Therapy Manufacturing (iCTC)**: The company operates a 136,000-square-foot, state-of-the-art Cell Therapy Center in Philadelphia, PA, for proprietary GMP manufacturing of TIL therapies. ## Market Standing - **Valuation/Market Cap**: As of early 2026, market capitalization is approximately $2.5–3.0 billion (fluctuates with FDA news and clinical data). Check current price on NASDAQ: IOVA. - **Key Metric (Revenue)**: Iovance generated its first commercial revenue from Lifileucel/Amtagvi in 2024. Annual revenue for 2025 was approximately $180–220 million (estimate based on analyst reports; exact figure not yet fully disclosed). The company is not yet profitable. - **Key Metric (Funding)**: As a public company, Iovance has raised over $1.5 billion through public offerings and debt financings. Notable recent raise: a public offering in 2022 and subsequent at-the-market offerings. - **Notable Investors/Partners**: - Novartis (license partner for IOV-3001) - Major institutional investors (e.g., BlackRock, Vanguard, and several healthcare-focused funds) - Collaborations with major cancer centers for clinical trials (e.g., MD Anderson, Memorial Sloan Kettering, etc.) - **Growth Signals**: - FDA approval of Lifileucel (Amtagvi) in early 2024 — a landmark first-in-class approval for TIL therapy in solid tumors. - Rapid commercial launch and expansion of treatment centers across the U.S. - Multiple ongoing Phase 2/3 trials in large indications (NSCLC, endometrial cancer, frontline melanoma). - Investment in next-generation gene-edited TIL (IOV-4001) and engineered IL-2 (IOV-3001) to improve efficacy and expand addressable patient populations. ## Competitive Advantages - **First-to-market TIL therapy**: Iovance is the only company with an FDA-approved TIL therapy for a solid tumor (Amtagvi for melanoma), giving it a significant head start in manufacturing, commercial infrastructure, and physician education. - **Proprietary manufacturing platform**: The in-house iCTC facility in Philadelphia enables scalable, standardized GMP production of personalized TIL therapies, a major barrier to entry for competitors. - **Broad solid tumor pipeline**: Unlike CAR-T therapies (primarily effective in blood cancers), TIL therapy has shown promise across multiple solid tumor types, providing a large addressable market. - **Polyclonal T cell approach**: The therapy targets a broad range of neoantigens unique to each patient’s tumor, potentially reducing the risk of immune escape compared to single-target therapies. ## Strategic Focus - **Commercial expansion**: Scaling up the launch of Amtagvi for advanced melanoma and expanding treatment center network globally. - **Pipeline acceleration**: Advancing pivotal trials in NSCLC (IOV-LUN-202) and endometrial cancer (IOV-END-201) to secure additional FDA approvals. - **Next-generation innovation**: Developing gene-edited TIL (IOV-4001) to enhance persistence and efficacy, and engineered IL-2 (IOV-3001) to improve the TIL therapy cycle. - **Manufacturing optimization**: Continuing to improve manufacturing efficiency and turnaround time at the iCTC facility to support growing demand and reduce costs. ## Why Work Here - **Mission-driven culture**: The company is deeply patient-centric, with a clear focus on delivering transformative therapies to cancer patients. Employees often cite the meaningful impact of their work as a key motivator. - **Values**: Integrity, agility, innovation, collaboration, and excellence are core to the company’s operating philosophy. The culture emphasizes transparency, teamwork, and high ethical standards. - **Diversity, Equity, and Inclusion**: Iovance has a stated commitment to DEI, recognizing that internal diversity is critical to serving diverse patient populations and driving innovation. - **Remote/Hybrid policy**: Many roles (especially in clinical, medical affairs, marketing, and commercial functions) are remote or hybrid. Laboratory and manufacturing roles are based on-site in Philadelphia, PA (iCTC) or San Carlos, CA (HQ). - **Benefits**: Competitive salaries, annual cash bonuses, long-term incentives (stock options/RSUs), 401(k) with match, Employee Stock Purchase Plan, comprehensive medical/dental/vision (low employee cost), Health Savings Account contributions, paid parental leave, tuition assistance, wellness program (gym discounts), and professional development opportunities. - **Work environment**: Agile and fast-paced, typical of a biotech company at a critical growth stage. The company values data-driven decision-making and encourages employees to bring their best efforts every day. ## Sources 1. [iovance.com](https://www.iovance.com/) 2. [iovance.com - About Us](https://www.iovance.com/about-iovance-biotherapeutics/) 3. [iovance.com - Culture](https://www.iovance.com/culture/) 4. 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