---
title: 'Senior/Research Associate, mRNA Engineering at NewLimit'
canonical: 'https://feeny.ai/job/senior-research-associate-mrna-engineering-newlimit-south-san-francisco-h10v20kcztq2'
type: 'job'
last_seen: '2026-11-06'
---

# Senior/Research Associate, mRNA Engineering at NewLimit

- **Company:** NewLimit
- **Location:** South San Francisco, CA
- **Posted:** 2026-10-20
- **Last confirmed live:** 2026-11-06
- **Apply:** https://job-boards.greenhouse.io/newlimit/jobs/6230282004

## Job description

## About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

We are seeking a Research Associate to join our mRNA Engineering team. In this role, you will generate the mRNAs that power NewLimit's research programs, executing the workflow from DNA template through in vitro transcription (IVT) and downstream purification. You will produce research grade mRNA materials, keep rigorous records of how each batch was made, and work closely with scientists across our research and Delivery Sciences teams. This is a lab-based role ideal for an early-career scientist who wants to build deep expertise in mRNA process development in a fast-paced research environment. You will receive hands-on training from expert scientists and see the direct impact of your work on our programs.

## What you'll do

As a member of our team, you will:

mRNA production

- Execute established protocols for DNA template preparation, in vitro transcription, and downstream purification to generate research-grade mRNA
- Run routine analytical assays to assess mRNA integrity and purity
- Under the guidance of senior scientists, help troubleshoot production issues and contribute to experiments that optimize yield, purity, and recovery

Documentation and lab operations

- Maintain detailed, accurate records of all experiments in Electronic Lab Notebooks
- Follow and help maintain SOPs; contribute to drafting and updating protocols as workflows evolve
- Manage raw material and mRNA inventory, including sample tracking, storage, and reagent ordering
- Maintain lab equipment and follow lab safety practices

Collaboration

- Work closely with Delivery Sciences and research teams to coordinate material needs and hand off mRNA for downstream studies
- Present experiment results at team meetings

## Requirements

- B.S. in Life Sciences, Chemistry, Engineering, or a related field with 1-2 years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
- Hands-on experience with molecular biology techniques such as cloning, nucleic acid purification, PCR, and gel electrophoresis
- Strong attention to detail and good documentation practices
- Ability to execute protocols accurately and manage multiple tasks efficiently
- Excellent communication and organizational skills
- Interest in mRNA process science and eagerness to learn new techniques

## Nice to have

- Experience producing mRNA through IVT and downstream purification
- Familiarity with plasmid and mRNA analytics such as HPLC, UV-Vis, and TapeStation/CGE
- Experience with plasmid DNA preparation and linearization
- Exposure to column-based purification and tangential flow filtration (TFF)
- Familiarity with automation liquid handling-based methods for mRNA purification, including experience operating such as Hamiltons and Tecans

## Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site

Salary Range: $75,000 - $100,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers

*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

## About NewLimit

## Company Overview
- **One-liner**: NewLimit is a biotechnology company developing epigenetic reprogramming medicines to radically extend human healthspan by reversing cellular aging.
- **Entity Type**: Private (Series B)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2022
- **Founders**: Jacob Kimmel (Co-founder & President), Brian Armstrong (Co-founder), Blake Byers (Co-founder)

## Core Business
- **Primary industry/industries**: Biotechnology, Epigenetic Reprogramming, Longevity Therapeutics, Drug Discovery
- **Target customers**: B2B (pharmaceutical partners, clinical development), B2C (ultimately patients with age-related diseases)
- **Mission or purpose statement**: To radically extend human healthspan by creating the first medicines that reverse cellular aging at the epigenetic level.

## Products & Services
- **Discovery Engine**: An AI-powered platform that designs epigenetic payloads to make old cells look and act young. It tests thousands of designs simultaneously using genomics and retrains models iteratively on new data.
- **Therapeutics (Pipeline)**: Medicines focused on restoring youthful function in the liver, immune system, and vasculature. Initial programs target diseases resembling accelerated aging, with the goal of restoring youthful metabolism, energy levels, resilience to disease, and cognition.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed
- **Key Metric**: Total Funding of **$215M** (across three rounds); Annual Revenue estimated at **$12.8M** [linkedin.com](https://linkedin.com/company/newlimit)
- **Notable Investors/Partners**: Kleiner Perkins (led Series B), Valor Equity Partners, Quiet Capital, S32, Duke University Management Company, Liberty Mutual Investments, Fred Ehrsam, Elad Gil, Joe Lonsdale, Eric Schmidt, Garry Tan, Brian Armstrong, Blake Byers [newlimit.com](https://www.newlimit.com/company)
- **Growth Signals**: 44 employees (+40.5% YoY), 12 active job postings (+100% YoY), LinkedIn followers grew 157.6% in the past year, and the company closed a $130M Series B in May 2025 led by Kleiner Perkins [linkedin.com](https://linkedin.com/company/newlimit).

## Competitive Advantages
- **Proprietary AI Platform**: A frontier intelligence system that designs, tests, and retrains models on epigenetic reprogramming at unprecedented scale.
- **Scientific Moats**: Deep expertise in epigenetic reprogramming (a validated but complex mechanism for reversing cellular age); a team with backgrounds from Calico, UCSF, and Stanford.
- **Founding Team & Backing**: Co-founded by Brian Armstrong (CEO of Coinbase) and Blake Byers (early investor in OpenAI, Anthropic, Neuralink), providing deep capital access and a culture of ambitious, long-term execution.

## Strategic Focus
- **Current priorities**: Advancing pipeline programs into the clinic (Head of Clinical Development role is open); scaling the Discovery Engine; building the team across computational biology, immunology, and manufacturing.
- **Direction for growth**: Transition from a discovery-stage R&D company to a clinical-stage therapeutics company; generating large revenue streams to fund the mission; expanding into new cell types and disease areas.

## Why Work Here
- **Culture**: "Not for the faint of heart" — a high-performance, mission-focused team. No pure management roles; everyone executes. Values include safety then speed, clear communication, inherent optimism, independent thinking, and top talent in every seat [newlimit.com](https://www.newlimit.com/careers).
- **Remote/Hybrid/Office**: Likely on-site/hybrid given the lab-based nature of the work (headquarters in South San Francisco).
- **Notable Perks**: Competitive salaries, comprehensive health benefits (medical, dental, vision), equity packages, 401(k) with up to 4% match, generous parental leave, 20 days PTO + 15 holidays, free EV charging [newlimit.com](https://www.newlimit.com/careers).
- **Engineering Culture**: Strong emphasis on computational biology, machine learning, and functional genomics. The team spans both wet-lab and dry-lab disciplines, with a focus on building scalable methods and iterative data-driven discovery.

## Sources
1. [NewLimit Website](https://www.newlimit.com/)
2. [NewLimit Careers Page](https://www.newlimit.com/careers)
3. [NewLimit Company Page](https://www.newlimit.com/company)
4. [NewLimit Team Page](https://www.newlimit.com/team)
5. [NewLimit LinkedIn Page](https://www.linkedin.com/company/newlimit)

## Other roles at NewLimit

- [Group Lead, Immunology](https://feeny.ai/job/group-lead-immunology-newlimit-south-san-francisco-wfjbzx3hytgf) — South San Francisco, CA
- [Scientist, mRNA Downstream Purification](https://feeny.ai/job/scientist-mrna-downstream-purification-newlimit-south-san-francisco-2a496dgy9747) — South San Francisco, CA
- [Scientist, mRNA Analytical Development](https://feeny.ai/job/scientist-mrna-analytical-development-newlimit-south-san-francisco-e26js8ad15e6) — South San Francisco, CA
- [Scientist- Delivery Sciences-targeted LNPs (tLNPs)](https://feeny.ai/job/scientist-delivery-sciences-targeted-lnps-tlnps-newlimit-south-san-francisco-xpfgfvhhqns1) — South San Francisco, CA
- [Scientist, Metabolism](https://feeny.ai/job/scientist-metabolism-newlimit-south-san-francisco-5k9gbm6gpcwn) — South San Francisco, CA
- [Senior/Research Associate, Single Cell Technology](https://feeny.ai/job/senior-research-associate-single-cell-technology-newlimit-south-san-francisco-mxftfy5f8ab1) — South San Francisco, CA
- [Senior Scientist / Scientist, In Vivo Pharmacology](https://feeny.ai/job/senior-scientist-scientist-in-vivo-pharmacology-newlimit-south-san-francisco-t4a3w08ps5rd) — South San Francisco, CA
- [Senior Manager, Lab Operations](https://feeny.ai/job/senior-manager-lab-operations-newlimit-south-san-francisco-2s9yfb1zrv9n) — South San Francisco, CA
- [Director / Senior Director, Clinical Operations](https://feeny.ai/job/director-senior-director-clinical-operations-newlimit-south-san-francisco-3myq4z294a7c) — South San Francisco, CA
- [Talent Lead](https://feeny.ai/job/talent-lead-newlimit-south-san-francisco-gyv2et7crq90) — South San Francisco, CA